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Illumina Body Map 2, young vs old
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Results for NKX2-5
Z-value: 1.96
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Transcription factors associated with NKX2-5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-5 | hg19_v2_chr5_-_172662303_172662360 | -0.11 | 5.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.8 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 9.9 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.4 | 8.6 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.2 | 6.5 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.0 | 5.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 4.7 | GO:0008228 | opsonization(GO:0008228) |
| 0.3 | 4.5 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.0 | 4.3 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.1 | 3.5 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.1 | 3.3 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 14.6 | GO:0042599 | lamellar body(GO:0042599) |
| 0.2 | 12.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 8.9 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 6.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 6.3 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 5.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 4.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 2.7 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.1 | 2.5 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 1.8 | GO:0032433 | filopodium tip(GO:0032433) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 8.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 8.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 6.9 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 1.3 | 6.4 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
| 0.0 | 6.3 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.1 | 4.5 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 4.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.2 | 3.5 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 3.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.2 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 4.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 3.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 3.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 2.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.7 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.5 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 4.5 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 4.3 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 2.5 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.1 | 2.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 2.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.7 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.1 | 1.7 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 1.7 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 1.2 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |