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Illumina Body Map 2, young vs old

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Results for POU5F1_POU2F3

Z-value: 0.63

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Transcription factors associated with POU5F1_POU2F3

Gene Symbol Gene ID Gene Info
POU5F1
ENSG00000204531.11 POU class 5 homeobox 1
POU2F3
ENSG00000137709.5 POU class 2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU5F1hg19_v2_chr6_-_31138439_311384750.327.6e-02Click!
POU2F3hg19_v2_chr11_+_120107344_1201073510.261.5e-01Click!

Activity profile of POU5F1_POU2F3 motif

Sorted Z-values of POU5F1_POU2F3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_23063100 30.57 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr14_-_107049312 26.05 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr22_+_23154239 24.74 ENST00000390315.2
IGLV3-10
immunoglobulin lambda variable 3-10
chr22_+_23089870 24.55 ENST00000390311.2
IGLV3-16
immunoglobulin lambda variable 3-16
chr14_-_106552755 24.07 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr14_-_107035208 23.78 ENST00000390626.2
IGHV5-51
immunoglobulin heavy variable 5-51
chr22_+_22764088 22.86 ENST00000390299.2
IGLV1-40
immunoglobulin lambda variable 1-40
chr22_+_22735135 22.43 ENST00000390297.2
IGLV1-44
immunoglobulin lambda variable 1-44
chr14_-_107170409 22.42 ENST00000390633.2
IGHV1-69
immunoglobulin heavy variable 1-69
chr2_+_89998789 22.21 ENST00000453166.2
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr16_+_32063311 22.00 ENST00000426099.1
AC142381.1
AC142381.1
chr14_-_107211459 21.50 ENST00000390636.2
IGHV3-73
immunoglobulin heavy variable 3-73
chr2_-_89399845 21.47 ENST00000479981.1
IGKV1-16
immunoglobulin kappa variable 1-16
chr14_-_106539557 21.28 ENST00000390599.2
IGHV1-8
immunoglobulin heavy variable 1-8
chr16_+_32077386 20.76 ENST00000354689.6
IGHV3OR16-9
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr2_+_89975669 20.52 ENST00000474213.1
IGKV2D-30
immunoglobulin kappa variable 2D-30
chr2_-_89521942 20.26 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chr14_-_107083690 20.21 ENST00000455737.1
ENST00000390629.2
IGHV4-59
immunoglobulin heavy variable 4-59
chr14_-_106478603 20.16 ENST00000390596.2
IGHV4-4
immunoglobulin heavy variable 4-4
chr14_-_106791536 20.06 ENST00000390613.2
IGHV3-30
immunoglobulin heavy variable 3-30
chr14_-_107078851 19.97 ENST00000390628.2
IGHV1-58
immunoglobulin heavy variable 1-58
chr14_-_107095662 19.90 ENST00000390630.2
IGHV4-61
immunoglobulin heavy variable 4-61
chr22_+_22550113 19.89 ENST00000390285.3
IGLV6-57
immunoglobulin lambda variable 6-57
chr2_+_89196746 19.85 ENST00000390244.2
IGKV5-2
immunoglobulin kappa variable 5-2
chr22_+_23029188 19.82 ENST00000390305.2
IGLV3-25
immunoglobulin lambda variable 3-25
chr2_+_89952792 19.82 ENST00000390265.2
IGKV1D-33
immunoglobulin kappa variable 1D-33
chr22_+_22385332 19.36 ENST00000390282.2
IGLV4-69
immunoglobulin lambda variable 4-69
chr22_+_22786288 19.34 ENST00000390301.2
IGLV1-36
immunoglobulin lambda variable 1-36
chr22_+_22453093 19.31 ENST00000390283.2
IGLV8-61
immunoglobulin lambda variable 8-61
chr14_-_106586656 19.26 ENST00000390602.2
IGHV3-13
immunoglobulin heavy variable 3-13
chr2_-_89545079 19.21 ENST00000468494.1
IGKV2-30
immunoglobulin kappa variable 2-30
chr2_-_89568263 19.00 ENST00000473726.1
IGKV1-33
immunoglobulin kappa variable 1-33
chr2_+_90139056 18.94 ENST00000492446.1
IGKV1D-16
immunoglobulin kappa variable 1D-16
chr14_-_106573756 18.85 ENST00000390601.2
IGHV3-11
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr14_-_106830057 18.71 ENST00000390616.2
IGHV4-34
immunoglobulin heavy variable 4-34
chr22_+_22712087 18.54 ENST00000390294.2
IGLV1-47
immunoglobulin lambda variable 1-47
chr14_-_106816253 18.08 ENST00000390615.2
IGHV3-33
immunoglobulin heavy variable 3-33
chr2_+_90077680 18.00 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr14_-_106610852 17.91 ENST00000390603.2
IGHV3-15
immunoglobulin heavy variable 3-15
chr2_+_114163945 17.76 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr2_+_90121477 17.74 ENST00000483379.1
IGKV1D-17
immunoglobulin kappa variable 1D-17
chr2_-_89597542 17.36 ENST00000465170.1
IGKV1-37
immunoglobulin kappa variable 1-37 (non-functional)
chr2_-_89417335 17.35 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr16_+_33020496 16.89 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr2_-_89442621 16.69 ENST00000492167.1
IGKV3-20
immunoglobulin kappa variable 3-20
chr21_+_10862622 16.68 ENST00000302092.5
ENST00000559480.1
IGHV1OR21-1
immunoglobulin heavy variable 1/OR21-1 (non-functional)
chr7_-_142511084 16.68 ENST00000417977.2
TRBV30
T cell receptor beta variable 30 (gene/pseudogene)
chr14_-_106733624 16.66 ENST00000390610.2
IGHV1-24
immunoglobulin heavy variable 1-24
chr2_+_90192768 16.57 ENST00000390275.2
IGKV1D-13
immunoglobulin kappa variable 1D-13
chr2_-_182521823 16.54 ENST00000410087.3
ENST00000409440.3
CERKL
ceramide kinase-like
chr15_-_22473353 16.37 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr16_+_33006369 16.29 ENST00000425181.3
IGHV3OR16-10
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr22_+_22516550 16.28 ENST00000390284.2
IGLV4-60
immunoglobulin lambda variable 4-60
chr22_+_23077065 16.27 ENST00000390310.2
IGLV2-18
immunoglobulin lambda variable 2-18
chr22_+_23134974 16.14 ENST00000390314.2
IGLV2-11
immunoglobulin lambda variable 2-11
chr14_-_106878083 16.11 ENST00000390619.2
IGHV4-39
immunoglobulin heavy variable 4-39
chr2_+_89923550 16.07 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr22_+_23010756 15.95 ENST00000390304.2
IGLV3-27
immunoglobulin lambda variable 3-27
chr14_-_107114267 15.87 ENST00000454421.2
IGHV3-64
immunoglobulin heavy variable 3-64
chr2_+_90043607 15.76 ENST00000462693.1
IGKV2D-24
immunoglobulin kappa variable 2D-24 (non-functional)
chr2_-_89340242 15.74 ENST00000480492.1
IGKV1-12
immunoglobulin kappa variable 1-12
chr2_-_89247338 15.69 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr2_+_90153696 15.68 ENST00000417279.2
IGKV3D-15
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr2_+_90248739 15.68 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr14_-_106494587 15.64 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr2_-_89266286 15.50 ENST00000464162.1
IGKV1-6
immunoglobulin kappa variable 1-6
chr2_+_90060377 15.46 ENST00000436451.2
IGKV6D-21
immunoglobulin kappa variable 6D-21 (non-functional)
chr6_-_154567984 14.96 ENST00000517438.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr16_-_33647696 14.84 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9
Uncharacterized protein
chr2_+_90198535 14.66 ENST00000390276.2
IGKV1D-12
immunoglobulin kappa variable 1D-12
chr16_+_33629600 14.58 ENST00000562905.2
IGHV3OR16-13
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr14_-_106845789 14.43 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr4_-_71532207 14.17 ENST00000543780.1
ENST00000391614.3
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_+_90458201 14.08 ENST00000603238.1
CH17-132F21.1
Uncharacterized protein
chrX_-_48776292 13.83 ENST00000376509.4
PIM2
pim-2 oncogene
chr2_+_89890533 13.44 ENST00000429992.2
IGKV2D-40
immunoglobulin kappa variable 2D-40
chr16_+_23847267 13.36 ENST00000321728.7
PRKCB
protein kinase C, beta
chr2_+_89184868 13.06 ENST00000390243.2
IGKV4-1
immunoglobulin kappa variable 4-1
chr14_+_22180536 12.52 ENST00000390424.2
TRAV2
T cell receptor alpha variable 2
chr4_+_40194570 12.32 ENST00000507851.1
RHOH
ras homolog family member H
chr6_-_108145499 12.11 ENST00000369020.3
ENST00000369022.2
SCML4
sex comb on midleg-like 4 (Drosophila)
chr14_-_107283278 12.03 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr14_-_106453155 11.88 ENST00000390594.2
IGHV1-2
immunoglobulin heavy variable 1-2
chr2_+_89986318 11.64 ENST00000491977.1
IGKV2D-29
immunoglobulin kappa variable 2D-29
chr6_-_32784687 11.50 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr4_-_71532339 11.24 ENST00000254801.4
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr14_-_106692191 11.24 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr2_-_89327228 11.13 ENST00000483158.1
IGKV3-11
immunoglobulin kappa variable 3-11
chr14_-_106805716 10.95 ENST00000438142.2
IGHV4-31
immunoglobulin heavy variable 4-31
chr2_+_87565634 10.94 ENST00000421835.2
IGKV3OR2-268
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr22_+_22697537 10.87 ENST00000427632.2
IGLV9-49
immunoglobulin lambda variable 9-49
chr2_-_89619904 10.77 ENST00000498574.1
IGKV1-39
immunoglobulin kappa variable 1-39 (gene/pseudogene)
chr2_-_89385283 10.51 ENST00000390252.2
IGKV3-15
immunoglobulin kappa variable 3-15
chr15_-_22448819 10.48 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr2_-_90538397 10.31 ENST00000443397.3
RP11-685N3.1
Uncharacterized protein
chr3_+_98250743 10.25 ENST00000284311.3
GPR15
G protein-coupled receptor 15
chr2_-_89278535 10.15 ENST00000390247.2
IGKV3-7
immunoglobulin kappa variable 3-7 (non-functional)
chr22_+_23101182 10.14 ENST00000390312.2
IGLV2-14
immunoglobulin lambda variable 2-14
chr2_+_90211643 10.10 ENST00000390277.2
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr22_+_23222886 10.05 ENST00000390319.2
IGLV3-1
immunoglobulin lambda variable 3-1
chr16_+_23847339 10.05 ENST00000303531.7
PRKCB
protein kinase C, beta
chr6_-_11779403 9.82 ENST00000414691.3
ADTRP
androgen-dependent TFPI-regulating protein
chr2_+_89901292 9.79 ENST00000448155.2
IGKV1D-39
immunoglobulin kappa variable 1D-39
chr19_+_35820064 9.73 ENST00000341773.6
ENST00000600131.1
ENST00000270311.6
ENST00000595780.1
ENST00000597916.1
ENST00000593867.1
ENST00000600424.1
ENST00000599811.1
ENST00000536635.2
ENST00000085219.5
ENST00000544992.2
ENST00000419549.2
CD22
CD22 molecule
chr4_-_71532601 9.66 ENST00000510614.1
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr22_+_22707260 9.65 ENST00000390293.1
IGLV5-48
immunoglobulin lambda variable 5-48 (non-functional)
chr19_+_14693888 9.64 ENST00000547437.1
ENST00000397439.2
ENST00000417570.1
CLEC17A
C-type lectin domain family 17, member A
chr1_-_206306107 9.53 ENST00000436158.1
ENST00000455672.1
RP11-38J22.6
RP11-38J22.6
chr2_+_90259593 9.48 ENST00000471857.1
IGKV1D-8
immunoglobulin kappa variable 1D-8
chr14_-_106758101 9.40 ENST00000390611.2
IGHV2-26
immunoglobulin heavy variable 2-26
chr22_+_23165153 9.28 ENST00000390317.2
IGLV2-8
immunoglobulin lambda variable 2-8
chr2_-_113594279 9.24 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr2_+_90024732 9.18 ENST00000390268.2
IGKV2D-26
immunoglobulin kappa variable 2D-26
chr6_+_26251835 9.16 ENST00000356350.2
HIST1H2BH
histone cluster 1, H2bh
chr2_+_90273679 9.09 ENST00000423080.2
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr2_-_89476644 9.04 ENST00000484817.1
IGKV2-24
immunoglobulin kappa variable 2-24
chr2_-_89513402 9.03 ENST00000498435.1
IGKV1-27
immunoglobulin kappa variable 1-27
chr22_+_23040274 8.96 ENST00000390306.2
IGLV2-23
immunoglobulin lambda variable 2-23
chr14_-_106926724 8.89 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr12_-_123201337 8.79 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr14_-_106994333 8.76 ENST00000390624.2
IGHV3-48
immunoglobulin heavy variable 3-48
chr14_-_106622419 8.76 ENST00000390604.2
IGHV3-16
immunoglobulin heavy variable 3-16 (non-functional)
chr7_-_3083573 8.71 ENST00000396946.4
CARD11
caspase recruitment domain family, member 11
chr4_-_71532668 8.69 ENST00000510437.1
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr2_-_89459813 8.68 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr16_+_23847355 8.64 ENST00000498058.1
PRKCB
protein kinase C, beta
chr14_-_106866934 8.61 ENST00000390618.2
IGHV3-38
immunoglobulin heavy variable 3-38 (non-functional)
chr14_-_107013465 8.59 ENST00000390625.2
IGHV3-49
immunoglobulin heavy variable 3-49
chr6_-_128222103 8.58 ENST00000434358.1
ENST00000543064.1
ENST00000368248.2
THEMIS
thymocyte selection associated
chr14_-_107219365 8.48 ENST00000424969.2
IGHV3-74
immunoglobulin heavy variable 3-74
chr14_-_106518922 8.48 ENST00000390598.2
IGHV3-7
immunoglobulin heavy variable 3-7
chr16_+_33605231 8.46 ENST00000570121.2
IGHV3OR16-12
immunoglobulin heavy variable 3/OR16-12 (non-functional)
chr3_+_46395219 8.44 ENST00000445132.2
ENST00000292301.4
CCR2
chemokine (C-C motif) receptor 2
chr5_+_156607829 8.37 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chr14_-_106967788 8.32 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr1_+_27668505 8.31 ENST00000318074.5
SYTL1
synaptotagmin-like 1
chr5_-_111091948 8.29 ENST00000447165.2
NREP
neuronal regeneration related protein
chr14_+_22236722 8.23 ENST00000390428.3
TRAV6
T cell receptor alpha variable 6
chr22_+_23114284 8.21 ENST00000390313.2
IGLV3-12
immunoglobulin lambda variable 3-12
chr22_-_24096562 8.20 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr14_-_107199464 8.16 ENST00000433072.2
IGHV3-72
immunoglobulin heavy variable 3-72
chr19_-_39108552 8.14 ENST00000591517.1
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr2_+_68962014 8.10 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr22_+_23213658 7.93 ENST00000390318.2
IGLV4-3
immunoglobulin lambda variable 4-3
chr2_+_90229045 7.88 ENST00000390278.2
IGKV1D-42
immunoglobulin kappa variable 1D-42 (non-functional)
chr22_-_24096630 7.87 ENST00000248948.3
VPREB3
pre-B lymphocyte 3
chr19_-_39108568 7.71 ENST00000586296.1
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr6_-_31560729 7.66 ENST00000340027.5
ENST00000376073.4
ENST00000376072.3
NCR3
natural cytotoxicity triggering receptor 3
chr4_+_71091786 7.52 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr7_-_3083472 7.51 ENST00000356408.3
CARD11
caspase recruitment domain family, member 11
chr13_-_99959641 7.32 ENST00000376414.4
GPR183
G protein-coupled receptor 183
chr14_-_107131560 7.29 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr14_-_106963409 7.28 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr6_-_26216872 7.24 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr3_+_46395579 7.19 ENST00000421659.1
CCR2
chemokine (C-C motif) receptor 2
chr15_-_20193370 7.04 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr5_+_54398463 7.00 ENST00000274306.6
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr4_+_40194609 6.99 ENST00000508513.1
RHOH
ras homolog family member H
chr14_-_106725723 6.93 ENST00000390609.2
IGHV3-23
immunoglobulin heavy variable 3-23
chr2_+_90108504 6.82 ENST00000390271.2
IGKV6D-41
immunoglobulin kappa variable 6D-41 (non-functional)
chr1_-_157746909 6.78 ENST00000392274.3
ENST00000361516.3
ENST00000368181.4
FCRL2
Fc receptor-like 2
chr14_+_22689792 6.78 ENST00000390462.1
TRAV35
T cell receptor alpha variable 35
chr1_-_157789850 6.69 ENST00000491942.1
ENST00000358292.3
ENST00000368176.3
FCRL1
Fc receptor-like 1
chr22_+_22676808 6.57 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr19_-_39108643 6.57 ENST00000396857.2
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr13_-_99910673 6.57 ENST00000397473.2
ENST00000397470.2
GPR18
G protein-coupled receptor 18
chr15_-_20170354 6.53 ENST00000338912.5
IGHV1OR15-9
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr14_-_107179265 6.50 ENST00000390634.2
IGHV2-70
immunoglobulin heavy variable 2-70
chr22_+_22930626 6.27 ENST00000390302.2
IGLV2-33
immunoglobulin lambda variable 2-33 (non-functional)
chr5_-_66492562 6.10 ENST00000256447.4
CD180
CD180 molecule
chr4_-_164534657 6.07 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr1_-_108231101 6.04 ENST00000544443.1
ENST00000415432.2
VAV3
vav 3 guanine nucleotide exchange factor
chr17_-_62009702 5.92 ENST00000006750.3
CD79B
CD79b molecule, immunoglobulin-associated beta
chr7_+_50348268 5.92 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr14_+_22739823 5.87 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr17_-_62009621 5.85 ENST00000349817.2
ENST00000392795.3
CD79B
CD79b molecule, immunoglobulin-associated beta
chr17_-_79620721 5.77 ENST00000571004.1
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr12_+_93115281 5.72 ENST00000549856.1
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr16_+_32859034 5.63 ENST00000567458.2
ENST00000560724.1
IGHV2OR16-5
immunoglobulin heavy variable 2/OR16-5 (non-functional)
chr14_+_22111077 5.62 ENST00000390423.2
TRAV1-2
T cell receptor alpha variable 1-2
chr8_-_134114721 5.60 ENST00000522119.1
ENST00000523610.1
ENST00000521302.1
ENST00000519558.1
ENST00000519747.1
ENST00000517648.1
SLA
Src-like-adaptor
chr12_+_93096619 5.57 ENST00000397833.3
C12orf74
chromosome 12 open reading frame 74
chr9_-_34691201 5.56 ENST00000378800.3
ENST00000311925.2
CCL19
chemokine (C-C motif) ligand 19
chr22_+_22730353 5.56 ENST00000390296.2
IGLV5-45
immunoglobulin lambda variable 5-45
chr19_-_18508396 5.51 ENST00000595840.1
ENST00000339007.3
LRRC25
leucine rich repeat containing 25
chr16_+_31366536 5.50 ENST00000562522.1
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr22_+_22723969 5.42 ENST00000390295.2
IGLV7-46
immunoglobulin lambda variable 7-46 (gene/pseudogene)
chr8_-_134114866 5.41 ENST00000524345.1
SLA
Src-like-adaptor
chr5_-_175965008 5.40 ENST00000537487.1
RNF44
ring finger protein 44
chr18_-_30353025 5.39 ENST00000359358.4
KLHL14
kelch-like family member 14
chr17_-_73840774 5.36 ENST00000207549.4
UNC13D
unc-13 homolog D (C. elegans)
chr14_+_22089953 5.34 ENST00000542354.1
TRAV1-1
T cell receptor alpha variable 1-1
chr12_-_45269430 5.31 ENST00000395487.2
NELL2
NEL-like 2 (chicken)
chr4_+_153021899 5.30 ENST00000509332.1
ENST00000504144.1
ENST00000499452.2
RP11-18H21.1
RP11-18H21.1
chr9_-_35618364 5.29 ENST00000378431.1
ENST00000378430.3
ENST00000259633.4
CD72
CD72 molecule
chr8_+_56792377 5.24 ENST00000520220.2
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr22_+_22781853 5.20 ENST00000390300.2
IGLV5-37
immunoglobulin lambda variable 5-37
chr12_-_123187890 5.10 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr1_-_228645556 5.07 ENST00000366695.2
HIST3H2A
histone cluster 3, H2a
chr22_+_22749343 5.04 ENST00000390298.2
IGLV7-43
immunoglobulin lambda variable 7-43

Network of associatons between targets according to the STRING database.

First level regulatory network of POU5F1_POU2F3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 32.0 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
7.6 22.9 GO:0035700 astrocyte chemotaxis(GO:0035700) regulation of astrocyte chemotaxis(GO:2000458)
6.9 1195.1 GO:0006958 complement activation, classical pathway(GO:0006958)
4.3 4.3 GO:0043309 regulation of eosinophil degranulation(GO:0043309)
3.8 11.5 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
3.7 14.7 GO:0002432 granuloma formation(GO:0002432)
3.4 13.7 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
3.4 10.1 GO:0070666 regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
3.1 9.2 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
3.0 15.0 GO:0044027 hypermethylation of CpG island(GO:0044027)
2.6 7.7 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
2.3 520.8 GO:0002377 immunoglobulin production(GO:0002377)
2.0 8.1 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
1.9 5.6 GO:2000547 regulation of dendritic cell dendrite assembly(GO:2000547)
1.5 6.0 GO:0042495 detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
1.5 5.9 GO:2000146 negative regulation of cell migration(GO:0030336) negative regulation of cell motility(GO:2000146)
1.5 4.4 GO:0097534 lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535)
1.4 4.2 GO:1903980 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973) positive regulation of microglial cell activation(GO:1903980)
1.3 4.0 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
1.0 8.2 GO:0033029 neutrophil apoptotic process(GO:0001781) regulation of neutrophil apoptotic process(GO:0033029)
1.0 4.1 GO:0007019 microtubule depolymerization(GO:0007019)
1.0 6.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.9 7.0 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.9 22.4 GO:0015671 oxygen transport(GO:0015671)
0.8 4.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.8 4.9 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.8 2.4 GO:0002740 negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.7 8.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.7 4.3 GO:0071877 regulation of adrenergic receptor signaling pathway(GO:0071877)
0.7 5.7 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.7 4.2 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.7 2.7 GO:0060168 positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.7 2.0 GO:1990709 maintenance of synapse structure(GO:0099558) presynaptic active zone organization(GO:1990709)
0.7 2.6 GO:0002678 positive regulation of chronic inflammatory response(GO:0002678)
0.7 3.9 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.6 2.5 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.6 3.7 GO:0021993 initiation of neural tube closure(GO:0021993)
0.6 3.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.6 4.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.6 1.8 GO:2000196 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.6 3.5 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.6 1.1 GO:0016068 regulation of type I hypersensitivity(GO:0001810) positive regulation of type I hypersensitivity(GO:0001812) positive regulation of hypersensitivity(GO:0002885) type I hypersensitivity(GO:0016068)
0.6 9.7 GO:0001865 NK T cell differentiation(GO:0001865)
0.6 10.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.6 6.8 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.6 1.7 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.6 2.8 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.5 2.2 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.5 3.2 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.5 3.8 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.5 1.6 GO:0046080 dUTP metabolic process(GO:0046080) dUTP catabolic process(GO:0046081)
0.5 1.6 GO:0061386 closure of optic fissure(GO:0061386)
0.5 2.1 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.5 8.6 GO:0043383 negative T cell selection(GO:0043383)
0.5 1.5 GO:0061054 dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.5 4.0 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.5 1.0 GO:0002461 tolerance induction dependent upon immune response(GO:0002461) regulation of tolerance induction dependent upon immune response(GO:0002652)
0.5 1.5 GO:0035283 rhombomere 3 development(GO:0021569) rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.5 3.4 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.5 3.3 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.5 1.9 GO:0035910 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.5 3.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.4 2.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.4 1.3 GO:0060596 mammary placode formation(GO:0060596)
0.4 1.3 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.4 1.8 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.4 22.2 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.4 4.3 GO:0051873 killing by host of symbiont cells(GO:0051873)
0.4 6.0 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.4 5.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.4 1.7 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.4 3.4 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.4 2.1 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.4 1.2 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.4 1.2 GO:1903450 regulation of G1 to G0 transition(GO:1903450) positive regulation of G1 to G0 transition(GO:1903452)
0.4 1.2 GO:0032917 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.4 8.4 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.4 10.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.4 1.9 GO:0072101 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.4 1.5 GO:0018277 protein deamination(GO:0018277)
0.4 1.5 GO:0052419 multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.4 1.5 GO:0043375 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.4 2.9 GO:1902510 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) regulation of apoptotic DNA fragmentation(GO:1902510)
0.4 5.3 GO:0032119 sequestering of zinc ion(GO:0032119)
0.4 2.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.3 2.8 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.3 4.4 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.3 1.7 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 1.3 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.3 2.9 GO:0070995 NADPH oxidation(GO:0070995)
0.3 1.6 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892) regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.3 5.0 GO:0070914 UV-damage excision repair(GO:0070914)
0.3 0.9 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.3 1.5 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.3 4.3 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.3 1.5 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.3 4.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.3 1.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.3 0.9 GO:0016321 female meiosis chromosome segregation(GO:0016321)
0.3 27.1 GO:0045576 mast cell activation(GO:0045576)
0.3 0.8 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.3 4.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.3 0.8 GO:1904586 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828)
0.3 1.0 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.3 1.8 GO:0002468 dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.3 1.0 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.3 0.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 1.8 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.3 0.8 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.3 1.0 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.3 1.0 GO:0035915 pore formation in membrane of other organism(GO:0035915)
0.2 1.5 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 2.4 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 10.2 GO:0072678 T cell migration(GO:0072678)
0.2 2.7 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.2 0.7 GO:0006173 dADP biosynthetic process(GO:0006173)
0.2 1.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.2 1.3 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.2 6.9 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 0.9 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) renal water absorption(GO:0070295)
0.2 1.9 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.2 0.8 GO:0060023 soft palate development(GO:0060023)
0.2 1.5 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.2 1.7 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.2 2.5 GO:0009304 tRNA transcription(GO:0009304)
0.2 0.8 GO:1901963 regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901963)
0.2 6.6 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.2 4.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.2 1.4 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.2 1.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.2 3.3 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.2 0.6 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.2 9.4 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.2 1.5 GO:0010165 response to X-ray(GO:0010165)
0.2 3.9 GO:0002115 store-operated calcium entry(GO:0002115)
0.2 17.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 1.8 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 0.7 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.2 3.0 GO:0002507 tolerance induction(GO:0002507)
0.2 1.5 GO:0097324 melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 2.4 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 1.5 GO:0071494 cellular response to UV-C(GO:0071494)
0.2 0.8 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030) non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.2 0.5 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.2 3.8 GO:0035641 locomotory exploration behavior(GO:0035641)
0.2 3.3 GO:0021781 glial cell fate commitment(GO:0021781)
0.2 1.9 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.2 0.2 GO:0035494 SNARE complex disassembly(GO:0035494)
0.2 0.3 GO:0042701 progesterone secretion(GO:0042701)
0.2 2.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.2 2.0 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.2 0.9 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.2 0.9 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.2 0.3 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.2 0.9 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.2 19.2 GO:0030183 B cell differentiation(GO:0030183)
0.2 6.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 0.1 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 3.0 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.6 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 5.4 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.1 2.6 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 1.3 GO:1901660 cellular response to corticosterone stimulus(GO:0071386) calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.1 0.7 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.7 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.1 9.6 GO:0007140 male meiosis(GO:0007140)
0.1 2.9 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 1.7 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.4 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 1.0 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 6.4 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 0.4 GO:0046041 ITP metabolic process(GO:0046041)
0.1 1.6 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 2.5 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.1 0.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 0.4 GO:0035281 pre-miRNA export from nucleus(GO:0035281)
0.1 3.1 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.1 0.6 GO:0035026 leading edge cell differentiation(GO:0035026)
0.1 1.0 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 12.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 1.6 GO:0042756 drinking behavior(GO:0042756)
0.1 0.4 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 10.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 0.4 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.1 1.1 GO:0055118 intracellular sequestering of iron ion(GO:0006880) negative regulation of cardiac muscle contraction(GO:0055118) sequestering of iron ion(GO:0097577)
0.1 1.9 GO:0051601 exocyst localization(GO:0051601)
0.1 0.2 GO:1904796 regulation of core promoter binding(GO:1904796)
0.1 1.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 1.1 GO:0051712 positive regulation of killing of cells of other organism(GO:0051712)
0.1 0.6 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.1 1.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 2.3 GO:0030225 macrophage differentiation(GO:0030225)
0.1 0.5 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.4 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.1 4.4 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 1.0 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.1 0.1 GO:1900157 regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 2.8 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 0.5 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.1 0.5 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 1.7 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 6.7 GO:0006968 cellular defense response(GO:0006968)
0.1 0.5 GO:0090131 mesenchyme migration(GO:0090131)
0.1 3.6 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.1 2.0 GO:0036035 osteoclast development(GO:0036035)
0.1 4.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.3 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 0.6 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 0.5 GO:0015870 acetylcholine transport(GO:0015870)
0.1 7.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 1.0 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 1.4 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 2.3 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.7 GO:0055064 chloride ion homeostasis(GO:0055064)
0.1 2.6 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.1 9.3 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 2.5 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.1 1.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.8 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 2.2 GO:2000479 regulation of cAMP-dependent protein kinase activity(GO:2000479)
0.1 2.3 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.1 13.9 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 0.7 GO:0007099 centriole replication(GO:0007099)
0.1 0.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 20.0 GO:0002250 adaptive immune response(GO:0002250)
0.1 0.3 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 1.0 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.6 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.1 1.9 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
0.1 4.1 GO:0042220 response to cocaine(GO:0042220)
0.1 3.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 0.3 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.1 0.7 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.3 GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003256)
0.1 0.7 GO:0046886 positive regulation of hormone biosynthetic process(GO:0046886)
0.1 0.3 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.1 3.4 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.1 0.3 GO:0061525 hindgut development(GO:0061525)
0.1 0.5 GO:0007635 chemosensory behavior(GO:0007635)
0.1 1.7 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.2 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.9 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 0.3 GO:0048840 otolith development(GO:0048840)
0.1 0.9 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.5 GO:0021514 ventral spinal cord interneuron differentiation(GO:0021514)
0.1 0.9 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 1.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 2.8 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.1 1.9 GO:0001556 oocyte maturation(GO:0001556)
0.1 0.3 GO:0048539 bone marrow development(GO:0048539)
0.1 0.3 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.1 0.8 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 1.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 2.4 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.1 0.8 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.1 0.5 GO:0048263 determination of dorsal identity(GO:0048263)
0.1 0.6 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.1 0.4 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.1 1.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 0.9 GO:0097264 self proteolysis(GO:0097264)
0.1 0.7 GO:0015871 choline transport(GO:0015871)
0.1 0.3 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 2.7 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.8 GO:0008228 opsonization(GO:0008228)
0.1 0.6 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.1 0.7 GO:1901987 regulation of cell cycle phase transition(GO:1901987)
0.1 0.5 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 0.4 GO:0000023 maltose metabolic process(GO:0000023)
0.1 2.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.5 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 1.4 GO:0030728 ovulation(GO:0030728)
0.0 5.2 GO:0030098 lymphocyte differentiation(GO:0030098)
0.0 2.2 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 1.8 GO:0046039 GTP metabolic process(GO:0046039)
0.0 0.5 GO:0010830 regulation of myotube differentiation(GO:0010830)
0.0 0.1 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0 1.2 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 1.2 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.5 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.6 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.0 0.2 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0 1.0 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.3 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.5 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.0 0.4 GO:0042118 endothelial cell activation(GO:0042118)
0.0 5.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0 0.5 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.3 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 3.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 2.6 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 0.4 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.0 1.4 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.6 GO:0098869 cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.9 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.6 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 0.2 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.0 20.6 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.4 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 1.3 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 0.4 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 1.0 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 0.4 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.6 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 1.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.0 0.1 GO:0019087 transformation of host cell by virus(GO:0019087)
0.0 0.3 GO:0014820 tonic smooth muscle contraction(GO:0014820)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.3 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.6 GO:0019532 oxalate transport(GO:0019532)
0.0 0.4 GO:0003360 brainstem development(GO:0003360)
0.0 1.0 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.1 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 0.7 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 1.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 6.5 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.4 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.6 GO:0048286 lung alveolus development(GO:0048286)
0.0 1.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.1 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 1.3 GO:0003407 neural retina development(GO:0003407)
0.0 0.2 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.0 0.1 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.0 2.6 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.6 GO:0001707 mesoderm formation(GO:0001707) mesoderm morphogenesis(GO:0048332)
0.0 0.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.1 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.9 GO:0006024 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)
0.0 2.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.3 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:0060613 fat pad development(GO:0060613)
0.0 0.1 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.9 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.3 GO:0046040 IMP metabolic process(GO:0046040)
0.0 0.2 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.4 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.8 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) response to interleukin-12(GO:0070671) cellular response to interleukin-12(GO:0071349)
0.0 0.2 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.2 GO:1902969 mitotic DNA replication(GO:1902969)
0.0 0.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 1.0 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 0.2 GO:0030168 platelet activation(GO:0030168)
0.0 0.1 GO:0009397 folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.0 0.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.5 GO:0045453 bone resorption(GO:0045453)
0.0 0.4 GO:0071392 cellular response to estradiol stimulus(GO:0071392)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 403.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
1.7 10.1 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
1.7 11.8 GO:0019815 B cell receptor complex(GO:0019815)
1.6 6.5 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
1.5 6.0 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
1.0 225.7 GO:0072562 blood microparticle(GO:0072562)
0.8 14.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.7 15.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.7 2.9 GO:0043293 apoptosome(GO:0043293)
0.7 4.2 GO:0097441 basilar dendrite(GO:0097441)
0.6 2.5 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.6 2.9 GO:1990031 pinceau fiber(GO:1990031)
0.6 43.0 GO:0001772 immunological synapse(GO:0001772)
0.6 3.4 GO:0097524 sperm plasma membrane(GO:0097524)
0.5 7.2 GO:0033269 internode region of axon(GO:0033269)
0.5 1.5 GO:0097179 protease inhibitor complex(GO:0097179)
0.4 2.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.4 1.3 GO:0036398 TCR signalosome(GO:0036398)
0.4 2.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.4 13.5 GO:0031528 microvillus membrane(GO:0031528)
0.4 1.2 GO:0009346 citrate lyase complex(GO:0009346)
0.4 1.1 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.3 5.8 GO:0061700 GATOR2 complex(GO:0061700)
0.3 1.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.3 0.7 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.3 0.6 GO:0000815 ESCRT III complex(GO:0000815)
0.3 0.9 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.3 1.5 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.3 5.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 0.3 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.3 19.3 GO:0001917 photoreceptor inner segment(GO:0001917)
0.3 0.8 GO:0005588 collagen type V trimer(GO:0005588)
0.3 1.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 2.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 1.4 GO:1990037 Lewy body core(GO:1990037)
0.2 5.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.2 514.4 GO:0005615 extracellular space(GO:0005615)
0.2 2.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 1.9 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.2 4.3 GO:0031143 pseudopodium(GO:0031143)
0.2 13.1 GO:0008180 COP9 signalosome(GO:0008180)
0.2 1.4 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.2 3.7 GO:0001726 ruffle(GO:0001726)
0.2 1.5 GO:0032009 early phagosome(GO:0032009)
0.2 7.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 4.2 GO:0035102 PRC1 complex(GO:0035102)
0.2 1.5 GO:0046930 pore complex(GO:0046930)
0.2 9.4 GO:0008305 integrin complex(GO:0008305)
0.2 1.7 GO:0071438 invadopodium membrane(GO:0071438)
0.2 5.8 GO:0016580 Sin3 complex(GO:0016580)
0.2 1.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 1.1 GO:0030863 cortical cytoskeleton(GO:0030863)
0.2 1.1 GO:0042584 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.2 35.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2 4.0 GO:0042629 mast cell granule(GO:0042629)
0.2 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.1 GO:0060187 cell pole(GO:0060187)
0.1 0.9 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 1.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 9.4 GO:0000786 nucleosome(GO:0000786)
0.1 0.4 GO:0042565 RNA nuclear export complex(GO:0042565)
0.1 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.6 GO:0032301 MutSalpha complex(GO:0032301)
0.1 3.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 1.5 GO:0036157 outer dynein arm(GO:0036157)
0.1 11.5 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 0.7 GO:0098536 deuterosome(GO:0098536)
0.1 0.3 GO:0097447 dendritic tree(GO:0097447)
0.1 6.8 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.9 GO:0035976 AP1 complex(GO:0035976)
0.1 8.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.5 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.1 0.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 3.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 11.3 GO:0043204 perikaryon(GO:0043204)
0.1 7.7 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 12.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.5 GO:0030426 growth cone(GO:0030426)
0.1 4.1 GO:0031519 PcG protein complex(GO:0031519)
0.1 1.0 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.7 GO:0033263 CORVET complex(GO:0033263)
0.1 0.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.8 GO:0042589 zymogen granule(GO:0042588) zymogen granule membrane(GO:0042589)
0.1 1.7 GO:0000346 transcription export complex(GO:0000346)
0.1 0.5 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.9 GO:0000145 exocyst(GO:0000145)
0.1 2.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 3.8 GO:0016235 aggresome(GO:0016235)
0.1 0.6 GO:0016589 NURF complex(GO:0016589)
0.1 0.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.6 GO:0042382 paraspeckles(GO:0042382)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)
0.1 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 1.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 292.4 GO:0005576 extracellular region(GO:0005576)
0.1 5.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.3 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 0.2 GO:0000811 GINS complex(GO:0000811)
0.0 3.3 GO:0043235 receptor complex(GO:0043235)
0.0 1.1 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 1.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 1.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.0 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.7 GO:0031094 platelet dense tubular network(GO:0031094) platelet dense tubular network membrane(GO:0031095)
0.0 2.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664)
0.0 1.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.9 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 3.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 39.1 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 2.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.7 GO:0043596 site of double-strand break(GO:0035861) nuclear replication fork(GO:0043596)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0042581 specific granule(GO:0042581)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 32.0 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
5.9 386.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
5.6 1239.3 GO:0003823 antigen binding(GO:0003823)
2.8 14.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
1.9 30.9 GO:0046625 sphingolipid binding(GO:0046625)
1.9 9.6 GO:0042806 fucose binding(GO:0042806)
1.4 5.6 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
1.4 4.2 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
1.2 15.0 GO:0051525 NFAT protein binding(GO:0051525)
1.1 11.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
1.0 12.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.0 22.4 GO:0005344 oxygen transporter activity(GO:0005344)
1.0 2.9 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.9 1.8 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.9 22.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.8 4.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.7 6.0 GO:0071723 lipopeptide binding(GO:0071723)
0.7 6.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.7 18.4 GO:0050700 CARD domain binding(GO:0050700)
0.7 2.8 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.7 2.7 GO:0052642 lysophosphatidic acid phosphatase activity(GO:0052642)
0.7 2.6 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.6 13.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.6 2.5 GO:0001026 TFIIIB-type transcription factor activity(GO:0001026)
0.6 7.3 GO:0008142 oxysterol binding(GO:0008142)
0.6 16.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.6 19.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.6 3.9 GO:0033613 activating transcription factor binding(GO:0033613)
0.5 1.6 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.5 1.6 GO:0004170 dUTP diphosphatase activity(GO:0004170)
0.5 4.3 GO:0015057 thrombin receptor activity(GO:0015057)
0.5 4.8 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.5 4.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.5 2.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.5 2.0 GO:0050308 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) phosphofructokinase activity(GO:0008443) carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.5 2.0 GO:0019862 IgA binding(GO:0019862)
0.5 1.5 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) DNA/RNA helicase activity(GO:0033677)
0.5 3.4 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.5 3.3 GO:0016160 amylase activity(GO:0016160)
0.5 1.4 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.5 4.6 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.5 1.8 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.4 7.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.4 2.6 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.4 2.8 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.4 1.2 GO:0004145 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.4 1.2 GO:0003878 ATP citrate synthase activity(GO:0003878)
0.4 8.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.3 2.4 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.3 1.7 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.3 7.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 1.0 GO:0042007 interleukin-18 binding(GO:0042007)
0.3 35.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 2.5 GO:0004771 sterol esterase activity(GO:0004771)
0.3 3.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.3 2.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.3 2.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.3 3.7 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.3 6.1 GO:0005522 profilin binding(GO:0005522)
0.3 0.8 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.3 8.8 GO:0019992 diacylglycerol binding(GO:0019992)
0.3 1.8 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.3 0.8 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.2 1.2 GO:0097100 supercoiled DNA binding(GO:0097100)
0.2 7.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 6.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 1.7 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.2 8.3 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 0.9 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.2 0.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 1.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.2 0.6 GO:0031628 opioid receptor binding(GO:0031628)
0.2 1.0 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.2 6.0 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.2 0.8 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.2 6.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 9.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 1.2 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.2 1.1 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.2 1.7 GO:0045545 syndecan binding(GO:0045545)
0.2 1.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 0.4 GO:0032427 GBD domain binding(GO:0032427)
0.2 3.9 GO:0051400 BH domain binding(GO:0051400)
0.2 1.5 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.2 1.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.2 3.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 3.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 1.0 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.2 2.9 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.2 0.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 1.5 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 0.5 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.2 0.7 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.2 1.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 1.0 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 1.6 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 0.9 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 1.8 GO:0035325 Toll-like receptor binding(GO:0035325)
0.1 2.4 GO:0045159 myosin II binding(GO:0045159)
0.1 0.6 GO:0004967 glucagon receptor activity(GO:0004967)
0.1 3.3 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.7 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.1 6.7 GO:0042287 MHC protein binding(GO:0042287)
0.1 4.6 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 6.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.9 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.5 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.1 1.5 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 0.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.4 GO:0090631 pre-miRNA transporter activity(GO:0090631)
0.1 2.1 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.6 GO:0032143 single thymine insertion binding(GO:0032143)
0.1 0.5 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 1.2 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 1.7 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 2.5 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 0.7 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.1 2.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 1.0 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 1.4 GO:0003712 transcription cofactor activity(GO:0003712)
0.1 0.3 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.1 0.8 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1 1.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.5 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.1 3.8 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 2.7 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.5 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.1 1.6 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 1.1 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.6 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 2.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.6 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 2.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 3.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 1.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.5 GO:0045503 dynein light chain binding(GO:0045503)
0.1 1.0 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.7 GO:0004064 arylesterase activity(GO:0004064)
0.1 3.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.4 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.4 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 2.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.5 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.1 3.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 3.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 3.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.5 GO:0048037 cofactor binding(GO:0048037)
0.1 3.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.5 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 0.4 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 1.4 GO:0000150 recombinase activity(GO:0000150)
0.1 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.2 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 0.2 GO:0047291 neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.1 0.7 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 2.1 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.7 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 3.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.9 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.2 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.1 0.7 GO:0019956 chemokine binding(GO:0019956)
0.1 5.0 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.5 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.3 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.2 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 1.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 0.2 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.1 0.4 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.1 0.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 1.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 18.8 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 3.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 1.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.4 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 2.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.5 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.2 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 1.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 5.4 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.7 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.8 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 8.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.0 1.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.4 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 4.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:1990948 5S rRNA binding(GO:0008097) ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.0 0.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 1.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.0 0.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.3 GO:0042731 PH domain binding(GO:0042731)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 3.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.7 GO:0004871 signal transducer activity(GO:0004871)
0.0 0.1 GO:0016768 spermine synthase activity(GO:0016768)
0.0 0.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.5 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 1.0 GO:0030332 cyclin binding(GO:0030332)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.8 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.4 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.2 GO:0008047 enzyme activator activity(GO:0008047)
0.0 0.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.0 GO:0017016 Ras GTPase binding(GO:0017016)
0.0 0.1 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 55.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.8 2.3 PID REELIN PATHWAY Reelin signaling pathway
0.6 20.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5 25.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.5 55.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.4 28.4 PID BCR 5PATHWAY BCR signaling pathway
0.4 16.8 PID IL27 PATHWAY IL27-mediated signaling events
0.3 10.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 2.8 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.2 4.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 19.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 10.0 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.2 1.5 PID IL5 PATHWAY IL5-mediated signaling events
0.2 6.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 9.5 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.2 5.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 1.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 0.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 2.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.4 ST GA12 PATHWAY G alpha 12 Pathway
0.1 5.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.6 PID IL23 PATHWAY IL23-mediated signaling events
0.1 4.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 6.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 3.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 15.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.1 0.7 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 3.6 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 3.1 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 1.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 2.1 PID CONE PATHWAY Visual signal transduction: Cones
0.1 18.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 0.9 PID IFNG PATHWAY IFN-gamma pathway
0.1 3.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 6.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 1.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 3.0 PID BARD1 PATHWAY BARD1 signaling events
0.0 6.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 3.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 2.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 1.7 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 2.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.7 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.0 PID ENDOTHELIN PATHWAY Endothelins
0.0 2.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.2 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.3 PID ALK1 PATHWAY ALK1 signaling events
0.0 5.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.1 PID FOXO PATHWAY FoxO family signaling
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 1.0 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.8 3.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.6 27.1 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.5 40.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.5 10.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 38.7 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.4 23.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.3 8.0 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.3 11.0 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.3 4.0 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.2 6.0 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.2 14.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 4.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 7.4 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.2 4.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 5.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 9.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 10.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 3.8 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.2 1.7 REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES Genes involved in Transmission across Chemical Synapses
0.2 22.6 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 9.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 7.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 13.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.5 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 1.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.8 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.1 0.8 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 4.4 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.5 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 29.4 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 5.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 4.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.9 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 3.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 28.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 3.4 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 1.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 0.6 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.1 4.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 9.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 1.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.1 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.1 3.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 1.9 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 6.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.0 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 0.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 5.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.0 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 2.2 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 0.5 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 3.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.5 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 3.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 4.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.5 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 6.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 2.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 6.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.8 REACTOME SIGNALING BY WNT Genes involved in Signaling by Wnt
0.0 1.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.1 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 1.2 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.9 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.4 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.0 0.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.3 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 1.0 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.3 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.2 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME SIGNALING BY NOTCH Genes involved in Signaling by NOTCH
0.0 0.8 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.8 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.1 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.5 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 1.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.1 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants