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Illumina Body Map 2, young vs old

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Results for MECOM

Z-value: 0.11

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Transcription factors associated with MECOM

Gene Symbol Gene ID Gene Info
MECOM
ENSG00000085276.13 MDS1 and EVI1 complex locus

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MECOMhg19_v2_chr3_-_168864427_168864464-0.106.0e-01Click!

Activity profile of MECOM motif

Sorted Z-values of MECOM motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_24722995 1.80 ENST00000581714.1
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr12_-_86650154 1.68 ENST00000552435.2
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr12_-_86650045 1.68 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr10_-_21186144 1.56 ENST00000377119.1
NEBL
nebulette
chr7_+_35756092 1.45 ENST00000458087.3
AC018647.3
AC018647.3
chr7_+_35756186 1.43 ENST00000430518.1
AC018647.3
AC018647.3
chr3_-_178103144 1.39 ENST00000417383.1
ENST00000418585.1
ENST00000411727.1
ENST00000439810.1
RP11-33A14.1
RP11-33A14.1
chr1_+_74701062 1.37 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr12_-_86650077 1.32 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_+_172422026 1.26 ENST00000367725.4
C1orf105
chromosome 1 open reading frame 105
chr1_+_109102652 1.19 ENST00000370035.3
ENST00000405454.1
FAM102B
family with sequence similarity 102, member B
chr5_-_96209315 1.11 ENST00000504056.1
CTD-2260A17.2
Uncharacterized protein
chr13_-_103053946 1.10 ENST00000376131.4
FGF14
fibroblast growth factor 14
chr15_-_64673630 1.10 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr16_-_27899478 1.07 ENST00000380897.3
GSG1L
GSG1-like
chr12_+_20848377 1.07 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr4_-_88449771 1.04 ENST00000535835.1
SPARCL1
SPARC-like 1 (hevin)
chr1_+_86934526 1.01 ENST00000394711.1
CLCA1
chloride channel accessory 1
chr8_-_27115903 0.98 ENST00000350889.4
ENST00000519997.1
ENST00000519614.1
ENST00000522908.1
ENST00000265770.7
STMN4
stathmin-like 4
chr7_+_97361388 0.95 ENST00000350485.4
ENST00000346867.4
TAC1
tachykinin, precursor 1
chr9_+_109213096 0.94 ENST00000425709.1
RP11-308N19.1
RP11-308N19.1
chr1_-_157811588 0.94 ENST00000368174.4
CD5L
CD5 molecule-like
chr15_-_37392086 0.93 ENST00000561208.1
MEIS2
Meis homeobox 2
chr5_-_11903337 0.93 ENST00000502551.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr10_-_69455873 0.92 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr6_+_29624898 0.90 ENST00000396704.3
ENST00000483013.1
ENST00000490427.1
ENST00000416766.2
ENST00000376891.4
ENST00000376898.3
ENST00000396701.2
ENST00000494692.1
ENST00000431798.2
MOG
myelin oligodendrocyte glycoprotein
chr6_+_69942298 0.89 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr8_-_38008783 0.88 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr3_-_167371740 0.87 ENST00000466760.1
ENST00000479765.1
WDR49
WD repeat domain 49
chr10_-_50122277 0.84 ENST00000374160.3
LRRC18
leucine rich repeat containing 18
chr15_-_79103757 0.83 ENST00000388820.4
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr1_+_50569575 0.79 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr6_+_44310376 0.78 ENST00000515220.1
ENST00000323108.8
SPATS1
spermatogenesis associated, serine-rich 1
chr2_-_145275211 0.77 ENST00000462355.1
ZEB2
zinc finger E-box binding homeobox 2
chr11_+_44748361 0.77 ENST00000533202.1
ENST00000533080.1
ENST00000520358.2
ENST00000520999.2
TSPAN18
tetraspanin 18
chr12_+_106976678 0.76 ENST00000392842.1
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr8_-_27115931 0.76 ENST00000523048.1
STMN4
stathmin-like 4
chr20_+_32782375 0.74 ENST00000568305.1
ASIP
agouti signaling protein
chr3_+_152552685 0.72 ENST00000305097.3
P2RY1
purinergic receptor P2Y, G-protein coupled, 1
chr1_-_161193349 0.72 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr12_-_21556577 0.71 ENST00000450590.1
ENST00000453443.1
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr5_+_118965244 0.71 ENST00000515256.1
ENST00000509264.1
FAM170A
family with sequence similarity 170, member A
chr12_+_12202785 0.71 ENST00000586576.1
ENST00000464885.2
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr15_-_37391507 0.71 ENST00000557796.2
ENST00000397620.2
MEIS2
Meis homeobox 2
chr18_-_22931103 0.70 ENST00000577461.1
ZNF521
zinc finger protein 521
chr12_+_20848282 0.69 ENST00000545604.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr1_+_214163033 0.68 ENST00000607425.1
PROX1
prospero homeobox 1
chr17_+_53344945 0.66 ENST00000575345.1
HLF
hepatic leukemia factor
chr2_-_145275109 0.66 ENST00000431672.2
ZEB2
zinc finger E-box binding homeobox 2
chr6_+_44310421 0.65 ENST00000288390.2
SPATS1
spermatogenesis associated, serine-rich 1
chr1_-_68962782 0.63 ENST00000456315.2
DEPDC1
DEP domain containing 1
chr19_-_14316980 0.63 ENST00000361434.3
ENST00000340736.6
LPHN1
latrophilin 1
chr8_-_122653630 0.63 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr7_-_8302164 0.62 ENST00000447326.1
ENST00000406470.2
ICA1
islet cell autoantigen 1, 69kDa
chr17_-_37308824 0.61 ENST00000415163.1
ENST00000441877.1
ENST00000444911.2
PLXDC1
plexin domain containing 1
chr1_-_68962805 0.61 ENST00000370966.5
DEPDC1
DEP domain containing 1
chr7_+_73275483 0.61 ENST00000320531.2
WBSCR28
Williams-Beuren syndrome chromosome region 28
chr2_-_39456673 0.60 ENST00000378803.1
ENST00000395035.3
CDKL4
cyclin-dependent kinase-like 4
chr4_-_88450372 0.60 ENST00000543631.1
SPARCL1
SPARC-like 1 (hevin)
chr9_+_127023704 0.60 ENST00000373596.1
ENST00000425237.1
NEK6
NIMA-related kinase 6
chr17_-_29648761 0.60 ENST00000247270.3
ENST00000462804.2
EVI2A
ecotropic viral integration site 2A
chr15_-_83837983 0.59 ENST00000562702.1
HDGFRP3
Hepatoma-derived growth factor-related protein 3
chr12_+_20848486 0.59 ENST00000545102.1
SLCO1C1
solute carrier organic anion transporter family, member 1C1
chr17_-_66951474 0.59 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr1_-_110155671 0.59 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr6_-_31514516 0.58 ENST00000303892.5
ENST00000483251.1
ATP6V1G2
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr5_-_83016632 0.58 ENST00000515590.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr1_-_232651312 0.57 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr5_-_127674883 0.57 ENST00000507835.1
FBN2
fibrillin 2
chr15_+_71185148 0.57 ENST00000443425.2
ENST00000560755.1
LRRC49
leucine rich repeat containing 49
chr11_+_5775923 0.57 ENST00000317254.3
OR52N4
olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)
chrX_-_49965663 0.57 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
AKAP4
A kinase (PRKA) anchor protein 4
chr7_-_6006768 0.56 ENST00000441023.2
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr4_-_88450244 0.55 ENST00000503414.1
SPARCL1
SPARC-like 1 (hevin)
chr3_-_145968900 0.54 ENST00000460350.1
PLSCR4
phospholipid scramblase 4
chr4_-_74847800 0.53 ENST00000296029.3
PF4
platelet factor 4
chr11_-_126810521 0.53 ENST00000530572.1
RP11-688I9.4
RP11-688I9.4
chr1_-_146696901 0.52 ENST00000369272.3
ENST00000441068.2
FMO5
flavin containing monooxygenase 5
chrX_-_101694853 0.52 ENST00000372749.1
NXF2B
nuclear RNA export factor 2B
chr17_-_66951382 0.52 ENST00000586539.1
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr13_+_49280951 0.52 ENST00000282018.3
CYSLTR2
cysteinyl leukotriene receptor 2
chr16_+_2867228 0.52 ENST00000005995.3
ENST00000574813.1
PRSS21
protease, serine, 21 (testisin)
chr4_-_185303418 0.52 ENST00000610223.1
ENST00000608785.1
RP11-290F5.1
RP11-290F5.1
chr7_-_6007070 0.52 ENST00000337579.3
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr15_+_71839566 0.51 ENST00000357769.4
THSD4
thrombospondin, type I, domain containing 4
chr14_-_25479811 0.51 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr11_+_60145997 0.51 ENST00000530614.1
ENST00000530027.1
ENST00000530234.2
ENST00000528215.1
ENST00000531787.1
MS4A7
MS4A14
membrane-spanning 4-domains, subfamily A, member 7
membrane-spanning 4-domains, subfamily A, member 14
chr12_+_57522439 0.51 ENST00000338962.4
LRP1
low density lipoprotein receptor-related protein 1
chr13_+_102142296 0.51 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr1_+_82266053 0.51 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr7_+_35756066 0.50 ENST00000449644.1
AC018647.3
AC018647.3
chr12_+_12202774 0.50 ENST00000589718.1
BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr3_+_119013185 0.49 ENST00000264245.4
ARHGAP31
Rho GTPase activating protein 31
chr15_-_30686052 0.49 ENST00000562729.1
CHRFAM7A
CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
chr7_+_17338239 0.49 ENST00000242057.4
AHR
aryl hydrocarbon receptor
chr19_+_48497901 0.49 ENST00000339841.2
ELSPBP1
epididymal sperm binding protein 1
chr19_+_48497962 0.49 ENST00000596043.1
ENST00000597519.1
ELSPBP1
epididymal sperm binding protein 1
chr9_-_112970436 0.48 ENST00000400613.4
C9orf152
chromosome 9 open reading frame 152
chr3_-_145968857 0.48 ENST00000433593.2
ENST00000476202.1
ENST00000460885.1
PLSCR4
phospholipid scramblase 4
chr8_-_133637624 0.48 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr3_-_145968923 0.48 ENST00000493382.1
ENST00000354952.2
ENST00000383083.2
PLSCR4
phospholipid scramblase 4
chrX_+_101502170 0.48 ENST00000372757.1
NXF2
nuclear RNA export factor 2
chr15_-_30261066 0.47 ENST00000558447.1
TJP1
tight junction protein 1
chr8_+_110374683 0.46 ENST00000378402.5
PKHD1L1
polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
chr3_-_193272874 0.46 ENST00000342695.4
ATP13A4
ATPase type 13A4
chr7_+_6797288 0.46 ENST00000433859.2
ENST00000359718.3
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chr7_-_8302298 0.45 ENST00000446305.1
ICA1
islet cell autoantigen 1, 69kDa
chrY_+_15418467 0.45 ENST00000595988.1
AC010877.1
Uncharacterized protein
chr15_-_48470558 0.45 ENST00000324324.7
MYEF2
myelin expression factor 2
chr1_-_91182794 0.44 ENST00000370445.4
BARHL2
BarH-like homeobox 2
chrX_+_86772787 0.44 ENST00000373114.4
KLHL4
kelch-like family member 4
chr12_+_7169887 0.43 ENST00000542978.1
C1S
complement component 1, s subcomponent
chrX_+_30261847 0.43 ENST00000378981.3
ENST00000397550.1
MAGEB1
melanoma antigen family B, 1
chr9_-_13175823 0.43 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr16_+_33204156 0.43 ENST00000398667.4
TP53TG3C
TP53 target 3C
chrX_-_43741594 0.42 ENST00000536181.1
ENST00000378069.4
MAOB
monoamine oxidase B
chr5_+_171621176 0.42 ENST00000398186.4
EFCAB9
EF-hand calcium binding domain 9
chr7_-_8302207 0.42 ENST00000407906.1
ICA1
islet cell autoantigen 1, 69kDa
chr2_+_97779233 0.42 ENST00000461153.2
ENST00000420699.2
ANKRD36
ankyrin repeat domain 36
chr1_+_3668962 0.42 ENST00000294600.2
CCDC27
coiled-coil domain containing 27
chr5_+_167956121 0.42 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr10_+_29577974 0.42 ENST00000375500.3
LYZL1
lysozyme-like 1
chr8_-_114449112 0.41 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CSMD3
CUB and Sushi multiple domains 3
chr15_-_48470544 0.40 ENST00000267836.6
MYEF2
myelin expression factor 2
chr2_-_145275828 0.40 ENST00000392861.2
ENST00000409211.1
ZEB2
zinc finger E-box binding homeobox 2
chr17_-_37309480 0.40 ENST00000539608.1
PLXDC1
plexin domain containing 1
chr1_-_85156417 0.40 ENST00000422026.1
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr17_+_53345080 0.39 ENST00000572002.1
HLF
hepatic leukemia factor
chr4_+_189060573 0.39 ENST00000332517.3
TRIML1
tripartite motif family-like 1
chr4_+_71200681 0.38 ENST00000273936.5
CABS1
calcium-binding protein, spermatid-specific 1
chr3_+_57875711 0.38 ENST00000442599.2
SLMAP
sarcolemma associated protein
chr7_+_6796986 0.38 ENST00000297186.3
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chr2_-_224467093 0.38 ENST00000305409.2
SCG2
secretogranin II
chr1_-_157069590 0.38 ENST00000454449.2
ETV3L
ets variant 3-like
chr12_-_85430024 0.37 ENST00000547836.1
ENST00000532498.2
TSPAN19
tetraspanin 19
chr5_+_140739537 0.37 ENST00000522605.1
PCDHGB2
protocadherin gamma subfamily B, 2
chr16_+_14280564 0.37 ENST00000572567.1
MKL2
MKL/myocardin-like 2
chr16_+_9449445 0.37 ENST00000564305.1
RP11-243A14.1
RP11-243A14.1
chr3_-_119379427 0.36 ENST00000264231.3
ENST00000468801.1
ENST00000538678.1
POPDC2
popeye domain containing 2
chr2_+_44066101 0.36 ENST00000272286.2
ABCG8
ATP-binding cassette, sub-family G (WHITE), member 8
chr11_+_17316870 0.36 ENST00000458064.2
NUCB2
nucleobindin 2
chr16_-_80673633 0.36 ENST00000561616.1
CDYL2
chromodomain protein, Y-like 2
chr17_-_56494882 0.36 ENST00000584437.1
RNF43
ring finger protein 43
chr7_-_121944491 0.35 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chrX_-_62974941 0.35 ENST00000374872.1
ENST00000253401.6
ENST00000374870.4
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr6_-_56492816 0.35 ENST00000522360.1
DST
dystonin
chr14_+_29236269 0.35 ENST00000313071.4
FOXG1
forkhead box G1
chr18_-_67624160 0.34 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr5_+_121465234 0.34 ENST00000504912.1
ENST00000505843.1
ZNF474
zinc finger protein 474
chr7_-_112726393 0.33 ENST00000449591.1
ENST00000449735.1
ENST00000438062.1
ENST00000424100.1
GPR85
G protein-coupled receptor 85
chr6_+_89674246 0.33 ENST00000369474.1
AL079342.1
Uncharacterized protein; cDNA FLJ27030 fis, clone SLV07741
chr19_+_15121532 0.33 ENST00000292574.3
CCDC105
coiled-coil domain containing 105
chr12_-_81763184 0.33 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr19_-_53632912 0.32 ENST00000601215.1
ZNF415
zinc finger protein 415
chr5_-_115910091 0.32 ENST00000257414.8
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr5_+_20616500 0.32 ENST00000512688.1
RP11-774D14.1
RP11-774D14.1
chr12_-_81763127 0.32 ENST00000541017.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr6_+_46714654 0.31 ENST00000565422.1
ANKRD66
ankyrin repeat domain 66
chr2_-_56150910 0.31 ENST00000424836.2
ENST00000438672.1
ENST00000440439.1
ENST00000429909.1
ENST00000424207.1
ENST00000452337.1
ENST00000355426.3
ENST00000439193.1
ENST00000421664.1
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr10_+_78078088 0.30 ENST00000496424.2
C10orf11
chromosome 10 open reading frame 11
chr6_+_46714680 0.30 ENST00000536046.1
ANKRD66
ankyrin repeat domain 66
chr17_-_56494908 0.30 ENST00000577716.1
RNF43
ring finger protein 43
chr15_+_100348193 0.30 ENST00000558188.1
CTD-2054N24.2
Uncharacterized protein
chr3_-_193272741 0.30 ENST00000392443.3
ATP13A4
ATPase type 13A4
chr9_+_82186682 0.30 ENST00000376552.2
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr7_-_15601595 0.30 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr8_-_6420565 0.30 ENST00000338312.6
ANGPT2
angiopoietin 2
chr1_+_209859510 0.30 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_-_104238574 0.30 ENST00000425410.1
AMY1B
amylase, alpha 1B (salivary)
chr1_-_68962744 0.29 ENST00000525124.1
DEPDC1
DEP domain containing 1
chr12_-_95945246 0.29 ENST00000258499.3
USP44
ubiquitin specific peptidase 44
chr12_+_85430110 0.29 ENST00000393212.3
ENST00000393217.2
LRRIQ1
leucine-rich repeats and IQ motif containing 1
chr11_+_61008514 0.29 ENST00000312403.5
PGA5
pepsinogen 5, group I (pepsinogen A)
chr6_-_49917157 0.29 ENST00000398721.2
DEFB133
defensin, beta 133
chr2_+_172543919 0.29 ENST00000452242.1
ENST00000340296.4
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr12_-_129570545 0.29 ENST00000389441.4
TMEM132D
transmembrane protein 132D
chr6_+_49431073 0.29 ENST00000335783.3
CENPQ
centromere protein Q
chr2_+_172543967 0.28 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr20_-_52645231 0.28 ENST00000448484.1
BCAS1
breast carcinoma amplified sequence 1
chr12_+_96588368 0.28 ENST00000547860.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr2_-_1629176 0.28 ENST00000366424.2
AC144450.2
AC144450.2
chr2_-_145275228 0.27 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2
zinc finger E-box binding homeobox 2
chr12_+_57522258 0.27 ENST00000553277.1
ENST00000243077.3
LRP1
low density lipoprotein receptor-related protein 1
chr8_+_72740402 0.27 ENST00000521467.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr11_-_94965667 0.27 ENST00000542176.1
ENST00000278499.2
SESN3
sestrin 3
chr12_-_24097236 0.27 ENST00000538083.1
SOX5
SRY (sex determining region Y)-box 5
chr5_-_171404730 0.27 ENST00000518752.1
FBXW11
F-box and WD repeat domain containing 11
chr11_-_104769141 0.26 ENST00000508062.1
ENST00000422698.2
CASP12
caspase 12 (gene/pseudogene)
chr2_+_172544294 0.26 ENST00000358002.6
ENST00000435234.1
ENST00000443458.1
ENST00000412370.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr4_-_76944621 0.26 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr7_-_30008849 0.26 ENST00000409497.1
SCRN1
secernin 1
chr12_+_57522692 0.26 ENST00000554174.1
LRP1
low density lipoprotein receptor-related protein 1
chr12_+_41831485 0.25 ENST00000539469.2
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4
chr3_-_119379719 0.25 ENST00000493094.1
POPDC2
popeye domain containing 2
chr14_-_102701740 0.25 ENST00000561150.1
ENST00000522867.1
MOK
MOK protein kinase
chr8_-_39695719 0.25 ENST00000347580.4
ENST00000379853.2
ENST00000521880.1
ADAM2
ADAM metallopeptidase domain 2
chr19_-_35981358 0.25 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr3_-_149093499 0.25 ENST00000472441.1
TM4SF1
transmembrane 4 L six family member 1
chr8_+_58658679 0.24 ENST00000518934.1
CTD-2339F6.1
CTD-2339F6.1
chr9_+_82186872 0.24 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.2 0.7 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.2 2.1 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 0.7 GO:2000979 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 0.9 GO:0018963 insecticide metabolic process(GO:0017143) phthalate metabolic process(GO:0018963)
0.2 1.0 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.2 2.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 0.6 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.7 GO:0060406 positive regulation of penile erection(GO:0060406)
0.1 0.4 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.1 1.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 0.4 GO:1904730 negative regulation of intestinal phytosterol absorption(GO:0010949) negative regulation of intestinal cholesterol absorption(GO:0045796) intestinal phytosterol absorption(GO:0060752) negative regulation of intestinal lipid absorption(GO:1904730)
0.1 0.6 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.5 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.1 1.4 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.4 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.8 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 2.3 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.1 0.5 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.1 0.5 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.1 1.1 GO:0042908 xenobiotic transport(GO:0042908)
0.1 0.8 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1 0.2 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 0.2 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 0.4 GO:0018032 protein amidation(GO:0018032)
0.1 0.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.5 GO:0017121 phospholipid scrambling(GO:0017121)
0.1 0.6 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.1 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 0.6 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.4 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.4 GO:0010269 response to selenium ion(GO:0010269)
0.0 0.1 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.2 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.2 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 1.6 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.3 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.3 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.2 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 1.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 2.5 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.5 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 1.0 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.1 GO:0018277 protein deamination(GO:0018277)
0.0 0.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 1.0 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.4 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.4 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.1 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.0 0.4 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.3 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 0.5 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.4 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 1.6 GO:0008542 visual learning(GO:0008542)
0.0 0.3 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.1 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.2 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:1901189 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.3 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.5 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.3 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0001834 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.3 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0097679 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679)
0.1 0.5 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.1 0.3 GO:0044299 C-fiber(GO:0044299)
0.1 0.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.5 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 0.4 GO:0031673 H zone(GO:0031673)
0.1 0.9 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.0 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.9 GO:0005916 fascia adherens(GO:0005916)
0.0 0.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 1.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 0.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.4 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.2 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.5 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 1.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.4 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.3 GO:0042599 lamellar body(GO:0042599)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.7 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.3 1.0 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.3 2.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.3 1.8 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.2 0.7 GO:0031685 adenosine receptor binding(GO:0031685)
0.2 0.7 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.2 0.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.4 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.1 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.4 GO:0031013 troponin I binding(GO:0031013)
0.1 0.5 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 0.3 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.7 GO:0031781 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 0.4 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.5 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 1.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.7 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.9 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 0.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.6 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 1.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.4 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 1.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 1.6 GO:0031005 filamin binding(GO:0031005)
0.0 0.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.6 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 1.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 1.0 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 2.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.4 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.2 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.0 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.8 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.7 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.7 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.7 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 1.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines