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Illumina Body Map 2, young vs old

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Results for NKX6-3

Z-value: 0.06

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
NKX6-3
ENSG00000165066.11 NK6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX6-3hg19_v2_chr8_-_41504878_41504878-0.421.7e-02Click!

Activity profile of NKX6-3 motif

Sorted Z-values of NKX6-3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_13517565 1.10 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr6_-_9933500 0.85 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr20_-_7921090 0.72 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr8_+_92261516 0.67 ENST00000276609.3
ENST00000309536.2
SLC26A7
solute carrier family 26 (anion exchanger), member 7
chr18_+_20494078 0.61 ENST00000579124.1
ENST00000577588.1
ENST00000582354.1
ENST00000581819.1
RBBP8
retinoblastoma binding protein 8
chr17_-_10372875 0.56 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr6_+_130339710 0.55 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr2_+_234826016 0.50 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr3_+_121902511 0.50 ENST00000490131.1
CASR
calcium-sensing receptor
chr20_-_33735070 0.48 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr17_-_64225508 0.48 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr5_-_142780280 0.43 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr3_+_138340049 0.41 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr9_+_125132803 0.40 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr20_+_30697298 0.38 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr12_-_94673956 0.37 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr3_+_138340067 0.37 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr9_+_125133467 0.34 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_-_141747950 0.34 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr9_+_125133315 0.33 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr14_+_67831576 0.30 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chrX_+_43515467 0.30 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr20_-_21086975 0.29 ENST00000420705.1
ENST00000593272.1
LINC00237
long intergenic non-protein coding RNA 237
chr17_-_38956205 0.27 ENST00000306658.7
KRT28
keratin 28
chr7_+_129984630 0.27 ENST00000355388.3
ENST00000497503.1
ENST00000463587.1
ENST00000461828.1
ENST00000494311.1
ENST00000466363.2
ENST00000485477.1
ENST00000431780.2
ENST00000474905.1
CPA5
carboxypeptidase A5
chr20_+_11008408 0.27 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chr6_+_114178512 0.25 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr6_-_49931818 0.25 ENST00000322066.3
DEFB114
defensin, beta 114
chr1_-_151431647 0.24 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr13_-_81801115 0.22 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr1_-_204183071 0.22 ENST00000308302.3
GOLT1A
golgi transport 1A
chr17_+_4692230 0.21 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr21_-_35796241 0.21 ENST00000450895.1
AP000322.53
AP000322.53
chr15_+_90735145 0.21 ENST00000559792.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chrX_+_107288239 0.19 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr3_+_136649311 0.19 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chrX_+_107288197 0.18 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr1_-_151431674 0.18 ENST00000531094.1
POGZ
pogo transposable element with ZNF domain
chrX_+_107020963 0.18 ENST00000509000.2
NCBP2L
nuclear cap binding protein subunit 2-like
chrX_+_107288280 0.18 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr1_-_151431909 0.18 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr5_-_58295712 0.18 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_+_78400375 0.17 ENST00000602452.2
MEI4
meiosis-specific 4 homolog (S. cerevisiae)
chr3_-_141719195 0.14 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr13_+_53602894 0.14 ENST00000219022.2
OLFM4
olfactomedin 4
chr20_-_29978286 0.13 ENST00000376315.2
DEFB119
defensin, beta 119
chr12_-_52761262 0.12 ENST00000257901.3
KRT85
keratin 85
chr19_+_50016610 0.11 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr11_-_115127611 0.10 ENST00000545094.1
CADM1
cell adhesion molecule 1
chr8_+_77593448 0.10 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr4_+_71384300 0.10 ENST00000504451.1
AMTN
amelotin
chr8_+_77593474 0.08 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr15_+_93443419 0.05 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr7_+_138145076 0.05 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr4_-_123542224 0.05 ENST00000264497.3
IL21
interleukin 21
chr14_+_88851874 0.03 ENST00000393545.4
ENST00000356583.5
ENST00000555401.1
ENST00000553885.1
SPATA7
spermatogenesis associated 7
chr7_-_84122033 0.03 ENST00000424555.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chrX_+_150565038 0.02 ENST00000370361.1
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr16_-_67517716 0.02 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr14_-_51027838 0.01 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr19_+_4402659 0.00 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.2 0.6 GO:0001835 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 0.5 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 0.7 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.3 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1 0.5 GO:0050955 thermoception(GO:0050955)
0.1 0.2 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1 0.5 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 1.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.1 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.0 0.6 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.7 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.0 0.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.6 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.4 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.5 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.2 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.5 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.6 GO:0032982 myosin filament(GO:0032982)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0052853 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.2 1.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.5 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.4 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 1.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.6 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.6 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle