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Illumina Body Map 2, young vs old

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Results for PITX2

Z-value: 0.21

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.11 paired like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111544207_1115442400.125.1e-01Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_34458771 1.55 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr10_-_49482907 1.31 ENST00000374201.3
ENST00000407470.4
FRMPD2
FERM and PDZ domain containing 2
chr15_+_54901540 1.26 ENST00000539562.2
UNC13C
unc-13 homolog C (C. elegans)
chr9_+_34458851 1.04 ENST00000545019.1
DNAI1
dynein, axonemal, intermediate chain 1
chr11_+_61522844 0.94 ENST00000265460.5
MYRF
myelin regulatory factor
chr10_+_18240834 0.89 ENST00000377371.3
ENST00000539911.1
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr10_+_18240814 0.88 ENST00000377374.4
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr9_-_8857776 0.87 ENST00000481079.1
PTPRD
protein tyrosine phosphatase, receptor type, D
chr10_+_18240753 0.86 ENST00000377369.2
SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr9_+_12693336 0.85 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr4_-_36245561 0.73 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr11_-_36619771 0.68 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chr13_-_36429763 0.66 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr7_-_122339162 0.66 ENST00000340112.2
RNF133
ring finger protein 133
chr15_-_89764929 0.62 ENST00000268125.5
RLBP1
retinaldehyde binding protein 1
chr16_-_5116025 0.58 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
C16orf89
chromosome 16 open reading frame 89
chr16_-_68014732 0.56 ENST00000268793.4
DPEP3
dipeptidase 3
chr18_-_3880051 0.55 ENST00000584874.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr1_+_92417716 0.51 ENST00000402388.1
BRDT
bromodomain, testis-specific
chr3_+_119421849 0.49 ENST00000273390.5
ENST00000463700.1
MAATS1
MYCBP-associated, testis expressed 1
chr19_-_51893827 0.49 ENST00000574814.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr19_-_51893782 0.47 ENST00000570516.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr20_+_44350968 0.46 ENST00000279058.3
SPINT4
serine peptidase inhibitor, Kunitz type 4
chr12_-_90049828 0.46 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_+_205538165 0.46 ENST00000536357.1
MFSD4
major facilitator superfamily domain containing 4
chr1_+_2407754 0.44 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2
phospholipase C, eta 2
chr12_-_90049878 0.43 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr6_+_43215727 0.43 ENST00000304139.5
TTBK1
tau tubulin kinase 1
chr6_+_46661575 0.38 ENST00000450697.1
TDRD6
tudor domain containing 6
chr13_-_95131923 0.36 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr11_-_5248294 0.36 ENST00000335295.4
HBB
hemoglobin, beta
chr17_+_4643337 0.32 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr3_-_49837254 0.31 ENST00000412678.2
ENST00000343366.4
ENST00000487256.1
CDHR4
cadherin-related family member 4
chr8_-_42360015 0.31 ENST00000522707.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr1_-_165414414 0.31 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr5_-_64920115 0.30 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr3_+_158787041 0.29 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr8_-_10512569 0.26 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr17_+_4643300 0.26 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr17_+_79495397 0.25 ENST00000417245.2
ENST00000334850.7
FSCN2
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr17_-_40021656 0.25 ENST00000319121.3
KLHL11
kelch-like family member 11
chr3_-_69249863 0.23 ENST00000478263.1
ENST00000462512.1
FRMD4B
FERM domain containing 4B
chr10_-_61900762 0.21 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_4643161 0.21 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chr16_+_58010339 0.20 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr1_-_98515395 0.17 ENST00000424528.2
MIR137HG
MIR137 host gene (non-protein coding)
chr4_-_68620053 0.17 ENST00000420975.2
ENST00000226413.4
GNRHR
gonadotropin-releasing hormone receptor
chr12_+_40787194 0.16 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr5_-_92023923 0.16 ENST00000503489.1
CTC-529L17.2
CTC-529L17.2
chr19_+_2476116 0.15 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr2_+_120770581 0.15 ENST00000263713.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr2_+_120770645 0.14 ENST00000443902.2
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr9_-_98268883 0.13 ENST00000551630.1
ENST00000548420.1
PTCH1
patched 1
chr5_+_64920543 0.13 ENST00000399438.3
ENST00000510585.2
TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr19_-_46142362 0.11 ENST00000586770.1
ENST00000591721.1
EML2
echinoderm microtubule associated protein like 2
chr1_+_22328144 0.10 ENST00000290122.3
ENST00000374663.1
CELA3A
chymotrypsin-like elastase family, member 3A
chr1_+_180875711 0.10 ENST00000434447.1
RP11-46A10.2
RP11-46A10.2
chr7_+_73868220 0.09 ENST00000455841.2
GTF2IRD1
GTF2I repeat domain containing 1
chrX_-_48931648 0.08 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr10_+_103986085 0.08 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr7_+_73868439 0.08 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chrX_-_21676442 0.08 ENST00000379499.2
KLHL34
kelch-like family member 34
chr21_-_19775973 0.08 ENST00000284885.3
TMPRSS15
transmembrane protease, serine 15
chr8_+_123875624 0.07 ENST00000534247.1
ZHX2
zinc fingers and homeoboxes 2
chr9_-_127358087 0.06 ENST00000475178.1
NR6A1
nuclear receptor subfamily 6, group A, member 1
chrX_-_6146876 0.06 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr2_+_120770686 0.05 ENST00000331393.4
ENST00000443124.1
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr16_+_28722684 0.05 ENST00000331666.6
ENST00000395587.1
ENST00000569690.1
ENST00000564243.1
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr8_-_27462822 0.05 ENST00000522098.1
CLU
clusterin
chr3_+_158787098 0.04 ENST00000397832.2
ENST00000451172.1
ENST00000482126.1
IQCJ
IQ motif containing J
chr16_-_12070468 0.03 ENST00000538896.1
RP11-166B2.1
Putative NPIP-like protein LOC729978
chr3_+_139062838 0.03 ENST00000310776.4
ENST00000465056.1
ENST00000465373.1
MRPS22
mitochondrial ribosomal protein S22
chr2_-_121223697 0.02 ENST00000593290.1
FLJ14816
long intergenic non-protein coding RNA 1101
chr4_+_70916119 0.01 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr1_+_22303503 0.00 ENST00000337107.6
CELA3B
chymotrypsin-like elastase family, member 3B
chr4_-_76912070 0.00 ENST00000395711.4
ENST00000356260.5
SDAD1
SDA1 domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.2 0.5 GO:0051039 histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.1 1.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 2.6 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.7 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.1 0.9 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 2.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.9 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.1 0.4 GO:0030185 nitric oxide transport(GO:0030185)
0.1 1.0 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.3 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.4 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.2 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.5 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.1 GO:0010157 response to chlorate(GO:0010157)
0.0 0.2 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.7 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 1.3 GO:0070830 bicellular tight junction assembly(GO:0070830)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 GO:0036157 outer dynein arm(GO:0036157)
0.2 0.5 GO:0001534 radial spoke(GO:0001534)
0.1 1.3 GO:0044305 calyx of Held(GO:0044305)
0.1 0.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.2 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.4 GO:0033391 chromatoid body(GO:0033391)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 2.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.6 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 0.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.4 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 0.4 GO:0030492 hemoglobin binding(GO:0030492)
0.1 0.2 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.1 2.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 1.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.9 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0005119 smoothened binding(GO:0005119)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors