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Illumina Body Map 2, young vs old

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Results for PAX1_PAX9

Z-value: 0.64

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.9 paired box 1
PAX9
ENSG00000198807.8 paired box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX9hg19_v2_chr14_+_37131058_371311390.241.9e-01Click!
PAX1hg19_v2_chr20_+_21686290_21686311-0.163.8e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_20566616 3.86 ENST00000569163.1
ACSM2B
acyl-CoA synthetase medium-chain family member 2B
chr4_+_123747834 3.54 ENST00000264498.3
FGF2
fibroblast growth factor 2 (basic)
chr4_+_123747979 3.30 ENST00000608478.1
FGF2
fibroblast growth factor 2 (basic)
chr2_-_207630033 2.83 ENST00000449792.1
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr2_-_207629997 2.76 ENST00000454776.2
MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr9_+_33750667 2.55 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
PRSS3
protease, serine, 3
chr7_+_36429424 2.48 ENST00000396068.2
ANLN
anillin, actin binding protein
chr7_+_36429409 2.41 ENST00000265748.2
ANLN
anillin, actin binding protein
chr14_+_24540046 2.24 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6
copine VI (neuronal)
chr19_-_409134 2.17 ENST00000332235.6
C2CD4C
C2 calcium-dependent domain containing 4C
chr9_+_33750515 2.12 ENST00000361005.5
PRSS3
protease, serine, 3
chr6_-_137366163 2.11 ENST00000367748.1
IL20RA
interleukin 20 receptor, alpha
chr5_+_55354822 1.78 ENST00000511861.1
CTD-2227I18.1
CTD-2227I18.1
chr9_-_104249400 1.65 ENST00000374848.3
TMEM246
transmembrane protein 246
chr18_-_47813940 1.44 ENST00000586837.1
ENST00000412036.2
ENST00000589940.1
CXXC1
CXXC finger protein 1
chr19_-_18995029 1.42 ENST00000596048.1
CERS1
ceramide synthase 1
chr11_+_61522844 1.31 ENST00000265460.5
MYRF
myelin regulatory factor
chr18_-_47814032 1.30 ENST00000589548.1
ENST00000591474.1
CXXC1
CXXC finger protein 1
chr4_-_171011084 1.29 ENST00000337664.4
AADAT
aminoadipate aminotransferase
chr9_+_33795533 1.27 ENST00000379405.3
PRSS3
protease, serine, 3
chr18_+_39766626 1.25 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
LINC00907
long intergenic non-protein coding RNA 907
chr9_-_124991124 1.22 ENST00000394319.4
ENST00000340587.3
LHX6
LIM homeobox 6
chr3_+_195447738 1.11 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
MUC20
mucin 20, cell surface associated
chr7_-_22234381 1.09 ENST00000458533.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr4_-_171011323 1.08 ENST00000509167.1
ENST00000353187.2
ENST00000507375.1
ENST00000515480.1
AADAT
aminoadipate aminotransferase
chr2_-_175712270 1.06 ENST00000295497.7
ENST00000444394.1
CHN1
chimerin 1
chr17_+_39969183 1.01 ENST00000321562.4
FKBP10
FK506 binding protein 10, 65 kDa
chr2_-_175711978 0.99 ENST00000409089.2
CHN1
chimerin 1
chr8_-_23282820 0.98 ENST00000520871.1
LOXL2
lysyl oxidase-like 2
chr8_-_23282797 0.95 ENST00000524144.1
LOXL2
lysyl oxidase-like 2
chr19_+_14184370 0.88 ENST00000590772.1
hsa-mir-1199
hsa-mir-1199
chr1_-_162838551 0.84 ENST00000367910.1
ENST00000367912.2
ENST00000367911.2
C1orf110
chromosome 1 open reading frame 110
chr4_-_163085141 0.81 ENST00000427802.2
ENST00000306100.5
FSTL5
follistatin-like 5
chr8_-_23261589 0.78 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2
lysyl oxidase-like 2
chr20_-_17641097 0.78 ENST00000246043.4
RRBP1
ribosome binding protein 1
chr11_+_63870660 0.72 ENST00000246841.3
FLRT1
fibronectin leucine rich transmembrane protein 1
chr19_-_5838734 0.69 ENST00000532464.1
ENST00000528505.1
FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr19_-_5838768 0.68 ENST00000527106.1
ENST00000531199.1
ENST00000529165.1
FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr17_+_39968926 0.68 ENST00000585664.1
ENST00000585922.1
ENST00000429461.1
FKBP10
FK506 binding protein 10, 65 kDa
chr17_-_3461092 0.67 ENST00000301365.4
ENST00000572519.1
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr10_-_99393242 0.65 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
MORN4
MORN repeat containing 4
chr10_-_99393208 0.54 ENST00000307450.6
MORN4
MORN repeat containing 4
chr6_+_159291090 0.50 ENST00000367073.4
ENST00000608817.1
C6orf99
chromosome 6 open reading frame 99
chr12_+_57828521 0.50 ENST00000309668.2
INHBC
inhibin, beta C
chr7_-_19157248 0.47 ENST00000242261.5
TWIST1
twist family bHLH transcription factor 1
chr19_+_48337701 0.47 ENST00000535362.1
TPRX2P
tetra-peptide repeat homeobox 2 pseudogene
chrX_-_132091284 0.46 ENST00000370833.2
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr3_-_57113281 0.46 ENST00000468466.1
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr11_+_6947720 0.45 ENST00000414517.2
ZNF215
zinc finger protein 215
chr17_+_15848231 0.44 ENST00000304222.2
ADORA2B
adenosine A2b receptor
chr1_-_204165610 0.38 ENST00000367194.4
KISS1
KiSS-1 metastasis-suppressor
chr11_-_67397371 0.34 ENST00000376693.2
ENST00000301490.4
NUDT8
nudix (nucleoside diphosphate linked moiety X)-type motif 8
chr9_+_96793076 0.33 ENST00000375360.3
PTPDC1
protein tyrosine phosphatase domain containing 1
chrX_-_153707545 0.32 ENST00000357360.4
LAGE3
L antigen family, member 3
chr6_+_3118926 0.29 ENST00000380379.5
BPHL
biphenyl hydrolase-like (serine hydrolase)
chr2_-_39414848 0.29 ENST00000451199.1
CDKL4
cyclin-dependent kinase-like 4
chr9_-_21142144 0.27 ENST00000380229.2
IFNW1
interferon, omega 1
chr12_+_58138800 0.24 ENST00000547992.1
ENST00000552816.1
ENST00000547472.1
TSPAN31
tetraspanin 31
chr22_+_39745930 0.22 ENST00000318801.4
ENST00000216155.7
ENST00000406293.3
ENST00000328933.5
SYNGR1
synaptogyrin 1
chr9_+_6716478 0.21 ENST00000452643.1
RP11-390F4.3
RP11-390F4.3
chr12_-_122658746 0.20 ENST00000377035.1
IL31
interleukin 31
chr14_+_64854958 0.19 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr6_+_34857019 0.19 ENST00000360359.3
ENST00000535627.1
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr17_-_39968406 0.17 ENST00000393928.1
LEPREL4
leprecan-like 4
chr6_+_159290917 0.14 ENST00000367072.1
C6orf99
chromosome 6 open reading frame 99
chr2_+_234160340 0.14 ENST00000417017.1
ENST00000392020.4
ENST00000392018.1
ATG16L1
autophagy related 16-like 1 (S. cerevisiae)
chr14_+_39703112 0.13 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr6_+_132891461 0.11 ENST00000275198.1
TAAR6
trace amine associated receptor 6
chr4_+_75230853 0.09 ENST00000244869.2
EREG
epiregulin
chr16_-_84076241 0.08 ENST00000568178.1
SLC38A8
solute carrier family 38, member 8
chr2_+_234160217 0.08 ENST00000392017.4
ENST00000347464.5
ENST00000444735.1
ENST00000373525.5
ENST00000419681.1
ATG16L1
autophagy related 16-like 1 (S. cerevisiae)
chr5_+_133842243 0.07 ENST00000515627.2
AC005355.2
AC005355.2
chr13_+_21141270 0.06 ENST00000319980.6
ENST00000537103.1
ENST00000389373.3
IFT88
intraflagellar transport 88 homolog (Chlamydomonas)
chr13_+_98086445 0.05 ENST00000245304.4
RAP2A
RAP2A, member of RAS oncogene family
chr12_-_101801505 0.01 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
ARL1
ADP-ribosylation factor-like 1
chr1_+_213031570 0.00 ENST00000366971.4
FLVCR1
feline leukemia virus subgroup C cellular receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0042660 positive regulation of cell fate specification(GO:0042660)
1.6 4.9 GO:0000921 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.7 2.7 GO:0018277 protein deamination(GO:0018277)
0.5 1.4 GO:0072720 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.4 1.7 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.4 2.4 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512) L-kynurenine metabolic process(GO:0097052)
0.3 5.6 GO:0006108 malate metabolic process(GO:0006108)
0.2 5.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.2 0.5 GO:2000276 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.1 0.4 GO:0002880 chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
0.1 1.3 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 1.4 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 1.2 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.4 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.1 0.7 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.0 2.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 2.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.2 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0 2.1 GO:0045124 regulation of bone resorption(GO:0045124)
0.0 2.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.0 2.7 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 1.1 GO:0048012 hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.0 3.9 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.2 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.3 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.9 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 2.7 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 5.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.1 GO:0031528 microvillus membrane(GO:0031528)
0.0 2.0 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 2.7 GO:0005604 basement membrane(GO:0005604)
0.0 0.7 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0047536 2-aminoadipate transaminase activity(GO:0047536)
0.7 2.7 GO:0045322 unmethylated CpG binding(GO:0045322)
0.6 5.6 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.4 2.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.3 2.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.3 3.9 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.2 1.4 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.2 7.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.5 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 1.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.2 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 1.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 1.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 2.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 1.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 2.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 5.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.8 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 7.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.8 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 2.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.5 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 3.9 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 2.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors