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Illumina Body Map 2, young vs old

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Results for NKX1-2_RAX

Z-value: 0.38

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Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
NKX1-2
ENSG00000229544.6 NK1 homeobox 2
RAX
ENSG00000134438.9 retina and anterior neural fold homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RAXhg19_v2_chr18_-_56940611_56940660-0.261.6e-01Click!
NKX1-2hg19_v2_chr10_-_126138622_126138753-0.202.7e-01Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_114827818 2.84 ENST00000420625.2
PLS3
plastin 3
chr12_-_22063787 2.61 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr10_-_4285835 2.59 ENST00000454470.1
LINC00702
long intergenic non-protein coding RNA 702
chrX_+_114827851 2.34 ENST00000539310.1
PLS3
plastin 3
chr7_+_70597109 2.23 ENST00000333538.5
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr14_+_32798462 2.20 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr2_+_217524323 2.02 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr14_+_32798547 1.97 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr10_-_4285923 1.95 ENST00000418372.1
ENST00000608792.1
LINC00702
long intergenic non-protein coding RNA 702
chr1_+_201979645 1.77 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr10_+_6779326 1.73 ENST00000417112.1
RP11-554I8.2
RP11-554I8.2
chrX_+_43515467 1.72 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr6_+_53964336 1.67 ENST00000447836.2
ENST00000511678.1
MLIP
muscular LMNA-interacting protein
chr3_-_151034734 1.66 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr4_+_77356248 1.62 ENST00000296043.6
SHROOM3
shroom family member 3
chr9_+_124329336 1.62 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chrX_-_21676442 1.54 ENST00000379499.2
KLHL34
kelch-like family member 34
chr13_-_36050819 1.46 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr6_+_53883708 1.36 ENST00000514921.1
ENST00000274897.5
ENST00000370877.2
MLIP
muscular LMNA-interacting protein
chr10_+_99205959 1.35 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr1_+_62439037 1.34 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr3_-_120400960 1.33 ENST00000476082.2
HGD
homogentisate 1,2-dioxygenase
chr10_+_24755416 1.22 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr9_-_95166976 1.20 ENST00000447356.1
OGN
osteoglycin
chr7_+_120628731 1.18 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr9_-_95166841 1.16 ENST00000262551.4
OGN
osteoglycin
chr5_-_35938674 1.16 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL
calcyphosine-like
chr7_-_7575477 1.13 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chr1_-_151804314 1.12 ENST00000318247.6
RORC
RAR-related orphan receptor C
chr5_-_102898465 1.05 ENST00000507423.1
ENST00000230792.2
NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr17_+_1666108 1.03 ENST00000570731.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_+_99205894 0.96 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr6_-_94129244 0.96 ENST00000369303.4
ENST00000369297.1
EPHA7
EPH receptor A7
chr11_-_59383617 0.95 ENST00000263847.1
OSBP
oxysterol binding protein
chr1_+_186265399 0.88 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr12_+_18414446 0.88 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr1_+_160370344 0.87 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr1_+_162336686 0.86 ENST00000420220.1
C1orf226
chromosome 1 open reading frame 226
chr11_+_71900572 0.86 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr11_+_71900703 0.86 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr7_-_107443652 0.84 ENST00000340010.5
ENST00000422236.2
ENST00000453332.1
SLC26A3
solute carrier family 26 (anion exchanger), member 3
chr3_+_28390637 0.84 ENST00000420223.1
ENST00000383768.2
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr11_+_112047087 0.82 ENST00000526088.1
ENST00000532593.1
ENST00000531169.1
BCO2
beta-carotene oxygenase 2
chr12_+_7014126 0.82 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr8_-_101571933 0.81 ENST00000520311.1
ANKRD46
ankyrin repeat domain 46
chr12_+_7013897 0.77 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr13_+_36050881 0.77 ENST00000537702.1
NBEA
neurobeachin
chr3_-_105587879 0.76 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr8_+_92261516 0.74 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr16_+_82068585 0.72 ENST00000563491.1
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr2_-_198540751 0.72 ENST00000429081.1
RFTN2
raftlin family member 2
chr1_-_159832438 0.72 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr2_-_190446738 0.70 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr10_-_92681033 0.70 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr19_-_46285736 0.70 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase
chr14_+_74034310 0.68 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chrX_+_130192318 0.67 ENST00000370922.1
ARHGAP36
Rho GTPase activating protein 36
chr3_+_183853052 0.65 ENST00000273783.3
ENST00000432569.1
ENST00000444495.1
EIF2B5
eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
chr12_+_7014064 0.64 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr17_-_10372875 0.63 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr8_-_101571964 0.61 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ANKRD46
ankyrin repeat domain 46
chr20_+_43990576 0.59 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr8_-_29605625 0.58 ENST00000506121.3
LINC00589
long intergenic non-protein coding RNA 589
chr4_-_74486217 0.58 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr19_+_48949087 0.57 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chr1_-_159915386 0.56 ENST00000361509.3
ENST00000368094.1
IGSF9
immunoglobulin superfamily, member 9
chr11_+_22689648 0.53 ENST00000278187.3
GAS2
growth arrest-specific 2
chr6_+_160542870 0.52 ENST00000324965.4
ENST00000457470.2
SLC22A1
solute carrier family 22 (organic cation transporter), member 1
chr11_+_118398178 0.52 ENST00000302783.4
ENST00000539546.1
TTC36
tetratricopeptide repeat domain 36
chr4_-_103749105 0.51 ENST00000394801.4
ENST00000394804.2
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chrX_+_135618258 0.51 ENST00000440515.1
ENST00000456412.1
VGLL1
vestigial like 1 (Drosophila)
chrX_+_19362011 0.51 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr7_+_100770328 0.50 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr9_+_109685630 0.50 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr4_-_175041663 0.50 ENST00000503140.1
RP11-148L24.1
RP11-148L24.1
chr11_-_4389616 0.49 ENST00000408920.2
OR52B4
olfactory receptor, family 52, subfamily B, member 4
chr5_-_82969363 0.49 ENST00000503117.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr17_+_59489112 0.48 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr6_-_167040731 0.48 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr6_-_167040693 0.48 ENST00000366863.2
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr4_-_103749313 0.47 ENST00000394803.5
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr2_-_198540719 0.46 ENST00000295049.4
RFTN2
raftlin family member 2
chr3_+_195447738 0.46 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
MUC20
mucin 20, cell surface associated
chr5_-_82969405 0.44 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr17_-_27418537 0.43 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr2_-_220264703 0.43 ENST00000519905.1
ENST00000523282.1
ENST00000434339.1
ENST00000457935.1
DNPEP
aspartyl aminopeptidase
chr5_+_63802109 0.43 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr11_-_102651343 0.42 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chrM_+_9207 0.41 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr21_-_37914898 0.41 ENST00000399136.1
CLDN14
claudin 14
chr8_-_30670384 0.40 ENST00000221138.4
ENST00000518243.1
PPP2CB
protein phosphatase 2, catalytic subunit, beta isozyme
chr4_-_103749179 0.39 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr19_-_36001113 0.39 ENST00000434389.1
DMKN
dermokine
chrX_+_77154935 0.38 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr7_+_138145076 0.38 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr12_-_74686314 0.37 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr2_+_191221240 0.36 ENST00000409027.1
ENST00000458193.1
INPP1
inositol polyphosphate-1-phosphatase
chr15_-_43882140 0.36 ENST00000429176.1
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1
chr16_-_55866997 0.36 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr4_-_10686475 0.34 ENST00000226951.6
CLNK
cytokine-dependent hematopoietic cell linker
chr11_-_123814580 0.34 ENST00000321252.2
OR6T1
olfactory receptor, family 6, subfamily T, member 1
chr19_+_37742773 0.34 ENST00000438770.2
ENST00000591116.1
ENST00000592712.1
AC012309.5
AC012309.5
chr9_+_125133467 0.33 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr14_+_20187174 0.33 ENST00000557414.1
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr12_+_8309630 0.33 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr5_-_94890648 0.32 ENST00000513823.1
ENST00000514952.1
ENST00000358746.2
TTC37
tetratricopeptide repeat domain 37
chr16_-_20702578 0.32 ENST00000307493.4
ENST00000219151.4
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr1_+_43148059 0.30 ENST00000321358.7
ENST00000332220.6
YBX1
Y box binding protein 1
chr11_-_63376013 0.30 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr5_+_66300446 0.30 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr9_-_21239978 0.30 ENST00000380222.2
IFNA14
interferon, alpha 14
chr12_+_82347498 0.29 ENST00000550506.1
RP11-362A1.1
RP11-362A1.1
chr1_-_190446759 0.29 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr4_-_103749205 0.29 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr3_-_55539287 0.29 ENST00000472238.1
RP11-875H7.5
RP11-875H7.5
chr8_+_105602961 0.28 ENST00000521923.1
RP11-127H5.1
Uncharacterized protein
chr14_+_67831576 0.28 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr17_-_4938712 0.28 ENST00000254853.5
ENST00000424747.1
SLC52A1
solute carrier family 52 (riboflavin transporter), member 1
chr3_-_105588231 0.27 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr12_+_16500571 0.27 ENST00000543076.1
ENST00000396210.3
MGST1
microsomal glutathione S-transferase 1
chr10_-_105845536 0.27 ENST00000393211.3
COL17A1
collagen, type XVII, alpha 1
chr4_-_103748880 0.27 ENST00000453744.2
ENST00000349311.8
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr2_+_187371440 0.26 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chr7_-_99716952 0.26 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr19_+_8740061 0.26 ENST00000593792.1
CTD-2586B10.1
CTD-2586B10.1
chr2_-_239197201 0.25 ENST00000254658.3
PER2
period circadian clock 2
chr2_-_239197238 0.25 ENST00000254657.3
PER2
period circadian clock 2
chr1_+_158449668 0.25 ENST00000368152.1
OR10R2
olfactory receptor, family 10, subfamily R, member 2
chr6_-_111927449 0.24 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr3_+_186353756 0.24 ENST00000431018.1
ENST00000450521.1
ENST00000539949.1
FETUB
fetuin B
chr7_-_99716940 0.24 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr19_+_48949030 0.24 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr4_-_74486109 0.23 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr4_+_66536248 0.23 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr2_-_74619152 0.22 ENST00000440727.1
ENST00000409240.1
DCTN1
dynactin 1
chr12_+_32832203 0.22 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
DNM1L
dynamin 1-like
chr12_-_23737534 0.21 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr6_-_82957433 0.20 ENST00000306270.7
IBTK
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr12_+_64798826 0.20 ENST00000540203.1
XPOT
exportin, tRNA
chr6_-_111927062 0.20 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr15_+_93447675 0.20 ENST00000536619.1
CHD2
chromodomain helicase DNA binding protein 2
chr12_+_16500599 0.19 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
MGST1
microsomal glutathione S-transferase 1
chr6_+_52442083 0.19 ENST00000606714.1
TRAM2-AS1
TRAM2 antisense RNA 1 (head to head)
chr4_-_141348789 0.19 ENST00000414773.1
CLGN
calmegin
chr4_-_74486347 0.19 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr16_-_48281444 0.19 ENST00000537808.1
ENST00000569991.1
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr7_-_99717463 0.19 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr9_+_135937365 0.18 ENST00000372080.4
ENST00000351304.7
CEL
carboxyl ester lipase
chr4_-_68829144 0.18 ENST00000508048.1
TMPRSS11A
transmembrane protease, serine 11A
chr3_-_11685345 0.18 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr11_-_121986923 0.18 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr11_+_29181503 0.17 ENST00000530960.1
RP11-466I1.1
RP11-466I1.1
chr1_-_28969517 0.16 ENST00000263974.4
ENST00000373824.4
TAF12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr4_+_31998999 0.16 ENST00000513211.1
RP11-734I18.1
RP11-734I18.1
chr6_+_30687978 0.16 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr20_-_1447547 0.16 ENST00000476071.1
NSFL1C
NSFL1 (p97) cofactor (p47)
chr8_+_9413410 0.14 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr13_+_111748183 0.14 ENST00000422994.1
LINC00368
long intergenic non-protein coding RNA 368
chr9_+_34646651 0.14 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr11_-_74800799 0.14 ENST00000305159.3
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr9_+_34646624 0.13 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr9_-_5339873 0.13 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr17_-_33390667 0.12 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr22_-_28490123 0.12 ENST00000442232.1
TTC28
tetratricopeptide repeat domain 28
chr19_+_46236509 0.12 ENST00000457052.2
AC074212.3
Uncharacterized protein
chr14_-_53258314 0.12 ENST00000216410.3
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr19_-_36822551 0.12 ENST00000591372.1
LINC00665
long intergenic non-protein coding RNA 665
chr12_-_10959892 0.12 ENST00000240615.2
TAS2R8
taste receptor, type 2, member 8
chr10_-_99205607 0.11 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr11_-_124981475 0.11 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
TMEM218
transmembrane protein 218
chr19_-_3985455 0.11 ENST00000309311.6
EEF2
eukaryotic translation elongation factor 2
chr12_+_112279782 0.11 ENST00000550735.2
MAPKAPK5
mitogen-activated protein kinase-activated protein kinase 5
chr16_-_48281305 0.11 ENST00000356608.2
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr4_-_68829226 0.11 ENST00000396188.2
TMPRSS11A
transmembrane protease, serine 11A
chr20_-_1447467 0.11 ENST00000353088.2
ENST00000350991.4
NSFL1C
NSFL1 (p97) cofactor (p47)
chr10_-_105845674 0.09 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr8_+_105235572 0.08 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr6_+_154360476 0.08 ENST00000428397.2
OPRM1
opioid receptor, mu 1
chr12_+_90674665 0.08 ENST00000549313.1
RP11-753N8.1
RP11-753N8.1
chr4_+_110736659 0.08 ENST00000394631.3
ENST00000226796.6
GAR1
GAR1 ribonucleoprotein
chr19_-_36822595 0.08 ENST00000585356.1
ENST00000438368.2
ENST00000590622.1
LINC00665
long intergenic non-protein coding RNA 665
chr11_-_111741994 0.08 ENST00000398006.2
ALG9
ALG9, alpha-1,2-mannosyltransferase
chr2_-_86422095 0.07 ENST00000254636.5
IMMT
inner membrane protein, mitochondrial
chr21_-_35796241 0.07 ENST00000450895.1
AP000322.53
AP000322.53
chr6_-_49937338 0.07 ENST00000398718.1
DEFB113
defensin, beta 113
chr2_-_74618907 0.06 ENST00000421392.1
ENST00000437375.1
DCTN1
dynactin 1
chr1_-_211307404 0.05 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr6_+_78400375 0.05 ENST00000602452.2
MEI4
meiosis-specific 4 homolog (S. cerevisiae)
chr3_+_186560476 0.05 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr1_+_28261492 0.05 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr8_+_29605825 0.05 ENST00000522158.1
AC145110.1
AC145110.1
chr14_+_55493920 0.05 ENST00000395472.2
ENST00000555846.1
SOCS4
suppressor of cytokine signaling 4
chr3_+_186560462 0.05 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr16_-_52061283 0.04 ENST00000566314.1
C16orf97
chromosome 16 open reading frame 97
chr8_-_94179079 0.03 ENST00000521906.1
C8orf87
chromosome 8 open reading frame 87
chr9_-_7961080 0.03 ENST00000435444.1
RP11-29B9.2
RP11-29B9.2
chr6_+_34204642 0.03 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr17_-_40337470 0.03 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr19_+_36239576 0.03 ENST00000587751.1
LIN37
lin-37 homolog (C. elegans)
chr1_+_192605252 0.03 ENST00000391995.2
ENST00000543215.1
RGS13
regulator of G-protein signaling 13

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.5 4.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.4 1.1 GO:0019364 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.3 1.6 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 0.9 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 0.8 GO:0042214 terpene metabolic process(GO:0042214)
0.2 0.7 GO:1903414 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.2 5.2 GO:0051639 actin filament network formation(GO:0051639)
0.2 0.5 GO:0001300 chronological cell aging(GO:0001300)
0.2 0.5 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 1.3 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 1.7 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 2.4 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 1.8 GO:0060056 mammary gland involution(GO:0060056)
0.1 1.6 GO:0045176 apical protein localization(GO:0045176)
0.1 1.0 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 0.9 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.1 0.3 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.1 0.4 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.1 0.5 GO:0019249 lactate biosynthetic process(GO:0019249) regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.1 1.2 GO:0032596 protein transport into membrane raft(GO:0032596)
0.1 0.3 GO:0018874 benzoate metabolic process(GO:0018874)
0.1 1.6 GO:0019532 oxalate transport(GO:0019532)
0.1 0.5 GO:0048241 epinephrine transport(GO:0048241)
0.1 0.2 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.1 2.0 GO:0010226 response to lithium ion(GO:0010226)
0.1 1.7 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.4 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.3 GO:0032218 riboflavin transport(GO:0032218)
0.1 2.3 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.5 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 1.0 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.4 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.7 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 1.0 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 2.6 GO:0010107 potassium ion import(GO:0010107)
0.0 0.9 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.2 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 1.1 GO:0036315 cellular response to sterol(GO:0036315)
0.0 0.1 GO:0097018 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.9 GO:0044126 regulation of growth of symbiont in host(GO:0044126)
0.0 0.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.7 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 1.9 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.0 0.7 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.8 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.6 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.0 0.9 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.1 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.7 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.3 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.4 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.3 GO:0015865 purine nucleotide transport(GO:0015865)
0.0 0.1 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:1990032 parallel fiber(GO:1990032)
0.3 2.6 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 4.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.2 0.9 GO:0060187 cell pole(GO:0060187)
0.1 0.3 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.1 0.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.3 GO:0055087 Ski complex(GO:0055087)
0.1 1.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.5 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 1.0 GO:0043203 axon hillock(GO:0043203)
0.0 0.3 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.1 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.0 0.8 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.8 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.3 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 5.2 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.6 GO:0032982 myosin filament(GO:0032982)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.9 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.7 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 2.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 3.0 GO:0016605 PML body(GO:0016605)
0.0 1.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.4 1.7 GO:0061714 folic acid receptor activity(GO:0061714)
0.2 0.7 GO:0097689 iron channel activity(GO:0097689)
0.2 0.7 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 1.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 1.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.2 4.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 1.7 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 2.1 GO:0008142 oxysterol binding(GO:0008142)
0.1 2.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.5 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.1 0.5 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.7 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.1 1.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.4 GO:0052829 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.1 0.4 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1 0.3 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 2.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 1.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.3 GO:0032217 riboflavin transporter activity(GO:0032217)
0.1 2.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 2.1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.4 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.7 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.6 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.9 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.4 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.8 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.5 GO:0043295 glutathione binding(GO:0043295)
0.0 0.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.3 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 6.4 GO:0051015 actin filament binding(GO:0051015)
0.0 2.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.0 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.6 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.6 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.5 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.9 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.7 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 2.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.9 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 2.6 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 1.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.9 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 2.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 1.0 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.7 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression