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Illumina Body Map 2, young vs old

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Results for NKX2-6

Z-value: 0.56

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
NKX2-6
ENSG00000180053.6 NK2 homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-6hg19_v2_chr8_-_23563922_23564111-0.468.8e-03Click!

Activity profile of NKX2-6 motif

Sorted Z-values of NKX2-6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_22788560 6.31 ENST00000390468.1
TRAV41
T cell receptor alpha variable 41
chr19_+_3178736 4.50 ENST00000246115.3
S1PR4
sphingosine-1-phosphate receptor 4
chr22_-_37882395 4.42 ENST00000416983.3
ENST00000424765.2
ENST00000356998.3
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr7_+_142498725 4.29 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr7_+_142028105 4.02 ENST00000390353.2
TRBV6-1
T cell receptor beta variable 6-1
chr14_+_22580233 3.90 ENST00000390454.2
TRAV25
T cell receptor alpha variable 25
chr22_+_22723969 3.86 ENST00000390295.2
IGLV7-46
immunoglobulin lambda variable 7-46 (gene/pseudogene)
chr6_-_159466136 3.82 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr9_-_137809718 3.76 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr6_-_159466042 3.48 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr22_+_44577237 3.47 ENST00000415224.1
ENST00000417767.1
PARVG
parvin, gamma
chr12_-_15103621 3.37 ENST00000536592.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr1_+_158900568 3.34 ENST00000458222.1
PYHIN1
pyrin and HIN domain family, member 1
chr22_+_23229960 3.18 ENST00000526893.1
ENST00000532223.2
ENST00000531372.1
IGLL5
immunoglobulin lambda-like polypeptide 5
chr7_-_38389573 3.16 ENST00000390344.2
TRGV5
T cell receptor gamma variable 5
chr12_+_113354341 3.14 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr3_-_121379739 2.97 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr3_-_120365866 2.94 ENST00000475447.2
HGD
homogentisate 1,2-dioxygenase
chr1_+_158259558 2.91 ENST00000368170.3
CD1C
CD1c molecule
chr3_+_114012819 2.89 ENST00000383671.3
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr15_+_81475047 2.87 ENST00000559388.1
IL16
interleukin 16
chr2_+_219246746 2.85 ENST00000233202.6
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr17_-_29645836 2.84 ENST00000578584.1
CTD-2370N5.3
CTD-2370N5.3
chr14_+_22265444 2.81 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr15_-_55563072 2.81 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr22_-_24096562 2.79 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr22_+_22749343 2.69 ENST00000390298.2
IGLV7-43
immunoglobulin lambda variable 7-43
chr2_-_87088995 2.66 ENST00000393759.2
ENST00000349455.3
ENST00000331469.2
ENST00000431506.2
ENST00000393761.2
ENST00000390655.6
CD8B
CD8b molecule
chr16_-_20556492 2.56 ENST00000568098.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr9_+_215158 2.54 ENST00000479404.1
DOCK8
dedicator of cytokinesis 8
chr2_-_182521823 2.52 ENST00000410087.3
ENST00000409440.3
CERKL
ceramide kinase-like
chr4_-_48082192 2.47 ENST00000507351.1
TXK
TXK tyrosine kinase
chr1_-_108231101 2.43 ENST00000544443.1
ENST00000415432.2
VAV3
vav 3 guanine nucleotide exchange factor
chr22_-_24096630 2.42 ENST00000248948.3
VPREB3
pre-B lymphocyte 3
chr14_+_91709103 2.38 ENST00000553725.1
CTD-2547L24.3
HCG1816139; Uncharacterized protein
chr1_+_158223923 2.25 ENST00000289429.5
CD1A
CD1a molecule
chr12_-_68845165 2.19 ENST00000360485.3
ENST00000441255.2
RP11-81H14.2
RP11-81H14.2
chr2_-_112237835 2.15 ENST00000442293.1
ENST00000439494.1
MIR4435-1HG
MIR4435-1 host gene (non-protein coding)
chr16_-_20367584 2.09 ENST00000570689.1
UMOD
uromodulin
chr11_-_65629497 2.08 ENST00000532134.1
CFL1
cofilin 1 (non-muscle)
chr11_-_104827425 2.08 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_+_14561422 2.05 ENST00000541056.1
ATF7IP
activating transcription factor 7 interacting protein
chr6_-_32977345 2.04 ENST00000450833.2
ENST00000374813.1
ENST00000229829.5
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr14_+_23002427 2.01 ENST00000390527.1
TRAJ10
T cell receptor alpha joining 10
chrY_+_15418467 2.01 ENST00000595988.1
AC010877.1
Uncharacterized protein
chr19_+_7701985 2.00 ENST00000595950.1
ENST00000441779.2
ENST00000221283.5
ENST00000414284.2
STXBP2
syntaxin binding protein 2
chr14_-_60337684 1.99 ENST00000267484.5
RTN1
reticulon 1
chr17_-_57229155 1.96 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr14_-_106805716 1.89 ENST00000438142.2
IGHV4-31
immunoglobulin heavy variable 4-31
chr19_-_43835582 1.86 ENST00000595748.1
CTC-490G23.2
CTC-490G23.2
chr22_+_44577724 1.81 ENST00000466375.2
PARVG
parvin, gamma
chr13_-_30951074 1.79 ENST00000416261.1
LINC00426
long intergenic non-protein coding RNA 426
chr12_-_371994 1.78 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr2_+_87769459 1.76 ENST00000414030.1
ENST00000437561.1
LINC00152
long intergenic non-protein coding RNA 152
chr9_-_4859260 1.73 ENST00000599351.1
AL158147.2
HCG2011465; Uncharacterized protein
chr2_+_102927962 1.72 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
IL1RL1
IL18R1
interleukin 1 receptor-like 1
interleukin 18 receptor 1
chr19_-_49843539 1.71 ENST00000602554.1
ENST00000358234.4
CTC-301O7.4
CTC-301O7.4
chr17_-_72527605 1.66 ENST00000392621.1
ENST00000314401.3
CD300LB
CD300 molecule-like family member b
chr3_-_46249878 1.64 ENST00000296140.3
CCR1
chemokine (C-C motif) receptor 1
chr9_+_125132803 1.63 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_+_122709200 1.62 ENST00000227348.4
CRTAM
cytotoxic and regulatory T cell molecule
chr11_-_6640585 1.58 ENST00000533371.1
ENST00000528657.1
ENST00000436873.2
ENST00000299427.6
TPP1
tripeptidyl peptidase I
chr11_-_65624415 1.57 ENST00000524553.1
ENST00000527344.1
CFL1
cofilin 1 (non-muscle)
chr3_+_121796697 1.57 ENST00000482356.1
ENST00000393627.2
CD86
CD86 molecule
chr13_-_30951282 1.53 ENST00000420219.1
LINC00426
long intergenic non-protein coding RNA 426
chr12_-_89919965 1.52 ENST00000548729.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr19_+_55385682 1.50 ENST00000391726.3
FCAR
Fc fragment of IgA, receptor for
chr17_+_57807062 1.50 ENST00000587259.1
VMP1
vacuole membrane protein 1
chr2_+_70142189 1.49 ENST00000264444.2
MXD1
MAX dimerization protein 1
chr3_+_42544084 1.45 ENST00000543411.1
ENST00000438259.2
ENST00000439731.1
ENST00000325123.4
VIPR1
vasoactive intestinal peptide receptor 1
chr9_+_127023704 1.38 ENST00000373596.1
ENST00000425237.1
NEK6
NIMA-related kinase 6
chr19_-_44174305 1.38 ENST00000601723.1
ENST00000339082.3
PLAUR
plasminogen activator, urokinase receptor
chr6_+_33043703 1.36 ENST00000418931.2
ENST00000535465.1
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr11_-_62521614 1.35 ENST00000527994.1
ENST00000394807.3
ZBTB3
zinc finger and BTB domain containing 3
chr9_+_125133315 1.33 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr12_-_89920030 1.32 ENST00000413530.1
ENST00000547474.1
GALNT4
POC1B-GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr10_-_6019552 1.31 ENST00000379977.3
ENST00000397251.3
ENST00000397248.2
IL15RA
interleukin 15 receptor, alpha
chr3_+_186435137 1.31 ENST00000447445.1
KNG1
kininogen 1
chr12_-_39300071 1.30 ENST00000550863.1
CPNE8
copine VIII
chr10_-_6019984 1.28 ENST00000525219.2
IL15RA
interleukin 15 receptor, alpha
chr11_-_104480019 1.27 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
RP11-886D15.1
chr5_-_169725231 1.26 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_-_26216872 1.25 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr19_-_44174330 1.21 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr9_-_215744 1.21 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr1_+_16767167 1.20 ENST00000337132.5
NECAP2
NECAP endocytosis associated 2
chr7_+_31726822 1.19 ENST00000409146.3
PPP1R17
protein phosphatase 1, regulatory subunit 17
chr5_-_111091948 1.16 ENST00000447165.2
NREP
neuronal regeneration related protein
chr4_+_89299885 1.16 ENST00000380265.5
ENST00000273960.3
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr10_+_121652204 1.16 ENST00000369075.3
ENST00000543134.1
SEC23IP
SEC23 interacting protein
chr10_-_6019455 1.14 ENST00000530685.1
ENST00000397255.3
ENST00000379971.1
ENST00000528354.1
ENST00000397250.2
ENST00000429135.2
IL15RA
interleukin 15 receptor, alpha
chr3_+_186435065 1.14 ENST00000287611.2
ENST00000265023.4
KNG1
kininogen 1
chr1_+_110162448 1.11 ENST00000342115.4
ENST00000469039.2
ENST00000474459.1
ENST00000528667.1
AMPD2
adenosine monophosphate deaminase 2
chr8_-_17942432 1.10 ENST00000381733.4
ENST00000314146.10
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr12_+_60083118 1.10 ENST00000261187.4
ENST00000543448.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr12_-_89919765 1.09 ENST00000541909.1
ENST00000313546.3
POC1B
POC1 centriolar protein B
chr1_-_21113105 1.09 ENST00000375000.1
ENST00000419490.1
ENST00000414993.1
ENST00000443615.1
ENST00000312239.5
HP1BP3
heterochromatin protein 1, binding protein 3
chr17_+_41150793 1.07 ENST00000586277.1
RPL27
ribosomal protein L27
chr17_+_41150479 1.06 ENST00000589913.1
RPL27
ribosomal protein L27
chr2_-_100721801 1.06 ENST00000424600.1
ENST00000441400.1
AFF3
AF4/FMR2 family, member 3
chr1_+_171217677 1.06 ENST00000402921.2
FMO1
flavin containing monooxygenase 1
chr1_-_31538517 1.02 ENST00000440538.2
ENST00000423018.2
ENST00000424085.2
ENST00000426105.2
ENST00000257075.5
ENST00000373747.3
ENST00000525843.1
ENST00000373742.2
PUM1
pumilio RNA-binding family member 1
chr2_+_70142232 0.98 ENST00000540449.1
MXD1
MAX dimerization protein 1
chr15_-_20170354 0.98 ENST00000338912.5
IGHV1OR15-9
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr2_-_175462456 0.97 ENST00000409891.1
ENST00000410117.1
WIPF1
WAS/WASL interacting protein family, member 1
chr22_-_50523807 0.97 ENST00000442311.1
ENST00000538737.1
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr1_+_110163202 0.97 ENST00000531203.1
ENST00000256578.3
AMPD2
adenosine monophosphate deaminase 2
chr22_-_50523688 0.97 ENST00000450140.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr20_-_1373726 0.96 ENST00000400137.4
FKBP1A
FK506 binding protein 1A, 12kDa
chr2_-_100721923 0.95 ENST00000356421.2
AFF3
AF4/FMR2 family, member 3
chr5_-_139937895 0.95 ENST00000336283.6
SRA1
steroid receptor RNA activator 1
chr8_+_41386761 0.95 ENST00000523277.2
GINS4
GINS complex subunit 4 (Sld5 homolog)
chr1_+_16767195 0.95 ENST00000504551.2
ENST00000457722.2
ENST00000406746.1
ENST00000443980.2
NECAP2
NECAP endocytosis associated 2
chr2_-_100721178 0.95 ENST00000409236.2
AFF3
AF4/FMR2 family, member 3
chr9_+_131452239 0.94 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr16_-_47493041 0.94 ENST00000565940.2
ITFG1
integrin alpha FG-GAP repeat containing 1
chr3_+_119499331 0.94 ENST00000393716.2
ENST00000466380.1
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr2_-_202298268 0.93 ENST00000440597.1
TRAK2
trafficking protein, kinesin binding 2
chr22_-_50523843 0.93 ENST00000535444.1
ENST00000431262.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr6_+_42584847 0.91 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr11_+_118754475 0.91 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr5_-_18746250 0.90 ENST00000512978.1
CTD-2023M8.1
CTD-2023M8.1
chr10_-_101841588 0.90 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr19_-_2282167 0.88 ENST00000342063.3
C19orf35
chromosome 19 open reading frame 35
chr21_-_46964306 0.87 ENST00000443742.1
ENST00000528477.1
ENST00000567670.1
SLC19A1
solute carrier family 19 (folate transporter), member 1
chr11_-_129817448 0.86 ENST00000304538.6
PRDM10
PR domain containing 10
chr8_+_20054878 0.84 ENST00000276390.2
ENST00000519667.1
ATP6V1B2
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
chr9_+_116263639 0.83 ENST00000343817.5
RGS3
regulator of G-protein signaling 3
chr20_-_1373682 0.82 ENST00000381724.3
FKBP1A
FK506 binding protein 1A, 12kDa
chr17_-_34890037 0.81 ENST00000589404.1
MYO19
myosin XIX
chr2_-_25565377 0.81 ENST00000264709.3
ENST00000406659.3
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr17_+_41150290 0.80 ENST00000589037.1
ENST00000253788.5
RPL27
ribosomal protein L27
chr2_-_175462934 0.80 ENST00000392546.2
ENST00000436221.1
WIPF1
WAS/WASL interacting protein family, member 1
chr14_+_65182395 0.79 ENST00000554088.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr9_+_4839762 0.79 ENST00000448872.2
ENST00000441844.1
RCL1
RNA terminal phosphate cyclase-like 1
chr9_-_19065082 0.79 ENST00000415524.1
HAUS6
HAUS augmin-like complex, subunit 6
chr11_-_129817356 0.78 ENST00000526082.1
PRDM10
PR domain containing 10
chr8_-_145086922 0.78 ENST00000530478.1
PARP10
poly (ADP-ribose) polymerase family, member 10
chr9_-_70465758 0.77 ENST00000489273.1
CBWD5
COBW domain containing 5
chr17_-_6524159 0.76 ENST00000589033.1
KIAA0753
KIAA0753
chr11_+_94277017 0.76 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr4_+_70916119 0.76 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr3_-_39196049 0.74 ENST00000514182.1
CSRNP1
cysteine-serine-rich nuclear protein 1
chr17_-_7216939 0.73 ENST00000573684.1
GPS2
G protein pathway suppressor 2
chr6_+_10528560 0.73 ENST00000379597.3
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr15_-_65579177 0.73 ENST00000444347.2
ENST00000261888.6
PARP16
poly (ADP-ribose) polymerase family, member 16
chr1_-_1763721 0.73 ENST00000437146.1
GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr4_+_17579110 0.72 ENST00000606142.1
LAP3
leucine aminopeptidase 3
chr20_-_1373606 0.72 ENST00000381715.1
ENST00000439640.2
ENST00000381719.3
FKBP1A
FK506 binding protein 1A, 12kDa
chr22_-_50523760 0.69 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr1_+_158969752 0.68 ENST00000566111.1
IFI16
interferon, gamma-inducible protein 16
chr3_-_42003613 0.67 ENST00000414606.1
ULK4
unc-51 like kinase 4
chr3_-_56950407 0.67 ENST00000496106.1
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr17_-_29624343 0.67 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr11_+_65627865 0.65 ENST00000308110.4
MUS81
MUS81 structure-specific endonuclease subunit
chr12_+_118454500 0.65 ENST00000537315.1
ENST00000229043.3
ENST00000484086.2
ENST00000420967.1
ENST00000454402.2
ENST00000392542.2
ENST00000535092.1
RFC5
replication factor C (activator 1) 5, 36.5kDa
chr4_-_170924888 0.64 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibrillar-associated protein 3-like
chrX_-_47341928 0.64 ENST00000313116.7
ZNF41
zinc finger protein 41
chr2_-_31361543 0.63 ENST00000349752.5
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chrX_+_139791917 0.63 ENST00000607004.1
ENST00000370535.3
LINC00632
long intergenic non-protein coding RNA 632
chr3_+_171561127 0.62 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr1_-_78444738 0.62 ENST00000436586.2
ENST00000370768.2
FUBP1
far upstream element (FUSE) binding protein 1
chr1_+_173793777 0.62 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr17_+_66511224 0.62 ENST00000588178.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr1_+_1243947 0.61 ENST00000379031.5
PUSL1
pseudouridylate synthase-like 1
chr4_+_91048706 0.61 ENST00000509176.1
CCSER1
coiled-coil serine-rich protein 1
chr17_-_5522731 0.60 ENST00000576905.1
NLRP1
NLR family, pyrin domain containing 1
chr1_+_159796534 0.60 ENST00000289707.5
SLAMF8
SLAM family member 8
chr1_-_149400542 0.60 ENST00000392948.2
HIST2H3PS2
histone cluster 2, H3, pseudogene 2
chr7_+_141463897 0.59 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr13_-_26452679 0.59 ENST00000596729.1
AL138815.2
Uncharacterized protein
chr17_-_34890665 0.58 ENST00000586007.1
MYO19
myosin XIX
chr1_+_54569968 0.58 ENST00000391366.1
AL161915.1
Uncharacterized protein
chrX_+_52841228 0.57 ENST00000351072.1
ENST00000425386.1
ENST00000375503.3
XAGE5
X antigen family, member 5
chr3_-_48732926 0.57 ENST00000453202.1
IP6K2
inositol hexakisphosphate kinase 2
chr6_-_34664612 0.56 ENST00000374023.3
ENST00000374026.3
C6orf106
chromosome 6 open reading frame 106
chr5_-_133510456 0.56 ENST00000520417.1
SKP1
S-phase kinase-associated protein 1
chrX_-_47518498 0.54 ENST00000335890.2
UXT
ubiquitously-expressed, prefoldin-like chaperone
chr17_+_33914424 0.53 ENST00000590432.1
AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr7_+_75544466 0.53 ENST00000421059.1
ENST00000394893.1
ENST00000412521.1
ENST00000414186.1
POR
P450 (cytochrome) oxidoreductase
chr17_-_34890732 0.53 ENST00000268852.9
MYO19
myosin XIX
chr1_-_115259337 0.52 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr1_+_159796589 0.52 ENST00000368104.4
SLAMF8
SLAM family member 8
chr2_-_69870747 0.52 ENST00000409068.1
AAK1
AP2 associated kinase 1
chr3_-_187694195 0.52 ENST00000446091.1
RP11-132N15.3
RP11-132N15.3
chr1_+_156338993 0.52 ENST00000368249.1
ENST00000368246.2
ENST00000537040.1
ENST00000400992.2
ENST00000255013.3
ENST00000451864.2
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chr19_+_58144529 0.52 ENST00000347302.3
ENST00000254182.7
ENST00000391703.3
ENST00000541801.1
ENST00000299871.5
ENST00000544273.1
ZNF211
zinc finger protein 211
chr4_+_70146217 0.51 ENST00000335568.5
ENST00000511240.1
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chrX_-_47518527 0.50 ENST00000333119.3
UXT
ubiquitously-expressed, prefoldin-like chaperone
chr6_+_126102292 0.49 ENST00000368357.3
NCOA7
nuclear receptor coactivator 7
chr11_+_65627974 0.49 ENST00000525768.1
MUS81
MUS81 structure-specific endonuclease subunit
chr17_-_34890617 0.48 ENST00000586886.1
ENST00000585719.1
ENST00000585818.1
MYO19
myosin XIX
chr6_-_15586238 0.47 ENST00000462989.2
DTNBP1
dystrobrevin binding protein 1
chr1_-_173793246 0.47 ENST00000345664.6
ENST00000367710.3
CENPL
centromere protein L
chr10_+_135204338 0.46 ENST00000468317.2
RP11-108K14.8
Mitochondrial GTPase 1
chr17_+_25621102 0.45 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
WSB1
WD repeat and SOCS box containing 1
chr3_-_160167301 0.45 ENST00000494486.1
TRIM59
tripartite motif containing 59
chr5_+_52083730 0.45 ENST00000282588.6
ENST00000274311.2
ITGA1
PELO
integrin, alpha 1
pelota homolog (Drosophila)
chr19_+_17186577 0.44 ENST00000595618.1
ENST00000594824.1
MYO9B
myosin IXB
chr19_-_51611623 0.44 ENST00000421832.2
CTU1
cytosolic thiouridylase subunit 1

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.9 2.8 GO:0055073 cadmium ion homeostasis(GO:0055073)
0.8 2.5 GO:0061485 memory T cell proliferation(GO:0061485)
0.7 2.0 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.5 3.7 GO:0051510 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.5 1.6 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.5 3.4 GO:0071461 cellular response to redox state(GO:0071461)
0.4 5.2 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.4 2.1 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.4 2.8 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.4 2.5 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.3 2.9 GO:0006572 tyrosine catabolic process(GO:0006572)
0.3 2.6 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.3 0.9 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.3 1.5 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.2 4.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.2 1.0 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.2 2.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.2 0.9 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.2 4.5 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.2 0.6 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
0.2 2.5 GO:0022417 protein maturation by protein folding(GO:0022417)
0.2 2.1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.2 2.1 GO:0032264 IMP salvage(GO:0032264)
0.2 0.9 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 0.9 GO:0030070 insulin processing(GO:0030070)
0.2 0.5 GO:0046210 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210)
0.2 1.2 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.2 0.5 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.2 3.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 3.6 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 3.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.4 GO:0070995 NADPH oxidation(GO:0070995)
0.1 0.7 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 1.1 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 1.6 GO:0002860 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.1 0.8 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.1 2.9 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 1.0 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 0.3 GO:1900737 regulation of proteinase activated receptor activity(GO:1900276) negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900737)
0.1 0.9 GO:0046618 drug export(GO:0046618)
0.1 8.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 2.9 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.1 0.8 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 0.7 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 2.4 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 1.0 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.1 0.6 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 1.8 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 0.4 GO:0034227 tRNA thio-modification(GO:0034227)
0.1 0.4 GO:1990523 bone regeneration(GO:1990523)
0.1 1.6 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 0.4 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.2 GO:0015680 intracellular copper ion transport(GO:0015680)
0.1 0.6 GO:0010265 SCF complex assembly(GO:0010265)
0.1 3.0 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.1 2.0 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 0.6 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 0.4 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.3 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.1 0.8 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.3 GO:1903936 response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.0 0.4 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 2.0 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 0.9 GO:0048535 lymph node development(GO:0048535)
0.0 0.3 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 2.6 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 2.4 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.0 9.1 GO:0002377 immunoglobulin production(GO:0002377)
0.0 1.1 GO:0070828 heterochromatin organization(GO:0070828)
0.0 0.1 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.0 3.8 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 1.0 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 1.4 GO:2000772 regulation of cellular senescence(GO:2000772)
0.0 0.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.7 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.7 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 1.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.4 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 1.0 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 1.1 GO:0006672 ceramide metabolic process(GO:0006672)
0.0 0.5 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 1.2 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.4 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 1.8 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 1.3 GO:0045576 mast cell activation(GO:0045576)
0.0 4.5 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 3.9 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.0 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 1.6 GO:0045453 bone resorption(GO:0045453)
0.0 1.5 GO:0007566 embryo implantation(GO:0007566)
0.0 0.4 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.8 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.8 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.3 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 1.6 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.7 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.8 GO:0034080 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 3.0 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 2.0 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 2.5 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 1.4 GO:0031295 T cell costimulation(GO:0031295)
0.0 3.0 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.8 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.7 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.4 GO:0044804 nucleophagy(GO:0044804)
0.0 0.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 1.0 GO:2000273 positive regulation of receptor activity(GO:2000273)
0.0 7.8 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 0.0 GO:2000466 negative regulation of glycogen (starch) synthase activity(GO:2000466)
0.0 0.1 GO:0044211 CTP salvage(GO:0044211)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:1990425 ryanodine receptor complex(GO:1990425)
0.4 3.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.3 1.3 GO:0036398 TCR signalosome(GO:0036398)
0.2 0.9 GO:0000811 GINS complex(GO:0000811)
0.2 2.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.2 2.0 GO:0044194 cytolytic granule(GO:0044194)
0.2 0.6 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.2 1.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 8.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 3.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.4 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.1 0.3 GO:0039713 viral factory(GO:0039713) cytoplasmic viral factory(GO:0039714) host cell viral assembly compartment(GO:0072517)
0.1 0.5 GO:0045178 basal part of cell(GO:0045178)
0.1 2.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 2.7 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.5 GO:0070847 core mediator complex(GO:0070847)
0.1 3.1 GO:0030125 clathrin vesicle coat(GO:0030125)
0.1 0.1 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 0.4 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.1 0.3 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.1 0.6 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.1 4.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 3.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.5 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 2.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.3 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 5.0 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.0 GO:0001741 XY body(GO:0001741)
0.0 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 3.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 3.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.1 GO:0060170 ciliary membrane(GO:0060170)
0.0 3.6 GO:0005901 caveola(GO:0005901)
0.0 0.8 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 3.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 2.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 3.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 3.0 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.0 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.0 1.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 2.6 GO:0035579 specific granule membrane(GO:0035579)
0.0 2.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 9.6 GO:0016607 nuclear speck(GO:0016607)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 3.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 3.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.1 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 3.0 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.9 4.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.6 3.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.5 5.2 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.4 1.2 GO:0002113 interleukin-33 binding(GO:0002113)
0.4 1.1 GO:0048257 3'-flap endonuclease activity(GO:0048257)
0.4 1.5 GO:0019862 IgA binding(GO:0019862)
0.4 2.6 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.3 4.5 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.3 1.5 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.3 3.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 1.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.3 3.0 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.3 3.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2 1.8 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.2 3.8 GO:0033691 sialic acid binding(GO:0033691)
0.2 0.9 GO:0008518 reduced folate carrier activity(GO:0008518)
0.2 2.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2 2.6 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.2 2.5 GO:0046625 sphingolipid binding(GO:0046625)
0.2 2.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 0.5 GO:0047726 iron-cytochrome-c reductase activity(GO:0047726)
0.2 2.5 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 1.0 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.2 0.8 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.2 1.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.7 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 0.9 GO:0070728 leucine binding(GO:0070728)
0.1 8.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 1.1 GO:0017040 ceramidase activity(GO:0017040)
0.1 2.0 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.6 GO:0052839 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.1 2.1 GO:0019864 IgG binding(GO:0019864)
0.1 0.3 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.1 2.9 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 1.6 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.3 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.1 0.1 GO:0001159 core promoter proximal region DNA binding(GO:0001159)
0.1 2.1 GO:0050700 CARD domain binding(GO:0050700)
0.1 2.8 GO:0031489 myosin V binding(GO:0031489)
0.1 0.7 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 2.9 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.2 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.1 3.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 1.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.8 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 0.6 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.9 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 0.4 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 0.4 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.1 0.3 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 1.4 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 2.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.8 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 8.4 GO:0003823 antigen binding(GO:0003823)
0.1 1.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.9 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.2 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.0 0.4 GO:0048495 Roundabout binding(GO:0048495)
0.0 1.0 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.9 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.6 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 1.2 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.0 0.7 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.0 0.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.7 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 1.6 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.9 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 2.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.3 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 2.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 3.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.2 GO:0015315 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 3.7 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.7 GO:0031491 nucleosome binding(GO:0031491)
0.0 1.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 2.7 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.1 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 3.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 7.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.2 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.9 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 2.5 PID ALK2 PATHWAY ALK2 signaling events
0.1 3.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 2.6 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 2.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 6.0 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 3.2 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 3.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 5.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 5.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.8 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.7 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 2.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.4 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.6 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 1.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.2 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 2.4 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 3.7 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 1.6 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 3.7 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.1 2.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 4.0 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 2.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 3.7 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 2.8 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 4.6 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 10.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 1.1 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 3.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 2.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.1 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.7 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.0 0.7 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 3.0 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.0 0.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 4.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.6 REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0 0.4 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 3.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 2.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.7 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.1 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors