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Illumina Body Map 2, young vs old

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Results for PKNOX1_TGIF2

Z-value: 0.26

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Transcription factors associated with PKNOX1_TGIF2

Gene Symbol Gene ID Gene Info
PKNOX1
ENSG00000160199.10 PBX/knotted 1 homeobox 1
TGIF2
ENSG00000118707.5 TGFB induced factor homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TGIF2hg19_v2_chr20_+_35202909_352030750.451.0e-02Click!
PKNOX1hg19_v2_chr21_+_44394620_443947370.029.1e-01Click!

Activity profile of PKNOX1_TGIF2 motif

Sorted Z-values of PKNOX1_TGIF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_33447584 4.29 ENST00000297991.4
AQP3
aquaporin 3 (Gill blood group)
chr1_+_207262540 3.61 ENST00000452902.2
C4BPB
complement component 4 binding protein, beta
chr21_-_34185944 3.11 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr1_+_207262578 3.05 ENST00000243611.5
ENST00000367076.3
C4BPB
complement component 4 binding protein, beta
chr1_+_207262170 2.99 ENST00000367078.3
C4BPB
complement component 4 binding protein, beta
chr1_+_207262627 2.97 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr21_-_34186006 2.64 ENST00000490358.1
C21orf62
chromosome 21 open reading frame 62
chr21_-_34185989 2.40 ENST00000487113.1
ENST00000382373.4
C21orf62
chromosome 21 open reading frame 62
chr3_+_186692745 2.29 ENST00000438590.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chrX_+_135730297 2.18 ENST00000370629.2
CD40LG
CD40 ligand
chr4_-_175443484 2.18 ENST00000514584.1
ENST00000542498.1
ENST00000296521.7
ENST00000422112.2
ENST00000504433.1
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr4_-_175443943 2.17 ENST00000296522.6
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr3_+_52828805 1.98 ENST00000416872.2
ENST00000449956.2
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr14_-_94857004 1.93 ENST00000557492.1
ENST00000448921.1
ENST00000437397.1
ENST00000355814.4
ENST00000393088.4
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_94856987 1.90 ENST00000449399.3
ENST00000404814.4
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_94856951 1.90 ENST00000553327.1
ENST00000556955.1
ENST00000557118.1
ENST00000440909.1
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr3_+_111260954 1.87 ENST00000283285.5
CD96
CD96 molecule
chrX_+_135730373 1.83 ENST00000370628.2
CD40LG
CD40 ligand
chr2_+_113885138 1.81 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr3_+_111260856 1.77 ENST00000352690.4
CD96
CD96 molecule
chr4_-_175443788 1.76 ENST00000541923.1
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr15_+_96904487 1.69 ENST00000600790.1
AC087477.1
Uncharacterized protein
chr22_+_35776354 1.64 ENST00000412893.1
HMOX1
heme oxygenase (decycling) 1
chr12_+_103981044 1.63 ENST00000388887.2
STAB2
stabilin 2
chr3_-_27763803 1.61 ENST00000449599.1
EOMES
eomesodermin
chr3_+_111260980 1.61 ENST00000438817.2
CD96
CD96 molecule
chr7_+_142448053 1.61 ENST00000422143.2
TRBV29-1
T cell receptor beta variable 29-1
chr8_-_17752912 1.58 ENST00000398054.1
ENST00000381840.2
FGL1
fibrinogen-like 1
chr7_+_29234028 1.57 ENST00000222792.6
CHN2
chimerin 2
chr1_-_54872059 1.51 ENST00000371320.3
SSBP3
single stranded DNA binding protein 3
chr10_-_73848531 1.48 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr7_+_29234101 1.45 ENST00000435288.2
CHN2
chimerin 2
chr11_+_6411670 1.45 ENST00000530395.1
ENST00000527275.1
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr11_-_67415048 1.43 ENST00000529256.1
ACY3
aspartoacylase (aminocyclase) 3
chr7_+_29234375 1.43 ENST00000409350.1
ENST00000495789.2
ENST00000539389.1
CHN2
chimerin 2
chr11_+_6411636 1.40 ENST00000299397.3
ENST00000356761.2
ENST00000342245.4
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr2_+_234959323 1.40 ENST00000373368.1
ENST00000168148.3
SPP2
secreted phosphoprotein 2, 24kDa
chrX_-_39923656 1.39 ENST00000413905.1
BCOR
BCL6 corepressor
chr2_-_190446738 1.35 ENST00000427419.1
ENST00000455320.1
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr2_+_113321939 1.35 ENST00000458012.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr10_-_73848764 1.34 ENST00000317376.4
ENST00000412663.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr4_+_74347400 1.33 ENST00000226355.3
AFM
afamin
chr2_+_234668894 1.32 ENST00000305208.5
ENST00000608383.1
ENST00000360418.3
UGT1A8
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr3_-_27764190 1.27 ENST00000537516.1
EOMES
eomesodermin
chr6_+_31887761 1.25 ENST00000413154.1
C2
complement component 2
chr16_-_30457048 1.23 ENST00000500504.2
ENST00000542752.1
SEPHS2
selenophosphate synthetase 2
chr7_-_148580563 1.22 ENST00000476773.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr17_-_29151686 1.20 ENST00000544695.1
CRLF3
cytokine receptor-like factor 3
chr13_-_46716969 1.18 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_-_64225508 1.17 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr8_+_11666649 1.16 ENST00000528643.1
ENST00000525777.1
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr18_-_67624412 1.16 ENST00000580335.1
CD226
CD226 molecule
chr15_+_94406289 1.14 ENST00000554530.1
RP11-76E17.3
RP11-76E17.3
chr2_+_234959376 1.13 ENST00000425558.1
SPP2
secreted phosphoprotein 2, 24kDa
chr4_+_8183793 1.11 ENST00000509119.1
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr9_-_115653176 1.09 ENST00000374228.4
SLC46A2
solute carrier family 46, member 2
chr1_-_203151933 1.07 ENST00000404436.2
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr17_-_29151794 1.06 ENST00000324238.6
CRLF3
cytokine receptor-like factor 3
chr5_-_169725231 1.06 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr16_+_27413483 1.04 ENST00000337929.3
ENST00000564089.1
IL21R
interleukin 21 receptor
chr6_+_31674639 1.04 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F
MEGT1
lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr19_+_7733929 1.02 ENST00000221515.2
RETN
resistin
chr14_+_22958441 1.02 ENST00000390488.1
TRAJ49
T cell receptor alpha joining 49
chr6_+_26124373 1.01 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr6_+_138188551 1.00 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr18_+_54318566 0.99 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr13_+_24844857 0.99 ENST00000409126.1
ENST00000343003.6
SPATA13
spermatogenesis associated 13
chr12_+_62654155 0.98 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15
ubiquitin specific peptidase 15
chr14_+_103566481 0.98 ENST00000380069.3
EXOC3L4
exocyst complex component 3-like 4
chr1_+_154966058 0.97 ENST00000392487.1
LENEP
lens epithelial protein
chr6_+_50061315 0.94 ENST00000415106.1
RP11-397G17.1
RP11-397G17.1
chr6_-_24911195 0.93 ENST00000259698.4
FAM65B
family with sequence similarity 65, member B
chr14_-_23762777 0.92 ENST00000431326.2
HOMEZ
homeobox and leucine zipper encoding
chr16_-_79634595 0.91 ENST00000326043.4
ENST00000393350.1
MAF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr19_+_36393422 0.91 ENST00000437550.2
HCST
hematopoietic cell signal transducer
chr16_+_50776021 0.91 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD
cylindromatosis (turban tumor syndrome)
chr14_+_22265444 0.91 ENST00000390430.2
TRAV8-1
T cell receptor alpha variable 8-1
chr13_-_39564993 0.90 ENST00000423210.1
STOML3
stomatin (EPB72)-like 3
chr9_-_111696340 0.90 ENST00000374647.5
IKBKAP
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
chr17_-_72358001 0.88 ENST00000375366.3
BTBD17
BTB (POZ) domain containing 17
chr2_-_8464760 0.86 ENST00000430192.1
LINC00299
long intergenic non-protein coding RNA 299
chr18_+_3450161 0.85 ENST00000551402.1
ENST00000577543.1
TGIF1
TGFB-induced factor homeobox 1
chr19_+_36393367 0.81 ENST00000246551.4
HCST
hematopoietic cell signal transducer
chr4_+_146539415 0.81 ENST00000281317.5
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr8_+_28174649 0.81 ENST00000301908.3
PNOC
prepronociceptin
chr15_-_41805994 0.80 ENST00000561619.1
ENST00000263800.6
ENST00000355166.5
ENST00000453182.2
LTK
leukocyte receptor tyrosine kinase
chr18_+_3449695 0.80 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr14_-_94759408 0.80 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_-_145715565 0.80 ENST00000369288.2
ENST00000369290.1
ENST00000401557.3
CD160
CD160 molecule
chr3_-_190167571 0.80 ENST00000354905.2
TMEM207
transmembrane protein 207
chr5_+_95187934 0.78 ENST00000357880.3
ENST00000436592.1
C5orf27
chromosome 5 open reading frame 27
chr22_-_37640277 0.78 ENST00000401529.3
ENST00000249071.6
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr15_-_61521495 0.78 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr19_-_54604083 0.78 ENST00000391761.1
ENST00000356532.3
ENST00000359649.4
ENST00000358375.4
ENST00000391760.1
ENST00000351806.4
OSCAR
osteoclast associated, immunoglobulin-like receptor
chr18_+_3449821 0.77 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1
chr6_-_32140886 0.76 ENST00000395496.1
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr14_-_94759361 0.76 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr18_+_54318893 0.75 ENST00000593058.1
WDR7
WD repeat domain 7
chr16_+_2588012 0.73 ENST00000354836.5
ENST00000389224.3
PDPK1
3-phosphoinositide dependent protein kinase-1
chr11_-_71810258 0.73 ENST00000544594.1
LAMTOR1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr2_-_225811747 0.73 ENST00000409592.3
DOCK10
dedicator of cytokinesis 10
chr9_-_132805430 0.71 ENST00000446176.2
ENST00000355681.3
ENST00000420781.1
FNBP1
formin binding protein 1
chr14_+_103566665 0.71 ENST00000559116.1
EXOC3L4
exocyst complex component 3-like 4
chr2_-_74780176 0.71 ENST00000409549.1
LOXL3
lysyl oxidase-like 3
chr8_+_28174496 0.70 ENST00000518479.1
PNOC
prepronociceptin
chr2_-_18770802 0.69 ENST00000416783.1
NT5C1B
5'-nucleotidase, cytosolic IB
chr18_+_54318616 0.69 ENST00000254442.3
WDR7
WD repeat domain 7
chr12_+_69201923 0.69 ENST00000462284.1
ENST00000258149.5
ENST00000356290.4
ENST00000540827.1
ENST00000428863.2
ENST00000393412.3
MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
chr22_-_37640456 0.68 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr7_+_76139741 0.68 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
UPK3B
uroplakin 3B
chr3_-_111852061 0.68 ENST00000488580.1
ENST00000460387.2
ENST00000484193.1
ENST00000487901.1
GCSAM
germinal center-associated, signaling and motility
chr1_+_28844648 0.66 ENST00000373832.1
ENST00000373831.3
RCC1
regulator of chromosome condensation 1
chr7_+_70229899 0.66 ENST00000443672.1
AUTS2
autism susceptibility candidate 2
chr16_-_69418553 0.66 ENST00000569542.2
TERF2
telomeric repeat binding factor 2
chr21_+_30503282 0.66 ENST00000399925.1
MAP3K7CL
MAP3K7 C-terminal like
chr11_+_193065 0.65 ENST00000342878.2
SCGB1C1
secretoglobin, family 1C, member 1
chr9_-_123639445 0.65 ENST00000312189.6
PHF19
PHD finger protein 19
chr12_-_91398796 0.64 ENST00000261172.3
ENST00000551767.1
EPYC
epiphycan
chr21_+_30502806 0.63 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr8_+_38244638 0.63 ENST00000526356.1
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr7_+_100187196 0.63 ENST00000468962.1
ENST00000427939.2
FBXO24
F-box protein 24
chr5_-_65018834 0.63 ENST00000506816.1
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr16_+_2587998 0.63 ENST00000441549.3
ENST00000268673.7
PDPK1
3-phosphoinositide dependent protein kinase-1
chr16_-_50715239 0.63 ENST00000330943.4
ENST00000300590.3
SNX20
sorting nexin 20
chr3_-_142166796 0.62 ENST00000392981.2
XRN1
5'-3' exoribonuclease 1
chr12_-_121734489 0.62 ENST00000412367.2
ENST00000402834.4
ENST00000404169.3
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr7_+_76139833 0.62 ENST00000257632.5
UPK3B
uroplakin 3B
chr7_+_99971129 0.62 ENST00000394000.2
ENST00000350573.2
PILRA
paired immunoglobin-like type 2 receptor alpha
chr16_+_2587965 0.61 ENST00000342085.4
ENST00000566659.1
PDPK1
3-phosphoinositide dependent protein kinase-1
chr10_+_51565188 0.61 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
NCOA4
nuclear receptor coactivator 4
chr4_-_38807199 0.61 ENST00000508364.1
TLR1
toll-like receptor 1
chr14_+_22471345 0.61 ENST00000390446.3
TRAV18
T cell receptor alpha variable 18
chr11_-_1782625 0.60 ENST00000438213.1
CTSD
cathepsin D
chr3_-_111852128 0.59 ENST00000308910.4
GCSAM
germinal center-associated, signaling and motility
chr7_+_99971068 0.58 ENST00000198536.2
ENST00000453419.1
PILRA
paired immunoglobin-like type 2 receptor alpha
chr2_-_192015697 0.58 ENST00000409995.1
STAT4
signal transducer and activator of transcription 4
chr3_+_52719936 0.58 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr19_-_48547294 0.57 ENST00000293255.2
CABP5
calcium binding protein 5
chr15_+_68346501 0.57 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr10_+_94608245 0.57 ENST00000443748.2
ENST00000260762.6
EXOC6
exocyst complex component 6
chr16_-_69418649 0.56 ENST00000566257.1
TERF2
telomeric repeat binding factor 2
chr8_+_31496809 0.56 ENST00000518104.1
ENST00000519301.1
NRG1
neuregulin 1
chr3_-_142166904 0.55 ENST00000264951.4
XRN1
5'-3' exoribonuclease 1
chr7_-_104909435 0.55 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr14_-_50474238 0.55 ENST00000399206.1
C14orf182
chromosome 14 open reading frame 182
chr1_-_32384693 0.55 ENST00000602683.1
ENST00000470404.1
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr22_-_50219548 0.54 ENST00000404034.1
BRD1
bromodomain containing 1
chr8_-_8318847 0.54 ENST00000521218.1
CTA-398F10.2
CTA-398F10.2
chr6_+_31865552 0.53 ENST00000469372.1
ENST00000497706.1
C2
complement component 2
chr16_-_50715196 0.53 ENST00000423026.2
SNX20
sorting nexin 20
chr2_-_18770812 0.53 ENST00000359846.2
ENST00000304081.4
ENST00000600945.1
ENST00000532967.1
ENST00000444297.2
NT5C1B
NT5C1B-RDH14
5'-nucleotidase, cytosolic IB
NT5C1B-RDH14 readthrough
chr17_-_40337470 0.52 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr6_-_132967142 0.51 ENST00000275216.1
TAAR1
trace amine associated receptor 1
chr9_+_127023704 0.51 ENST00000373596.1
ENST00000425237.1
NEK6
NIMA-related kinase 6
chr9_-_123605177 0.51 ENST00000373904.5
ENST00000210313.3
PSMD5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
chr16_-_31076332 0.50 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr7_+_1272522 0.50 ENST00000316333.8
UNCX
UNC homeobox
chrX_-_148713440 0.50 ENST00000536359.1
ENST00000316916.8
TMEM185A
transmembrane protein 185A
chr2_-_74779744 0.49 ENST00000409249.1
LOXL3
lysyl oxidase-like 3
chr2_-_3504587 0.48 ENST00000415131.1
ADI1
acireductone dioxygenase 1
chr2_-_61765732 0.48 ENST00000443240.1
ENST00000436018.1
XPO1
exportin 1 (CRM1 homolog, yeast)
chr22_-_50946113 0.48 ENST00000216080.5
ENST00000474879.2
ENST00000380796.3
LMF2
lipase maturation factor 2
chr1_+_41448820 0.48 ENST00000372616.1
CTPS1
CTP synthase 1
chr4_+_3076388 0.47 ENST00000355072.5
HTT
huntingtin
chr2_+_85804614 0.47 ENST00000263864.5
ENST00000409760.1
VAMP8
vesicle-associated membrane protein 8
chr12_+_57522692 0.47 ENST00000554174.1
LRP1
low density lipoprotein receptor-related protein 1
chr3_-_52719912 0.47 ENST00000420148.1
PBRM1
polybromo 1
chr1_+_22778337 0.47 ENST00000404138.1
ENST00000400239.2
ENST00000375647.4
ENST00000374651.4
ZBTB40
zinc finger and BTB domain containing 40
chr12_-_133186983 0.47 ENST00000544018.2
LRCOL1
leucine rich colipase-like 1
chr6_+_112375462 0.47 ENST00000361714.1
WISP3
WNT1 inducible signaling pathway protein 3
chr16_-_30569584 0.47 ENST00000252797.2
ENST00000568114.1
ZNF764
AC002310.13
zinc finger protein 764
Uncharacterized protein
chr13_+_33160553 0.47 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr2_+_66918558 0.46 ENST00000435389.1
ENST00000428590.1
ENST00000412944.1
AC007392.3
AC007392.3
chr6_-_101329191 0.46 ENST00000324723.6
ENST00000369162.2
ENST00000522650.1
ASCC3
activating signal cointegrator 1 complex subunit 3
chr10_-_11574274 0.45 ENST00000277575.5
USP6NL
USP6 N-terminal like
chr14_-_106573756 0.45 ENST00000390601.2
IGHV3-11
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr9_-_99180597 0.45 ENST00000375256.4
ZNF367
zinc finger protein 367
chr20_+_54987168 0.45 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr3_-_52719810 0.44 ENST00000424867.1
ENST00000394830.3
ENST00000431678.1
ENST00000450271.1
PBRM1
polybromo 1
chr1_-_225615599 0.44 ENST00000421383.1
ENST00000272163.4
LBR
lamin B receptor
chr4_+_2420659 0.43 ENST00000382849.2
RP11-503N18.1
RP11-503N18.1
chr3_-_183273477 0.42 ENST00000341319.3
KLHL6
kelch-like family member 6
chr7_-_99332719 0.42 ENST00000336374.2
CYP3A7
cytochrome P450, family 3, subfamily A, polypeptide 7
chr18_+_3451584 0.42 ENST00000551541.1
TGIF1
TGFB-induced factor homeobox 1
chr12_-_15114191 0.41 ENST00000541380.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr8_-_99837856 0.41 ENST00000518165.1
ENST00000419617.2
STK3
serine/threonine kinase 3
chr5_-_180666570 0.39 ENST00000509535.1
GNB2L1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
chr7_-_156685841 0.39 ENST00000354505.4
ENST00000540390.1
LMBR1
limb development membrane protein 1
chr12_+_122326662 0.39 ENST00000261817.2
ENST00000538613.1
ENST00000542602.1
PSMD9
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr13_+_24844819 0.39 ENST00000399949.2
SPATA13
spermatogenesis associated 13
chr16_-_31076273 0.39 ENST00000426488.2
ZNF668
zinc finger protein 668
chr18_-_67872891 0.38 ENST00000454359.1
ENST00000437017.1
RTTN
rotatin
chr12_+_121647868 0.38 ENST00000359949.7
ENST00000541532.1
ENST00000543171.1
ENST00000538701.1
P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr20_-_33872518 0.38 ENST00000374436.3
EIF6
eukaryotic translation initiation factor 6
chr12_-_21757774 0.37 ENST00000261195.2
GYS2
glycogen synthase 2 (liver)
chr5_+_43603229 0.37 ENST00000344920.4
ENST00000512996.2
NNT
nicotinamide nucleotide transhydrogenase
chr12_+_34175398 0.37 ENST00000538927.1
ALG10
ALG10, alpha-1,2-glucosyltransferase
chr6_-_31651817 0.37 ENST00000375863.3
ENST00000375860.2
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr20_-_31124186 0.36 ENST00000375678.3
C20orf112
chromosome 20 open reading frame 112
chr20_-_33872548 0.36 ENST00000374443.3
EIF6
eukaryotic translation initiation factor 6

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX1_TGIF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
1.3 12.7 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
1.0 2.9 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.7 4.3 GO:0070295 renal water absorption(GO:0070295)
0.6 6.1 GO:2001300 lipoxin metabolic process(GO:2001300)
0.6 3.0 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.5 1.5 GO:2000744 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.5 0.5 GO:0051604 protein maturation(GO:0051604)
0.4 1.2 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.4 1.2 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.4 2.8 GO:0023021 termination of signal transduction(GO:0023021)
0.3 1.4 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.3 1.0 GO:2000870 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.3 1.0 GO:0072573 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
0.3 1.2 GO:1903824 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.3 0.9 GO:1990108 protein linear deubiquitination(GO:1990108)
0.3 1.3 GO:0070980 biphenyl catabolic process(GO:0070980)
0.2 1.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 1.2 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.2 1.2 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.2 0.7 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.2 1.1 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.2 0.6 GO:0034130 toll-like receptor 1 signaling pathway(GO:0034130)
0.2 0.8 GO:0009236 cobalamin biosynthetic process(GO:0009236)
0.2 1.8 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 1.2 GO:0002729 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729)
0.2 0.9 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 1.3 GO:0008218 bioluminescence(GO:0008218)
0.2 0.7 GO:0098582 innate vocalization behavior(GO:0098582)
0.2 0.5 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
0.2 1.3 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.2 0.5 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.1 0.7 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 4.0 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 0.7 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 1.5 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.1 2.0 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.6 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 0.4 GO:0044782 cilium organization(GO:0044782)
0.1 0.6 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 0.7 GO:0060620 regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.1 0.4 GO:0008057 eye pigment granule organization(GO:0008057)
0.1 2.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.3 GO:0007000 nucleolus organization(GO:0007000)
0.1 0.7 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 1.4 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 1.8 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.1 0.5 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.1 0.5 GO:1904502 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.1 0.5 GO:0035063 nuclear speck organization(GO:0035063)
0.1 1.2 GO:0051918 negative regulation of smooth muscle cell apoptotic process(GO:0034392) negative regulation of fibrinolysis(GO:0051918)
0.1 2.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 1.7 GO:0051601 exocyst localization(GO:0051601)
0.1 0.8 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.2 GO:0061110 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.5 GO:0006740 NADPH regeneration(GO:0006740)
0.1 5.8 GO:0006953 acute-phase response(GO:0006953)
0.1 0.2 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.1 0.4 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.2 GO:0070101 positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.1 0.9 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.1 GO:2000224 regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.4 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 1.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.3 GO:0006172 ADP biosynthetic process(GO:0006172)
0.1 0.4 GO:0071461 cellular response to redox state(GO:0071461)
0.1 0.3 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.1 1.2 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.1 0.3 GO:0010157 response to chlorate(GO:0010157)
0.1 0.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.6 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.1 1.6 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.8 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.3 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.5 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 2.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 1.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.8 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.2 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.0 0.4 GO:0044334 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.2 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.3 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.1 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304)
0.0 0.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.2 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.0 0.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.4 GO:0032308 regulation of prostaglandin secretion(GO:0032306) positive regulation of prostaglandin secretion(GO:0032308)
0.0 0.1 GO:0097359 UDP-glucosylation(GO:0097359)
0.0 0.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:0042214 terpene metabolic process(GO:0042214)
0.0 0.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.8 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.4 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.9 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0048213 Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0 0.3 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.2 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.4 GO:0014029 neural crest formation(GO:0014029)
0.0 2.3 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.0 0.2 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.0 0.1 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
0.0 0.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.1 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.1 GO:0060164 trochlear nerve development(GO:0021558) regulation of timing of neuron differentiation(GO:0060164)
0.0 0.3 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 1.3 GO:0051180 vitamin transport(GO:0051180)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.5 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.6 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.9 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.7 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.3 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.2 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.1 GO:0051836 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.0 0.0 GO:0071879 UDP-glucose catabolic process(GO:0006258) positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.8 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.4 GO:0002467 germinal center formation(GO:0002467)
0.0 0.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0 0.5 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.2 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 1.6 GO:0046849 bone remodeling(GO:0046849)
0.0 0.2 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.6 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.8 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 1.0 GO:0045576 mast cell activation(GO:0045576)
0.0 0.8 GO:0043029 T cell homeostasis(GO:0043029)
0.0 0.2 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.2 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0 0.5 GO:2000772 regulation of cellular senescence(GO:2000772)
0.0 0.2 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.5 GO:0051602 response to electrical stimulus(GO:0051602)
0.0 0.9 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.5 GO:0032094 response to food(GO:0032094)
0.0 0.1 GO:0071481 cellular response to X-ray(GO:0071481) negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.7 GO:0006897 endocytosis(GO:0006897)
0.0 1.2 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.7 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 1.1 GO:0036398 TCR signalosome(GO:0036398)
0.2 0.6 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 1.6 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.6 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.3 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 1.2 GO:0030870 Mre11 complex(GO:0030870)
0.1 13.5 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1 0.9 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 2.3 GO:0042599 lamellar body(GO:0042599)
0.1 0.3 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 2.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 2.4 GO:0000145 exocyst(GO:0000145)
0.1 1.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 5.7 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.9 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.4 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.6 GO:0044754 autolysosome(GO:0044754)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.5 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 1.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 3.5 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.8 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.5 GO:0097225 sperm midpiece(GO:0097225)
0.0 2.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 1.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.4 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 1.1 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.3 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 8.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 8.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.4 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.8 GO:0005901 caveola(GO:0005901)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.3 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0031105 septin complex(GO:0031105)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.1 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
1.3 4.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.9 4.3 GO:0015254 glycerol channel activity(GO:0015254)
0.7 2.0 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.6 1.8 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.5 1.4 GO:0097689 iron channel activity(GO:0097689)
0.4 1.2 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.4 1.6 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.3 1.3 GO:0008431 vitamin E binding(GO:0008431)
0.3 1.2 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.2 0.7 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.2 2.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 0.7 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.2 1.5 GO:0001515 opioid peptide activity(GO:0001515)
0.2 2.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 1.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.2 0.5 GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.2 1.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.4 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 1.4 GO:0004046 aminoacylase activity(GO:0004046)
0.1 1.1 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 0.5 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.1 1.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1 1.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.6 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 0.4 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.6 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 1.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.5 GO:0003883 CTP synthase activity(GO:0003883)
0.1 0.4 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.1 2.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.5 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.1 3.4 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.2 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.9 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.9 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 1.3 GO:0045159 myosin II binding(GO:0045159)
0.1 0.3 GO:0070012 oligopeptidase activity(GO:0070012)
0.1 0.5 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.8 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.1 0.3 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.1 0.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 1.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.8 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 1.1 GO:0004568 chitinase activity(GO:0004568)
0.1 9.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.2 GO:0019808 polyamine binding(GO:0019808)
0.1 0.7 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.8 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 1.6 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.2 GO:0052839 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 1.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.0 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 2.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.1 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.2 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 1.2 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.4 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.2 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.0 1.7 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 4.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 1.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.3 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.5 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.2 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) PTB domain binding(GO:0051425)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.2 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 2.6 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.0 1.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.4 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.4 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.0 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 2.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.3 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 2.0 GO:0031072 heat shock protein binding(GO:0031072)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 18.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 1.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 5.1 PID CD40 PATHWAY CD40/CD40L signaling
0.1 4.8 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 6.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 2.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 3.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.8 PID IL1 PATHWAY IL1-mediated signaling events
0.0 3.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 4.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.5 PID ATM PATHWAY ATM pathway
0.0 0.6 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.5 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 1.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.9 PID INSULIN PATHWAY Insulin Pathway
0.0 0.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.4 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.6 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 14.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.3 4.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 12.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.0 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.6 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 3.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.4 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 1.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.7 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.3 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 2.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.9 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 5.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 1.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 1.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.4 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.6 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 3.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.9 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0 0.4 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)