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Illumina Body Map 2, young vs old

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Results for ONECUT2_ONECUT3

Z-value: 0.39

Motif logo

Transcription factors associated with ONECUT2_ONECUT3

Gene Symbol Gene ID Gene Info
ENSG00000119547.5 one cut homeobox 2
ENSG00000205922.4 one cut homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ONECUT2hg19_v2_chr18_+_55102917_551029850.222.4e-01Click!
ONECUT3hg19_v2_chr19_+_1752372_17523720.183.1e-01Click!

Activity profile of ONECUT2_ONECUT3 motif

Sorted Z-values of ONECUT2_ONECUT3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_63428752 7.28 ENST00000295894.5
synaptoporin
chr14_-_24047965 5.51 ENST00000397118.3
ENST00000356300.4
junctophilin 4
chr10_+_95517616 4.43 ENST00000371418.4
leucine-rich, glioma inactivated 1
chr10_+_95517660 4.28 ENST00000371413.3
leucine-rich, glioma inactivated 1
chr10_+_95517566 4.00 ENST00000542308.1
leucine-rich, glioma inactivated 1
chr12_-_62586543 3.53 ENST00000416284.3
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr11_+_134144139 3.50 ENST00000389887.5
galactosidase, beta 1-like 3
chr8_+_77316233 3.39 ENST00000603284.1
ENST00000603837.1
RP11-706J10.2
long intergenic non-protein coding RNA 1109
chr2_-_192016316 3.27 ENST00000358470.4
ENST00000432798.1
ENST00000450994.1
signal transducer and activator of transcription 4
chr3_-_187388173 3.23 ENST00000287641.3
somatostatin
chr2_-_192016276 2.96 ENST00000413064.1
signal transducer and activator of transcription 4
chr16_+_72459838 2.93 ENST00000564508.1
AC004158.3
chr3_+_63428982 2.76 ENST00000479198.1
ENST00000460711.1
ENST00000465156.1
synaptoporin
chr1_-_116383322 2.57 ENST00000429731.1
nescient helix loop helix 2
chr1_+_198608292 2.50 ENST00000418674.1
protein tyrosine phosphatase, receptor type, C
chr1_-_116383738 2.46 ENST00000320238.3
nescient helix loop helix 2
chr11_-_35440796 2.38 ENST00000278379.3
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr20_-_1974692 2.36 ENST00000217305.2
ENST00000539905.1
prodynorphin
chr5_+_126984710 2.30 ENST00000379445.3
cortexin 3
chr14_+_77607026 2.29 ENST00000600936.1
Uncharacterized protein; cDNA FLJ43210 fis, clone FEBRA2020582
chr1_+_198607801 2.23 ENST00000367379.1
protein tyrosine phosphatase, receptor type, C
chr7_-_30009542 2.22 ENST00000438497.1
secernin 1
chr1_+_198608146 2.16 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
protein tyrosine phosphatase, receptor type, C
chr5_-_156772729 2.12 ENST00000312349.4
fibronectin type III domain containing 9
chr2_+_58655520 2.07 ENST00000455219.3
ENST00000449448.2
long intergenic non-protein coding RNA 1122
chr2_-_220174166 2.03 ENST00000409251.3
ENST00000451506.1
ENST00000295718.2
ENST00000446182.1
protein tyrosine phosphatase, receptor type, N
chr5_-_160279207 2.02 ENST00000327245.5
ATPase, class V, type 10B
chr13_-_36429763 1.98 ENST00000379893.1
doublecortin-like kinase 1
chr17_+_61151306 1.97 ENST00000580068.1
ENST00000580466.1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr7_-_30008849 1.91 ENST00000409497.1
secernin 1
chr7_-_143059780 1.88 ENST00000409578.1
ENST00000409346.1
family with sequence similarity 131, member B
chr1_+_190448095 1.81 ENST00000424735.1
RP11-547I7.2
chr7_-_143059845 1.77 ENST00000443739.2
family with sequence similarity 131, member B
chr2_+_166095898 1.75 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
sodium channel, voltage-gated, type II, alpha subunit
chr13_-_84456527 1.74 ENST00000377084.2
SLIT and NTRK-like family, member 1
chr18_-_70211691 1.68 ENST00000269503.4
cerebellin 2 precursor
chr7_-_107968921 1.64 ENST00000442580.1
neuronal cell adhesion molecule
chr1_-_111150048 1.63 ENST00000485317.1
potassium voltage-gated channel, shaker-related subfamily, member 2
chr11_-_35440579 1.61 ENST00000606205.1
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr7_-_104909435 1.61 ENST00000357311.3
SRSF protein kinase 2
chr7_-_107968999 1.60 ENST00000456431.1
neuronal cell adhesion molecule
chr7_-_100239132 1.56 ENST00000223051.3
ENST00000431692.1
transferrin receptor 2
chr5_-_156772568 1.55 ENST00000520782.1
fibronectin type III domain containing 9
chr14_+_62585332 1.54 ENST00000554895.1
long intergenic non-protein coding RNA 643
chr5_-_82969405 1.51 ENST00000510978.1
hyaluronan and proteoglycan link protein 1
chr6_+_15401075 1.49 ENST00000541660.1
jumonji, AT rich interactive domain 2
chr17_-_37764128 1.49 ENST00000302584.4
neuronal differentiation 2
chr10_+_68685764 1.48 ENST00000361320.4
leucine rich repeat transmembrane neuronal 3
chr17_+_44701402 1.44 ENST00000575068.1
N-ethylmaleimide-sensitive factor
chr12_-_27924209 1.39 ENST00000381273.3
MANSC domain containing 4
chr2_-_50201327 1.28 ENST00000412315.1
neurexin 1
chr2_+_215275771 1.25 ENST00000312504.5
ENST00000427124.1
von Willebrand factor C domain containing protein 2-like
chr7_-_121944491 1.22 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZ family zinc finger 1
chr1_-_26233423 1.22 ENST00000357865.2
stathmin 1
chr1_-_243326612 1.17 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
centrosomal protein 170kDa
chr7_+_43152212 1.16 ENST00000453890.1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr7_+_129906660 1.11 ENST00000222481.4
carboxypeptidase A2 (pancreatic)
chr14_+_22265444 1.10 ENST00000390430.2
T cell receptor alpha variable 8-1
chr5_+_161277603 1.10 ENST00000519621.1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_-_20985632 1.09 ENST00000359001.5
Kv channel interacting protein 4
chr4_-_102267953 1.08 ENST00000523694.2
ENST00000507176.1
protein phosphatase 3, catalytic subunit, alpha isozyme
chr6_+_37475109 1.06 ENST00000570443.2
RP1-153P14.8
chr9_-_28670283 1.06 ENST00000379992.2
leucine rich repeat and Ig domain containing 2
chr8_+_104831440 1.04 ENST00000515551.1
regulating synaptic membrane exocytosis 2
chr3_-_46930171 1.04 ENST00000593391.1
Uncharacterized protein
chr19_+_3880581 1.03 ENST00000450849.2
ENST00000301260.6
ENST00000398448.3
ataxia, cerebellar, Cayman type
chr17_-_2304365 1.03 ENST00000575394.1
ENST00000174618.4
MAX network transcriptional repressor
chr2_+_105050794 1.03 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
long intergenic non-protein coding RNA 1102
chrX_+_123480194 1.01 ENST00000371139.4
SH2 domain containing 1A
chr6_-_116479897 0.99 ENST00000418500.1
collagen, type X, alpha 1
chr4_-_70826725 0.99 ENST00000353151.3
casein beta
chr16_+_25228242 0.95 ENST00000219660.5
aquaporin 8
chr14_+_77425972 0.95 ENST00000553613.1
RP11-7F17.7
chr2_-_55646412 0.89 ENST00000413716.2
coiled-coil domain containing 88A
chr10_+_70980051 0.85 ENST00000354624.5
ENST00000395086.2
hexokinase domain containing 1
chr11_-_107729287 0.84 ENST00000375682.4
solute carrier family 35, member F2
chr9_+_77230499 0.83 ENST00000396204.2
RAR-related orphan receptor B
chr12_-_68797580 0.82 ENST00000539404.1
RP11-81H14.2
chr1_+_117297007 0.81 ENST00000369478.3
ENST00000369477.1
CD2 molecule
chr11_-_107729504 0.80 ENST00000265836.7
solute carrier family 35, member F2
chr12_+_20848377 0.80 ENST00000540354.1
ENST00000266509.2
ENST00000381552.1
solute carrier organic anion transporter family, member 1C1
chr2_-_163695128 0.79 ENST00000332142.5
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr3_-_155394099 0.78 ENST00000414191.1
phospholipase C, eta 1
chr7_+_39125365 0.77 ENST00000559001.1
ENST00000464276.2
POU class 6 homeobox 2
chr12_+_20848282 0.77 ENST00000545604.1
solute carrier organic anion transporter family, member 1C1
chr2_+_157330081 0.76 ENST00000409674.1
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr7_+_43152191 0.76 ENST00000395891.2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr3_-_130745403 0.75 ENST00000504725.1
ENST00000509060.1
asteroid homolog 1 (Drosophila)
chr3_-_108836945 0.74 ENST00000483760.1
MORC family CW-type zinc finger 1
chr14_+_22782867 0.73 ENST00000390467.3
T cell receptor alpha variable 40
chr1_+_206730484 0.73 ENST00000304534.8
Ras association (RalGDS/AF-6) domain family member 5
chr11_+_60467047 0.71 ENST00000300226.2
membrane-spanning 4-domains, subfamily A, member 8
chr12_+_4385230 0.71 ENST00000536537.1
cyclin D2
chr6_+_126221034 0.70 ENST00000433571.1
nuclear receptor coactivator 7
chr3_-_186080012 0.70 ENST00000544847.1
ENST00000265022.3
diacylglycerol kinase, gamma 90kDa
chr16_-_28192360 0.69 ENST00000570033.1
exportin 6
chr14_+_88490894 0.68 ENST00000556033.1
ENST00000553929.1
ENST00000555996.1
ENST00000556673.1
ENST00000557339.1
ENST00000556684.1
long intergenic non-protein coding RNA 1146
chr15_+_54901540 0.68 ENST00000539562.2
unc-13 homolog C (C. elegans)
chr3_-_155394152 0.67 ENST00000494598.1
phospholipase C, eta 1
chr13_-_46952645 0.67 ENST00000439642.1
KIAA0226-like
chr4_+_156824840 0.66 ENST00000536354.2
tryptophan 2,3-dioxygenase
chr2_-_208030886 0.64 ENST00000426163.1
Kruppel-like factor 7 (ubiquitous)
chrX_+_47093171 0.64 ENST00000377078.2
ubiquitin specific peptidase 11
chr3_-_194119083 0.64 ENST00000401815.1
glycoprotein V (platelet)
chr10_-_62332357 0.63 ENST00000503366.1
ankyrin 3, node of Ranvier (ankyrin G)
chr1_+_205538165 0.62 ENST00000536357.1
major facilitator superfamily domain containing 4
chr12_+_9144626 0.62 ENST00000543895.1
killer cell lectin-like receptor subfamily G, member 1
chr19_+_7598890 0.61 ENST00000221249.6
ENST00000601668.1
ENST00000601001.1
patatin-like phospholipase domain containing 6
chr17_-_79876010 0.61 ENST00000328666.6
sirtuin 7
chr8_+_31497271 0.59 ENST00000520407.1
neuregulin 1
chr7_-_28220354 0.59 ENST00000283928.5
JAZF zinc finger 1
chr3_+_121774202 0.58 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86 molecule
chr4_-_69434245 0.57 ENST00000317746.2
UDP glucuronosyltransferase 2 family, polypeptide B17
chr12_-_10601963 0.56 ENST00000543893.1
killer cell lectin-like receptor subfamily C, member 1
chr11_+_4510109 0.55 ENST00000307632.3
olfactory receptor, family 52, subfamily K, member 1
chr2_-_214017151 0.55 ENST00000452786.1
IKAROS family zinc finger 2 (Helios)
chr4_-_102268628 0.55 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
protein phosphatase 3, catalytic subunit, alpha isozyme
chr2_-_163695238 0.54 ENST00000328032.4
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr4_+_174818390 0.54 ENST00000509968.1
ENST00000512263.1
RP11-161D15.1
chr11_-_107729887 0.54 ENST00000525815.1
solute carrier family 35, member F2
chrX_-_119693745 0.53 ENST00000371323.2
cullin 4B
chr10_-_121296045 0.53 ENST00000392865.1
regulator of G-protein signaling 10
chr7_-_151330218 0.52 ENST00000476632.1
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr20_+_58571419 0.51 ENST00000244049.3
ENST00000350849.6
ENST00000456106.1
cadherin 26
chr12_+_64846129 0.51 ENST00000540417.1
ENST00000539810.1
TANK-binding kinase 1
chr9_+_74729511 0.50 ENST00000545168.1
guanine deaminase
chr14_+_23004404 0.49 ENST00000390528.1
T cell receptor alpha joining 9
chr17_+_7461613 0.48 ENST00000438470.1
ENST00000436057.1
tumor necrosis factor (ligand) superfamily, member 13
chr4_-_102268708 0.48 ENST00000525819.1
protein phosphatase 3, catalytic subunit, alpha isozyme
chr2_+_108863651 0.47 ENST00000329106.2
ENST00000376700.1
sulfotransferase family, cytosolic, 1C, member 3
chr11_-_47736896 0.47 ENST00000525123.1
ENST00000528244.1
ENST00000532595.1
ENST00000529154.1
ENST00000530969.1
ATP/GTP binding protein-like 2
chr12_+_100594557 0.47 ENST00000546902.1
ENST00000552376.1
ENST00000551617.1
ARP6 actin-related protein 6 homolog (yeast)
chr6_+_105404899 0.47 ENST00000345080.4
lin-28 homolog B (C. elegans)
chr9_+_95726243 0.46 ENST00000416701.2
FYVE, RhoGEF and PH domain containing 3
chr7_-_112727774 0.46 ENST00000297146.3
ENST00000501255.2
G protein-coupled receptor 85
chr17_-_4167142 0.45 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ankyrin repeat and FYVE domain containing 1
chr21_-_15918618 0.45 ENST00000400564.1
ENST00000400566.1
SAM domain, SH3 domain and nuclear localization signals 1
chr16_-_75467318 0.44 ENST00000283882.3
craniofacial development protein 1
chr11_-_60623437 0.44 ENST00000332539.4
prostaglandin D2 receptor 2
chr7_+_128784712 0.43 ENST00000289407.4
tetraspanin 33
chr19_+_7599128 0.43 ENST00000545201.2
patatin-like phospholipase domain containing 6
chr12_-_122018114 0.43 ENST00000539394.1
lysine (K)-specific demethylase 2B
chr1_+_110655050 0.43 ENST00000334179.3
ubiquitin-like 4B
chr1_-_182921119 0.42 ENST00000423786.1
SHC SH2-domain binding protein 1-like
chr3_-_71632894 0.42 ENST00000493089.1
forkhead box P1
chr9_-_117420052 0.41 ENST00000423632.1
RP11-402G3.5
chr7_-_23510086 0.41 ENST00000258729.3
insulin-like growth factor 2 mRNA binding protein 3
chr12_+_41831485 0.41 ENST00000539469.2
ENST00000298919.7
PDZ domain containing ring finger 4
chr16_+_73266661 0.41 ENST00000561802.1
AC140912.1
chr2_+_168725458 0.40 ENST00000392690.3
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr19_+_35940486 0.39 ENST00000246549.2
free fatty acid receptor 2
chr1_+_114473350 0.38 ENST00000503968.1
homeodomain interacting protein kinase 1
chr12_+_64845864 0.38 ENST00000538890.1
TANK-binding kinase 1
chr17_+_7461849 0.37 ENST00000338784.4
tumor necrosis factor (ligand) superfamily, member 13
chr7_+_129007964 0.37 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
adenosylhomocysteinase-like 2
chr14_+_29241910 0.37 ENST00000399387.4
ENST00000552957.1
ENST00000548213.1
chromosome 14 open reading frame 23
chr4_-_102268484 0.36 ENST00000394853.4
protein phosphatase 3, catalytic subunit, alpha isozyme
chrX_+_10124977 0.36 ENST00000380833.4
chloride channel, voltage-sensitive 4
chr2_+_58655461 0.36 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
long intergenic non-protein coding RNA 1122
chr6_+_56954919 0.35 ENST00000508603.1
ENST00000491832.2
ENST00000370710.6
zinc finger protein 451
chr2_+_102413726 0.34 ENST00000350878.4
mitogen-activated protein kinase kinase kinase kinase 4
chr18_+_11752783 0.34 ENST00000585642.1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr2_+_7017796 0.33 ENST00000382040.3
radical S-adenosyl methionine domain containing 2
chr6_-_113754604 0.33 ENST00000421737.1
RP1-124C6.1
chr12_-_122017542 0.33 ENST00000446152.2
lysine (K)-specific demethylase 2B
chr4_+_175839551 0.33 ENST00000404450.4
ENST00000514159.1
ADAM metallopeptidase domain 29
chr2_-_32490859 0.32 ENST00000404025.2
NLR family, CARD domain containing 4
chr7_-_78400598 0.32 ENST00000536571.1
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr4_+_175839506 0.32 ENST00000505141.1
ENST00000359240.3
ENST00000445694.1
ADAM metallopeptidase domain 29
chr14_+_23012122 0.32 ENST00000390534.1
T cell receptor alpha joining 3
chr16_-_30621663 0.31 ENST00000287461.3
zinc finger protein 689
chr1_+_223354486 0.31 ENST00000446145.1
RP11-239E10.3
chr6_+_27925019 0.31 ENST00000244623.1
olfactory receptor, family 2, subfamily B, member 6
chr19_+_37997812 0.30 ENST00000542455.1
ENST00000587143.1
zinc finger protein 793
chr17_+_31318886 0.29 ENST00000269053.3
ENST00000394638.1
sperm acrosome associated 3
chr15_+_48051920 0.29 ENST00000559196.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chrX_-_133792480 0.28 ENST00000359237.4
placenta-specific 1
chr5_+_162887556 0.28 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
hyaluronan-mediated motility receptor (RHAMM)
chr17_+_17685422 0.27 ENST00000395774.1
retinoic acid induced 1
chr5_-_121659052 0.27 ENST00000512105.1
CTD-2544H17.1
chr16_-_75467274 0.26 ENST00000566254.1
craniofacial development protein 1
chr15_+_36338242 0.26 ENST00000560056.1
RP11-684B21.1
chr6_+_158733692 0.25 ENST00000367094.2
ENST00000367097.3
tubby like protein 4
chr9_+_33629119 0.24 ENST00000331828.4
T cell receptor beta variable 21/OR9-2 (pseudogene)
chr5_+_180794269 0.24 ENST00000456475.1
olfactory receptor, family 4, subfamily F, member 3
chr8_-_117043 0.24 ENST00000320901.3
olfactory receptor, family 4, subfamily F, member 21
chr7_+_133615169 0.24 ENST00000541309.1
exocyst complex component 4
chrX_-_16887963 0.24 ENST00000380084.4
retinoblastoma binding protein 7
chr1_+_248201474 0.24 ENST00000366479.2
olfactory receptor, family 2, subfamily L, member 2
chr1_-_146068184 0.24 ENST00000604894.1
ENST00000369323.3
ENST00000479926.2
neuroblastoma breakpoint family, member 11
chr17_+_7461781 0.23 ENST00000349228.4
tumor necrosis factor (ligand) superfamily, member 13
chr12_+_4699244 0.22 ENST00000540757.2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr1_+_367640 0.22 ENST00000426406.1
olfactory receptor, family 4, subfamily F, member 29
chr18_+_29671812 0.22 ENST00000261593.3
ENST00000578914.1
ring finger protein 138, E3 ubiquitin protein ligase
chr9_-_27529726 0.22 ENST00000262244.5
MOB kinase activator 3B
chr4_+_71587669 0.22 ENST00000381006.3
ENST00000226328.4
RUN and FYVE domain containing 3
chr4_+_71588372 0.22 ENST00000536664.1
RUN and FYVE domain containing 3
chr5_-_162873821 0.22 ENST00000599797.1
Uncharacterized protein
chr12_+_32832134 0.21 ENST00000452533.2
dynamin 1-like
chr12_+_48866448 0.21 ENST00000266594.1
acidic (leucine-rich) nuclear phosphoprotein 32 family, member D

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT2_ONECUT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 6.9 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.6 3.2 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.6 2.5 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.5 2.0 GO:1990502 dense core granule maturation(GO:1990502)
0.4 5.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.4 4.0 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 1.5 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.3 1.6 GO:0021633 optic nerve structural organization(GO:0021633)
0.3 1.6 GO:0035063 nuclear speck organization(GO:0035063)
0.3 1.6 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.3 1.0 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763)
0.2 1.0 GO:1903487 regulation of lactation(GO:1903487)
0.2 0.7 GO:2000616 negative regulation of histone H3-K9 acetylation(GO:2000616)
0.2 0.9 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 1.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 3.2 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 0.6 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.2 0.5 GO:0006147 guanine catabolic process(GO:0006147)
0.2 0.7 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.2 1.1 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.2 1.4 GO:0035494 SNARE complex disassembly(GO:0035494)
0.2 0.8 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.2 0.8 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.2 0.6 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.1 1.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.4 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.4 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.1 4.3 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 0.7 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 1.6 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.9 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 0.7 GO:0044026 DNA hypermethylation(GO:0044026)
0.1 0.6 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 1.8 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.1 0.8 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.1 1.1 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 0.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 0.8 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 1.0 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 1.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 1.5 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.4 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.7 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.3 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 0.2 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.1 2.0 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.6 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.1 0.5 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.7 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 0.5 GO:0048549 endosome localization(GO:0032439) positive regulation of pinocytosis(GO:0048549)
0.1 0.3 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.1 4.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.3 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 12.7 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
0.0 0.1 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.0 1.1 GO:0071420 cellular response to histamine(GO:0071420)
0.0 5.2 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.4 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 2.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 1.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.3 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0 0.2 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.4 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.4 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:1900005 positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)
0.0 0.2 GO:0002760 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.0 0.3 GO:0070269 pyroptosis(GO:0070269)
0.0 1.0 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.7 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.5 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 1.0 GO:0006833 water transport(GO:0006833)
0.0 0.5 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.7 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 1.4 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.2 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.5 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.5 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.5 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.1 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.8 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.7 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0 1.3 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 2.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.7 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.4 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 1.5 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.1 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097)
0.0 0.3 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.5 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.9 GO:0006968 cellular defense response(GO:0006968)
0.0 0.1 GO:0030050 vesicle transport along actin filament(GO:0030050)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.5 GO:0030314 junctional membrane complex(GO:0030314)
0.3 10.0 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 2.5 GO:0005955 calcineurin complex(GO:0005955)
0.1 3.9 GO:0043194 axon initial segment(GO:0043194)
0.1 1.8 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 1.6 GO:0033010 paranodal junction(GO:0033010)
0.1 1.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.4 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 4.6 GO:0030673 axolemma(GO:0030673)
0.1 0.7 GO:0044305 calyx of Held(GO:0044305)
0.1 0.5 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.4 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.5 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 1.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 1.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.3 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 4.1 GO:0043679 axon terminus(GO:0043679)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 1.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.4 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 2.5 GO:0005814 centriole(GO:0005814)
0.0 0.4 GO:0071437 invadopodium(GO:0071437)
0.0 1.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 16.0 GO:0045202 synapse(GO:0045202)
0.0 0.7 GO:0031519 PcG protein complex(GO:0031519)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.4 4.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 1.6 GO:0004998 transferrin receptor activity(GO:0004998)
0.3 2.4 GO:0001515 opioid peptide activity(GO:0001515)
0.3 3.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.2 0.8 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.2 2.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 1.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 6.9 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 0.5 GO:0008892 guanine deaminase activity(GO:0008892)
0.2 0.6 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1 0.4 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.1 0.4 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 3.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.7 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 1.1 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 4.1 GO:0016805 dipeptidase activity(GO:0016805)
0.1 0.8 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.6 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 0.7 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.6 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 2.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.0 GO:0015250 water channel activity(GO:0015250)
0.1 0.4 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.0 0.5 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 3.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.9 GO:0043422 protein kinase B binding(GO:0043422)
0.0 2.5 GO:0030507 spectrin binding(GO:0030507)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 1.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.2 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 1.0 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0051400 BH domain binding(GO:0051400)
0.0 2.4 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.6 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.5 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 2.2 GO:0005267 potassium channel activity(GO:0005267)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 7.6 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 1.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 8.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.6 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.7 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.5 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.9 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 5.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.0 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.6 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 2.4 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 3.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 4.0 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.4 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 3.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.7 REACTOME G1 PHASE Genes involved in G1 Phase