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Illumina Body Map 2, young vs old

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Results for OTX2_CRX

Z-value: 0.63

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Transcription factors associated with OTX2_CRX

Gene Symbol Gene ID Gene Info
OTX2
ENSG00000165588.12 orthodenticle homeobox 2
CRX
ENSG00000105392.11 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OTX2hg19_v2_chr14_-_57277163_572771680.541.6e-03Click!
CRXhg19_v2_chr19_+_48325097_483252110.327.1e-02Click!

Activity profile of OTX2_CRX motif

Sorted Z-values of OTX2_CRX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_32290218 5.02 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA
dystrobrevin, alpha
chr12_+_6949964 3.22 ENST00000541978.1
ENST00000435982.2
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr3_-_179691866 2.72 ENST00000464614.1
ENST00000476138.1
ENST00000463761.1
PEX5L
peroxisomal biogenesis factor 5-like
chr18_-_40857493 2.66 ENST00000255224.3
SYT4
synaptotagmin IV
chr15_-_27184664 2.18 ENST00000541819.2
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr1_+_169079823 2.16 ENST00000367813.3
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chrX_-_15619076 2.15 ENST00000252519.3
ACE2
angiotensin I converting enzyme 2
chr22_-_38380543 2.06 ENST00000396884.2
SOX10
SRY (sex determining region Y)-box 10
chr18_-_64271316 1.94 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr17_+_68101117 1.94 ENST00000587698.1
ENST00000587892.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr18_-_70532906 1.80 ENST00000299430.2
ENST00000397929.1
NETO1
neuropilin (NRP) and tolloid (TLL)-like 1
chr3_-_179692042 1.76 ENST00000468741.1
PEX5L
peroxisomal biogenesis factor 5-like
chr2_-_175711133 1.74 ENST00000409597.1
ENST00000413882.1
CHN1
chimerin 1
chr18_-_64271363 1.73 ENST00000262150.2
CDH19
cadherin 19, type 2
chr14_-_22005343 1.72 ENST00000327430.3
SALL2
spalt-like transcription factor 2
chr6_+_54173227 1.72 ENST00000259782.4
ENST00000370864.3
TINAG
tubulointerstitial nephritis antigen
chr6_+_34433844 1.64 ENST00000244458.2
ENST00000374043.2
PACSIN1
protein kinase C and casein kinase substrate in neurons 1
chr5_-_149669192 1.59 ENST00000398376.3
CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr1_-_165414414 1.47 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr5_+_161494770 1.43 ENST00000414552.2
ENST00000361925.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr8_+_104892639 1.42 ENST00000436393.2
RIMS2
regulating synaptic membrane exocytosis 2
chr5_+_161494521 1.41 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr6_-_42690312 1.41 ENST00000230381.5
PRPH2
peripherin 2 (retinal degeneration, slow)
chr14_-_22005018 1.41 ENST00000546363.1
SALL2
spalt-like transcription factor 2
chr17_+_48911942 1.40 ENST00000426127.1
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr14_-_22005197 1.36 ENST00000541965.1
SALL2
spalt-like transcription factor 2
chr5_-_24645078 1.35 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr17_-_38859996 1.34 ENST00000264651.2
KRT24
keratin 24
chr10_+_18240834 1.31 ENST00000377371.3
ENST00000539911.1
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr8_+_70378852 1.31 ENST00000525061.1
ENST00000458141.2
ENST00000260128.4
SULF1
sulfatase 1
chr5_-_95768973 1.31 ENST00000311106.3
PCSK1
proprotein convertase subtilisin/kexin type 1
chr14_-_22005062 1.31 ENST00000317492.5
SALL2
spalt-like transcription factor 2
chr10_+_18240753 1.29 ENST00000377369.2
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr12_+_40787194 1.27 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr11_-_62752429 1.18 ENST00000377871.3
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr11_-_62752455 1.18 ENST00000360421.4
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr11_-_62752162 1.18 ENST00000458333.2
ENST00000421062.2
SLC22A6
solute carrier family 22 (organic anion transporter), member 6
chr5_-_41794313 1.18 ENST00000512084.1
OXCT1
3-oxoacid CoA transferase 1
chr5_-_41510725 1.17 ENST00000328457.3
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr15_+_43885252 1.17 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr17_+_68100989 1.16 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr13_+_36050881 1.16 ENST00000537702.1
NBEA
neurobeachin
chr15_+_33603147 1.14 ENST00000415757.3
ENST00000389232.4
RYR3
ryanodine receptor 3
chr8_-_91095099 1.13 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr1_+_159141397 1.13 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr15_+_43985084 1.10 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr10_+_18240814 1.08 ENST00000377374.4
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr10_-_21186144 1.05 ENST00000377119.1
NEBL
nebulette
chr11_-_111794446 1.04 ENST00000527950.1
CRYAB
crystallin, alpha B
chr11_-_111783595 1.04 ENST00000528628.1
CRYAB
crystallin, alpha B
chr18_-_21891460 1.03 ENST00000357041.4
OSBPL1A
oxysterol binding protein-like 1A
chr3_+_173302222 1.02 ENST00000361589.4
NLGN1
neuroligin 1
chr10_+_95848824 1.00 ENST00000371385.3
ENST00000371375.1
PLCE1
phospholipase C, epsilon 1
chr18_-_40857447 0.99 ENST00000590752.1
ENST00000596867.1
SYT4
synaptotagmin IV
chr17_+_74536115 0.96 ENST00000592014.1
PRCD
progressive rod-cone degeneration
chr14_-_101034407 0.96 ENST00000443071.2
ENST00000557378.1
BEGAIN
brain-enriched guanylate kinase-associated
chr9_+_103204553 0.96 ENST00000502978.1
ENST00000334943.6
MSANTD3-TMEFF1
TMEFF1
MSANTD3-TMEFF1 readthrough
transmembrane protein with EGF-like and two follistatin-like domains 1
chr12_-_16758059 0.94 ENST00000261169.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr13_-_36050819 0.93 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chrX_-_21676442 0.92 ENST00000379499.2
KLHL34
kelch-like family member 34
chr8_+_70379072 0.92 ENST00000529134.1
SULF1
sulfatase 1
chr16_+_58010339 0.91 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr1_+_209757051 0.91 ENST00000009105.1
ENST00000423146.1
ENST00000361322.2
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr12_-_16758304 0.91 ENST00000320122.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr9_+_12693336 0.90 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr12_+_78224667 0.89 ENST00000549464.1
NAV3
neuron navigator 3
chr7_-_83824169 0.89 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chrX_-_6146876 0.89 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr8_+_134029937 0.89 ENST00000518108.1
TG
thyroglobulin
chr5_-_41510656 0.89 ENST00000377801.3
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr5_+_50678921 0.88 ENST00000230658.7
ISL1
ISL LIM homeobox 1
chr15_+_54901540 0.87 ENST00000539562.2
UNC13C
unc-13 homolog C (C. elegans)
chrX_+_17653413 0.85 ENST00000398097.3
NHS
Nance-Horan syndrome (congenital cataracts and dental anomalies)
chr10_-_116418053 0.84 ENST00000277895.5
ABLIM1
actin binding LIM protein 1
chr13_-_62001982 0.84 ENST00000409186.1
PCDH20
protocadherin 20
chr16_-_58004992 0.81 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
CNGB1
cyclic nucleotide gated channel beta 1
chr7_+_73868220 0.80 ENST00000455841.2
GTF2IRD1
GTF2I repeat domain containing 1
chr8_+_54764346 0.78 ENST00000297313.3
ENST00000344277.6
RGS20
regulator of G-protein signaling 20
chr6_-_154568815 0.76 ENST00000519344.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr2_+_219472488 0.75 ENST00000450993.2
PLCD4
phospholipase C, delta 4
chrX_+_28605516 0.75 ENST00000378993.1
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr10_-_86001210 0.75 ENST00000372105.3
LRIT1
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
chr11_-_36619771 0.75 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chr14_-_101034811 0.74 ENST00000553553.1
BEGAIN
brain-enriched guanylate kinase-associated
chr18_+_616672 0.74 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chr10_-_104178857 0.74 ENST00000020673.5
PSD
pleckstrin and Sec7 domain containing
chr16_+_81272287 0.74 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr3_-_149095652 0.73 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr5_-_36301984 0.73 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RANBP3L
RAN binding protein 3-like
chr1_-_102312517 0.72 ENST00000338858.5
OLFM3
olfactomedin 3
chr9_-_28670283 0.72 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr10_-_61122934 0.71 ENST00000512919.1
FAM13C
family with sequence similarity 13, member C
chr1_+_20396649 0.70 ENST00000375108.3
PLA2G5
phospholipase A2, group V
chr18_+_616711 0.68 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr20_-_18774614 0.68 ENST00000412553.1
LINC00652
long intergenic non-protein coding RNA 652
chr22_-_38480100 0.67 ENST00000427592.1
SLC16A8
solute carrier family 16 (monocarboxylate transporter), member 8
chr1_+_202431859 0.67 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr3_+_4535025 0.65 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr2_+_219472637 0.65 ENST00000417849.1
PLCD4
phospholipase C, delta 4
chr2_+_115219171 0.64 ENST00000409163.1
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr6_+_155537771 0.64 ENST00000275246.7
TIAM2
T-cell lymphoma invasion and metastasis 2
chr11_-_71752571 0.63 ENST00000544238.1
NUMA1
nuclear mitotic apparatus protein 1
chr19_-_55865908 0.62 ENST00000590900.1
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr1_-_39395165 0.61 ENST00000372985.3
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr7_-_17598506 0.61 ENST00000451792.1
AC017060.1
AC017060.1
chr1_+_66999268 0.60 ENST00000371039.1
ENST00000424320.1
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr18_-_40857329 0.60 ENST00000593720.1
SYT4
synaptotagmin IV
chr3_-_9291063 0.58 ENST00000383836.3
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr9_+_34992846 0.58 ENST00000443266.1
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr2_-_30144432 0.58 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr7_+_123295861 0.57 ENST00000458573.2
ENST00000456238.2
LMOD2
leiomodin 2 (cardiac)
chr11_-_71753188 0.57 ENST00000543009.1
NUMA1
nuclear mitotic apparatus protein 1
chr1_-_117664317 0.57 ENST00000256649.4
ENST00000369464.3
ENST00000485032.1
TRIM45
tripartite motif containing 45
chr1_+_180875711 0.57 ENST00000434447.1
RP11-46A10.2
RP11-46A10.2
chr2_+_170366203 0.56 ENST00000284669.1
KLHL41
kelch-like family member 41
chr3_-_48229846 0.56 ENST00000302506.3
ENST00000351231.3
ENST00000437972.1
CDC25A
cell division cycle 25A
chr1_+_171939240 0.56 ENST00000523513.1
DNM3
dynamin 3
chr1_+_144989309 0.56 ENST00000596396.1
AL590452.1
Uncharacterized protein
chrX_-_33357558 0.56 ENST00000288447.4
DMD
dystrophin
chr9_-_39288092 0.55 ENST00000323947.7
ENST00000297668.6
ENST00000377656.2
ENST00000377659.1
CNTNAP3
contactin associated protein-like 3
chr6_-_154568551 0.54 ENST00000519190.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr18_-_35145689 0.54 ENST00000591287.1
ENST00000601019.1
ENST00000601392.1
CELF4
CUGBP, Elav-like family member 4
chr8_-_114449112 0.54 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CSMD3
CUB and Sushi multiple domains 3
chr4_+_154125565 0.53 ENST00000338700.5
TRIM2
tripartite motif containing 2
chr12_-_86650045 0.52 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr10_-_69455873 0.51 ENST00000433211.2
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr17_-_43209862 0.51 ENST00000322765.5
PLCD3
phospholipase C, delta 3
chr12_-_66275350 0.50 ENST00000536648.1
RP11-366L20.2
Uncharacterized protein
chr7_-_83824449 0.50 ENST00000420047.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr1_+_164528866 0.50 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr13_-_49975632 0.50 ENST00000457041.1
ENST00000355854.4
CAB39L
calcium binding protein 39-like
chr11_-_71752838 0.50 ENST00000537930.1
NUMA1
nuclear mitotic apparatus protein 1
chr6_+_148593425 0.50 ENST00000367469.1
SASH1
SAM and SH3 domain containing 1
chr3_+_111393501 0.49 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr11_-_128894053 0.49 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr1_-_102312600 0.49 ENST00000359814.3
OLFM3
olfactomedin 3
chr12_-_13248598 0.49 ENST00000337630.6
ENST00000545699.1
GSG1
germ cell associated 1
chr12_-_13248562 0.48 ENST00000457134.2
ENST00000537302.1
GSG1
germ cell associated 1
chr5_-_11589131 0.48 ENST00000511377.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr7_+_123241908 0.48 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ASB15
ankyrin repeat and SOCS box containing 15
chr9_-_8857776 0.48 ENST00000481079.1
PTPRD
protein tyrosine phosphatase, receptor type, D
chr5_-_11588907 0.48 ENST00000513598.1
ENST00000503622.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr17_+_12626199 0.48 ENST00000609971.1
AC005358.1
AC005358.1
chr5_-_88178964 0.48 ENST00000513252.1
ENST00000508569.1
ENST00000510942.1
ENST00000506554.1
MEF2C
myocyte enhancer factor 2C
chr4_+_96012614 0.48 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr1_+_164528616 0.48 ENST00000340699.3
PBX1
pre-B-cell leukemia homeobox 1
chr17_-_43210580 0.48 ENST00000538093.1
ENST00000590644.1
PLCD3
phospholipase C, delta 3
chr17_-_39661849 0.48 ENST00000246635.3
ENST00000336861.3
ENST00000587544.1
ENST00000587435.1
KRT13
keratin 13
chr4_+_96012585 0.47 ENST00000502683.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr5_-_58882219 0.47 ENST00000505453.1
ENST00000360047.5
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_9808887 0.47 ENST00000226193.5
RCVRN
recoverin
chr21_-_19775973 0.46 ENST00000284885.3
TMPRSS15
transmembrane protease, serine 15
chr10_+_52750930 0.46 ENST00000401604.2
PRKG1
protein kinase, cGMP-dependent, type I
chr3_-_50605150 0.45 ENST00000357203.3
C3orf18
chromosome 3 open reading frame 18
chr18_-_35145593 0.45 ENST00000334919.5
ENST00000591282.1
ENST00000588597.1
CELF4
CUGBP, Elav-like family member 4
chr15_-_74495188 0.43 ENST00000563965.1
ENST00000395105.4
STRA6
stimulated by retinoic acid 6
chr5_+_63461642 0.43 ENST00000296615.6
ENST00000381081.2
ENST00000389100.4
RNF180
ring finger protein 180
chr11_-_128712362 0.43 ENST00000392664.2
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr6_-_35480640 0.43 ENST00000428978.1
ENST00000322263.4
TULP1
tubby like protein 1
chr11_-_30608413 0.42 ENST00000528686.1
MPPED2
metallophosphoesterase domain containing 2
chr6_-_139613269 0.42 ENST00000358430.3
TXLNB
taxilin beta
chr17_-_36499693 0.42 ENST00000342292.4
GPR179
G protein-coupled receptor 179
chr5_+_50679506 0.42 ENST00000511384.1
ISL1
ISL LIM homeobox 1
chr3_-_50605077 0.42 ENST00000426034.1
ENST00000441239.1
C3orf18
chromosome 3 open reading frame 18
chr14_+_23846328 0.42 ENST00000382809.2
CMTM5
CKLF-like MARVEL transmembrane domain containing 5
chr9_+_75229616 0.41 ENST00000340019.3
TMC1
transmembrane channel-like 1
chr12_-_86650154 0.41 ENST00000552435.2
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr15_+_63050785 0.41 ENST00000472902.1
TLN2
talin 2
chr3_+_69915385 0.40 ENST00000314589.5
MITF
microphthalmia-associated transcription factor
chrX_+_135279179 0.40 ENST00000370676.3
FHL1
four and a half LIM domains 1
chr12_-_55375622 0.40 ENST00000316577.8
TESPA1
thymocyte expressed, positive selection associated 1
chr9_-_13279589 0.40 ENST00000319217.7
MPDZ
multiple PDZ domain protein
chr7_+_73868439 0.39 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr12_-_67197760 0.39 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1
glutamate receptor interacting protein 1
chr9_+_82188077 0.39 ENST00000425506.1
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr15_-_35047166 0.39 ENST00000290374.4
GJD2
gap junction protein, delta 2, 36kDa
chr19_+_39989580 0.39 ENST00000596614.1
ENST00000205143.4
DLL3
delta-like 3 (Drosophila)
chr19_+_50183032 0.38 ENST00000527412.1
PRMT1
protein arginine methyltransferase 1
chr7_+_73868120 0.38 ENST00000265755.3
GTF2IRD1
GTF2I repeat domain containing 1
chr5_+_150040403 0.37 ENST00000517768.1
ENST00000297130.4
MYOZ3
myozenin 3
chr3_-_47950745 0.37 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr5_-_33984741 0.37 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
SLC45A2
solute carrier family 45, member 2
chr2_-_214016314 0.36 ENST00000434687.1
ENST00000374319.4
IKZF2
IKAROS family zinc finger 2 (Helios)
chr15_-_34610962 0.36 ENST00000290209.5
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr12_-_21556577 0.36 ENST00000450590.1
ENST00000453443.1
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr13_-_95131923 0.36 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr19_-_44123734 0.36 ENST00000598676.1
ZNF428
zinc finger protein 428
chr10_-_49482907 0.36 ENST00000374201.3
ENST00000407470.4
FRMPD2
FERM and PDZ domain containing 2
chr19_-_44124019 0.36 ENST00000300811.3
ZNF428
zinc finger protein 428
chr7_+_136553824 0.36 ENST00000320658.5
ENST00000453373.1
ENST00000397608.3
ENST00000402486.3
ENST00000401861.1
CHRM2
cholinergic receptor, muscarinic 2
chr16_-_325910 0.35 ENST00000359740.5
ENST00000316163.5
ENST00000431291.2
ENST00000397770.3
ENST00000397768.3
RGS11
regulator of G-protein signaling 11
chr3_-_98241358 0.35 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1
claudin domain containing 1
chr2_+_55746722 0.35 ENST00000339012.3
CCDC104
coiled-coil domain containing 104
chr18_-_35145728 0.35 ENST00000361795.5
ENST00000603232.1
CELF4
CUGBP, Elav-like family member 4
chr10_+_102505468 0.35 ENST00000361791.3
ENST00000355243.3
ENST00000428433.1
ENST00000370296.2
PAX2
paired box 2
chrX_-_100129128 0.35 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr5_-_524445 0.34 ENST00000514375.1
ENST00000264938.3
SLC9A3
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
chr8_-_87755878 0.34 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr11_-_40315640 0.34 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr5_-_88179017 0.34 ENST00000514028.1
ENST00000514015.1
ENST00000503075.1
ENST00000437473.2
MEF2C
myocyte enhancer factor 2C

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX2_CRX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0048174 negative regulation of short-term neuronal synaptic plasticity(GO:0048174)
1.2 3.5 GO:0097254 renal tubular secretion(GO:0097254)
0.5 2.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.4 2.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051)
0.4 4.5 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560)
0.4 1.8 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.3 1.4 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.3 1.3 GO:0048936 visceral motor neuron differentiation(GO:0021524) peripheral nervous system neuron axonogenesis(GO:0048936) cardiac cell fate determination(GO:0060913) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.3 2.2 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.3 1.6 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.3 2.2 GO:0044861 protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281)
0.3 0.9 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.3 1.0 GO:0098942 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.2 5.0 GO:0071420 cellular response to histamine(GO:0071420)
0.2 2.1 GO:0032888 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.2 0.6 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.2 0.7 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.2 1.2 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.2 1.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.2 1.8 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.2 3.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 1.2 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.6 GO:0036269 swimming behavior(GO:0036269)
0.1 0.9 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 1.5 GO:0072025 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
0.1 1.8 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.5 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1 1.3 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 1.4 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.7 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.6 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.1 1.6 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 0.7 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.1 1.1 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 0.9 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.3 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.1 5.0 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.6 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.3 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.1 1.8 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.4 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 2.3 GO:0097320 membrane tubulation(GO:0097320)
0.1 0.4 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.5 GO:0007386 compartment pattern specification(GO:0007386)
0.1 1.1 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.9 GO:0015705 iodide transport(GO:0015705)
0.1 0.5 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.4 GO:1901631 positive regulation of presynaptic membrane organization(GO:1901631) positive regulation of synaptic vesicle clustering(GO:2000809)
0.1 1.5 GO:0015671 oxygen transport(GO:0015671)
0.1 0.2 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.1 0.4 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.1 3.5 GO:0010107 potassium ion import(GO:0010107)
0.1 0.5 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.1 0.4 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.1 0.4 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.8 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.1 0.4 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 0.8 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.7 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 0.5 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 3.2 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.2 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.4 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.4 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.2 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.1 GO:1903980 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) positive regulation of microglial cell activation(GO:1903980)
0.0 0.3 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 1.5 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 1.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.6 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.0 0.6 GO:0043587 tongue morphogenesis(GO:0043587)
0.0 0.5 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 1.0 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 1.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.4 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 1.1 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.4 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 6.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.4 GO:0015824 proline transport(GO:0015824)
0.0 0.1 GO:0033122 negative regulation of cyclic nucleotide catabolic process(GO:0030806) negative regulation of cAMP catabolic process(GO:0030821) negative regulation of purine nucleotide catabolic process(GO:0033122)
0.0 0.4 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 1.4 GO:0007340 acrosome reaction(GO:0007340)
0.0 0.2 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.3 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.2 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:1903625 negative regulation of DNA catabolic process(GO:1903625)
0.0 0.2 GO:0032252 secretory granule localization(GO:0032252)
0.0 0.3 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.4 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 1.5 GO:0048747 muscle fiber development(GO:0048747)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 1.0 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.7 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.3 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.6 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.3 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.0 7.1 GO:0001654 eye development(GO:0001654)
0.0 0.7 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.3 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.0 0.5 GO:0008037 cell recognition(GO:0008037)
0.0 0.2 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.2 GO:0007097 nuclear migration(GO:0007097)
0.0 1.0 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 1.3 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:0032127 dense core granule membrane(GO:0032127)
0.2 2.1 GO:0055028 cortical microtubule(GO:0055028)
0.2 0.6 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 5.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 5.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.8 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 2.1 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.9 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.9 GO:0044305 calyx of Held(GO:0044305)
0.1 2.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 1.1 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.7 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.8 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.6 GO:0016013 syntrophin complex(GO:0016013)
0.0 2.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.3 GO:0097441 basilar dendrite(GO:0097441)
0.0 1.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 4.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.4 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.6 GO:0034709 methylosome(GO:0034709)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 1.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 1.4 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.5 GO:0005916 fascia adherens(GO:0005916)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 5.0 GO:0042383 sarcolemma(GO:0042383)
0.0 2.8 GO:0005901 caveola(GO:0005901)
0.0 0.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 3.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.5 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.2 GO:0005827 polar microtubule(GO:0005827)
0.0 0.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.7 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.2 GO:0031672 A band(GO:0031672)
0.0 0.7 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 1.9 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 1.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 7.9 GO:0030425 dendrite(GO:0030425)
0.0 2.2 GO:0005795 Golgi stack(GO:0005795)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.4 1.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 3.7 GO:0030348 syntaxin-3 binding(GO:0030348)
0.3 1.2 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.3 1.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.3 2.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.2 0.9 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.2 2.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 4.4 GO:0031404 chloride ion binding(GO:0031404)
0.2 0.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 2.8 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.2 0.6 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.2 2.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.2 0.7 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 1.1 GO:0005499 vitamin D binding(GO:0005499)
0.2 0.8 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 0.8 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 1.3 GO:0042835 BRE binding(GO:0042835)
0.1 1.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 3.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.5 GO:0015154 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 1.1 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.8 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 0.2 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 2.1 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 2.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 0.9 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 3.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 3.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 1.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.4 GO:0051373 FATZ binding(GO:0051373)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.6 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.1 1.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.4 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 0.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 1.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 1.7 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.3 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.1 1.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.3 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.1 0.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.7 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 2.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 3.2 GO:0030507 spectrin binding(GO:0030507)
0.0 1.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.5 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.5 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.4 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0031208 POZ domain binding(GO:0031208)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 1.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.7 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 5.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.6 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 1.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.8 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.4 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.0 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 1.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.5 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.4 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 1.3 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.2 GO:0016918 retinal binding(GO:0016918)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.8 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 2.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.9 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 REACTOME INCRETIN SYNTHESIS SECRETION AND INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.1 5.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 3.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 2.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.6 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.6 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 2.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 2.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 1.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 1.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.0 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors