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Illumina Body Map 2, young vs old

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Results for PRDM4

Z-value: 0.43

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Transcription factors associated with PRDM4

Gene Symbol Gene ID Gene Info
PRDM4
ENSG00000110851.7 PR/SET domain 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM4hg19_v2_chr12_-_108154925_1081549450.412.0e-02Click!

Activity profile of PRDM4 motif

Sorted Z-values of PRDM4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_73072534 2.42 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr9_-_127263265 1.73 ENST00000373587.3
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr17_+_42634844 1.26 ENST00000315323.3
FZD2
frizzled family receptor 2
chr9_-_16727978 1.08 ENST00000418777.1
ENST00000468187.2
BNC2
basonuclin 2
chr19_+_41117770 1.05 ENST00000601032.1
LTBP4
latent transforming growth factor beta binding protein 4
chr1_+_55107449 1.01 ENST00000421030.2
ENST00000545244.1
ENST00000339553.5
ENST00000409996.1
ENST00000454855.2
MROH7
maestro heat-like repeat family member 7
chr7_+_90893783 1.01 ENST00000287934.2
FZD1
frizzled family receptor 1
chr4_+_2451700 0.77 ENST00000506607.1
RP11-503N18.3
Uncharacterized protein
chr1_+_6511651 0.68 ENST00000434576.1
ESPN
espin
chr1_+_55107489 0.66 ENST00000395690.2
MROH7
maestro heat-like repeat family member 7
chr1_-_68516393 0.56 ENST00000395201.1
DIRAS3
DIRAS family, GTP-binding RAS-like 3
chr3_-_169381166 0.54 ENST00000486748.1
MECOM
MDS1 and EVI1 complex locus
chr2_-_179343226 0.52 ENST00000434643.2
FKBP7
FK506 binding protein 7
chr20_-_49639631 0.51 ENST00000424171.1
ENST00000439216.1
ENST00000371571.4
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr19_-_49371711 0.51 ENST00000355496.5
ENST00000263265.6
PLEKHA4
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr13_+_52436111 0.51 ENST00000242819.4
CCDC70
coiled-coil domain containing 70
chr1_+_172502336 0.50 ENST00000263688.3
SUCO
SUN domain containing ossification factor
chr8_-_135652051 0.47 ENST00000522257.1
ZFAT
zinc finger and AT hook domain containing
chr1_+_172502244 0.44 ENST00000610051.1
SUCO
SUN domain containing ossification factor
chr2_-_179343268 0.43 ENST00000424785.2
FKBP7
FK506 binding protein 7
chr22_+_38864041 0.42 ENST00000216014.4
ENST00000409006.3
KDELR3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr19_-_53636125 0.39 ENST00000601493.1
ENST00000599261.1
ENST00000597503.1
ENST00000500065.4
ENST00000243643.4
ENST00000594011.1
ENST00000455735.2
ENST00000595193.1
ENST00000448501.1
ENST00000421033.1
ENST00000440291.1
ENST00000595813.1
ENST00000600574.1
ENST00000596051.1
ENST00000601110.1
ZNF415
zinc finger protein 415
chr11_-_441964 0.36 ENST00000332826.6
ANO9
anoctamin 9
chr10_+_88728189 0.35 ENST00000416348.1
ADIRF
adipogenesis regulatory factor
chr14_+_105953246 0.31 ENST00000392531.3
CRIP1
cysteine-rich protein 1 (intestinal)
chr17_+_7788104 0.29 ENST00000380358.4
CHD3
chromodomain helicase DNA binding protein 3
chr1_-_43232649 0.29 ENST00000372526.2
ENST00000236040.4
ENST00000296388.5
ENST00000397054.3
LEPRE1
leucine proline-enriched proteoglycan (leprecan) 1
chr19_-_35264089 0.28 ENST00000588760.1
ENST00000329285.8
ENST00000587354.2
ZNF599
zinc finger protein 599
chr14_+_105953204 0.28 ENST00000409393.2
CRIP1
cysteine-rich protein 1 (intestinal)
chr2_+_219264762 0.25 ENST00000452977.1
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr20_-_61569227 0.24 ENST00000266070.4
ENST00000395335.2
ENST00000266071.5
DIDO1
death inducer-obliterator 1
chr14_+_64565442 0.23 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr1_+_27114418 0.22 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr5_+_102455968 0.22 ENST00000358359.3
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr16_+_88636875 0.21 ENST00000569435.1
ZC3H18
zinc finger CCCH-type containing 18
chr8_+_94712752 0.20 ENST00000522324.1
ENST00000522803.1
ENST00000423990.2
FAM92A1
family with sequence similarity 92, member A1
chr8_+_94712732 0.20 ENST00000518322.1
FAM92A1
family with sequence similarity 92, member A1
chr22_-_39636914 0.20 ENST00000381551.4
PDGFB
platelet-derived growth factor beta polypeptide
chr11_+_19138670 0.20 ENST00000446113.2
ENST00000399351.3
ZDHHC13
zinc finger, DHHC-type containing 13
chr11_+_8040739 0.20 ENST00000534099.1
TUB
tubby bipartite transcription factor
chr1_+_151043070 0.19 ENST00000368918.3
ENST00000368917.1
GABPB2
GA binding protein transcription factor, beta subunit 2
chr7_-_23571586 0.19 ENST00000538367.1
ENST00000392502.4
ENST00000297071.4
TRA2A
transformer 2 alpha homolog (Drosophila)
chr2_+_219264466 0.18 ENST00000273062.2
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr20_-_49639612 0.17 ENST00000396017.3
ENST00000433903.1
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr10_-_105212141 0.17 ENST00000369788.3
CALHM2
calcium homeostasis modulator 2
chr6_-_8064567 0.16 ENST00000543936.1
ENST00000397457.2
BLOC1S5
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr6_+_26045603 0.16 ENST00000540144.1
HIST1H3C
histone cluster 1, H3c
chr5_-_180688105 0.16 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr9_+_17135016 0.15 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
CNTLN
centlein, centrosomal protein
chr20_-_61569296 0.15 ENST00000370371.4
DIDO1
death inducer-obliterator 1
chr16_+_15068831 0.14 ENST00000535621.2
ENST00000566426.1
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr8_+_81397846 0.14 ENST00000379091.4
ZBTB10
zinc finger and BTB domain containing 10
chr5_+_102455853 0.14 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr11_+_58910295 0.14 ENST00000420244.1
FAM111A
family with sequence similarity 111, member A
chr16_+_15068955 0.13 ENST00000396410.4
ENST00000569715.1
ENST00000450288.2
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr5_-_102455801 0.13 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr16_+_15068916 0.13 ENST00000455313.2
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr19_+_42724423 0.13 ENST00000301215.3
ENST00000597945.1
ZNF526
zinc finger protein 526
chr4_-_83295103 0.10 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr16_+_88636789 0.10 ENST00000301011.5
ENST00000452588.2
ZC3H18
zinc finger CCCH-type containing 18
chr1_+_27114589 0.10 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr12_+_15475331 0.10 ENST00000281171.4
PTPRO
protein tyrosine phosphatase, receptor type, O
chr20_+_58296265 0.10 ENST00000395636.2
ENST00000361300.4
PHACTR3
phosphatase and actin regulator 3
chr12_+_15475462 0.09 ENST00000543886.1
ENST00000348962.2
PTPRO
protein tyrosine phosphatase, receptor type, O
chr1_+_16865561 0.09 ENST00000601199.1
AL355149.2
family with sequence similarity 231, member B
chr6_-_24721054 0.09 ENST00000378119.4
C6orf62
chromosome 6 open reading frame 62
chr20_+_62697564 0.08 ENST00000458442.1
TCEA2
transcription elongation factor A (SII), 2
chr15_+_74287035 0.08 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr5_+_159343688 0.07 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr12_+_50794947 0.07 ENST00000552445.1
LARP4
La ribonucleoprotein domain family, member 4
chr1_+_54359854 0.07 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
DIO1
deiodinase, iodothyronine, type I
chr11_+_47279504 0.06 ENST00000441012.2
ENST00000437276.1
ENST00000436029.1
ENST00000467728.1
ENST00000405853.3
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr7_+_143079000 0.05 ENST00000392910.2
ZYX
zyxin
chr4_-_83295296 0.05 ENST00000507010.1
ENST00000503822.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr5_-_61031495 0.04 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2
CTD-2170G1.2
chr1_+_27113963 0.04 ENST00000430292.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chrX_+_15808569 0.04 ENST00000380308.3
ENST00000307771.7
ZRSR2
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
chr20_+_61569463 0.04 ENST00000266069.3
GID8
GID complex subunit 8
chr9_-_70488865 0.04 ENST00000377392.5
CBWD5
COBW domain containing 5
chr9_+_96338647 0.03 ENST00000359246.4
PHF2
PHD finger protein 2
chr8_+_91952750 0.03 ENST00000521366.1
NECAB1
N-terminal EF-hand calcium binding protein 1
chr7_+_143078652 0.02 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr16_+_29823427 0.02 ENST00000358758.7
ENST00000567659.1
ENST00000572820.1
PRRT2
proline-rich transmembrane protein 2
chr14_+_32030582 0.02 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr16_+_29823552 0.02 ENST00000300797.6
PRRT2
proline-rich transmembrane protein 2
chr2_-_151905288 0.01 ENST00000409243.1
AC023469.1
HCG1817310; Uncharacterized protein
chr12_+_69979446 0.01 ENST00000543146.2
CCT2
chaperonin containing TCP1, subunit 2 (beta)

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0007538 primary sex determination(GO:0007538)
0.3 1.0 GO:0035425 autocrine signaling(GO:0035425)
0.1 0.4 GO:0010360 negative regulation of anion channel activity(GO:0010360) negative regulation of chloride transport(GO:2001226)
0.1 0.6 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.1 1.3 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.1 0.2 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 0.2 GO:1904586 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828)
0.1 0.2 GO:1905176 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.0 0.7 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.0 0.3 GO:0072719 cellular response to cisplatin(GO:0072719) regulation of response to drug(GO:2001023)
0.0 0.4 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 1.1 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.2 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 1.0 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.7 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.6 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.0 1.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.5 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.1 GO:0030578 PML body organization(GO:0030578)
0.0 0.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.0 0.5 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:1990909 Wnt signalosome(GO:1990909)
0.1 0.4 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.7 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.9 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 1.3 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 2.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.4 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 1.1 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.7 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 1.8 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0017147 Wnt-protein binding(GO:0017147)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)