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Illumina Body Map 2, young vs old

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Results for PRDM14

Z-value: 0.08

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.3 PR/SET domain 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg19_v2_chr8_-_70983506_709835620.038.8e-01Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_41924511 1.10 ENST00000377203.4
ENST00000539718.1
ENST00000588884.1
ENST00000293396.8
ENST00000586233.1
CD300LG
CD300 molecule-like family member g
chr17_+_41924536 1.04 ENST00000317310.4
CD300LG
CD300 molecule-like family member g
chr17_-_46692287 0.93 ENST00000239144.4
HOXB8
homeobox B8
chr17_-_46691990 0.58 ENST00000576562.1
HOXB8
homeobox B8
chr6_-_46048116 0.50 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr4_-_10459009 0.49 ENST00000507515.1
ZNF518B
zinc finger protein 518B
chr2_-_192711968 0.48 ENST00000304141.4
SDPR
serum deprivation response
chr1_+_36621174 0.48 ENST00000429533.2
MAP7D1
MAP7 domain containing 1
chr1_+_36621529 0.43 ENST00000316156.4
MAP7D1
MAP7 domain containing 1
chr3_-_134092561 0.32 ENST00000510560.1
ENST00000504234.1
ENST00000515172.1
AMOTL2
angiomotin like 2
chr17_-_19651668 0.31 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_+_36873677 0.31 ENST00000471200.1
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr11_+_64879317 0.31 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
TM7SF2
transmembrane 7 superfamily member 2
chr14_-_54425475 0.29 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr4_-_10458982 0.29 ENST00000326756.3
ZNF518B
zinc finger protein 518B
chr1_+_156052354 0.26 ENST00000368301.2
LMNA
lamin A/C
chr2_-_228244013 0.26 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr5_+_32711419 0.25 ENST00000265074.8
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chrX_+_15525426 0.25 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr4_+_141677577 0.24 ENST00000609937.1
RP11-102N12.3
RP11-102N12.3
chr6_-_109777128 0.23 ENST00000358807.3
ENST00000358577.3
MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr2_-_145278475 0.23 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr17_-_19651654 0.23 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_-_17485731 0.21 ENST00000395783.1
PEMT
phosphatidylethanolamine N-methyltransferase
chr19_+_3572758 0.19 ENST00000416526.1
HMG20B
high mobility group 20B
chr17_-_2117600 0.19 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor
chr8_+_101349823 0.19 ENST00000519566.1
KB-1991G8.1
KB-1991G8.1
chr1_-_33642151 0.19 ENST00000543586.1
TRIM62
tripartite motif containing 62
chr17_-_46692457 0.18 ENST00000468443.1
HOXB8
homeobox B8
chr5_+_32710736 0.18 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr19_-_5624057 0.18 ENST00000590262.1
SAFB2
scaffold attachment factor B2
chr3_+_155838337 0.17 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr2_-_145277882 0.17 ENST00000465070.1
ENST00000444559.1
ZEB2
zinc finger E-box binding homeobox 2
chr1_+_155006300 0.17 ENST00000295542.1
ENST00000392480.1
ENST00000423025.2
ENST00000368419.2
DCST1
DC-STAMP domain containing 1
chr17_-_19651598 0.16 ENST00000570414.1
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr7_+_150211918 0.15 ENST00000313543.4
GIMAP7
GTPase, IMAP family member 7
chr19_-_49314269 0.14 ENST00000545387.2
ENST00000316273.6
ENST00000402551.1
ENST00000598162.1
ENST00000599246.1
BCAT2
branched chain amino-acid transaminase 2, mitochondrial
chr12_-_76742183 0.14 ENST00000393262.3
BBS10
Bardet-Biedl syndrome 10
chr5_-_135528822 0.13 ENST00000607574.1
AC009014.3
AC009014.3
chr9_+_87283430 0.13 ENST00000376214.1
ENST00000376213.1
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr3_-_143567262 0.12 ENST00000474151.1
ENST00000316549.6
SLC9A9
solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9
chr17_-_73775839 0.12 ENST00000592643.1
ENST00000591890.1
ENST00000587171.1
ENST00000254810.4
ENST00000589599.1
H3F3B
H3 histone, family 3B (H3.3B)
chr2_+_113033164 0.12 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr11_-_62439727 0.11 ENST00000528862.1
C11orf48
chromosome 11 open reading frame 48
chr19_-_49314169 0.10 ENST00000597011.1
ENST00000601681.1
BCAT2
branched chain amino-acid transaminase 2, mitochondrial
chr4_+_4861385 0.10 ENST00000382723.4
MSX1
msh homeobox 1
chr20_-_48770174 0.09 ENST00000341698.2
TMEM189-UBE2V1
TMEM189-UBE2V1 readthrough
chr11_-_105892937 0.09 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4
Myb/SANT-like DNA-binding domain containing 4 with coiled-coils
chr6_+_43140095 0.09 ENST00000457278.2
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr3_+_16926441 0.09 ENST00000418129.2
ENST00000396755.2
PLCL2
phospholipase C-like 2
chr7_-_140714739 0.09 ENST00000467334.1
ENST00000324787.5
MRPS33
mitochondrial ribosomal protein S33
chr14_+_89290965 0.09 ENST00000345383.5
ENST00000536576.1
ENST00000346301.4
ENST00000338104.6
ENST00000354441.6
ENST00000380656.2
ENST00000556651.1
ENST00000554686.1
TTC8
tetratricopeptide repeat domain 8
chr3_+_37035289 0.08 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr9_+_132099158 0.08 ENST00000444125.1
RP11-65J3.1
RP11-65J3.1
chr7_-_140714430 0.08 ENST00000393008.3
MRPS33
mitochondrial ribosomal protein S33
chr6_+_133561725 0.08 ENST00000452339.2
EYA4
eyes absent homolog 4 (Drosophila)
chr11_-_46615498 0.08 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy/beclin-1 regulator 1
chr12_-_124456598 0.07 ENST00000539761.1
ENST00000539551.1
CCDC92
coiled-coil domain containing 92
chr5_-_108063949 0.07 ENST00000606054.1
LINC01023
long intergenic non-protein coding RNA 1023
chr8_+_110346546 0.06 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
ENY2
enhancer of yellow 2 homolog (Drosophila)
chr1_-_31845914 0.06 ENST00000373713.2
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr17_+_75450075 0.06 ENST00000592951.1
SEPT9
septin 9
chrX_+_41193407 0.06 ENST00000457138.2
ENST00000441189.2
DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr19_+_39109735 0.06 ENST00000593149.1
ENST00000248342.4
ENST00000538434.1
ENST00000588934.1
ENST00000545173.2
ENST00000589307.1
ENST00000586513.1
ENST00000591409.1
ENST00000592558.1
EIF3K
eukaryotic translation initiation factor 3, subunit K
chr5_-_55777586 0.05 ENST00000506836.1
CTC-236F12.4
Uncharacterized protein
chr2_-_208030295 0.05 ENST00000458272.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr3_-_47517302 0.05 ENST00000441517.2
ENST00000545718.1
SCAP
SREBF chaperone
chr2_-_208030647 0.05 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr3_+_10289707 0.05 ENST00000287652.4
TATDN2
TatD DNase domain containing 2
chr12_-_56326402 0.04 ENST00000547925.1
WIBG
within bgcn homolog (Drosophila)
chr8_-_102216925 0.04 ENST00000517844.1
ZNF706
zinc finger protein 706
chr3_+_37035263 0.04 ENST00000458205.2
ENST00000539477.1
MLH1
mutL homolog 1
chr12_-_49351303 0.04 ENST00000256682.4
ARF3
ADP-ribosylation factor 3
chr12_-_49351228 0.04 ENST00000541959.1
ENST00000447318.2
ARF3
ADP-ribosylation factor 3
chr17_+_75450146 0.04 ENST00000585929.1
ENST00000590917.1
SEPT9
septin 9
chr9_-_125148928 0.03 ENST00000600713.1
AL162424.1
Uncharacterized protein
chr1_+_153963227 0.03 ENST00000368567.4
ENST00000392558.4
RPS27
ribosomal protein S27
chr7_+_39989611 0.03 ENST00000181839.4
CDK13
cyclin-dependent kinase 13
chr17_+_75450099 0.03 ENST00000586433.1
SEPT9
septin 9
chr7_-_30066233 0.03 ENST00000222803.5
FKBP14
FK506 binding protein 14, 22 kDa
chr1_+_45274154 0.03 ENST00000450269.1
ENST00000453418.1
ENST00000409335.2
BTBD19
BTB (POZ) domain containing 19
chr17_+_47653178 0.03 ENST00000328741.5
NXPH3
neurexophilin 3
chr13_-_34250861 0.03 ENST00000445227.1
ENST00000454681.2
RP11-141M1.3
RP11-141M1.3
chr15_+_45694567 0.03 ENST00000559860.1
SPATA5L1
spermatogenesis associated 5-like 1
chr14_-_21492251 0.02 ENST00000554398.1
NDRG2
NDRG family member 2
chr19_-_53757941 0.02 ENST00000594517.1
ENST00000601413.1
ENST00000594681.1
ZNF677
zinc finger protein 677
chr2_-_37193606 0.02 ENST00000379213.2
ENST00000263918.4
STRN
striatin, calmodulin binding protein
chr1_-_42384343 0.01 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr15_+_45694523 0.01 ENST00000305560.6
SPATA5L1
spermatogenesis associated 5-like 1
chr2_-_208030886 0.01 ENST00000426163.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_+_65730385 0.01 ENST00000263441.7
ENST00000395325.3
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr17_+_39994032 0.01 ENST00000293303.4
ENST00000438813.1
KLHL10
kelch-like family member 10
chr19_-_6279932 0.00 ENST00000252674.7
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.1 0.2 GO:0006550 isoleucine catabolic process(GO:0006550)
0.1 0.2 GO:0019417 sulfur oxidation(GO:0019417)
0.1 0.3 GO:0048391 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.3 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0 1.7 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:0043060 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.1 GO:0090427 activation of meiosis(GO:0090427)
0.0 0.1 GO:0060532 bronchus cartilage development(GO:0060532) lung smooth muscle development(GO:0061145)
0.0 0.1 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.4 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.2 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.1 GO:0099551 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.0 0.2 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.2 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 0.1 GO:0050893 sensory processing(GO:0050893)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.1 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.2 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.3 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.0 GO:0002945 cyclin K-CDK13 complex(GO:0002945)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.2 GO:0080101 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.1 2.1 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.2 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.1 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0 0.1 GO:0070538 oleic acid binding(GO:0070538)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0010736 serum response element binding(GO:0010736)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)