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Illumina Body Map 2, young vs old

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Results for NFKB2

Z-value: 0.00

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Transcription factors associated with NFKB2

Gene Symbol Gene ID Gene Info
NFKB2
ENSG00000077150.13 nuclear factor kappa B subunit 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFKB2hg19_v2_chr10_+_104155450_1041554790.476.9e-03Click!

Activity profile of NFKB2 motif

Sorted Z-values of NFKB2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_30485267 5.44 ENST00000569725.1
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr19_+_42381173 5.16 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr17_-_34207295 5.02 ENST00000463941.1
ENST00000293272.3
CCL5
chemokine (C-C motif) ligand 5
chr20_+_43803517 4.95 ENST00000243924.3
PI3
peptidase inhibitor 3, skin-derived
chr2_+_219745020 4.77 ENST00000258411.3
WNT10A
wingless-type MMTV integration site family, member 10A
chr19_-_41859814 4.44 ENST00000221930.5
TGFB1
transforming growth factor, beta 1
chr19_+_42381337 4.40 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr19_-_3786253 4.28 ENST00000585778.1
MATK
megakaryocyte-associated tyrosine kinase
chr1_-_27961720 4.27 ENST00000545953.1
ENST00000374005.3
FGR
feline Gardner-Rasheed sarcoma viral oncogene homolog
chr19_-_3786354 4.13 ENST00000395040.2
ENST00000310132.6
MATK
megakaryocyte-associated tyrosine kinase
chr2_-_89417335 4.11 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr15_-_89438742 4.08 ENST00000562281.1
ENST00000562889.1
ENST00000359595.3
HAPLN3
hyaluronan and proteoglycan link protein 3
chr7_+_142031986 3.78 ENST00000547918.2
TRBV7-1
T cell receptor beta variable 7-1 (non-functional)
chr22_-_37640277 3.66 ENST00000401529.3
ENST00000249071.6
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr4_-_74864386 3.54 ENST00000296027.4
CXCL5
chemokine (C-X-C motif) ligand 5
chr11_-_5271122 3.54 ENST00000330597.3
HBG1
hemoglobin, gamma A
chr2_-_89292422 3.49 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr1_-_204436344 3.49 ENST00000367184.2
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr2_-_89310012 3.34 ENST00000493819.1
IGKV1-9
immunoglobulin kappa variable 1-9
chr22_-_37640456 3.32 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr6_+_31540056 3.09 ENST00000418386.2
LTA
lymphotoxin alpha
chr7_+_142423143 3.05 ENST00000390399.3
TRBV27
T cell receptor beta variable 27
chr1_-_207096529 2.90 ENST00000525793.1
ENST00000529560.1
FAIM3
Fas apoptotic inhibitory molecule 3
chr14_+_92789498 2.83 ENST00000531433.1
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr2_+_89952792 2.81 ENST00000390265.2
IGKV1D-33
immunoglobulin kappa variable 1D-33
chr2_-_89340242 2.80 ENST00000480492.1
IGKV1-12
immunoglobulin kappa variable 1-12
chr17_+_72462525 2.79 ENST00000360141.3
CD300A
CD300a molecule
chr12_+_8662057 2.76 ENST00000382064.2
CLEC4D
C-type lectin domain family 4, member D
chr19_+_17638059 2.74 ENST00000599164.1
ENST00000449408.2
ENST00000600871.1
ENST00000599124.1
FAM129C
family with sequence similarity 129, member C
chr2_+_90229045 2.71 ENST00000390278.2
IGKV1D-42
immunoglobulin kappa variable 1D-42 (non-functional)
chr2_-_89568263 2.69 ENST00000473726.1
IGKV1-33
immunoglobulin kappa variable 1-33
chr2_-_89247338 2.66 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr7_-_38403077 2.59 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr6_-_32157947 2.59 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr1_-_183559693 2.52 ENST00000367535.3
ENST00000413720.1
ENST00000418089.1
NCF2
neutrophil cytosolic factor 2
chr2_-_109605663 2.50 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
EDAR
ectodysplasin A receptor
chr19_-_8567478 2.50 ENST00000255612.3
PRAM1
PML-RARA regulated adaptor molecule 1
chr5_+_35852797 2.48 ENST00000508941.1
IL7R
interleukin 7 receptor
chr19_+_17638041 2.46 ENST00000601861.1
FAM129C
family with sequence similarity 129, member C
chr6_+_32605134 2.39 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr17_+_16318909 2.36 ENST00000577397.1
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr17_+_16318850 2.36 ENST00000338560.7
TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr12_-_52914155 2.34 ENST00000549420.1
ENST00000551275.1
ENST00000546577.1
KRT5
keratin 5
chr19_+_35940486 2.34 ENST00000246549.2
FFAR2
free fatty acid receptor 2
chr1_-_186649543 2.32 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr17_+_72462766 2.29 ENST00000392625.3
ENST00000361933.3
ENST00000310828.5
CD300A
CD300a molecule
chr1_-_183560011 2.29 ENST00000367536.1
NCF2
neutrophil cytosolic factor 2
chr7_-_38389573 2.24 ENST00000390344.2
TRGV5
T cell receptor gamma variable 5
chr22_+_37318082 2.24 ENST00000406230.1
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr1_-_204463829 2.23 ENST00000429009.1
ENST00000415899.1
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr8_+_22941868 2.23 ENST00000397703.2
TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr19_-_54746600 2.22 ENST00000245621.5
ENST00000270464.5
ENST00000419410.2
ENST00000391735.3
ENST00000396365.2
ENST00000440558.2
ENST00000407860.2
LILRA6
LILRB3
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr6_-_31324943 2.22 ENST00000412585.2
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr14_+_52313833 2.20 ENST00000553560.1
GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr11_-_104840093 2.19 ENST00000417440.2
ENST00000444739.2
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr19_-_6591113 2.18 ENST00000423145.3
ENST00000245903.3
CD70
CD70 molecule
chr19_+_48824711 2.17 ENST00000599704.1
EMP3
epithelial membrane protein 3
chr4_+_74735102 2.10 ENST00000395761.3
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr16_-_28192360 2.09 ENST00000570033.1
XPO6
exportin 6
chr7_+_142494795 2.07 ENST00000390417.1
TRBJ2-5
T cell receptor beta joining 2-5
chr7_+_142495131 2.05 ENST00000390419.1
TRBJ2-7
T cell receptor beta joining 2-7
chr1_-_202129704 2.04 ENST00000476061.1
ENST00000544762.1
ENST00000467283.1
ENST00000464870.1
ENST00000435759.2
ENST00000486116.1
ENST00000543735.1
ENST00000308986.5
ENST00000477625.1
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr6_+_32605195 2.03 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr1_-_202129105 2.00 ENST00000367279.4
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr10_-_125851961 2.00 ENST00000346248.5
CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr7_+_142494525 1.99 ENST00000390415.1
TRBJ2-3
T cell receptor beta joining 2-3
chr17_-_5487277 1.98 ENST00000572272.1
ENST00000354411.3
ENST00000577119.1
NLRP1
NLR family, pyrin domain containing 1
chr1_-_235116495 1.98 ENST00000549744.1
RP11-443B7.3
RP11-443B7.3
chr14_+_96152754 1.97 ENST00000340722.7
TCL1B
T-cell leukemia/lymphoma 1B
chr8_-_6795823 1.97 ENST00000297435.2
DEFA4
defensin, alpha 4, corticostatin
chr17_-_3819751 1.96 ENST00000225538.3
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr17_+_76126842 1.90 ENST00000590426.1
ENST00000590799.1
ENST00000318430.5
ENST00000589691.1
TMC8
transmembrane channel-like 8
chr2_+_74212073 1.89 ENST00000441217.1
AC073046.25
AC073046.25
chr14_-_23299009 1.87 ENST00000488800.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr17_+_76165213 1.87 ENST00000590201.1
SYNGR2
synaptogyrin 2
chr19_-_47734448 1.85 ENST00000439096.2
BBC3
BCL2 binding component 3
chr12_-_58131931 1.84 ENST00000547588.1
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr7_+_2559399 1.76 ENST00000222725.5
ENST00000359574.3
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chrX_+_64887512 1.75 ENST00000360270.5
MSN
moesin
chr20_-_4795747 1.74 ENST00000379376.2
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr2_+_61108771 1.74 ENST00000394479.3
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr2_-_197036289 1.74 ENST00000263955.4
STK17B
serine/threonine kinase 17b
chr19_-_10450328 1.73 ENST00000160262.5
ICAM3
intercellular adhesion molecule 3
chr19_-_51891209 1.71 ENST00000221973.3
ENST00000596399.1
LIM2
lens intrinsic membrane protein 2, 19kDa
chr3_+_126243126 1.69 ENST00000319340.2
CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr1_-_47655686 1.68 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr1_-_85462762 1.68 ENST00000284027.5
MCOLN2
mucolipin 2
chr3_+_53195136 1.65 ENST00000394729.2
ENST00000330452.3
PRKCD
protein kinase C, delta
chr16_-_74734742 1.65 ENST00000308807.7
ENST00000573267.1
MLKL
mixed lineage kinase domain-like
chr16_-_4466622 1.64 ENST00000570645.1
ENST00000574025.1
ENST00000572898.1
ENST00000537233.2
ENST00000571059.1
ENST00000251166.4
CORO7
coronin 7
chr1_+_111770232 1.64 ENST00000369744.2
CHI3L2
chitinase 3-like 2
chr16_+_81812863 1.64 ENST00000359376.3
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr1_+_111770278 1.64 ENST00000369748.4
CHI3L2
chitinase 3-like 2
chr17_+_38497640 1.60 ENST00000394086.3
RARA
retinoic acid receptor, alpha
chr21_+_42741979 1.60 ENST00000543692.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr17_+_40440481 1.59 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
STAT5A
signal transducer and activator of transcription 5A
chr7_+_142494920 1.58 ENST00000390418.1
TRBJ2-6
T cell receptor beta joining 2-6
chr1_+_2487800 1.58 ENST00000355716.4
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr11_-_75062730 1.57 ENST00000420843.2
ENST00000360025.3
ARRB1
arrestin, beta 1
chr6_+_106959718 1.57 ENST00000369066.3
AIM1
absent in melanoma 1
chr7_+_142494672 1.56 ENST00000390416.1
TRBJ2-4
T cell receptor beta joining 2-4
chr11_+_71934962 1.56 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr17_+_76164639 1.55 ENST00000225777.3
ENST00000585591.1
ENST00000589711.1
ENST00000588282.1
ENST00000589168.1
SYNGR2
synaptogyrin 2
chr1_+_2487402 1.55 ENST00000451778.1
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr19_+_859654 1.51 ENST00000592860.1
CFD
complement factor D (adipsin)
chr9_+_214842 1.48 ENST00000453981.1
ENST00000432829.2
DOCK8
dedicator of cytokinesis 8
chr9_+_82187487 1.46 ENST00000435650.1
ENST00000414465.1
ENST00000376537.4
ENST00000376534.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chrX_+_49028265 1.46 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr11_+_65405556 1.44 ENST00000534313.1
ENST00000533361.1
ENST00000526137.1
SIPA1
signal-induced proliferation-associated 1
chr17_-_53499218 1.43 ENST00000571578.1
MMD
monocyte to macrophage differentiation-associated
chr16_+_2867164 1.43 ENST00000455114.1
ENST00000450020.3
PRSS21
protease, serine, 21 (testisin)
chr1_+_2487078 1.43 ENST00000426449.1
ENST00000434817.1
ENST00000435221.2
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr7_-_5463175 1.42 ENST00000399537.4
ENST00000430969.1
TNRC18
trinucleotide repeat containing 18
chr9_+_82187630 1.40 ENST00000265284.6
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr14_-_51297360 1.39 ENST00000496749.1
NIN
ninein (GSK3B interacting protein)
chr16_-_4466565 1.39 ENST00000572467.1
ENST00000423908.2
ENST00000572044.1
ENST00000571052.1
CORO7-PAM16
CORO7
CORO7-PAM16 readthrough
coronin 7
chr1_+_207494853 1.39 ENST00000367064.3
ENST00000367063.2
ENST00000391921.4
ENST00000367067.4
ENST00000314754.8
ENST00000367065.5
ENST00000391920.4
ENST00000367062.4
ENST00000343420.6
CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr16_+_88704978 1.38 ENST00000244241.4
IL17C
interleukin 17C
chr6_+_143999185 1.36 ENST00000542769.1
ENST00000397980.3
PHACTR2
phosphatase and actin regulator 2
chr15_+_92397051 1.36 ENST00000424469.2
SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr19_+_54371114 1.35 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
MYADM
myeloid-associated differentiation marker
chr1_+_24118452 1.35 ENST00000421070.1
LYPLA2
lysophospholipase II
chr12_+_57522439 1.35 ENST00000338962.4
LRP1
low density lipoprotein receptor-related protein 1
chr11_-_75062829 1.34 ENST00000393505.4
ARRB1
arrestin, beta 1
chr6_+_143999072 1.34 ENST00000440869.2
ENST00000367582.3
ENST00000451827.2
PHACTR2
phosphatase and actin regulator 2
chr14_+_106355918 1.33 ENST00000414005.1
AL122127.25
AL122127.25
chr12_+_7055631 1.32 ENST00000543115.1
ENST00000399448.1
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_183604794 1.32 ENST00000367534.1
ENST00000359856.6
ENST00000294742.6
ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr8_+_90770008 1.31 ENST00000540020.1
RIPK2
receptor-interacting serine-threonine kinase 2
chr10_+_104154229 1.29 ENST00000428099.1
ENST00000369966.3
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr6_+_14117872 1.28 ENST00000379153.3
CD83
CD83 molecule
chr16_+_50776021 1.28 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr10_-_36813162 1.27 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr14_+_22947861 1.26 ENST00000390482.1
TRAJ57
T cell receptor alpha joining 57
chr12_-_127256858 1.26 ENST00000542248.1
ENST00000540684.1
LINC00944
long intergenic non-protein coding RNA 944
chr15_-_64648273 1.25 ENST00000607537.1
ENST00000303052.7
ENST00000303032.6
CSNK1G1
casein kinase 1, gamma 1
chr8_-_66754172 1.25 ENST00000401827.3
PDE7A
phosphodiesterase 7A
chr8_+_22436635 1.25 ENST00000452226.1
ENST00000397760.4
ENST00000339162.7
ENST00000397761.2
PDLIM2
PDZ and LIM domain 2 (mystique)
chr19_+_45504688 1.25 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr3_+_182971583 1.24 ENST00000460419.1
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr16_+_2880157 1.24 ENST00000382280.3
ZG16B
zymogen granule protein 16B
chr5_+_176731572 1.23 ENST00000503853.1
PRELID1
PRELI domain containing 1
chr16_+_2867228 1.23 ENST00000005995.3
ENST00000574813.1
PRSS21
protease, serine, 21 (testisin)
chr1_+_226250379 1.22 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr17_-_53499310 1.22 ENST00000262065.3
MMD
monocyte to macrophage differentiation-associated
chr11_+_34460447 1.21 ENST00000241052.4
CAT
catalase
chr11_-_64949305 1.20 ENST00000526623.1
AP003068.23
Uncharacterized protein
chr19_+_35485682 1.20 ENST00000599564.1
GRAMD1A
GRAM domain containing 1A
chr11_-_46142505 1.20 ENST00000524497.1
ENST00000418153.2
PHF21A
PHD finger protein 21A
chr8_+_90769967 1.19 ENST00000220751.4
RIPK2
receptor-interacting serine-threonine kinase 2
chr1_-_247615308 1.18 ENST00000318749.6
OR2B11
olfactory receptor, family 2, subfamily B, member 11
chr14_-_51297837 1.17 ENST00000245441.5
ENST00000389868.3
ENST00000382041.3
ENST00000324330.9
ENST00000453196.1
ENST00000453401.2
NIN
ninein (GSK3B interacting protein)
chr14_-_51297197 1.17 ENST00000382043.4
NIN
ninein (GSK3B interacting protein)
chr16_-_4465886 1.16 ENST00000539968.1
CORO7
coronin 7
chr9_+_135037334 1.16 ENST00000393229.3
ENST00000360670.3
ENST00000393228.4
ENST00000372179.3
NTNG2
netrin G2
chr2_-_16847084 1.16 ENST00000406434.1
ENST00000381323.3
FAM49A
family with sequence similarity 49, member A
chr1_+_111770294 1.15 ENST00000474304.2
CHI3L2
chitinase 3-like 2
chr15_+_77287426 1.15 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr11_-_57335750 1.15 ENST00000340573.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr6_-_10838710 1.15 ENST00000313243.2
MAK
male germ cell-associated kinase
chr6_+_135502408 1.14 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr16_-_88923285 1.14 ENST00000542788.1
ENST00000569433.1
ENST00000268695.5
ENST00000568311.1
GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr11_+_818902 1.12 ENST00000336615.4
PNPLA2
patatin-like phospholipase domain containing 2
chr1_+_2487631 1.12 ENST00000409119.1
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr1_+_203256898 1.12 ENST00000433008.1
RP11-134P9.3
RP11-134P9.3
chr17_-_5522731 1.11 ENST00000576905.1
NLRP1
NLR family, pyrin domain containing 1
chr3_+_52280220 1.11 ENST00000409502.3
ENST00000323588.4
PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr6_-_10838736 1.10 ENST00000536370.1
ENST00000474039.1
MAK
male germ cell-associated kinase
chr9_+_130911723 1.09 ENST00000277480.2
ENST00000373013.2
ENST00000540948.1
LCN2
lipocalin 2
chr8_+_22436248 1.08 ENST00000308354.7
PDLIM2
PDZ and LIM domain 2 (mystique)
chr7_+_143013198 1.07 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr4_-_74904398 1.07 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr2_+_202047843 1.07 ENST00000272879.5
ENST00000374650.3
ENST00000346817.5
ENST00000313728.7
ENST00000448480.1
CASP10
caspase 10, apoptosis-related cysteine peptidase
chr10_+_89622870 1.05 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chrX_+_103357202 1.05 ENST00000537356.3
ZCCHC18
zinc finger, CCHC domain containing 18
chr9_-_123691047 1.05 ENST00000373887.3
TRAF1
TNF receptor-associated factor 1
chr6_-_149806105 1.04 ENST00000389942.5
ENST00000416573.2
ENST00000542614.1
ENST00000409806.3
ZC3H12D
zinc finger CCCH-type containing 12D
chr14_+_24605361 1.04 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr8_+_32406137 1.04 ENST00000521670.1
NRG1
neuregulin 1
chr6_-_74233480 1.02 ENST00000455918.1
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr16_+_15737124 1.02 ENST00000396355.1
ENST00000396353.2
NDE1
nudE neurodevelopment protein 1
chr16_-_74734672 1.02 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr2_+_219081817 1.01 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr5_-_150466692 1.00 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNIP1
TNFAIP3 interacting protein 1
chr2_+_232575168 1.00 ENST00000440384.1
PTMA
prothymosin, alpha
chr16_-_88878305 1.00 ENST00000569616.1
ENST00000563655.1
ENST00000567713.1
ENST00000426324.2
ENST00000378364.3
APRT
adenine phosphoribosyltransferase
chr17_+_40440094 0.99 ENST00000546010.2
STAT5A
signal transducer and activator of transcription 5A
chr20_-_48330377 0.99 ENST00000371711.4
B4GALT5
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
chr1_-_85462623 0.99 ENST00000370608.3
MCOLN2
mucolipin 2
chr2_+_10183651 0.98 ENST00000305883.1
KLF11
Kruppel-like factor 11
chr4_+_2043689 0.98 ENST00000382878.3
ENST00000409248.4
C4orf48
chromosome 4 open reading frame 48
chr19_+_50094866 0.97 ENST00000418929.2
PRR12
proline rich 12
chr16_+_50775948 0.97 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
CYLD
cylindromatosis (turban tumor syndrome)
chr1_+_114472992 0.96 ENST00000514621.1
HIPK1
homeodomain interacting protein kinase 1
chr12_-_94673956 0.95 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr9_+_82188077 0.95 ENST00000425506.1
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr19_-_1885432 0.94 ENST00000250974.9
ABHD17A
abhydrolase domain containing 17A
chr14_+_100705322 0.94 ENST00000262238.4
YY1
YY1 transcription factor
chr9_+_130911770 0.94 ENST00000372998.1
LCN2
lipocalin 2
chr19_+_38794797 0.93 ENST00000301246.5
ENST00000588605.1
C19orf33
chromosome 19 open reading frame 33

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:2000417 negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) negative regulation of eosinophil migration(GO:2000417)
1.5 4.4 GO:0052031 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
1.3 5.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
1.2 3.7 GO:0090222 centrosome-templated microtubule nucleation(GO:0090222)
1.1 3.2 GO:1990108 protein linear deubiquitination(GO:1990108)
1.0 3.1 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
1.0 3.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.8 2.3 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.8 2.3 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.6 7.0 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.6 5.7 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.5 2.1 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.5 2.5 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
0.5 1.5 GO:0061485 memory T cell proliferation(GO:0061485)
0.5 1.4 GO:0035739 CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.4 2.2 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043) interleukin-3-mediated signaling pathway(GO:0038156)
0.4 2.0 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.4 1.6 GO:0002316 follicular B cell differentiation(GO:0002316)
0.4 2.0 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.4 2.0 GO:0002554 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.4 2.3 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.4 1.1 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.4 2.6 GO:0000255 allantoin metabolic process(GO:0000255)
0.3 1.0 GO:0044209 AMP salvage(GO:0044209)
0.3 1.7 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.3 1.6 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.3 1.6 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.3 4.8 GO:0048733 sebaceous gland development(GO:0048733)
0.3 1.2 GO:0060623 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.3 5.4 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.3 1.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.3 1.8 GO:0022614 membrane to membrane docking(GO:0022614)
0.3 0.6 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.3 1.4 GO:0042631 cellular response to water deprivation(GO:0042631)
0.3 7.9 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.3 2.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.3 1.6 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.3 1.1 GO:1903984 rhythmic synaptic transmission(GO:0060024) negative regulation of ribosome biogenesis(GO:0090071) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.3 4.7 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.2 1.7 GO:1901857 positive regulation of cellular respiration(GO:1901857)
0.2 4.4 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.2 2.9 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 2.2 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.2 4.3 GO:0043306 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.2 0.4 GO:1990535 neuron projection maintenance(GO:1990535)
0.2 2.2 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.2 1.3 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.2 1.8 GO:0007386 compartment pattern specification(GO:0007386)
0.2 2.0 GO:0019732 antifungal humoral response(GO:0019732)
0.2 0.9 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.2 2.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.2 0.8 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.2 2.5 GO:1902563 regulation of neutrophil degranulation(GO:0043313) regulation of neutrophil activation(GO:1902563)
0.2 1.9 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.2 2.5 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.2 0.5 GO:0042938 dipeptide transport(GO:0042938)
0.2 1.7 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.2 1.0 GO:1902045 negative regulation of Fas signaling pathway(GO:1902045)
0.2 1.3 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.2 1.1 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.2 0.5 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.2 0.6 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.2 0.9 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 0.6 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.2 3.9 GO:0007620 copulation(GO:0007620)
0.1 0.9 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 0.9 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.9 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.1 0.7 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.1 4.8 GO:0045730 respiratory burst(GO:0045730)
0.1 4.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 3.5 GO:0015671 oxygen transport(GO:0015671)
0.1 1.3 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.1 0.3 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.1 1.4 GO:0002084 protein depalmitoylation(GO:0002084)
0.1 1.2 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.1 0.8 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 0.4 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
0.1 1.4 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.1 0.5 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.1 1.7 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 1.1 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.1 0.7 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.1 1.7 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 0.5 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
0.1 0.2 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1 2.2 GO:0097264 self proteolysis(GO:0097264)
0.1 1.1 GO:0021769 orbitofrontal cortex development(GO:0021769)
0.1 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 1.9 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 5.7 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 0.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.4 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.1 0.9 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 0.9 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 0.4 GO:0032218 riboflavin transport(GO:0032218)
0.1 1.7 GO:0015732 prostaglandin transport(GO:0015732)
0.1 0.9 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 1.4 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 1.6 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1 12.2 GO:0030449 regulation of complement activation(GO:0030449)
0.1 1.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 2.0 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.3 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 9.6 GO:0042100 B cell proliferation(GO:0042100)
0.1 7.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 2.7 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.0 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 0.7 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 0.9 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 3.0 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 2.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 0.6 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.1 1.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 1.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.7 GO:0032494 response to peptidoglycan(GO:0032494)
0.1 0.5 GO:0080009 mRNA methylation(GO:0080009)
0.1 2.2 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.1 3.8 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.1 1.0 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.1 2.5 GO:0097186 amelogenesis(GO:0097186)
0.1 1.4 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.1 1.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 2.6 GO:0019835 cytolysis(GO:0019835)
0.1 0.4 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.1 1.9 GO:0032460 negative regulation of protein oligomerization(GO:0032460)
0.1 1.0 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.1 0.3 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.1 0.2 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.1 0.6 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.8 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.1 0.2 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.8 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 5.2 GO:0006611 protein export from nucleus(GO:0006611)
0.1 0.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.4 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.2 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 1.5 GO:2000772 regulation of cellular senescence(GO:2000772)
0.0 5.4 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.6 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.5 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 1.6 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 1.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 6.5 GO:0002377 immunoglobulin production(GO:0002377)
0.0 1.5 GO:0032288 myelin assembly(GO:0032288)
0.0 1.0 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.5 GO:0046638 positive regulation of alpha-beta T cell differentiation(GO:0046638)
0.0 0.9 GO:0045116 protein neddylation(GO:0045116)
0.0 0.6 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 1.1 GO:0032060 bleb assembly(GO:0032060)
0.0 0.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.8 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 2.8 GO:0002292 T cell differentiation involved in immune response(GO:0002292)
0.0 0.4 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.7 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.5 GO:0099639 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 0.9 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.2 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.0 0.8 GO:0051014 actin filament severing(GO:0051014)
0.0 7.5 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 1.2 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 1.2 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.1 GO:0070640 calcitriol biosynthetic process from calciol(GO:0036378) vitamin D3 metabolic process(GO:0070640)
0.0 0.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.6 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.2 GO:1904779 regulation of protein localization to centrosome(GO:1904779)
0.0 0.2 GO:0070836 caveola assembly(GO:0070836)
0.0 1.6 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.2 GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.0 0.1 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 0.3 GO:0009249 protein lipoylation(GO:0009249)
0.0 1.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.0 1.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 1.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.3 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.5 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 0.1 GO:1901355 cellular response to rapamycin(GO:0072752) response to rapamycin(GO:1901355)
0.0 0.2 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 1.8 GO:1900046 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0 4.7 GO:0009408 response to heat(GO:0009408)
0.0 0.2 GO:0050932 regulation of pigment cell differentiation(GO:0050932) positive regulation of pigment cell differentiation(GO:0050942)
0.0 0.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.4 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.3 GO:0002220 innate immune response activating cell surface receptor signaling pathway(GO:0002220) stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 2.0 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.2 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 1.7 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.4 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.1 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.1 GO:0035897 proteolysis in other organism(GO:0035897)
0.0 1.5 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 2.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 3.1 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 1.8 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 1.2 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.3 GO:0007512 adult heart development(GO:0007512)
0.0 0.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 3.7 GO:0002250 adaptive immune response(GO:0002250)
0.0 0.2 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.4 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.1 GO:0039533 regulation of MDA-5 signaling pathway(GO:0039533) positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 1.3 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 2.8 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.2 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.0 0.1 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.5 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 9.6 GO:0019815 B cell receptor complex(GO:0019815)
0.7 2.2 GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex(GO:0030526)
0.5 2.1 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.5 5.4 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.5 4.8 GO:0032010 phagolysosome(GO:0032010)
0.5 2.9 GO:0008537 proteasome activator complex(GO:0008537)
0.4 3.1 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.4 2.2 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.4 4.7 GO:0032584 growth cone membrane(GO:0032584)
0.4 3.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.4 1.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.3 1.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.3 4.3 GO:0005833 hemoglobin complex(GO:0005833)
0.2 3.7 GO:0036449 microtubule minus-end(GO:0036449)
0.2 2.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 4.4 GO:0042611 MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613)
0.2 0.6 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.2 0.9 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.2 6.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 1.4 GO:0070435 Shc-EGFR complex(GO:0070435)
0.2 1.2 GO:0001740 Barr body(GO:0001740)
0.1 1.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 4.7 GO:0031143 pseudopodium(GO:0031143)
0.1 0.5 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 0.7 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.6 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 0.3 GO:0034657 GID complex(GO:0034657)
0.1 1.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 1.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 0.7 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 2.1 GO:0097342 ripoptosome(GO:0097342)
0.1 1.7 GO:0042555 MCM complex(GO:0042555)
0.1 7.7 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 2.8 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 9.3 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 5.2 GO:0097542 ciliary tip(GO:0097542)
0.1 1.1 GO:0030057 desmosome(GO:0030057)
0.1 1.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 1.5 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.0 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 15.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 2.0 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 2.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 4.7 GO:0001533 cornified envelope(GO:0001533)
0.1 0.9 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.5 GO:0044294 dendritic growth cone(GO:0044294)
0.1 0.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 0.4 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.5 GO:0098845 postsynaptic endosome(GO:0098845)
0.1 0.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 7.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 4.5 GO:0035580 specific granule lumen(GO:0035580)
0.0 1.2 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 9.3 GO:0072562 blood microparticle(GO:0072562)
0.0 5.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 1.2 GO:0010369 chromocenter(GO:0010369)
0.0 1.0 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.7 GO:0032059 bleb(GO:0032059)
0.0 0.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.8 GO:0042627 chylomicron(GO:0042627)
0.0 1.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 3.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 9.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.9 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 3.2 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 2.3 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 2.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.4 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.6 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 4.1 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 1.1 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 2.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.5 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 1.0 GO:0005903 brush border(GO:0005903)
0.0 1.4 GO:1990391 DNA repair complex(GO:1990391)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 1.4 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 1.0 GO:0034774 secretory granule lumen(GO:0034774)
0.0 0.4 GO:0000346 transcription export complex(GO:0000346)
0.0 2.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.9 GO:0045178 basal part of cell(GO:0045178)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 1.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 1.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0032044 DSIF complex(GO:0032044)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 1.9 GO:0045177 apical part of cell(GO:0045177)
0.0 1.4 GO:0005643 nuclear pore(GO:0005643)
0.0 2.0 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.7 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 1.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.1 GO:0000922 spindle pole(GO:0000922)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.4 GO:0030686 90S preribosome(GO:0030686)
0.0 3.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 1.2 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
1.0 2.9 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.7 5.0 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.7 2.0 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.6 2.5 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.6 4.3 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.6 2.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.5 5.7 GO:0035005 lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.5 8.0 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.5 2.4 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.5 2.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.5 5.4 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.4 2.2 GO:0004914 interleukin-3 receptor activity(GO:0004912) interleukin-5 receptor activity(GO:0004914)
0.4 2.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.4 1.7 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.4 2.0 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.4 2.2 GO:0045569 TRAIL binding(GO:0045569)
0.4 2.8 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.4 1.8 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 5.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.3 2.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 0.9 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.3 5.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.3 1.1 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.3 0.9 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.3 1.1 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.3 4.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 3.4 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.3 1.8 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.3 0.8 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.2 1.0 GO:0002060 purine nucleobase binding(GO:0002060)
0.2 4.4 GO:0004568 chitinase activity(GO:0004568)
0.2 1.7 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.2 1.4 GO:0030492 hemoglobin binding(GO:0030492)
0.2 3.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 5.4 GO:0050700 CARD domain binding(GO:0050700)
0.2 1.2 GO:0004096 catalase activity(GO:0004096)
0.2 4.8 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.2 0.8 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.2 0.6 GO:0038131 neuregulin receptor activity(GO:0038131)
0.2 1.1 GO:0070026 nitric oxide binding(GO:0070026)
0.2 3.1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.2 1.4 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.2 6.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 2.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 1.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 1.4 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 1.7 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 6.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 2.2 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.4 GO:0017130 poly(C) RNA binding(GO:0017130)
0.1 1.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.3 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 1.1 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 0.5 GO:0005046 KDEL sequence binding(GO:0005046)
0.1 0.8 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1 0.4 GO:0004370 glycerol kinase activity(GO:0004370)
0.1 0.5 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.5 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 1.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 1.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.8 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 0.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 1.4 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.6 GO:0034594 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.1 0.5 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 23.8 GO:0003823 antigen binding(GO:0003823)
0.1 4.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 4.8 GO:0005109 frizzled binding(GO:0005109)
0.1 0.4 GO:0004803 transposase activity(GO:0004803)
0.1 0.4 GO:0032217 riboflavin transporter activity(GO:0032217)
0.1 0.4 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 1.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 1.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.7 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 0.7 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 1.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 1.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 1.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.4 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 1.4 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 8.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.0 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.6 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 0.3 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.1 0.2 GO:0016768 spermine synthase activity(GO:0016768)
0.1 0.5 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.3 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.1 1.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 3.4 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 5.7 GO:0005262 calcium channel activity(GO:0005262)
0.1 2.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 1.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 0.6 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 2.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.5 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.4 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.9 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 0.2 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820)
0.0 0.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.6 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.1 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 1.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0005230 extracellular ligand-gated ion channel activity(GO:0005230)
0.0 0.4 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 1.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.1 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 2.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.9 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.2 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 1.5 GO:0019956 chemokine binding(GO:0019956)
0.0 4.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.4 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.0 GO:0005123 death receptor binding(GO:0005123)
0.0 6.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.3 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 1.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.4 GO:0022821 potassium ion antiporter activity(GO:0022821)
0.0 0.6 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 1.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.2 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.0 0.4 GO:0035326 enhancer binding(GO:0035326)
0.0 3.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 1.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.6 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 2.2 GO:0051117 ATPase binding(GO:0051117)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 9.4 GO:0005525 GTP binding(GO:0005525)
0.0 0.2 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.7 GO:0043621 protein self-association(GO:0043621)
0.0 0.9 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.2 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.8 GO:0048306 calcium-dependent protein binding(GO:0048306)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.2 16.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 2.2 PID IL5 PATHWAY IL5-mediated signaling events
0.2 4.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 20.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 5.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 5.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 4.6 PID IL27 PATHWAY IL27-mediated signaling events
0.1 1.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 3.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 5.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 3.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 10.8 PID BCR 5PATHWAY BCR signaling pathway
0.1 4.0 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 2.3 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 2.2 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 1.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 5.5 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 1.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 7.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 1.3 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 1.5 PID IL23 PATHWAY IL23-mediated signaling events
0.1 0.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 1.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 1.6 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 1.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.8 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.4 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 6.0 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 2.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.0 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.2 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.2 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 1.4 PID FOXO PATHWAY FoxO family signaling
0.0 1.6 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID ARF 3PATHWAY Arf1 pathway
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.6 PID P75 NTR PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 2.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 5.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 2.5 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.2 13.0 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2 6.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 4.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 1.8 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.2 12.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 7.4 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.2 6.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 4.3 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 1.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 4.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 6.5 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.1 0.7 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 6.0 REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.1 1.3 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 2.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 5.5 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 2.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 1.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 4.4 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 9.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.6 REACTOME PI3K EVENTS IN ERBB4 SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.1 1.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 1.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 0.7 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 5.1 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 5.0 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 4.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.0 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 4.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.9 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 1.6 REACTOME KERATAN SULFATE KERATIN METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.0 0.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.7 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.6 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 4.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 2.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.7 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.4 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.2 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.2 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.1 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.4 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.3 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.4 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 0.2 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.1 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation