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Illumina Body Map 2, young vs old

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Results for NR4A1

Z-value: 0.31

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Transcription factors associated with NR4A1

Gene Symbol Gene ID Gene Info
ENSG00000123358.15 nuclear receptor subfamily 4 group A member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR4A1hg19_v2_chr12_+_52431016_524310710.144.6e-01Click!

Activity profile of NR4A1 motif

Sorted Z-values of NR4A1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_4854375 6.26 ENST00000521811.1
ENST00000519602.1
ENST00000323997.6
ENST00000522249.1
ENST00000519584.1
enolase 3 (beta, muscle)
chr17_+_4855053 5.72 ENST00000518175.1
enolase 3 (beta, muscle)
chr12_+_109577202 3.70 ENST00000377848.3
ENST00000377854.5
acetyl-CoA carboxylase beta
chr1_-_9563433 3.49 ENST00000441033.1
RP13-392I16.1
chr11_+_116700614 3.10 ENST00000375345.1
apolipoprotein C-III
chr1_+_236849754 3.07 ENST00000542672.1
ENST00000366578.4
actinin, alpha 2
chr11_+_116700600 3.03 ENST00000227667.3
apolipoprotein C-III
chr6_+_53948328 2.98 ENST00000370876.2
muscular LMNA-interacting protein
chr1_+_64059332 2.89 ENST00000540265.1
phosphoglucomutase 1
chr19_+_4153598 2.53 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
cAMP responsive element binding protein 3-like 3
chr6_+_53948221 2.50 ENST00000460844.2
muscular LMNA-interacting protein
chr3_+_46538981 2.23 ENST00000296142.3
receptor (chemosensory) transporter protein 3
chrX_+_2746818 2.21 ENST00000398806.3
glycogenin 2
chrX_+_2746850 2.12 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
glycogenin 2
chr10_-_74714533 1.89 ENST00000373032.3
phospholipase A2, group XIIB
chr4_-_111563076 1.78 ENST00000354925.2
ENST00000511990.1
paired-like homeodomain 2
chr4_-_65275100 1.58 ENST00000509536.1
trans-2,3-enoyl-CoA reductase-like
chr20_+_3052264 1.55 ENST00000217386.2
oxytocin/neurophysin I prepropeptide
chr4_-_111563279 1.54 ENST00000511837.1
paired-like homeodomain 2
chr14_-_20903801 1.50 ENST00000344581.4
kelch-like family member 33
chr6_+_44126545 1.48 ENST00000532171.1
ENST00000398776.1
ENST00000542245.1
calpain 11
chr17_+_1646130 1.42 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr14_+_38065052 1.24 ENST00000556845.1
tetratricopeptide repeat domain 6
chr10_+_101542462 1.21 ENST00000370449.4
ENST00000370434.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr6_+_133561725 1.21 ENST00000452339.2
eyes absent homolog 4 (Drosophila)
chr11_+_7618413 1.15 ENST00000528883.1
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr5_+_127039075 1.15 ENST00000514853.2
CTC-228N24.1
chr4_-_65275162 1.13 ENST00000381210.3
ENST00000507440.1
trans-2,3-enoyl-CoA reductase-like
chr4_+_100495864 1.09 ENST00000265517.5
ENST00000422897.2
microsomal triglyceride transfer protein
chr6_+_31895467 1.08 ENST00000556679.1
ENST00000456570.1
complement factor B
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chrX_-_43741594 1.07 ENST00000536181.1
ENST00000378069.4
monoamine oxidase B
chr1_+_16062820 1.07 ENST00000294454.5
solute carrier family 25, member 34
chr18_-_5197501 1.07 ENST00000580650.1
chromosome 18 open reading frame 42
chr11_-_111794446 1.05 ENST00000527950.1
crystallin, alpha B
chr20_+_12989895 1.02 ENST00000450297.1
serine palmitoyltransferase, long chain base subunit 3
chr11_+_86748957 1.02 ENST00000526733.1
ENST00000532959.1
transmembrane protein 135
chr12_+_6644443 1.01 ENST00000396858.1
glyceraldehyde-3-phosphate dehydrogenase
chr22_-_51016846 0.98 ENST00000312108.7
ENST00000395650.2
carnitine palmitoyltransferase 1B (muscle)
chr6_-_116381918 0.96 ENST00000606080.1
fyn-related kinase
chr7_-_107443652 0.93 ENST00000340010.5
ENST00000422236.2
ENST00000453332.1
solute carrier family 26 (anion exchanger), member 3
chr20_-_42815733 0.93 ENST00000342272.3
junctophilin 2
chr11_+_86749035 0.90 ENST00000305494.5
ENST00000535167.1
transmembrane protein 135
chr4_-_89744457 0.90 ENST00000395002.2
family with sequence similarity 13, member A
chr11_+_86748863 0.88 ENST00000340353.7
transmembrane protein 135
chr1_-_197036364 0.87 ENST00000367412.1
coagulation factor XIII, B polypeptide
chr5_-_124084493 0.86 ENST00000509799.1
zinc finger protein 608
chr6_+_31895480 0.86 ENST00000418949.2
ENST00000383177.3
ENST00000477310.1
complement component 2
Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr10_+_12110963 0.86 ENST00000263035.4
ENST00000437298.1
dehydrogenase E1 and transketolase domain containing 1
chr19_+_13134772 0.86 ENST00000587760.1
ENST00000585575.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr1_+_61869748 0.85 ENST00000357977.5
nuclear factor I/A
chr14_-_21566731 0.84 ENST00000360947.3
zinc finger protein 219
chr22_-_51017084 0.83 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
carnitine palmitoyltransferase 1B (muscle)
chr19_+_49713991 0.80 ENST00000597316.1
transient receptor potential cation channel, subfamily M, member 4
chr3_+_29322437 0.80 ENST00000434693.2
RNA binding motif, single stranded interacting protein 3
chr20_-_42816206 0.80 ENST00000372980.3
junctophilin 2
chr3_+_184038073 0.79 ENST00000428387.1
ENST00000434061.2
eukaryotic translation initiation factor 4 gamma, 1
chr15_-_42783303 0.76 ENST00000565380.1
ENST00000564754.1
zinc finger protein 106
chr12_-_118490403 0.76 ENST00000535496.1
WD repeat and SOCS box containing 2
chr3_+_184037466 0.76 ENST00000441154.1
eukaryotic translation initiation factor 4 gamma, 1
chr15_+_36887069 0.75 ENST00000566807.1
ENST00000567389.1
ENST00000562877.1
chromosome 15 open reading frame 41
chr5_-_126409159 0.74 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
chromosome 5 open reading frame 63
chr17_-_7307358 0.74 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr4_+_159593271 0.73 ENST00000512251.1
ENST00000511912.1
electron-transferring-flavoprotein dehydrogenase
chr7_+_6048856 0.70 ENST00000223029.3
ENST00000400479.2
ENST00000395236.2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr11_-_8680383 0.70 ENST00000299550.6
tripartite motif containing 66
chr12_+_58335360 0.70 ENST00000300145.3
XRCC6 binding protein 1
chr7_-_229557 0.70 ENST00000514988.1
Uncharacterized protein
chr16_+_691792 0.69 ENST00000307650.4
family with sequence similarity 195, member A
chr12_+_54378923 0.68 ENST00000303460.4
homeobox C10
chr12_+_54378849 0.66 ENST00000515593.1
homeobox C10
chr13_-_30881134 0.65 ENST00000380617.3
ENST00000441394.1
katanin p60 subunit A-like 1
chrX_+_114874727 0.64 ENST00000543070.1
plastin 3
chr6_+_31895287 0.64 ENST00000447952.2
complement component 2
chr20_+_12989596 0.64 ENST00000434210.1
ENST00000399002.2
serine palmitoyltransferase, long chain base subunit 3
chr17_+_7123125 0.63 ENST00000356839.5
ENST00000583312.1
ENST00000350303.5
acyl-CoA dehydrogenase, very long chain
chr17_+_7123207 0.63 ENST00000584103.1
ENST00000579886.2
acyl-CoA dehydrogenase, very long chain
chr5_-_142784003 0.63 ENST00000416954.2
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr3_-_48936272 0.62 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr10_-_128359074 0.61 ENST00000544758.1
chromosome 10 open reading frame 90
chr19_+_17416457 0.61 ENST00000252602.1
mitochondrial ribosomal protein L34
chr4_-_89744365 0.60 ENST00000513837.1
ENST00000503556.1
family with sequence similarity 13, member A
chr6_+_31895254 0.60 ENST00000299367.5
ENST00000442278.2
complement component 2
chr5_+_73109339 0.59 ENST00000296799.4
Rho guanine nucleotide exchange factor (GEF) 28
chr8_+_145065705 0.59 ENST00000533044.1
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr11_+_26353664 0.59 ENST00000531646.1
anoctamin 3
chr5_+_121187625 0.58 ENST00000321339.1
ferritin mitochondrial
chr4_-_89744314 0.57 ENST00000508369.1
family with sequence similarity 13, member A
chr4_-_74088800 0.56 ENST00000509867.2
ankyrin repeat domain 17
chr12_+_21679220 0.55 ENST00000256969.2
chromosome 12 open reading frame 39
chr6_-_43595039 0.55 ENST00000307114.7
GTP binding protein 2
chr19_-_11639931 0.55 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT signalling integrator
chr19_+_14138960 0.55 ENST00000431365.2
ENST00000585987.1
relaxin 3
chr20_+_12989822 0.55 ENST00000378194.4
serine palmitoyltransferase, long chain base subunit 3
chr14_-_21567009 0.54 ENST00000556174.1
ENST00000554478.1
ENST00000553980.1
ENST00000421093.2
zinc finger protein 219
chr18_-_5197224 0.54 ENST00000434239.3
chromosome 18 open reading frame 42
chr12_-_118490217 0.51 ENST00000542304.1
WD repeat and SOCS box containing 2
chrX_-_54824673 0.51 ENST00000218436.6
inter-alpha-trypsin inhibitor heavy chain family, member 6
chr22_-_31364187 0.48 ENST00000215862.4
ENST00000397641.3
MORC family CW-type zinc finger 2
chr19_+_17416609 0.48 ENST00000602206.1
mitochondrial ribosomal protein L34
chr11_+_3877412 0.47 ENST00000527651.1
stromal interaction molecule 1
chr2_-_207024134 0.47 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr17_-_36499693 0.47 ENST00000342292.4
G protein-coupled receptor 179
chr13_-_74993252 0.45 ENST00000325811.1
Uncharacterized protein
chr6_+_108616243 0.45 ENST00000421954.1
lactation elevated 1
chr19_-_11639910 0.45 ENST00000588998.1
ENST00000586149.1
ECSIT signalling integrator
chr8_+_145065521 0.45 ENST00000534791.1
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr18_+_43753974 0.44 ENST00000282059.6
ENST00000321319.6
chromosome 18 open reading frame 25
chr19_+_6372444 0.43 ENST00000245812.3
alkB, alkylation repair homolog 7 (E. coli)
chr11_-_113577052 0.43 ENST00000540540.1
ENST00000545579.1
ENST00000538955.1
ENST00000299882.5
transmembrane protease, serine 5
chr14_+_35591509 0.43 ENST00000604073.1
KIAA0391
chr16_+_53241854 0.40 ENST00000565803.1
chromodomain helicase DNA binding protein 9
chr17_+_79670386 0.40 ENST00000333676.3
ENST00000571730.1
ENST00000541223.1
mitochondrial ribosomal protein L12
Mitochondrial dicarboxylate carrier; Uncharacterized protein; cDNA FLJ60124, highly similar to Mitochondrial dicarboxylate carrier
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr2_+_175199674 0.40 ENST00000394967.2
Sp9 transcription factor
chr4_-_40632757 0.40 ENST00000511902.1
ENST00000505220.1
RNA binding motif protein 47
chr9_-_75567962 0.39 ENST00000297785.3
ENST00000376939.1
aldehyde dehydrogenase 1 family, member A1
chr22_+_24891210 0.39 ENST00000382760.2
ureidopropionase, beta
chr11_+_64073699 0.37 ENST00000405666.1
ENST00000468670.1
estrogen-related receptor alpha
chr10_-_75351088 0.37 ENST00000451492.1
ENST00000413442.1
ubiquitin specific peptidase 54
chr7_+_119913688 0.36 ENST00000331113.4
potassium voltage-gated channel, Shal-related subfamily, member 2
chr14_+_35591020 0.35 ENST00000603611.1
KIAA0391
chr12_-_16758835 0.34 ENST00000541295.1
LIM domain only 3 (rhombotin-like 2)
chr13_-_28896641 0.31 ENST00000543394.1
fms-related tyrosine kinase 1
chr10_+_104005272 0.31 ENST00000369983.3
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr11_-_113577014 0.31 ENST00000544634.1
ENST00000539732.1
ENST00000538770.1
ENST00000536856.1
ENST00000544476.1
transmembrane protease, serine 5
chr20_+_17680599 0.31 ENST00000246090.5
barrier to autointegration factor 2
chr11_+_3876859 0.30 ENST00000300737.4
stromal interaction molecule 1
chr1_+_165600436 0.29 ENST00000367888.4
ENST00000367885.1
ENST00000367884.2
microsomal glutathione S-transferase 3
chr1_+_173793777 0.29 ENST00000239457.5
aspartyl-tRNA synthetase 2, mitochondrial
chr1_+_176432298 0.28 ENST00000367661.3
ENST00000367662.3
pappalysin 2
chr12_+_50794891 0.28 ENST00000517559.1
La ribonucleoprotein domain family, member 4
chr3_+_138340049 0.28 ENST00000464668.1
Fas apoptotic inhibitory molecule
chr11_+_66624527 0.27 ENST00000393952.3
leucine rich repeat and fibronectin type III domain containing 4
chr5_-_142784101 0.27 ENST00000503201.1
ENST00000502892.1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr12_+_21525818 0.27 ENST00000240652.3
ENST00000542023.1
ENST00000537593.1
islet amyloid polypeptide
chr13_-_30880979 0.26 ENST00000414289.1
katanin p60 subunit A-like 1
chr4_+_57253672 0.26 ENST00000602927.1
RP11-646I6.5
chr2_-_44223138 0.26 ENST00000260665.7
leucine-rich pentatricopeptide repeat containing
chr20_+_17680587 0.25 ENST00000427254.1
ENST00000377805.3
barrier to autointegration factor 2
chr8_+_123793633 0.24 ENST00000314393.4
zinc fingers and homeoboxes 2
chr6_+_118869452 0.24 ENST00000357525.5
phospholamban
chr4_-_40632881 0.24 ENST00000511598.1
RNA binding motif protein 47
chr12_-_16758873 0.23 ENST00000535535.1
LIM domain only 3 (rhombotin-like 2)
chr7_-_135612198 0.23 ENST00000589735.1
leucine zipper protein 6
chr17_-_66287310 0.23 ENST00000582867.1
solute carrier family 16, member 6
chr17_-_66287257 0.22 ENST00000327268.4
solute carrier family 16, member 6
chr2_-_207024233 0.21 ENST00000423725.1
ENST00000233190.6
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr4_+_71108300 0.20 ENST00000304954.3
casein kappa
chr17_-_79283041 0.20 ENST00000332012.5
long intergenic non-protein coding RNA 482
chr5_-_142784888 0.20 ENST00000514699.1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr12_-_53320245 0.18 ENST00000552150.1
keratin 8
chr16_+_21312170 0.17 ENST00000338573.5
ENST00000561968.1
CRYM antisense RNA 1
chr5_-_53115506 0.17 ENST00000511953.1
ENST00000504552.1
CTD-2081C10.1
chr5_-_87564620 0.17 ENST00000506536.1
ENST00000512429.1
ENST00000514135.1
ENST00000296595.6
ENST00000509387.1
transmembrane protein 161B
chr7_-_37488547 0.17 ENST00000453399.1
engulfment and cell motility 1
chr18_-_60986962 0.16 ENST00000333681.4
B-cell CLL/lymphoma 2
chr12_+_50794947 0.16 ENST00000552445.1
La ribonucleoprotein domain family, member 4
chr3_-_113464906 0.14 ENST00000477813.1
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr7_-_37488777 0.14 ENST00000445322.1
ENST00000448602.1
engulfment and cell motility 1
chr4_-_40632844 0.13 ENST00000505414.1
RNA binding motif protein 47
chr14_+_32476072 0.12 ENST00000556949.1
Uncharacterized protein
chr3_-_44519131 0.12 ENST00000425708.2
ENST00000396077.2
zinc finger protein 445
chr8_+_99956662 0.12 ENST00000523368.1
ENST00000297565.4
ENST00000435298.2
odd-skipped related transciption factor 2
chr2_+_26568965 0.11 ENST00000260585.7
ENST00000447170.1
ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
chr11_-_111649074 0.11 ENST00000534218.1
RP11-108O10.2
chr14_+_35591735 0.11 ENST00000604948.1
ENST00000605201.1
ENST00000250377.7
ENST00000321130.10
ENST00000534898.4
KIAA0391
chr7_-_37488834 0.10 ENST00000310758.4
engulfment and cell motility 1
chr7_-_6048650 0.10 ENST00000382321.4
ENST00000406569.3
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr12_+_32655110 0.10 ENST00000546442.1
ENST00000583694.1
FYVE, RhoGEF and PH domain containing 4
chr1_+_156589051 0.09 ENST00000255039.1
hyaluronan and proteoglycan link protein 2
chr8_-_9761693 0.09 ENST00000521863.1
long intergenic non-protein coding RNA 599
chr10_-_69991865 0.08 ENST00000373673.3
atonal homolog 7 (Drosophila)
chr1_-_33777822 0.08 ENST00000330379.5
alpha 1,3-galactosyltransferase 2
chr10_+_26986582 0.07 ENST00000376215.5
ENST00000376203.5
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr14_-_35591679 0.07 ENST00000557278.1
protein phosphatase 2, regulatory subunit B'', gamma
chr8_+_133787586 0.07 ENST00000395379.1
ENST00000395386.2
ENST00000337920.4
PHD finger protein 20-like 1
chr1_-_161102367 0.06 ENST00000464113.1
death effector domain containing
chr12_+_32655048 0.06 ENST00000427716.2
ENST00000266482.3
FYVE, RhoGEF and PH domain containing 4
chr11_+_120971882 0.05 ENST00000392793.1
tectorin alpha
chr3_+_14989076 0.05 ENST00000413118.1
ENST00000425241.1
nuclear receptor subfamily 2, group C, member 2
chr5_+_159895275 0.04 ENST00000517927.1
microRNA 146a
chr17_+_9745786 0.04 ENST00000304773.5
glucagon-like peptide 2 receptor
chr7_+_99933730 0.04 ENST00000610247.1
paired immunoglobin-like type 2 receptor beta
chr15_-_42565023 0.03 ENST00000566474.1
transmembrane protein 87A
chr3_-_113465065 0.02 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr6_+_69942915 0.02 ENST00000604969.1
ENST00000603207.1
brain-specific angiogenesis inhibitor 3
chr7_-_6048702 0.01 ENST00000265849.7
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
chr13_-_33112823 0.01 ENST00000504114.1
NEDD4 binding protein 2-like 2
chr11_-_111649015 0.01 ENST00000529841.1
RP11-108O10.2
chr2_+_178257372 0.01 ENST00000264167.4
ENST00000409888.1
alkylglycerone phosphate synthase

Network of associatons between targets according to the STRING database.

First level regulatory network of NR4A1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.8 3.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.7 3.3 GO:0060127 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.6 3.7 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.5 1.5 GO:0002125 maternal aggressive behavior(GO:0002125) positive regulation of female receptivity(GO:0045925)
0.4 1.2 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.3 1.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.3 1.4 GO:0002034 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.2 0.7 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.2 0.8 GO:1904199 positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.2 12.0 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 2.9 GO:0019388 galactose catabolic process(GO:0019388)
0.2 2.7 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.2 0.6 GO:0006844 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.1 0.4 GO:1902356 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.1 1.1 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.1 1.7 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1 2.0 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 2.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.1 2.2 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.1 4.3 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 1.3 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.1 1.5 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 1.8 GO:0006853 carnitine shuttle(GO:0006853)
0.1 0.6 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 0.9 GO:0051013 microtubule severing(GO:0051013)
0.1 0.3 GO:0000961 negative regulation of mitochondrial RNA catabolic process(GO:0000961)
0.1 1.1 GO:0034378 chylomicron assembly(GO:0034378)
0.1 1.3 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 0.2 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.1 0.3 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.4 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 1.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.4 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.1 0.3 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.1 0.8 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.9 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.3 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.6 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 1.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 0.6 GO:0061590 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 0.9 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.1 2.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 2.4 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 1.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.7 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 1.9 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.1 GO:0036023 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0 1.0 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 0.8 GO:0072189 ureter development(GO:0072189)
0.0 0.3 GO:0097647 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.3 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.6 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0045475 locomotor rhythm(GO:0045475)
0.0 1.7 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.9 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.3 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0 0.2 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.2 GO:0051599 response to hydrostatic pressure(GO:0051599)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 12.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.7 6.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 2.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 1.7 GO:0030314 junctional membrane complex(GO:0030314)
0.1 1.0 GO:0097452 GAIT complex(GO:0097452)
0.1 0.7 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 0.9 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.1 1.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 1.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 3.1 GO:0031143 pseudopodium(GO:0031143)
0.1 0.9 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.1 GO:0097512 cardiac myofibril(GO:0097512)
0.1 1.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.9 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 2.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 5.3 GO:0016605 PML body(GO:0016605)
0.0 0.8 GO:0034706 sodium channel complex(GO:0034706)
0.0 1.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 2.8 GO:0005811 lipid particle(GO:0005811)
0.0 6.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.7 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 1.5 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.0 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 1.5 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.3 12.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.9 4.3 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.6 3.7 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.6 3.1 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.4 2.9 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 2.2 GO:0031849 olfactory receptor binding(GO:0031849)
0.3 2.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.3 1.0 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 0.7 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.2 1.8 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.2 1.3 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.2 0.6 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.1 0.4 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.1 0.9 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 1.1 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 1.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.4 GO:0004969 histamine receptor activity(GO:0004969)
0.1 1.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 2.5 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.2 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 1.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.9 GO:0001848 complement binding(GO:0001848)
0.0 0.6 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.4 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 3.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 1.9 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 2.7 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 1.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 1.1 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 0.1 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.0 0.8 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.4 GO:0008143 poly(A) binding(GO:0008143)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.0 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.7 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 4.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 7.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.2 13.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 6.1 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 3.1 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 3.2 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.8 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 1.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 1.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.1 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.3 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)