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Illumina Body Map 2, young vs old

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Results for MEF2B

Z-value: 0.06

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Transcription factors associated with MEF2B

Gene Symbol Gene ID Gene Info
MEF2B
ENSG00000213999.11 myocyte enhancer factor 2B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Bhg19_v2_chr19_-_19302931_19302974-0.354.7e-02Click!

Activity profile of MEF2B motif

Sorted Z-values of MEF2B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_49393092 7.69 ENST00000421952.2
DDN
dendrin
chr11_-_19223523 7.64 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr5_+_53751445 6.73 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr2_+_170366203 6.48 ENST00000284669.1
KLHL41
kelch-like family member 41
chr12_-_111358372 6.40 ENST00000548438.1
ENST00000228841.8
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr1_-_26394114 6.02 ENST00000374272.3
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr2_+_88367299 5.70 ENST00000419482.2
ENST00000444564.2
SMYD1
SET and MYND domain containing 1
chr4_+_120056939 5.57 ENST00000307128.5
MYOZ2
myozenin 2
chr2_-_211168332 5.50 ENST00000341685.4
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr2_+_168043793 5.08 ENST00000409273.1
ENST00000409605.1
XIRP2
xin actin-binding repeat containing 2
chr6_-_123958051 4.98 ENST00000546248.1
TRDN
triadin
chr6_-_123957942 4.94 ENST00000398178.3
TRDN
triadin
chr2_+_88367368 4.45 ENST00000438570.1
SMYD1
SET and MYND domain containing 1
chr7_-_113559104 4.39 ENST00000284601.3
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr8_+_1993152 4.37 ENST00000262113.4
MYOM2
myomesin 2
chr6_-_123958111 4.31 ENST00000542443.1
TRDN
triadin
chr3_+_42727011 4.30 ENST00000287777.4
KLHL40
kelch-like family member 40
chr16_-_31439735 4.27 ENST00000287490.4
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr3_-_52486841 4.14 ENST00000496590.1
TNNC1
troponin C type 1 (slow)
chr5_+_191592 4.01 ENST00000328278.3
LRRC14B
leucine rich repeat containing 14B
chr10_-_69455873 4.01 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_+_167063282 3.93 ENST00000361200.2
DUSP27
dual specificity phosphatase 27 (putative)
chr8_+_1993173 3.90 ENST00000523438.1
MYOM2
myomesin 2
chr14_-_94421923 3.81 ENST00000555507.1
ASB2
ankyrin repeat and SOCS box containing 2
chr14_-_94421605 3.57 ENST00000556062.1
ASB2
ankyrin repeat and SOCS box containing 2
chr1_-_201391149 3.53 ENST00000555948.1
ENST00000556362.1
TNNI1
troponin I type 1 (skeletal, slow)
chr16_+_31225337 3.50 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr17_-_9694614 3.43 ENST00000330255.5
ENST00000571134.1
DHRS7C
dehydrogenase/reductase (SDR family) member 7C
chrX_-_15332665 3.42 ENST00000537676.1
ENST00000344384.4
ASB11
ankyrin repeat and SOCS box containing 11
chr3_-_39234074 3.41 ENST00000340369.3
ENST00000421646.1
ENST00000396251.1
XIRP1
xin actin-binding repeat containing 1
chr7_+_143013198 2.92 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr2_+_239047337 2.80 ENST00000409223.1
ENST00000305959.4
KLHL30
kelch-like family member 30
chr11_+_1860200 2.68 ENST00000381911.1
TNNI2
troponin I type 2 (skeletal, fast)
chr2_+_220299547 2.64 ENST00000312358.7
SPEG
SPEG complex locus
chr20_+_10199566 2.61 ENST00000430336.1
SNAP25
synaptosomal-associated protein, 25kDa
chrX_-_63450480 2.57 ENST00000362002.2
ASB12
ankyrin repeat and SOCS box containing 12
chr11_+_1860832 2.56 ENST00000252898.7
TNNI2
troponin I type 2 (skeletal, fast)
chr19_-_40324255 2.54 ENST00000593685.1
ENST00000600611.1
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr11_+_1860682 2.39 ENST00000381906.1
TNNI2
troponin I type 2 (skeletal, fast)
chr11_-_47374246 2.34 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
MYBPC3
myosin binding protein C, cardiac
chr3_-_192445289 2.28 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
FGF12
fibroblast growth factor 12
chr20_+_10199468 2.27 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr19_-_40324767 2.24 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr10_-_75415825 2.20 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr3_+_54157480 2.11 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr5_-_131347583 2.00 ENST00000379255.1
ENST00000430403.1
ENST00000544770.1
ENST00000379246.1
ENST00000414078.1
ENST00000441995.1
ACSL6
acyl-CoA synthetase long-chain family member 6
chr15_+_42651691 1.95 ENST00000357568.3
ENST00000349748.3
ENST00000318023.7
ENST00000397163.3
CAPN3
calpain 3, (p94)
chr3_-_57326704 1.88 ENST00000487349.1
ENST00000389601.3
ASB14
ankyrin repeat and SOCS box containing 14
chr14_-_70546897 1.85 ENST00000394330.2
ENST00000533541.1
ENST00000216568.7
SLC8A3
solute carrier family 8 (sodium/calcium exchanger), member 3
chr20_+_61147651 1.82 ENST00000370527.3
ENST00000370524.2
C20orf166
chromosome 20 open reading frame 166
chr5_-_16509101 1.81 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr9_-_23779367 1.81 ENST00000440102.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr12_+_119616447 1.80 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr22_-_51017084 1.76 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr22_+_19706958 1.75 ENST00000395109.2
SEPT5
septin 5
chr1_+_160051319 1.63 ENST00000368088.3
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr8_-_70745575 1.61 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr5_+_155753745 1.55 ENST00000435422.3
ENST00000337851.4
ENST00000447401.1
SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr3_+_35683651 1.52 ENST00000187397.4
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr20_-_54580523 1.51 ENST00000064571.2
CBLN4
cerebellin 4 precursor
chr1_+_145413268 1.49 ENST00000421822.2
ENST00000336751.5
ENST00000497365.1
ENST00000475797.1
HFE2
hemochromatosis type 2 (juvenile)
chr20_+_44035847 1.47 ENST00000372712.2
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr2_-_86564776 1.44 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1
receptor accessory protein 1
chr1_+_26348259 1.43 ENST00000374280.3
EXTL1
exostosin-like glycosyltransferase 1
chr17_-_42188598 1.41 ENST00000591714.1
HDAC5
histone deacetylase 5
chr3_+_127634069 1.39 ENST00000405109.1
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chrX_-_142722897 1.39 ENST00000338017.4
SLITRK4
SLIT and NTRK-like family, member 4
chr8_-_7309887 1.38 ENST00000458665.1
ENST00000528168.1
SPAG11B
sperm associated antigen 11B
chr17_+_7184986 1.37 ENST00000317370.8
ENST00000571308.1
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr22_-_51016846 1.35 ENST00000312108.7
ENST00000395650.2
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr8_-_27115903 1.34 ENST00000350889.4
ENST00000519997.1
ENST00000519614.1
ENST00000522908.1
ENST00000265770.7
STMN4
stathmin-like 4
chr9_-_85882145 1.34 ENST00000328788.1
FRMD3
FERM domain containing 3
chr3_+_179370517 1.33 ENST00000263966.3
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr20_+_58251716 1.33 ENST00000355648.4
PHACTR3
phosphatase and actin regulator 3
chr8_+_7716700 1.31 ENST00000454911.2
ENST00000326625.5
SPAG11A
sperm associated antigen 11A
chr5_-_131347501 1.28 ENST00000543479.1
ACSL6
acyl-CoA synthetase long-chain family member 6
chr2_-_86564696 1.26 ENST00000437769.1
REEP1
receptor accessory protein 1
chr1_-_150693318 1.25 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
HORMAD1
HORMA domain containing 1
chr12_-_99548270 1.23 ENST00000546568.1
ENST00000332712.7
ENST00000546960.1
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_86564740 1.21 ENST00000540790.1
ENST00000428491.1
REEP1
receptor accessory protein 1
chr18_-_3219847 1.19 ENST00000261606.7
MYOM1
myomesin 1
chr17_+_20059302 1.18 ENST00000395530.2
SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr18_-_47792851 1.15 ENST00000398545.4
CCDC11
coiled-coil domain containing 11
chr18_-_3220106 1.15 ENST00000356443.4
ENST00000400569.3
MYOM1
myomesin 1
chr19_-_51220176 1.10 ENST00000359082.3
ENST00000293441.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr8_-_27115931 1.06 ENST00000523048.1
STMN4
stathmin-like 4
chr14_-_21493649 1.05 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG2
NDRG family member 2
chr5_-_131347306 1.04 ENST00000296869.4
ENST00000379249.3
ENST00000379272.2
ENST00000379264.2
ACSL6
acyl-CoA synthetase long-chain family member 6
chr10_+_86184676 1.04 ENST00000543283.1
CCSER2
coiled-coil serine-rich protein 2
chr6_-_25726781 1.04 ENST00000297012.3
HIST1H2AA
histone cluster 1, H2aa
chrX_+_107037451 1.01 ENST00000372379.2
NCBP2L
nuclear cap binding protein subunit 2-like
chr12_-_5352315 0.99 ENST00000536518.1
RP11-319E16.1
RP11-319E16.1
chr1_-_116311402 0.98 ENST00000261448.5
CASQ2
calsequestrin 2 (cardiac muscle)
chr8_-_72268889 0.98 ENST00000388742.4
EYA1
eyes absent homolog 1 (Drosophila)
chr2_-_220117867 0.89 ENST00000456818.1
ENST00000447205.1
TUBA4A
tubulin, alpha 4a
chr8_-_72268721 0.88 ENST00000419131.1
ENST00000388743.2
EYA1
eyes absent homolog 1 (Drosophila)
chr5_-_11903475 0.88 ENST00000508761.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr5_+_133772383 0.86 ENST00000513329.1
AC005355.1
AC005355.1
chr3_+_127634312 0.85 ENST00000407609.3
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr6_-_33160231 0.85 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr1_-_116311323 0.85 ENST00000456138.2
CASQ2
calsequestrin 2 (cardiac muscle)
chr12_-_120189900 0.84 ENST00000546026.1
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr3_+_138067521 0.84 ENST00000494949.1
MRAS
muscle RAS oncogene homolog
chr1_-_150693305 0.82 ENST00000368987.1
HORMAD1
HORMA domain containing 1
chr8_-_72268968 0.79 ENST00000388740.3
EYA1
eyes absent homolog 1 (Drosophila)
chr12_+_25205628 0.76 ENST00000554942.1
LRMP
lymphoid-restricted membrane protein
chr1_+_77333117 0.76 ENST00000477717.1
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr17_+_42248063 0.75 ENST00000293414.1
ASB16
ankyrin repeat and SOCS box containing 16
chr3_+_138067666 0.75 ENST00000475711.1
ENST00000464896.1
MRAS
muscle RAS oncogene homolog
chr19_+_37096194 0.75 ENST00000460670.1
ENST00000292928.2
ENST00000439428.1
ZNF382
zinc finger protein 382
chr12_-_7899958 0.75 ENST00000360345.3
CLEC4C
C-type lectin domain family 4, member C
chr14_-_21493884 0.75 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG2
NDRG family member 2
chr21_-_42219065 0.75 ENST00000400454.1
DSCAM
Down syndrome cell adhesion molecule
chr17_-_5322786 0.74 ENST00000225696.4
NUP88
nucleoporin 88kDa
chr5_-_11903337 0.74 ENST00000502551.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr4_+_146601356 0.74 ENST00000438731.1
ENST00000511965.1
C4orf51
chromosome 4 open reading frame 51
chr4_+_8321882 0.74 ENST00000509453.1
ENST00000503186.1
RP11-774O3.2
RP11-774O3.1
RP11-774O3.2
RP11-774O3.1
chr11_+_47293795 0.73 ENST00000422579.1
MADD
MAP-kinase activating death domain
chr11_-_88796803 0.65 ENST00000418177.2
ENST00000455756.2
GRM5
glutamate receptor, metabotropic 5
chr3_+_35683775 0.65 ENST00000452563.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr15_+_68346501 0.60 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr3_+_138067314 0.60 ENST00000423968.2
MRAS
muscle RAS oncogene homolog
chr18_-_35145981 0.58 ENST00000420428.2
ENST00000412753.1
CELF4
CUGBP, Elav-like family member 4
chr1_+_74701062 0.58 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr14_-_22005197 0.56 ENST00000541965.1
SALL2
spalt-like transcription factor 2
chr3_+_159570722 0.56 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr1_-_156460391 0.54 ENST00000360595.3
MEF2D
myocyte enhancer factor 2D
chr11_-_84634447 0.54 ENST00000532653.1
DLG2
discs, large homolog 2 (Drosophila)
chr5_+_55354822 0.51 ENST00000511861.1
CTD-2227I18.1
CTD-2227I18.1
chr15_+_40531243 0.50 ENST00000558055.1
ENST00000455577.2
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr11_-_84634217 0.50 ENST00000524982.1
DLG2
discs, large homolog 2 (Drosophila)
chr20_+_44657845 0.49 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr7_+_18535893 0.48 ENST00000432645.2
ENST00000441542.2
HDAC9
histone deacetylase 9
chrX_+_70521584 0.48 ENST00000373829.3
ENST00000538820.1
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr3_+_35683816 0.47 ENST00000438577.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr12_-_45269430 0.46 ENST00000395487.2
NELL2
NEL-like 2 (chicken)
chr10_-_31146615 0.43 ENST00000444692.2
ZNF438
zinc finger protein 438
chr17_-_27467418 0.43 ENST00000528564.1
MYO18A
myosin XVIIIA
chr1_+_84630367 0.42 ENST00000370680.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr16_-_56223480 0.42 ENST00000565155.1
RP11-461O7.1
RP11-461O7.1
chr12_-_45269769 0.42 ENST00000548826.1
NELL2
NEL-like 2 (chicken)
chr18_-_35145728 0.42 ENST00000361795.5
ENST00000603232.1
CELF4
CUGBP, Elav-like family member 4
chr17_-_42200996 0.41 ENST00000587135.1
ENST00000225983.6
ENST00000393622.2
ENST00000588703.1
HDAC5
histone deacetylase 5
chr6_+_42984723 0.41 ENST00000332245.8
KLHDC3
kelch domain containing 3
chr12_+_25205568 0.40 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr7_-_37488547 0.40 ENST00000453399.1
ELMO1
engulfment and cell motility 1
chr9_+_100263912 0.39 ENST00000259365.4
TMOD1
tropomodulin 1
chr10_-_97200772 0.38 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr12_+_52431016 0.35 ENST00000553200.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr12_+_25205666 0.34 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr12_-_7899935 0.34 ENST00000543765.1
CLEC4C
C-type lectin domain family 4, member C
chr10_+_118350468 0.34 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr15_+_40531621 0.34 ENST00000560346.1
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_92632542 0.33 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr7_+_133615169 0.33 ENST00000541309.1
EXOC4
exocyst complex component 4
chr10_+_118349920 0.30 ENST00000531984.1
PNLIPRP1
pancreatic lipase-related protein 1
chr7_-_121944491 0.29 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr10_+_118350522 0.28 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr20_+_44657807 0.27 ENST00000372315.1
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr19_+_56713670 0.21 ENST00000534327.1
ZSCAN5C
zinc finger and SCAN domain containing 5C
chr4_-_143767428 0.19 ENST00000513000.1
ENST00000509777.1
ENST00000503927.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr1_+_170633047 0.19 ENST00000239461.6
ENST00000497230.2
PRRX1
paired related homeobox 1
chr5_+_132009675 0.16 ENST00000231449.2
ENST00000350025.2
IL4
interleukin 4
chr4_+_44680429 0.16 ENST00000281543.5
GUF1
GUF1 GTPase homolog (S. cerevisiae)
chr14_-_22005343 0.15 ENST00000327430.3
SALL2
spalt-like transcription factor 2
chr7_-_105332084 0.14 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr16_+_50313426 0.14 ENST00000569265.1
ADCY7
adenylate cyclase 7
chr7_+_86781916 0.13 ENST00000579592.1
ENST00000434534.1
DMTF1
cyclin D binding myb-like transcription factor 1
chr1_-_23751189 0.11 ENST00000374601.3
ENST00000450454.2
TCEA3
transcription elongation factor A (SII), 3
chr11_+_71934962 0.11 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr17_-_42200958 0.10 ENST00000336057.5
HDAC5
histone deacetylase 5
chr7_+_18536090 0.08 ENST00000441986.1
HDAC9
histone deacetylase 9
chr16_-_67867749 0.05 ENST00000566758.1
ENST00000445712.2
ENST00000219172.3
ENST00000564817.1
CENPT
centromere protein T
chr7_+_86781847 0.05 ENST00000432366.2
ENST00000423590.2
ENST00000394703.5
DMTF1
cyclin D binding myb-like transcription factor 1
chr3_-_48598547 0.04 ENST00000536104.1
ENST00000452531.1
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr7_+_120629653 0.03 ENST00000450913.2
ENST00000340646.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr15_-_52970820 0.02 ENST00000261844.7
ENST00000399202.4
ENST00000562135.1
FAM214A
family with sequence similarity 214, member A
chr14_+_56046914 0.01 ENST00000413890.2
ENST00000395309.3
ENST00000554567.1
ENST00000555498.1
KTN1
kinectin 1 (kinesin receptor)
chr11_-_7904464 0.01 ENST00000502624.2
ENST00000527565.1
RP11-35J10.5
RP11-35J10.5
chr20_-_62582475 0.01 ENST00000369908.5
UCKL1
uridine-cytidine kinase 1-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.2 GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
1.2 4.9 GO:1990926 short-term synaptic potentiation(GO:1990926)
1.2 6.0 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
1.1 10.6 GO:0002074 extraocular skeletal muscle development(GO:0002074)
1.0 4.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
1.0 7.6 GO:0035995 detection of muscle stretch(GO:0035995)
0.8 2.3 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.7 2.1 GO:0060629 regulation of homologous chromosome segregation(GO:0060629)
0.6 4.3 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.6 6.4 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.5 6.5 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.4 1.3 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.4 1.1 GO:0050894 determination of affect(GO:0050894)
0.3 2.0 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.3 3.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 4.0 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.3 1.8 GO:0071313 cellular response to caffeine(GO:0071313)
0.3 2.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.3 10.1 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.3 0.8 GO:0040040 thermosensory behavior(GO:0040040)
0.2 2.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.2 0.9 GO:0060023 soft palate development(GO:0060023)
0.2 3.5 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 1.9 GO:1990034 calcium ion export from cell(GO:1990034)
0.2 13.5 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.2 2.9 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 1.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 3.9 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.2 0.7 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2 4.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.8 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.1 3.1 GO:0006853 carnitine shuttle(GO:0006853)
0.1 0.4 GO:1903028 positive regulation of opsonization(GO:1903028)
0.1 4.9 GO:0007520 myoblast fusion(GO:0007520)
0.1 7.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 4.3 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 0.7 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.9 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.1 1.6 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 1.0 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 0.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.5 GO:0016540 protein autoprocessing(GO:0016540)
0.1 3.4 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880)
0.1 5.1 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 0.7 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0 3.9 GO:0030239 myofibril assembly(GO:0030239)
0.0 0.8 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.6 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 1.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.6 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 2.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 1.4 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.3 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 1.6 GO:0010107 potassium ion import(GO:0010107)
0.0 1.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 4.3 GO:0005977 glycogen metabolic process(GO:0005977)
0.0 0.8 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 1.0 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.4 GO:0090050 peptidyl-lysine deacetylation(GO:0034983) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 2.2 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 4.4 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.6 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.8 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 2.2 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.8 GO:0032091 negative regulation of protein binding(GO:0032091)
0.0 1.3 GO:0006903 vesicle targeting(GO:0006903)
0.0 8.3 GO:0043687 post-translational protein modification(GO:0043687)
0.0 1.3 GO:0006986 response to unfolded protein(GO:0006986)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 16.1 GO:0030314 junctional membrane complex(GO:0030314)
1.2 4.7 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.7 7.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.7 4.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.6 11.2 GO:0005861 troponin complex(GO:0005861)
0.6 4.9 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.5 6.4 GO:0097512 cardiac myofibril(GO:0097512)
0.3 20.8 GO:0031430 M band(GO:0031430)
0.3 7.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 4.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 5.5 GO:0005859 muscle myosin complex(GO:0005859)
0.2 4.0 GO:0005916 fascia adherens(GO:0005916)
0.2 1.0 GO:0005846 nuclear cap binding complex(GO:0005846)
0.2 4.3 GO:0031672 A band(GO:0031672)
0.2 1.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 1.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 21.8 GO:0030018 Z disc(GO:0030018)
0.1 1.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 3.4 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 0.4 GO:0005899 insulin receptor complex(GO:0005899)
0.0 5.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 2.1 GO:0000795 synaptonemal complex(GO:0000795)
0.0 4.3 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 1.9 GO:0016528 sarcoplasm(GO:0016528)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 2.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.6 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.0 1.2 GO:0015030 Cajal body(GO:0015030)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 3.8 GO:0030426 growth cone(GO:0030426)
0.0 0.8 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.3 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 3.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.1 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 1.6 GO:0043204 perikaryon(GO:0043204)
0.0 1.7 GO:0042383 sarcolemma(GO:0042383)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.6 GO:0051373 FATZ binding(GO:0051373)
0.8 11.8 GO:0031014 troponin T binding(GO:0031014)
0.7 7.6 GO:0031433 telethonin binding(GO:0031433)
0.6 3.9 GO:0031849 olfactory receptor binding(GO:0031849)
0.5 13.0 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.4 8.0 GO:0031432 titin binding(GO:0031432)
0.4 3.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.4 1.1 GO:0031877 somatostatin receptor binding(GO:0031877)
0.3 6.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 4.0 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.3 1.9 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.2 1.4 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.2 1.9 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.2 1.5 GO:0098821 BMP receptor activity(GO:0098821)
0.2 1.3 GO:1904288 BAT3 complex binding(GO:1904288)
0.2 4.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 4.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 10.1 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 1.0 GO:0042835 BRE binding(GO:0042835)
0.1 3.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 2.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 5.1 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 4.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.9 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1 0.8 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 1.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.7 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 3.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.6 GO:0031013 troponin I binding(GO:0031013)
0.1 1.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.1 0.8 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.2 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 3.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 4.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 13.1 GO:0044325 ion channel binding(GO:0044325)
0.0 2.2 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 4.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 25.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.6 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 1.0 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.7 GO:0005123 death receptor binding(GO:0005123)
0.0 1.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.6 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.4 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.8 GO:0097110 scaffold protein binding(GO:0097110)
0.0 1.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 2.1 GO:0005262 calcium channel activity(GO:0005262)
0.0 2.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 2.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 3.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 PID BMP PATHWAY BMP receptor signaling
0.0 2.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID RHOA PATHWAY RhoA signaling pathway
0.0 2.4 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 27.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 4.9 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 4.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 3.1 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 20.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.9 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.9 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.7 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery