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Illumina Body Map 2, young vs old

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Results for PBX2

Z-value: 0.10

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
PBX2
ENSG00000204304.7 PBX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX2hg19_v2_chr6_-_32157947_32157992-0.125.1e-01Click!

Activity profile of PBX2 motif

Sorted Z-values of PBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_52864680 2.88 ENST00000406595.1
ENST00000485816.1
ENST00000434759.3
ENST00000346281.5
ENST00000266041.4
ITIH4
inter-alpha-trypsin inhibitor heavy chain family, member 4
chr4_-_100065419 2.47 ENST00000504125.1
ENST00000505590.1
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr8_-_6420930 2.43 ENST00000325203.5
ANGPT2
angiopoietin 2
chr10_-_45474237 1.88 ENST00000448778.1
ENST00000298295.3
C10orf10
chromosome 10 open reading frame 10
chr2_+_234601512 1.87 ENST00000305139.6
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_234602305 1.78 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr4_-_100065389 1.72 ENST00000512499.1
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr12_+_57390745 1.48 ENST00000600202.1
HBCBP
HBcAg-binding protein; Uncharacterized protein
chr4_-_100065440 1.43 ENST00000508393.1
ENST00000265512.7
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide
chr2_+_204732487 1.37 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr5_+_54320078 1.36 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr11_-_2162162 1.34 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr9_-_128246769 1.31 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr5_-_39462390 1.29 ENST00000511792.1
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr17_+_7758374 1.19 ENST00000301599.6
ENST00000574668.1
TMEM88
transmembrane protein 88
chr2_+_204732666 1.13 ENST00000295854.6
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr2_-_190044480 1.10 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr1_+_56880606 1.01 ENST00000451914.1
RP4-710M16.2
RP4-710M16.2
chr2_-_179659669 0.93 ENST00000436599.1
TTN
titin
chr7_+_134528635 0.82 ENST00000445569.2
CALD1
caldesmon 1
chr11_+_69455855 0.76 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr3_+_188889737 0.74 ENST00000345063.3
TPRG1
tumor protein p63 regulated 1
chr14_+_38033252 0.68 ENST00000554829.1
RP11-356O9.1
RP11-356O9.1
chr14_-_23624511 0.61 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr14_+_64854958 0.58 ENST00000555709.2
ENST00000554739.1
ENST00000554768.1
ENST00000216605.8
MTHFD1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
chr1_+_101702417 0.58 ENST00000305352.6
S1PR1
sphingosine-1-phosphate receptor 1
chr2_+_234104079 0.57 ENST00000417661.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr2_+_27255806 0.56 ENST00000238788.9
ENST00000404032.3
TMEM214
transmembrane protein 214
chr4_+_37962018 0.54 ENST00000504686.1
PTTG2
pituitary tumor-transforming 2
chrX_+_119737806 0.50 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr14_-_54317532 0.50 ENST00000418927.1
AL162759.1
AL162759.1
chr11_+_68228186 0.49 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
PPP6R3
protein phosphatase 6, regulatory subunit 3
chr2_+_20646824 0.46 ENST00000272233.4
RHOB
ras homolog family member B
chr10_+_69869237 0.45 ENST00000373675.3
MYPN
myopalladin
chr16_+_1832902 0.42 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2
nucleotide binding protein 2
chr11_-_104769141 0.41 ENST00000508062.1
ENST00000422698.2
CASP12
caspase 12 (gene/pseudogene)
chr3_-_129158676 0.40 ENST00000393278.2
MBD4
methyl-CpG binding domain protein 4
chrM_+_12331 0.38 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr22_-_30642728 0.37 ENST00000403987.3
LIF
leukemia inhibitory factor
chrX_+_46696372 0.34 ENST00000218340.3
RP2
retinitis pigmentosa 2 (X-linked recessive)
chr20_+_238357 0.30 ENST00000382376.3
DEFB132
defensin, beta 132
chr18_-_72920372 0.29 ENST00000581620.1
ENST00000582437.1
ZADH2
zinc binding alcohol dehydrogenase domain containing 2
chr3_-_129158850 0.28 ENST00000503197.1
ENST00000249910.1
ENST00000429544.2
ENST00000507208.1
MBD4
methyl-CpG binding domain protein 4
chr1_-_39339777 0.26 ENST00000397572.2
MYCBP
MYC binding protein
chr15_+_67418047 0.25 ENST00000540846.2
SMAD3
SMAD family member 3
chrX_+_56590002 0.25 ENST00000338222.5
UBQLN2
ubiquilin 2
chr7_-_33140498 0.25 ENST00000448915.1
RP9
retinitis pigmentosa 9 (autosomal dominant)
chr11_+_62432777 0.24 ENST00000532971.1
METTL12
methyltransferase like 12
chr4_+_71017791 0.22 ENST00000502294.1
C4orf40
chromosome 4 open reading frame 40
chr1_+_62417957 0.21 ENST00000307297.7
ENST00000543708.1
INADL
InaD-like (Drosophila)
chr4_+_71019903 0.21 ENST00000344526.5
C4orf40
chromosome 4 open reading frame 40
chr6_+_53976211 0.21 ENST00000503951.1
MLIP
muscular LMNA-interacting protein
chr2_-_31440377 0.19 ENST00000444918.2
ENST00000403897.3
CAPN14
calpain 14
chr2_+_12857015 0.18 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr9_+_107456660 0.16 ENST00000318763.5
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr9_-_5084580 0.15 ENST00000601793.1
AL161450.1
Uncharacterized protein
chr1_+_207038699 0.15 ENST00000367098.1
IL20
interleukin 20
chr6_+_160211481 0.13 ENST00000367034.4
MRPL18
mitochondrial ribosomal protein L18
chr12_+_53835539 0.12 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
PRR13
proline rich 13
chr13_+_108921977 0.11 ENST00000430559.1
ENST00000375887.4
TNFSF13B
tumor necrosis factor (ligand) superfamily, member 13b
chr2_+_12857043 0.11 ENST00000381465.2
TRIB2
tribbles pseudokinase 2
chr11_-_62432641 0.11 ENST00000528405.1
ENST00000524958.1
ENST00000525675.1
RP11-831H9.11
C11orf48
Uncharacterized protein
chromosome 11 open reading frame 48
chr7_-_32529973 0.10 ENST00000410044.1
ENST00000409987.1
ENST00000409782.1
ENST00000450169.2
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr12_+_53835508 0.10 ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
ENST00000541275.1
PRR13
PCBP2
proline rich 13
poly(rC) binding protein 2
chr17_-_29151794 0.08 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr8_+_110098850 0.06 ENST00000518632.1
TRHR
thyrotropin-releasing hormone receptor
chr22_+_42017987 0.05 ENST00000405506.1
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr13_-_107220455 0.05 ENST00000400198.3
ARGLU1
arginine and glutamate rich 1
chr11_-_111794446 0.05 ENST00000527950.1
CRYAB
crystallin, alpha B
chr12_+_53835425 0.05 ENST00000549924.1
PRR13
proline rich 13
chr2_+_33661382 0.05 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_-_115323245 0.04 ENST00000060969.5
ENST00000369528.5
SIKE1
suppressor of IKBKE 1
chr9_+_125273081 0.03 ENST00000335302.5
OR1J2
olfactory receptor, family 1, subfamily J, member 2
chr16_-_11492366 0.01 ENST00000595360.1
CTD-3088G3.8
Protein LOC388210

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.5 2.5 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.4 1.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 3.6 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.3 5.6 GO:0006069 ethanol oxidation(GO:0006069)
0.2 1.3 GO:0035026 leading edge cell differentiation(GO:0035026)
0.2 0.6 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.2 1.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.2 0.5 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.9 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 1.3 GO:2000467 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.1 0.6 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.6 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1 0.3 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
0.1 0.4 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 0.2 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.8 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 2.9 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.7 GO:0045008 depyrimidination(GO:0045008)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.5 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:0002636 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
0.0 0.4 GO:0097264 self proteolysis(GO:0097264)
0.0 0.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.6 GO:0015695 organic cation transport(GO:0015695)
0.0 0.1 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.5 GO:0061154 endothelial tube morphogenesis(GO:0061154)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0005588 collagen type V trimer(GO:0005588)
0.2 2.9 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 1.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.3 GO:1990075 periciliary membrane compartment(GO:1990075)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.0 1.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.4 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.0 2.5 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.2 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.9 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.6 GO:0019115 benzaldehyde dehydrogenase activity(GO:0019115)
0.2 0.6 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.1 0.7 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.1 0.4 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 3.6 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.9 GO:0031433 telethonin binding(GO:0031433)
0.0 0.1 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.0 0.6 GO:0019534 toxin transporter activity(GO:0019534)
0.0 1.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.3 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 1.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 1.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.8 GO:0005523 tropomyosin binding(GO:0005523)
0.0 2.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.4 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.3 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.6 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.6 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 3.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.3 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.1 2.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 1.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.5 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.8 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions