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Illumina Body Map 2, young vs old

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Results for NKX1-1

Z-value: 0.21

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.1 NK1 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX1-1hg19_v2_chr4_-_1400119_1400119-0.841.3e-09Click!

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_16500599 3.11 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr12_+_16500571 3.09 ENST00000543076.1
ENST00000396210.3
MGST1
microsomal glutathione S-transferase 1
chr12_+_16500037 2.98 ENST00000536371.1
ENST00000010404.2
MGST1
microsomal glutathione S-transferase 1
chr3_+_186560476 1.32 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr3_+_186560462 1.31 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr10_+_5238793 0.89 ENST00000263126.1
AKR1C4
aldo-keto reductase family 1, member C4
chr14_+_22670455 0.83 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr9_+_34646651 0.81 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr7_+_26331541 0.80 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
SNX10
sorting nexin 10
chr17_-_27418537 0.75 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr12_+_64798826 0.69 ENST00000540203.1
XPOT
exportin, tRNA
chr7_+_26331678 0.69 ENST00000446848.2
SNX10
sorting nexin 10
chr9_+_34646624 0.67 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr10_+_120789223 0.66 ENST00000425699.1
NANOS1
nanos homolog 1 (Drosophila)
chr1_+_161691353 0.65 ENST00000367948.2
FCRLB
Fc receptor-like B
chr7_+_50348268 0.64 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr4_-_89442940 0.64 ENST00000527353.1
PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chrX_+_19362011 0.60 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr13_-_36050819 0.59 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr2_-_47143160 0.58 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr1_-_21620877 0.55 ENST00000527991.1
ECE1
endothelin converting enzyme 1
chr2_-_47142884 0.52 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr7_+_2559399 0.50 ENST00000222725.5
ENST00000359574.3
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr22_+_22730353 0.50 ENST00000390296.2
IGLV5-45
immunoglobulin lambda variable 5-45
chr6_-_167040693 0.48 ENST00000366863.2
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr6_-_82957433 0.47 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr19_-_14228541 0.47 ENST00000590853.1
ENST00000308677.4
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr22_-_39151463 0.46 ENST00000405510.1
ENST00000433561.1
SUN2
Sad1 and UNC84 domain containing 2
chr22_+_41601209 0.46 ENST00000216237.5
L3MBTL2
l(3)mbt-like 2 (Drosophila)
chr2_+_8822113 0.46 ENST00000396290.1
ENST00000331129.3
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr5_+_66300464 0.46 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr10_+_99205894 0.45 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr3_+_158519654 0.44 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
MFSD1
major facilitator superfamily domain containing 1
chr10_-_99205607 0.44 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr17_+_57233087 0.43 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr10_+_99205959 0.41 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr1_-_221915418 0.41 ENST00000323825.3
ENST00000366899.3
DUSP10
dual specificity phosphatase 10
chr14_-_24711764 0.39 ENST00000557921.1
ENST00000558476.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr11_-_124981475 0.38 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr9_+_116225999 0.37 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr7_-_6048650 0.37 ENST00000382321.4
ENST00000406569.3
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr11_-_47198380 0.37 ENST00000419701.2
ENST00000526342.1
ENST00000528444.1
ENST00000530596.1
ENST00000525398.1
ENST00000319543.6
ENST00000426335.2
ENST00000527927.1
ENST00000525314.1
ARFGAP2
ADP-ribosylation factor GTPase activating protein 2
chr1_+_155278539 0.37 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chrX_+_55026763 0.37 ENST00000374987.3
APEX2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr10_+_1095416 0.37 ENST00000358220.1
WDR37
WD repeat domain 37
chr16_-_11036300 0.37 ENST00000331808.4
DEXI
Dexi homolog (mouse)
chr1_+_62439037 0.36 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr5_+_66300446 0.36 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr14_-_24711806 0.35 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr1_+_155278625 0.35 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr21_-_37914898 0.35 ENST00000399136.1
CLDN14
claudin 14
chr3_-_105587879 0.35 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr17_+_45286387 0.34 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr11_-_62521614 0.34 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr17_+_57232690 0.33 ENST00000262293.4
PRR11
proline rich 11
chr11_-_65625678 0.32 ENST00000308162.5
CFL1
cofilin 1 (non-muscle)
chr14_-_24711470 0.32 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr15_-_78526942 0.32 ENST00000258873.4
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr6_-_167040731 0.31 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr14_-_24711865 0.31 ENST00000399423.4
ENST00000267415.7
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr18_+_55888767 0.30 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr17_+_45286706 0.30 ENST00000393450.1
ENST00000572303.1
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr5_-_115890554 0.29 ENST00000509665.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr10_-_1094819 0.28 ENST00000429642.1
IDI1
isopentenyl-diphosphate delta isomerase 1
chr12_+_28410128 0.28 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr4_-_54232144 0.28 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
SCFD2
sec1 family domain containing 2
chr17_-_8055747 0.28 ENST00000317276.4
ENST00000581703.1
PER1
period circadian clock 1
chr17_-_45266542 0.27 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr2_+_105050794 0.26 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr15_+_96904487 0.26 ENST00000600790.1
AC087477.1
Uncharacterized protein
chr10_-_1095050 0.25 ENST00000381344.3
IDI1
isopentenyl-diphosphate delta isomerase 1
chr12_+_48499252 0.25 ENST00000549003.1
ENST00000550924.1
PFKM
phosphofructokinase, muscle
chr19_+_50270219 0.25 ENST00000354293.5
ENST00000359032.5
AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr7_+_99647411 0.25 ENST00000438937.1
ZSCAN21
zinc finger and SCAN domain containing 21
chrX_-_153363125 0.25 ENST00000407218.1
ENST00000453960.2
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr7_-_6048702 0.24 ENST00000265849.7
PMS2
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr18_+_63273310 0.23 ENST00000579862.1
RP11-775G23.1
RP11-775G23.1
chr11_-_62494821 0.23 ENST00000301785.5
HNRNPUL2
heterogeneous nuclear ribonucleoprotein U-like 2
chr17_-_57232596 0.23 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr14_+_32798462 0.22 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr7_-_33102338 0.22 ENST00000610140.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr7_-_33102399 0.21 ENST00000242210.7
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr11_-_59383617 0.21 ENST00000263847.1
OSBP
oxysterol binding protein
chr12_-_102513843 0.21 ENST00000551744.2
ENST00000552283.1
NUP37
nucleoporin 37kDa
chr17_-_10372875 0.20 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr7_+_6048856 0.20 ENST00000223029.3
ENST00000400479.2
ENST00000395236.2
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr12_+_2921788 0.19 ENST00000228799.2
ENST00000419778.2
ENST00000542548.1
ITFG2
integrin alpha FG-GAP repeat containing 2
chr3_-_105588231 0.19 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr11_-_111741994 0.19 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr15_-_75199213 0.19 ENST00000562698.1
FAM219B
family with sequence similarity 219, member B
chr4_+_128554081 0.18 ENST00000335251.6
ENST00000296461.5
INTU
inturned planar cell polarity protein
chr8_+_94929077 0.18 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr8_+_26371763 0.18 ENST00000521913.1
DPYSL2
dihydropyrimidinase-like 2
chr19_-_6424783 0.18 ENST00000398148.3
KHSRP
KH-type splicing regulatory protein
chr3_+_186288454 0.18 ENST00000265028.3
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr1_-_159915386 0.17 ENST00000361509.3
ENST00000368094.1
IGSF9
immunoglobulin superfamily, member 9
chr2_-_97405775 0.17 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
LMAN2L
lectin, mannose-binding 2-like
chr8_+_94929168 0.16 ENST00000518107.1
ENST00000396200.3
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr17_-_57232525 0.16 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr11_+_119205222 0.15 ENST00000311413.4
RNF26
ring finger protein 26
chr15_-_64386120 0.15 ENST00000300030.3
FAM96A
family with sequence similarity 96, member A
chr4_-_103682145 0.15 ENST00000226578.4
MANBA
mannosidase, beta A, lysosomal
chr3_+_57261743 0.15 ENST00000288266.3
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr11_+_72983246 0.14 ENST00000393590.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr7_+_99647389 0.14 ENST00000543588.1
ENST00000292450.4
ENST00000456748.2
ZSCAN21
zinc finger and SCAN domain containing 21
chr8_+_94929110 0.14 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr1_-_108507631 0.14 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr5_+_150226085 0.13 ENST00000522154.1
IRGM
immunity-related GTPase family, M
chr2_+_187371440 0.13 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr17_-_44657017 0.13 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
ARL17A
ADP-ribosylation factor-like 17A
chr11_-_118023594 0.12 ENST00000529878.1
SCN4B
sodium channel, voltage-gated, type IV, beta subunit
chr12_+_6961279 0.12 ENST00000229268.8
ENST00000389231.5
ENST00000542087.1
USP5
ubiquitin specific peptidase 5 (isopeptidase T)
chr17_-_61777459 0.12 ENST00000578993.1
ENST00000583211.1
ENST00000259006.3
LIMD2
LIM domain containing 2
chr17_-_44439084 0.12 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
ARL17B
ADP-ribosylation factor-like 17B
chrX_-_47509994 0.11 ENST00000343894.4
ELK1
ELK1, member of ETS oncogene family
chr9_+_124329336 0.11 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr2_-_167232484 0.11 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr1_-_231004220 0.11 ENST00000366663.5
C1orf198
chromosome 1 open reading frame 198
chr3_+_23851928 0.11 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr11_-_71823796 0.10 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr8_+_98656693 0.10 ENST00000519934.1
MTDH
metadherin
chr15_-_64385981 0.10 ENST00000557835.1
ENST00000380290.3
ENST00000559950.1
FAM96A
family with sequence similarity 96, member A
chr19_+_45504688 0.10 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr1_+_222910625 0.10 ENST00000360827.2
FAM177B
family with sequence similarity 177, member B
chr11_-_4629388 0.10 ENST00000526337.1
ENST00000300747.5
TRIM68
tripartite motif containing 68
chr4_-_19458597 0.09 ENST00000505347.1
RP11-3J1.1
RP11-3J1.1
chr17_-_8113886 0.09 ENST00000577833.1
ENST00000534871.1
ENST00000583915.1
ENST00000316199.6
ENST00000581511.1
ENST00000585124.1
AURKB
aurora kinase B
chr5_-_159546396 0.09 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr11_-_4629367 0.08 ENST00000533021.1
TRIM68
tripartite motif containing 68
chr11_-_71823715 0.08 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr6_-_85473073 0.07 ENST00000606621.1
TBX18
T-box 18
chr19_+_36249057 0.06 ENST00000301165.5
ENST00000536950.1
ENST00000537459.1
ENST00000421853.2
C19orf55
chromosome 19 open reading frame 55
chr1_+_46972668 0.06 ENST00000371956.4
ENST00000360032.3
DMBX1
diencephalon/mesencephalon homeobox 1
chr13_+_36050881 0.05 ENST00000537702.1
NBEA
neurobeachin
chr7_-_27239703 0.05 ENST00000222753.4
HOXA13
homeobox A13
chr19_-_8070474 0.05 ENST00000407627.2
ENST00000593807.1
ELAVL1
ELAV like RNA binding protein 1
chr16_-_66864806 0.05 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NAE1
NEDD8 activating enzyme E1 subunit 1
chr11_-_105892937 0.05 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr10_-_56560939 0.04 ENST00000373955.1
PCDH15
protocadherin-related 15
chr8_+_98656336 0.04 ENST00000336273.3
MTDH
metadherin
chr9_+_139780942 0.03 ENST00000247668.2
ENST00000359662.3
TRAF2
TNF receptor-associated factor 2
chrX_-_47509887 0.03 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
ELK1
ELK1, member of ETS oncogene family
chrX_+_72783026 0.03 ENST00000373504.6
ENST00000373502.5
CHIC1
cysteine-rich hydrophobic domain 1
chr7_-_99716914 0.03 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_+_174843548 0.02 ENST00000478442.1
ENST00000465412.1
RABGAP1L
RAB GTPase activating protein 1-like
chr8_+_94929273 0.02 ENST00000518573.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr17_-_40337470 0.00 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.2 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.9 2.6 GO:0097018 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.5 1.5 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.2 1.4 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.1 0.7 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 0.5 GO:0050992 dimethylallyl diphosphate biosynthetic process(GO:0050992) dimethylallyl diphosphate metabolic process(GO:0050993)
0.1 0.9 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 0.6 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.1 0.5 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.4 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.2 GO:0009405 pathogenesis(GO:0009405)
0.1 0.2 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.1 0.5 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.2 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.6 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.5 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.3 GO:0051511 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.2 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 1.5 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.5 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.3 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.6 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.4 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.1 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.0 0.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0060829 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827) negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0 0.1 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.7 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.5 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.9 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.2 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158) regulation of miRNA metabolic process(GO:2000628)
0.0 0.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.1 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.6 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.0 0.1 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.2 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.4 GO:0000470 maturation of LSU-rRNA(GO:0000470)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.6 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.1 1.4 GO:0070187 telosome(GO:0070187)
0.1 9.3 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.6 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.6 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.4 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 2.6 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.1 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.2 GO:0043295 glutathione binding(GO:0043295)
0.2 0.9 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.2 2.6 GO:0033691 sialic acid binding(GO:0033691)
0.2 0.6 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.7 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 0.5 GO:0004452 isopentenyl-diphosphate delta-isomerase activity(GO:0004452)
0.1 0.6 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.1 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.5 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 1.5 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.4 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.1 0.6 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.1 0.5 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 0.4 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0 0.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 1.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.4 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.2 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.9 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.2 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.3 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.0 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0005537 mannose binding(GO:0005537)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.1 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.1 GO:0035174 histone serine kinase activity(GO:0035174)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.2 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.9 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 2.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.2 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.1 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C