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Illumina Body Map 2, young vs old

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Results for NKX2-1

Z-value: 0.73

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Transcription factors associated with NKX2-1

Gene Symbol Gene ID Gene Info
NKX2-1
ENSG00000136352.13 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-1hg19_v2_chr14_-_36990061_369901540.569.4e-04Click!

Activity profile of NKX2-1 motif

Sorted Z-values of NKX2-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_101962128 5.97 ENST00000550514.1
MYBPC1
myosin binding protein C, slow type
chr3_-_42744312 3.44 ENST00000416756.1
ENST00000441594.1
HHATL
hedgehog acyltransferase-like
chr20_+_30407151 3.25 ENST00000375985.4
MYLK2
myosin light chain kinase 2
chr20_+_30407105 3.17 ENST00000375994.2
MYLK2
myosin light chain kinase 2
chr17_-_10452929 3.11 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chr19_+_38924316 3.10 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1
ryanodine receptor 1 (skeletal)
chr9_-_97356075 2.80 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr2_+_168043793 2.43 ENST00000409273.1
ENST00000409605.1
XIRP2
xin actin-binding repeat containing 2
chr8_+_22019168 2.38 ENST00000318561.3
ENST00000521315.1
ENST00000437090.2
ENST00000520605.1
ENST00000522109.1
ENST00000524255.1
ENST00000523296.1
ENST00000518615.1
SFTPC
surfactant protein C
chr3_-_42744270 1.85 ENST00000457462.1
HHATL
hedgehog acyltransferase-like
chr6_-_113953705 1.84 ENST00000452675.1
RP11-367G18.1
RP11-367G18.1
chr3_-_42744130 1.74 ENST00000417472.1
ENST00000442469.1
HHATL
hedgehog acyltransferase-like
chr15_-_42448788 1.74 ENST00000382396.4
ENST00000397272.3
PLA2G4F
phospholipase A2, group IVF
chr10_-_81320151 1.67 ENST00000372325.2
ENST00000372327.5
ENST00000417041.1
SFTPA2
surfactant protein A2
chr6_-_117747015 1.61 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr17_-_1508379 1.53 ENST00000412517.3
SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr3_+_121311966 1.45 ENST00000338040.4
FBXO40
F-box protein 40
chr14_+_81421710 1.43 ENST00000342443.6
TSHR
thyroid stimulating hormone receptor
chr16_+_28303804 1.39 ENST00000341901.4
SBK1
SH3 domain binding kinase 1
chr14_+_81421355 1.33 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr14_+_81421921 1.28 ENST00000554263.1
ENST00000554435.1
TSHR
thyroid stimulating hormone receptor
chrX_+_22056165 1.20 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr14_+_81421861 1.19 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr5_-_58335281 1.11 ENST00000358923.6
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_58571935 1.11 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_+_94393605 1.08 ENST00000556222.1
ENST00000554404.1
ENST00000557000.2
FAM181A
family with sequence similarity 181, member A
chr2_+_220299547 1.06 ENST00000312358.7
SPEG
SPEG complex locus
chr2_-_85895295 1.06 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr17_-_42466864 0.98 ENST00000353281.4
ENST00000262407.5
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr6_+_43968306 0.97 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr17_+_59529743 0.94 ENST00000589003.1
ENST00000393853.4
TBX4
T-box 4
chr14_+_22362613 0.92 ENST00000390438.2
TRAV8-4
T cell receptor alpha variable 8-4
chr11_+_60223225 0.90 ENST00000524807.1
ENST00000345732.4
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr7_-_24957699 0.85 ENST00000441059.1
ENST00000415162.1
OSBPL3
oxysterol binding protein-like 3
chr6_-_160679905 0.84 ENST00000366953.3
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr10_+_63808970 0.83 ENST00000309334.5
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_+_155755482 0.82 ENST00000472028.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr11_+_35160709 0.79 ENST00000415148.2
ENST00000433354.2
ENST00000449691.2
ENST00000437706.2
ENST00000360158.4
ENST00000428726.2
ENST00000526669.2
ENST00000433892.2
ENST00000278386.6
ENST00000434472.2
ENST00000352818.4
ENST00000442151.2
CD44
CD44 molecule (Indian blood group)
chrX_-_108976410 0.78 ENST00000504980.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr3_-_139195350 0.78 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr13_-_41240717 0.76 ENST00000379561.5
FOXO1
forkhead box O1
chr17_-_49198216 0.75 ENST00000262013.7
ENST00000357122.4
SPAG9
sperm associated antigen 9
chr6_-_134373732 0.73 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chrX_-_108976449 0.73 ENST00000469857.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr15_+_74911430 0.73 ENST00000562670.1
ENST00000564096.1
CLK3
CDC-like kinase 3
chr6_-_41673552 0.72 ENST00000419574.1
ENST00000445214.1
TFEB
transcription factor EB
chr1_-_17338386 0.71 ENST00000341676.5
ENST00000452699.1
ATP13A2
ATPase type 13A2
chr19_+_55014085 0.70 ENST00000351841.2
LAIR2
leukocyte-associated immunoglobulin-like receptor 2
chr19_-_10679644 0.70 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr16_+_640055 0.69 ENST00000568586.1
ENST00000538492.1
ENST00000248139.3
RAB40C
RAB40C, member RAS oncogene family
chr9_+_109685630 0.68 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr20_+_825275 0.67 ENST00000541082.1
FAM110A
family with sequence similarity 110, member A
chr12_-_54694758 0.65 ENST00000553070.1
NFE2
nuclear factor, erythroid 2
chr17_-_76778339 0.65 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
CYTH1
cytohesin 1
chr6_-_87804815 0.64 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr14_-_106068065 0.63 ENST00000390541.2
IGHE
immunoglobulin heavy constant epsilon
chr22_-_30968813 0.63 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr22_-_30968839 0.61 ENST00000445645.1
ENST00000416358.1
ENST00000423371.1
ENST00000411821.1
ENST00000448604.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_-_153538011 0.60 ENST00000368707.4
S100A2
S100 calcium binding protein A2
chr6_-_26056695 0.59 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr11_-_105948040 0.56 ENST00000534815.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr11_+_60223312 0.56 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr6_+_31674639 0.56 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr17_+_40610862 0.56 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr12_-_719573 0.55 ENST00000397265.3
NINJ2
ninjurin 2
chr15_-_94614049 0.54 ENST00000556447.1
ENST00000555772.1
CTD-3049M7.1
CTD-3049M7.1
chr8_-_16859690 0.54 ENST00000180166.5
FGF20
fibroblast growth factor 20
chrX_+_23928500 0.54 ENST00000435707.1
CXorf58
chromosome X open reading frame 58
chr9_+_33290491 0.53 ENST00000379540.3
ENST00000379521.4
ENST00000318524.6
NFX1
nuclear transcription factor, X-box binding 1
chr1_+_66999268 0.53 ENST00000371039.1
ENST00000424320.1
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr1_-_153538292 0.52 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chr3_-_56950407 0.51 ENST00000496106.1
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr8_-_114389353 0.48 ENST00000343508.3
CSMD3
CUB and Sushi multiple domains 3
chr1_-_175712665 0.47 ENST00000263525.2
TNR
tenascin R
chr8_+_145203548 0.47 ENST00000534366.1
MROH1
maestro heat-like repeat family member 1
chr1_-_228604328 0.46 ENST00000355586.4
ENST00000366698.2
ENST00000520264.1
ENST00000479800.1
ENST00000295033.3
TRIM17
tripartite motif containing 17
chr3_-_11685345 0.45 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr7_-_142583506 0.44 ENST00000359396.3
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr14_-_74892805 0.44 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr21_+_45773515 0.44 ENST00000397932.2
ENST00000300481.9
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr9_+_129986734 0.44 ENST00000444677.1
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr8_-_144679602 0.43 ENST00000526710.1
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr19_-_39390212 0.43 ENST00000437828.1
SIRT2
sirtuin 2
chr21_-_36421401 0.43 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr19_-_51336443 0.42 ENST00000598673.1
KLK15
kallikrein-related peptidase 15
chr15_-_102463298 0.42 ENST00000326183.3
OR4F4
olfactory receptor, family 4, subfamily F, member 4
chr15_+_76030311 0.42 ENST00000543887.1
AC019294.1
AC019294.1
chr11_-_105948129 0.41 ENST00000526793.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr5_+_131705438 0.40 ENST00000245407.3
SLC22A5
solute carrier family 22 (organic cation/carnitine transporter), member 5
chr10_+_111967345 0.39 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr1_-_175712829 0.39 ENST00000367674.2
TNR
tenascin R
chr3_+_19189946 0.39 ENST00000328405.2
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr17_+_61554829 0.38 ENST00000582627.1
ACE
angiotensin I converting enzyme
chr11_-_15643937 0.38 ENST00000533082.1
RP11-531H8.2
RP11-531H8.2
chr9_+_133986782 0.37 ENST00000372301.2
AIF1L
allograft inflammatory factor 1-like
chr6_-_71012773 0.37 ENST00000370496.3
ENST00000357250.6
COL9A1
collagen, type IX, alpha 1
chr5_-_134783038 0.36 ENST00000503143.2
C5orf20
chromosome 5 open reading frame 20
chr8_+_118147498 0.35 ENST00000519688.1
ENST00000456015.2
SLC30A8
solute carrier family 30 (zinc transporter), member 8
chr8_+_70404996 0.34 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr14_+_67708137 0.34 ENST00000556345.1
ENST00000555925.1
ENST00000557783.1
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr15_-_33360085 0.32 ENST00000334528.9
FMN1
formin 1
chr18_+_13382553 0.32 ENST00000586222.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr19_-_39390350 0.31 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr6_-_42858534 0.31 ENST00000408925.2
C6orf226
chromosome 6 open reading frame 226
chr20_-_35724388 0.30 ENST00000344359.3
ENST00000373664.3
RBL1
retinoblastoma-like 1 (p107)
chr16_+_640201 0.30 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr16_-_18937072 0.30 ENST00000569122.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr19_+_48972459 0.29 ENST00000427476.1
CYTH2
cytohesin 2
chr17_-_34195889 0.29 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chr10_-_103454876 0.29 ENST00000331272.7
FBXW4
F-box and WD repeat domain containing 4
chr2_+_220379052 0.28 ENST00000347842.3
ENST00000358078.4
ASIC4
acid-sensing (proton-gated) ion channel family member 4
chr19_+_50148087 0.28 ENST00000601038.1
ENST00000595242.1
SCAF1
SR-related CTD-associated factor 1
chr19_+_48972265 0.27 ENST00000452733.2
CYTH2
cytohesin 2
chr17_-_37123646 0.27 ENST00000378079.2
FBXO47
F-box protein 47
chr7_-_27224795 0.27 ENST00000006015.3
HOXA11
homeobox A11
chrX_+_136648297 0.27 ENST00000287538.5
ZIC3
Zic family member 3
chr7_-_142583478 0.26 ENST00000436401.1
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr10_+_82300575 0.26 ENST00000313455.4
SH2D4B
SH2 domain containing 4B
chr12_+_56401268 0.26 ENST00000262032.5
IKZF4
IKAROS family zinc finger 4 (Eos)
chr1_-_247876105 0.26 ENST00000302084.2
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr4_+_55524085 0.25 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr10_+_102222798 0.25 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chr16_+_2022036 0.25 ENST00000568546.1
TBL3
transducin (beta)-like 3
chr19_-_38720354 0.25 ENST00000416611.1
DPF1
D4, zinc and double PHD fingers family 1
chr1_-_156269428 0.24 ENST00000339922.3
VHLL
von Hippel-Lindau tumor suppressor-like
chr4_-_122872029 0.24 ENST00000502968.1
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr12_+_13349711 0.24 ENST00000538364.1
ENST00000396301.3
EMP1
epithelial membrane protein 1
chr6_+_42883727 0.24 ENST00000304672.1
ENST00000441198.1
ENST00000446507.1
PTCRA
pre T-cell antigen receptor alpha
chr16_-_67493110 0.23 ENST00000602876.1
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr17_-_34195862 0.23 ENST00000592980.1
ENST00000587626.1
C17orf66
chromosome 17 open reading frame 66
chr1_+_204485571 0.23 ENST00000454264.2
ENST00000367183.3
MDM4
Mdm4 p53 binding protein homolog (mouse)
chr20_-_56285595 0.23 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr11_+_105948216 0.23 ENST00000278618.4
AASDHPPT
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr2_-_105882585 0.23 ENST00000595531.1
AC012360.2
LOC644617 protein; Uncharacterized protein
chr3_+_184056614 0.22 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chr12_+_25205628 0.22 ENST00000554942.1
LRMP
lymphoid-restricted membrane protein
chr7_-_27224842 0.22 ENST00000517402.1
HOXA11
homeobox A11
chr1_+_206643806 0.22 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr12_+_121837905 0.22 ENST00000392465.3
ENST00000554606.1
ENST00000392464.2
ENST00000555076.1
RNF34
ring finger protein 34, E3 ubiquitin protein ligase
chr14_+_67707826 0.22 ENST00000261681.4
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr5_-_172662303 0.22 ENST00000517440.1
ENST00000329198.4
NKX2-5
NK2 homeobox 5
chr6_-_55740352 0.22 ENST00000370830.3
BMP5
bone morphogenetic protein 5
chr3_+_4535025 0.22 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr12_-_21810726 0.21 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr22_+_50986462 0.21 ENST00000395676.2
KLHDC7B
kelch domain containing 7B
chr19_+_1942453 0.21 ENST00000591752.1
CSNK1G2
casein kinase 1, gamma 2
chr17_+_59489112 0.21 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr10_-_98031155 0.21 ENST00000495266.1
BLNK
B-cell linker
chr21_+_33671264 0.21 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr9_-_5830768 0.21 ENST00000381506.3
ERMP1
endoplasmic reticulum metallopeptidase 1
chr12_-_21810765 0.20 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr19_+_39390320 0.20 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr12_-_67197760 0.20 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1
glutamate receptor interacting protein 1
chr2_+_152266604 0.20 ENST00000430328.2
RIF1
RAP1 interacting factor homolog (yeast)
chr3_+_172361483 0.20 ENST00000598405.1
AC007919.2
HCG1787166; PRO1163; Uncharacterized protein
chr5_-_146889619 0.20 ENST00000343218.5
DPYSL3
dihydropyrimidinase-like 3
chr1_-_153518270 0.20 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr1_+_228337553 0.19 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chrX_+_134478706 0.19 ENST00000370761.3
ENST00000339249.4
ENST00000370760.3
ZNF449
zinc finger protein 449
chr8_-_80680078 0.19 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr15_+_89182178 0.19 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr13_+_95364963 0.19 ENST00000438290.2
SOX21-AS1
SOX21 antisense RNA 1 (head to head)
chrX_+_153170455 0.19 ENST00000430697.1
ENST00000337474.5
ENST00000370049.1
AVPR2
arginine vasopressin receptor 2
chr11_-_88796803 0.19 ENST00000418177.2
ENST00000455756.2
GRM5
glutamate receptor, metabotropic 5
chr21_+_45432174 0.19 ENST00000380221.3
ENST00000291574.4
TRAPPC10
trafficking protein particle complex 10
chr18_+_42260861 0.19 ENST00000282030.5
SETBP1
SET binding protein 1
chr8_-_94752946 0.19 ENST00000519109.1
RBM12B
RNA binding motif protein 12B
chr11_-_65325430 0.19 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chrX_+_114423963 0.18 ENST00000424776.3
RBMXL3
RNA binding motif protein, X-linked-like 3
chrX_+_103029314 0.18 ENST00000429977.1
PLP1
proteolipid protein 1
chr1_-_152595579 0.17 ENST00000335674.1
LCE3A
late cornified envelope 3A
chr19_-_46234119 0.17 ENST00000317683.3
FBXO46
F-box protein 46
chr9_-_7800067 0.17 ENST00000358227.4
TMEM261
transmembrane protein 261
chr2_-_230787879 0.16 ENST00000435716.1
TRIP12
thyroid hormone receptor interactor 12
chr1_-_153517473 0.16 ENST00000368715.1
S100A4
S100 calcium binding protein A4
chr1_+_202431859 0.16 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr4_-_123377880 0.16 ENST00000226730.4
IL2
interleukin 2
chr1_-_62190793 0.16 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr3_+_4535155 0.15 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chrX_+_136648643 0.14 ENST00000370606.3
ZIC3
Zic family member 3
chr18_+_33877654 0.14 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr5_+_134094461 0.14 ENST00000452510.2
ENST00000354283.4
DDX46
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr1_-_33786699 0.14 ENST00000442999.3
A3GALT2
alpha 1,3-galactosyltransferase 2
chr1_-_38397384 0.13 ENST00000373027.1
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr6_-_27841289 0.13 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l
chr8_-_28747424 0.13 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
INTS9
integrator complex subunit 9
chr3_+_187930429 0.13 ENST00000420410.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_-_175870085 0.13 ENST00000409156.3
CHN1
chimerin 1
chr16_-_29757272 0.13 ENST00000329410.3
C16orf54
chromosome 16 open reading frame 54
chrY_-_25345070 0.13 ENST00000382510.4
ENST00000426000.2
ENST00000540248.1
ENST00000405239.1
DAZ1
deleted in azoospermia 1
chr19_+_751122 0.13 ENST00000215582.6
MISP
mitotic spindle positioning
chr12_+_6961279 0.12 ENST00000229268.8
ENST00000389231.5
ENST00000542087.1
USP5
ubiquitin specific peptidase 5 (isopeptidase T)
chr12_+_50479101 0.12 ENST00000551966.1
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr16_-_58663720 0.11 ENST00000564557.1
ENST00000569240.1
ENST00000441024.2
ENST00000569020.1
ENST00000317147.5
CNOT1
CCR4-NOT transcription complex, subunit 1
chr12_+_25205568 0.11 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr1_-_202679535 0.11 ENST00000367268.4
SYT2
synaptotagmin II
chr10_-_7708918 0.11 ENST00000256861.6
ENST00000397146.2
ENST00000446830.2
ENST00000397145.2
ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr11_-_65325203 0.11 ENST00000526927.1
ENST00000536982.1
LTBP3
latent transforming growth factor beta binding protein 3
chr7_+_99156145 0.11 ENST00000452314.1
ENST00000252713.4
ZNF655
zinc finger protein 655
chr1_-_25291475 0.10 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.0 GO:0060262 regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
1.3 5.2 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.9 6.4 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.7 2.8 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.3 1.6 GO:0010966 regulation of phosphate transport(GO:0010966)
0.3 6.0 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 0.7 GO:0061433 cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.2 1.2 GO:1904383 response to sodium phosphate(GO:1904383)
0.2 0.7 GO:1904351 negative regulation of protein catabolic process in the vacuole(GO:1904351) negative regulation of lysosomal protein catabolic process(GO:1905166)
0.2 2.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 3.1 GO:0071313 cellular response to caffeine(GO:0071313)
0.2 3.1 GO:0001778 plasma membrane repair(GO:0001778)
0.2 1.5 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 0.4 GO:0071415 cellular response to purine-containing compound(GO:0071415)
0.1 0.9 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 1.0 GO:0070417 cellular response to cold(GO:0070417)
0.1 0.4 GO:0060730 regulation of intestinal epithelial structure maintenance(GO:0060730)
0.1 0.3 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.1 1.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.8 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.3 GO:0038162 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.1 0.8 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 1.7 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.1 0.4 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.6 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.3 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.1 0.8 GO:1901374 acetate ester transport(GO:1901374)
0.1 0.5 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 0.5 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.7 GO:0048102 autophagic cell death(GO:0048102)
0.1 0.5 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.3 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.0 0.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.2 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.2 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0 0.8 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 4.8 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.8 GO:0060539 diaphragm development(GO:0060539) negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.3 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.4 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 1.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.6 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.2 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.5 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992) negative regulation of urine volume(GO:0035811)
0.0 0.5 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 1.5 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.0 0.2 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.7 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.7 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.5 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 1.7 GO:0003281 ventricular septum development(GO:0003281)
0.0 0.2 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.8 GO:0016577 histone demethylation(GO:0016577)
0.0 0.8 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.2 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.6 GO:0016486 peptide hormone processing(GO:0016486)
0.0 1.0 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.0 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 1.5 GO:0042100 B cell proliferation(GO:0042100)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.4 3.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.3 3.4 GO:0097486 multivesicular body lumen(GO:0097486)
0.2 0.9 GO:0072534 perineuronal net(GO:0072534)
0.2 6.0 GO:0032982 myosin filament(GO:0032982)
0.1 0.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.1 0.8 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.8 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 1.5 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.7 GO:0042599 lamellar body(GO:0042599)
0.1 1.1 GO:0043219 lateral loop(GO:0043219)
0.1 0.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.4 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 2.6 GO:0031941 filamentous actin(GO:0031941)
0.0 0.2 GO:0030891 VCB complex(GO:0030891)
0.0 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 8.9 GO:0030017 sarcomere(GO:0030017)
0.0 0.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.1 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.2 GO:0001939 female pronucleus(GO:0001939) male pronucleus(GO:0001940)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 2.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 11.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.4 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.7 5.2 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.7 2.8 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.6 6.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.5 1.5 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.2 0.7 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.2 6.0 GO:0031432 titin binding(GO:0031432)
0.2 0.8 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.2 1.0 GO:0070051 fibrinogen binding(GO:0070051)
0.1 1.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.7 GO:1903135 cupric ion binding(GO:1903135)
0.1 1.2 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 2.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 0.4 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.2 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 3.1 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.4 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.3 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.2 GO:0008384 IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
0.0 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 1.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.8 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 2.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.7 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.1 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.1 GO:0008859 exoribonuclease II activity(GO:0008859)
0.0 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.8 GO:0019841 retinol binding(GO:0019841)
0.0 0.8 GO:0070402 NADPH binding(GO:0070402)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 1.5 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134) glycosphingolipid binding(GO:0043208)
0.0 0.2 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 0.8 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.8 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.9 GO:0050699 WW domain binding(GO:0050699)
0.0 1.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.7 GO:0005272 sodium channel activity(GO:0005272)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 6.6 PID ARF6 PATHWAY Arf6 signaling events
0.1 3.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 5.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 1.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.9 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 1.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.1 5.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 2.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.7 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 1.2 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.2 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.8 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.4 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism