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Illumina Body Map 2, young vs old

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Results for REL

Z-value: 0.36

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Transcription factors associated with REL

Gene Symbol Gene ID Gene Info
REL
ENSG00000162924.9 REL proto-oncogene, NF-kB subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RELhg19_v2_chr2_+_61108771_611087910.154.1e-01Click!

Activity profile of REL motif

Sorted Z-values of REL motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_90077680 4.86 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr2_+_90153696 3.98 ENST00000417279.2
IGKV3D-15
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr22_+_22712087 3.97 ENST00000390294.2
IGLV1-47
immunoglobulin lambda variable 1-47
chr22_-_19512893 3.74 ENST00000403084.1
ENST00000413119.2
CLDN5
claudin 5
chr2_-_89247338 3.72 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr6_+_138188378 3.47 ENST00000420009.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr14_-_106610852 3.47 ENST00000390603.2
IGHV3-15
immunoglobulin heavy variable 3-15
chr2_-_89310012 3.44 ENST00000493819.1
IGKV1-9
immunoglobulin kappa variable 1-9
chr8_-_23712312 3.36 ENST00000290271.2
STC1
stanniocalcin 1
chr6_+_138188351 3.16 ENST00000421450.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr19_-_6591113 3.05 ENST00000423145.3
ENST00000245903.3
CD70
CD70 molecule
chr6_+_138188551 3.00 ENST00000237289.4
ENST00000433680.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr7_-_16844611 2.67 ENST00000401412.1
ENST00000419304.2
AGR2
anterior gradient 2
chr10_-_97050777 2.56 ENST00000329399.6
PDLIM1
PDZ and LIM domain 1
chr10_+_89419370 2.45 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr2_+_228678550 2.44 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr12_-_9913489 2.42 ENST00000228434.3
ENST00000536709.1
CD69
CD69 molecule
chr10_+_30723045 2.42 ENST00000542547.1
ENST00000415139.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr22_+_22676808 2.36 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr2_+_87808725 2.30 ENST00000413202.1
LINC00152
long intergenic non-protein coding RNA 152
chr19_-_46272106 2.26 ENST00000560168.1
SIX5
SIX homeobox 5
chr17_-_73511504 2.22 ENST00000581870.1
CASKIN2
CASK interacting protein 2
chr9_+_101705893 2.21 ENST00000375001.3
COL15A1
collagen, type XV, alpha 1
chr6_-_29527702 2.16 ENST00000377050.4
UBD
ubiquitin D
chr9_-_117880477 2.10 ENST00000534839.1
ENST00000340094.3
ENST00000535648.1
ENST00000346706.3
ENST00000345230.3
ENST00000350763.4
TNC
tenascin C
chr10_+_30722866 2.07 ENST00000263056.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr20_+_43803517 2.03 ENST00000243924.3
PI3
peptidase inhibitor 3, skin-derived
chr9_+_72658490 1.96 ENST00000377182.4
MAMDC2
MAM domain containing 2
chr18_+_21529811 1.92 ENST00000588004.1
LAMA3
laminin, alpha 3
chr15_-_20193370 1.88 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr11_-_5271122 1.84 ENST00000330597.3
HBG1
hemoglobin, gamma A
chr5_-_138842286 1.83 ENST00000515823.1
ECSCR
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr3_-_112360116 1.83 ENST00000206423.3
ENST00000439685.2
CCDC80
coiled-coil domain containing 80
chr3_-_168864315 1.77 ENST00000475754.1
ENST00000484519.1
MECOM
MDS1 and EVI1 complex locus
chr17_-_73511584 1.73 ENST00000321617.3
CASKIN2
CASK interacting protein 2
chr12_+_102271436 1.68 ENST00000544152.1
DRAM1
DNA-damage regulated autophagy modulator 1
chr10_-_6104253 1.61 ENST00000256876.6
ENST00000379954.1
ENST00000379959.3
IL2RA
interleukin 2 receptor, alpha
chr11_+_102188224 1.59 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr14_+_103589789 1.59 ENST00000558056.1
ENST00000560869.1
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr11_+_102188272 1.59 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr16_-_88717482 1.56 ENST00000261623.3
CYBA
cytochrome b-245, alpha polypeptide
chr6_-_31550192 1.55 ENST00000429299.2
ENST00000446745.2
LTB
lymphotoxin beta (TNF superfamily, member 3)
chr18_+_3252265 1.55 ENST00000580887.1
ENST00000536605.1
MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chrX_-_153599578 1.54 ENST00000360319.4
ENST00000344736.4
FLNA
filamin A, alpha
chr13_-_29069232 1.54 ENST00000282397.4
ENST00000541932.1
ENST00000539099.1
FLT1
fms-related tyrosine kinase 1
chr19_-_46272462 1.54 ENST00000317578.6
SIX5
SIX homeobox 5
chr1_-_159894319 1.54 ENST00000320307.4
TAGLN2
transgelin 2
chr4_+_74735102 1.53 ENST00000395761.3
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr1_-_113249948 1.52 ENST00000339083.7
ENST00000369642.3
RHOC
ras homolog family member C
chr1_-_29508321 1.50 ENST00000546138.1
SRSF4
serine/arginine-rich splicing factor 4
chr22_+_37318082 1.49 ENST00000406230.1
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr19_+_41725140 1.48 ENST00000359092.3
AXL
AXL receptor tyrosine kinase
chr11_-_128392085 1.46 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr5_+_118604385 1.43 ENST00000274456.6
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr20_+_44746939 1.43 ENST00000372276.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr1_-_204436344 1.43 ENST00000367184.2
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr4_-_76957214 1.41 ENST00000306621.3
CXCL11
chemokine (C-X-C motif) ligand 11
chr12_+_53491220 1.39 ENST00000548547.1
ENST00000301464.3
IGFBP6
insulin-like growth factor binding protein 6
chr12_-_7281469 1.38 ENST00000542370.1
ENST00000266560.3
RBP5
retinol binding protein 5, cellular
chr22_-_24181174 1.38 ENST00000318109.7
ENST00000406855.3
ENST00000404056.1
ENST00000476077.1
DERL3
derlin 3
chr22_+_46546406 1.37 ENST00000440343.1
ENST00000415785.1
PPARA
peroxisome proliferator-activated receptor alpha
chr1_+_201979743 1.35 ENST00000446188.1
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr12_+_50497784 1.35 ENST00000548814.1
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr19_+_41725088 1.34 ENST00000301178.4
AXL
AXL receptor tyrosine kinase
chr12_-_77272765 1.32 ENST00000547435.1
ENST00000552330.1
ENST00000546966.1
ENST00000311083.5
CSRP2
cysteine and glycine-rich protein 2
chr20_+_44746885 1.31 ENST00000372285.3
CD40
CD40 molecule, TNF receptor superfamily member 5
chr8_-_119964434 1.30 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr8_-_49834299 1.29 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr18_+_21452964 1.29 ENST00000587184.1
LAMA3
laminin, alpha 3
chr12_+_102271129 1.29 ENST00000258534.8
DRAM1
DNA-damage regulated autophagy modulator 1
chr11_-_65359947 1.28 ENST00000597463.1
AP001362.1
Uncharacterized protein
chrX_-_17878827 1.27 ENST00000360011.1
RAI2
retinoic acid induced 2
chr7_+_143771275 1.26 ENST00000408898.2
OR2A25
olfactory receptor, family 2, subfamily A, member 25
chr19_-_47734448 1.25 ENST00000439096.2
BBC3
BCL2 binding component 3
chr15_+_33010175 1.23 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1
gremlin 1, DAN family BMP antagonist
chr10_+_104154229 1.23 ENST00000428099.1
ENST00000369966.3
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr5_-_141703713 1.22 ENST00000511815.1
SPRY4
sprouty homolog 4 (Drosophila)
chr5_-_150467221 1.21 ENST00000522226.1
TNIP1
TNFAIP3 interacting protein 1
chr4_-_74904398 1.20 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr19_-_17958771 1.20 ENST00000534444.1
JAK3
Janus kinase 3
chr16_+_31044812 1.20 ENST00000313843.3
STX4
syntaxin 4
chr16_-_88717423 1.18 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
CYBA
cytochrome b-245, alpha polypeptide
chr3_+_89156674 1.18 ENST00000336596.2
EPHA3
EPH receptor A3
chr10_+_30723105 1.17 ENST00000375322.2
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr1_+_201979645 1.17 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr17_-_76356148 1.15 ENST00000587578.1
ENST00000330871.2
SOCS3
suppressor of cytokine signaling 3
chr18_+_21452804 1.15 ENST00000269217.6
LAMA3
laminin, alpha 3
chr10_+_90750378 1.14 ENST00000355740.2
ENST00000352159.4
FAS
Fas cell surface death receptor
chr1_-_204380919 1.14 ENST00000367188.4
PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr10_+_104155450 1.12 ENST00000471698.1
ENST00000189444.6
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr5_-_115890554 1.11 ENST00000509665.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr3_+_89156799 1.10 ENST00000452448.2
ENST00000494014.1
EPHA3
EPH receptor A3
chr4_+_169418195 1.10 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr4_-_74864386 1.08 ENST00000296027.4
CXCL5
chemokine (C-X-C motif) ligand 5
chr3_+_101546827 1.08 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr8_-_49833978 1.07 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr19_+_14142535 1.07 ENST00000263379.2
IL27RA
interleukin 27 receptor, alpha
chr2_+_201987200 1.06 ENST00000425030.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr2_-_43453734 1.05 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr1_-_207143802 1.05 ENST00000324852.4
ENST00000400962.3
FCAMR
Fc receptor, IgA, IgM, high affinity
chr12_+_51632638 1.04 ENST00000549732.2
DAZAP2
DAZ associated protein 2
chr6_+_152126790 1.04 ENST00000456483.2
ESR1
estrogen receptor 1
chr4_+_169418255 1.03 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr15_-_51610687 1.03 ENST00000559646.1
CYP19A1
cytochrome P450, family 19, subfamily A, polypeptide 1
chr12_+_51632666 1.02 ENST00000604900.1
DAZAP2
DAZ associated protein 2
chr6_+_135502408 1.01 ENST00000341911.5
ENST00000442647.2
ENST00000316528.8
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr5_-_150466692 1.00 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
TNIP1
TNFAIP3 interacting protein 1
chr1_+_16767195 0.97 ENST00000504551.2
ENST00000457722.2
ENST00000406746.1
ENST00000443980.2
NECAP2
NECAP endocytosis associated 2
chr19_+_41222998 0.96 ENST00000263370.2
ITPKC
inositol-trisphosphate 3-kinase C
chr19_-_4338838 0.92 ENST00000594605.1
STAP2
signal transducing adaptor family member 2
chr2_+_202047843 0.91 ENST00000272879.5
ENST00000374650.3
ENST00000346817.5
ENST00000313728.7
ENST00000448480.1
CASP10
caspase 10, apoptosis-related cysteine peptidase
chr1_-_209824643 0.91 ENST00000391911.1
ENST00000415782.1
LAMB3
laminin, beta 3
chr12_-_57504069 0.90 ENST00000543873.2
ENST00000554663.1
ENST00000557635.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr11_-_104893863 0.90 ENST00000260315.3
ENST00000526056.1
ENST00000531367.1
ENST00000456094.1
ENST00000444749.2
ENST00000393141.2
ENST00000418434.1
ENST00000393139.2
CASP5
caspase 5, apoptosis-related cysteine peptidase
chr17_+_40440481 0.87 ENST00000590726.2
ENST00000452307.2
ENST00000444283.1
ENST00000588868.1
STAT5A
signal transducer and activator of transcription 5A
chr1_+_110453203 0.85 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1
colony stimulating factor 1 (macrophage)
chr1_+_45274154 0.85 ENST00000450269.1
ENST00000453418.1
ENST00000409335.2
BTBD19
BTB (POZ) domain containing 19
chr3_-_156878540 0.84 ENST00000461804.1
CCNL1
cyclin L1
chr3_-_156878482 0.84 ENST00000295925.4
CCNL1
cyclin L1
chr14_-_53417732 0.82 ENST00000399304.3
ENST00000395631.2
ENST00000341590.3
ENST00000343279.4
FERMT2
fermitin family member 2
chr20_-_45530365 0.82 ENST00000414085.1
RP11-323C15.2
RP11-323C15.2
chr16_-_2059748 0.82 ENST00000562103.1
ENST00000431526.1
ZNF598
zinc finger protein 598
chr14_+_75988768 0.81 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr9_+_130547958 0.81 ENST00000421939.1
ENST00000373265.2
CDK9
cyclin-dependent kinase 9
chr16_+_27325202 0.81 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
IL4R
interleukin 4 receptor
chr9_+_130911723 0.80 ENST00000277480.2
ENST00000373013.2
ENST00000540948.1
LCN2
lipocalin 2
chr16_-_122619 0.80 ENST00000262316.6
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr11_+_46299199 0.80 ENST00000529193.1
ENST00000288400.3
CREB3L1
cAMP responsive element binding protein 3-like 1
chr19_-_17958832 0.80 ENST00000458235.1
JAK3
Janus kinase 3
chr17_+_40440094 0.80 ENST00000546010.2
STAT5A
signal transducer and activator of transcription 5A
chr13_-_38443860 0.80 ENST00000426868.2
ENST00000379681.3
ENST00000338947.5
ENST00000355779.2
ENST00000358477.2
ENST00000379673.2
TRPC4
transient receptor potential cation channel, subfamily C, member 4
chr21_+_34775698 0.78 ENST00000381995.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chr10_+_17270214 0.77 ENST00000544301.1
VIM
vimentin
chr9_+_130911770 0.77 ENST00000372998.1
LCN2
lipocalin 2
chr12_+_57388230 0.75 ENST00000300098.1
GPR182
G protein-coupled receptor 182
chr16_+_27324983 0.75 ENST00000566117.1
IL4R
interleukin 4 receptor
chr8_+_70404996 0.75 ENST00000402687.4
ENST00000419716.3
SULF1
sulfatase 1
chr21_+_34775772 0.74 ENST00000405436.1
IFNGR2
interferon gamma receptor 2 (interferon gamma transducer 1)
chrX_+_115567767 0.74 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr6_+_29910301 0.74 ENST00000376809.5
ENST00000376802.2
HLA-A
major histocompatibility complex, class I, A
chr21_+_46875424 0.73 ENST00000359759.4
COL18A1
collagen, type XVIII, alpha 1
chr2_+_220094479 0.73 ENST00000323348.5
ENST00000453432.1
ENST00000409849.1
ENST00000416565.1
ENST00000410034.3
ENST00000447157.1
ANKZF1
ankyrin repeat and zinc finger domain containing 1
chr6_-_131291572 0.72 ENST00000529208.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr2_+_162016916 0.72 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr15_+_57891609 0.71 ENST00000569089.1
MYZAP
myocardial zonula adherens protein
chr3_-_183967296 0.71 ENST00000455059.1
ENST00000445626.2
ALG3
ALG3, alpha-1,3- mannosyltransferase
chr11_+_120255997 0.70 ENST00000532993.1
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr1_+_145477060 0.70 ENST00000369308.3
LIX1L
Lix1 homolog (mouse)-like
chr10_+_90750493 0.69 ENST00000357339.2
ENST00000355279.2
FAS
Fas cell surface death receptor
chr17_+_34639793 0.68 ENST00000394465.2
ENST00000394463.2
ENST00000378342.4
CCL4L2
chemokine (C-C motif) ligand 4-like 2
chr17_+_38474489 0.68 ENST00000394089.2
ENST00000425707.3
RARA
retinoic acid receptor, alpha
chr5_-_149792295 0.68 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr1_-_154474589 0.68 ENST00000304760.2
SHE
Src homology 2 domain containing E
chr1_-_89738528 0.67 ENST00000343435.5
GBP5
guanylate binding protein 5
chr1_+_165796753 0.66 ENST00000367879.4
UCK2
uridine-cytidine kinase 2
chr1_-_9189144 0.66 ENST00000414642.2
GPR157
G protein-coupled receptor 157
chr6_+_151042224 0.66 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr19_+_41256764 0.66 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr9_-_115095123 0.65 ENST00000458258.1
PTBP3
polypyrimidine tract binding protein 3
chr3_+_93698974 0.64 ENST00000535334.1
ENST00000478400.1
ENST00000303097.7
ENST00000394222.3
ENST00000471138.1
ENST00000539730.1
ARL13B
ADP-ribosylation factor-like 13B
chr19_+_35940486 0.63 ENST00000246549.2
FFAR2
free fatty acid receptor 2
chr17_+_26662730 0.63 ENST00000226225.2
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr6_+_32121908 0.63 ENST00000375143.2
ENST00000424499.1
PPT2
palmitoyl-protein thioesterase 2
chr12_-_76425368 0.62 ENST00000602540.1
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr11_+_46316677 0.62 ENST00000534787.1
CREB3L1
cAMP responsive element binding protein 3-like 1
chr12_-_49504655 0.62 ENST00000551782.1
ENST00000267102.8
LMBR1L
limb development membrane protein 1-like
chr21_+_34638656 0.61 ENST00000290200.2
IL10RB
interleukin 10 receptor, beta
chr14_-_69446034 0.61 ENST00000193403.6
ACTN1
actinin, alpha 1
chr2_+_173940668 0.61 ENST00000375213.3
MLTK
Mitogen-activated protein kinase kinase kinase MLT
chr11_-_75062730 0.61 ENST00000420843.2
ENST00000360025.3
ARRB1
arrestin, beta 1
chr2_+_131975882 0.61 ENST00000356920.5
ENST00000358087.5
POTEE
POTE ankyrin domain family, member E
chr19_+_4229495 0.60 ENST00000221847.5
EBI3
Epstein-Barr virus induced 3
chr14_-_69262947 0.60 ENST00000557086.1
ZFP36L1
ZFP36 ring finger protein-like 1
chr1_+_110453514 0.60 ENST00000369802.3
ENST00000420111.2
CSF1
colony stimulating factor 1 (macrophage)
chr15_+_85923797 0.59 ENST00000559362.1
AKAP13
A kinase (PRKA) anchor protein 13
chr1_+_144339738 0.59 ENST00000538264.1
AL592284.1
Protein LOC642441
chr2_-_114647327 0.58 ENST00000602760.1
RP11-141B14.1
RP11-141B14.1
chr5_+_82767284 0.58 ENST00000265077.3
VCAN
versican
chr9_-_13279406 0.58 ENST00000546205.1
MPDZ
multiple PDZ domain protein
chr16_+_3096638 0.57 ENST00000336577.4
MMP25
matrix metallopeptidase 25
chr1_+_110453462 0.57 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr4_-_185395191 0.57 ENST00000510814.1
ENST00000507523.1
ENST00000506230.1
IRF2
interferon regulatory factor 2
chr11_+_66406149 0.57 ENST00000578778.1
ENST00000483858.1
ENST00000398692.4
ENST00000510173.2
ENST00000506523.2
ENST00000530235.1
ENST00000532968.1
RBM4
RNA binding motif protein 4
chr17_-_4643114 0.55 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr12_-_40013553 0.55 ENST00000308666.3
ABCD2
ATP-binding cassette, sub-family D (ALD), member 2
chr1_-_8086343 0.55 ENST00000474874.1
ENST00000469499.1
ENST00000377482.5
ERRFI1
ERBB receptor feedback inhibitor 1
chr6_+_32121789 0.55 ENST00000437001.2
ENST00000375137.2
PPT2
palmitoyl-protein thioesterase 2
chr2_-_232571621 0.55 ENST00000595658.1
MGC4771
MGC4771
chr14_-_69262916 0.54 ENST00000553375.1
ZFP36L1
ZFP36 ring finger protein-like 1
chr10_-_29923893 0.54 ENST00000355867.4
SVIL
supervillin
chr13_+_97928395 0.53 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr22_-_39268308 0.53 ENST00000407418.3
CBX6
chromobox homolog 6
chr12_+_56211703 0.53 ENST00000243045.5
ENST00000552672.1
ENST00000550836.1
ORMDL2
ORM1-like 2 (S. cerevisiae)
chr10_-_100027943 0.52 ENST00000260702.3
LOXL4
lysyl oxidase-like 4
chr12_+_51632600 0.51 ENST00000549555.1
ENST00000439799.2
ENST00000425012.2
DAZAP2
DAZ associated protein 2
chr6_-_143832820 0.51 ENST00000002165.6
FUCA2
fucosidase, alpha-L- 2, plasma
chr11_-_58345569 0.51 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr17_-_8286484 0.51 ENST00000582556.1
ENST00000584164.1
ENST00000293842.5
ENST00000584343.1
ENST00000578812.1
ENST00000583011.1
RPL26
ribosomal protein L26
chr17_-_4852332 0.51 ENST00000572383.1
PFN1
profilin 1
chr12_-_49318715 0.51 ENST00000444214.2
FKBP11
FK506 binding protein 11, 19 kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of REL

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.6 GO:0072573 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
1.0 3.8 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.9 2.6 GO:0045210 FasL biosynthetic process(GO:0045210)
0.8 2.4 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.8 2.4 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.6 1.2 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291)
0.6 2.5 GO:0000103 sulfate assimilation(GO:0000103)
0.6 2.3 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.6 2.3 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.5 2.7 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.5 1.5 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.5 2.5 GO:1903971 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.5 2.4 GO:0052027 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.5 1.4 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
0.4 1.3 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.4 1.3 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.4 2.1 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.4 2.8 GO:2000669 negative regulation of dendritic cell apoptotic process(GO:2000669)
0.4 1.6 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.4 1.2 GO:1902568 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.4 1.6 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.4 1.6 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.4 2.7 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.3 2.7 GO:0033590 response to cobalamin(GO:0033590) cellular response to erythropoietin(GO:0036018)
0.3 4.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.3 1.0 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.3 1.6 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.3 3.7 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.3 1.5 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043) interleukin-3-mediated signaling pathway(GO:0038156)
0.3 3.2 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.3 1.8 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.3 1.0 GO:2000863 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.3 1.5 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.2 1.7 GO:0000255 allantoin metabolic process(GO:0000255)
0.2 0.5 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.2 1.2 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.2 1.1 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.2 0.7 GO:0072616 interleukin-18 secretion(GO:0072616)
0.2 0.7 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.2 0.6 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.2 0.8 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.2 2.2 GO:0070842 aggresome assembly(GO:0070842)
0.2 0.9 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.2 1.5 GO:0030578 PML body organization(GO:0030578)
0.2 0.9 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.2 1.0 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.2 1.0 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.2 0.7 GO:0006238 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.1 0.7 GO:1902534 single-organism membrane invagination(GO:1902534)
0.1 5.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.4 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 4.4 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 2.5 GO:0060056 mammary gland involution(GO:0060056)
0.1 0.4 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.1 0.7 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 1.7 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 1.1 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.1 1.8 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 20.4 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.4 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 1.4 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 0.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.5 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.1 1.1 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.1 1.0 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.1 0.3 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
0.1 1.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 1.0 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 0.6 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.1 1.8 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 0.4 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 1.1 GO:1903943 negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 0.5 GO:2001153 regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.1 0.3 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.1 1.2 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.1 1.0 GO:1903243 negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.1 0.8 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.1 1.6 GO:0051601 exocyst localization(GO:0051601)
0.1 0.8 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.1 2.1 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.6 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.1 1.1 GO:0048302 regulation of isotype switching to IgG isotypes(GO:0048302)
0.1 0.7 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 1.8 GO:0015671 oxygen transport(GO:0015671)
0.1 0.5 GO:2000535 regulation of entry of bacterium into host cell(GO:2000535)
0.1 0.4 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.1 0.5 GO:1902231 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 0.5 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.6 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 2.0 GO:0007620 copulation(GO:0007620)
0.1 1.5 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.1 0.7 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.8 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 0.6 GO:0021943 formation of radial glial scaffolds(GO:0021943)
0.1 1.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 0.7 GO:0060019 radial glial cell differentiation(GO:0060019)
0.1 5.6 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 0.4 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.1 0.5 GO:1903288 positive regulation of potassium ion import(GO:1903288)
0.1 0.3 GO:0098502 DNA dephosphorylation(GO:0098502)
0.1 1.2 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.1 0.6 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 1.9 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 0.4 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 0.2 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.7 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 1.1 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.6 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.4 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.0 1.2 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.4 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.6 GO:0060022 hard palate development(GO:0060022)
0.0 0.0 GO:0042940 D-amino acid transport(GO:0042940)
0.0 0.2 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.0 1.8 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 7.4 GO:0002377 immunoglobulin production(GO:0002377)
0.0 1.5 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 1.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.4 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.4 GO:0045714 low-density lipoprotein particle receptor biosynthetic process(GO:0045713) regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714)
0.0 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.7 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.4 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.1 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.8 GO:0033622 integrin activation(GO:0033622)
0.0 0.1 GO:0061083 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0 0.8 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.6 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 1.2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.4 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 2.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.4 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.4 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 1.4 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.9 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.0 GO:1902598 creatine transport(GO:0015881) creatine transmembrane transport(GO:1902598)
0.0 1.2 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 1.0 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.3 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0 1.2 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.7 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.2 GO:0010628 positive regulation of gene expression(GO:0010628)
0.0 0.5 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 1.6 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.5 1.5 GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex(GO:0030526)
0.5 5.3 GO:0005610 laminin-5 complex(GO:0005610)
0.4 1.5 GO:0031523 Myb complex(GO:0031523)
0.4 2.5 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.3 2.7 GO:0043196 varicosity(GO:0043196)
0.2 0.6 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.2 2.2 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.2 1.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 4.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.4 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 0.4 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.9 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.1 1.4 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 2.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 2.8 GO:0033643 host cell part(GO:0033643)
0.1 3.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.4 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1 1.8 GO:0005833 hemoglobin complex(GO:0005833)
0.1 4.7 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 5.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.5 GO:0035339 SPOTS complex(GO:0035339)
0.1 1.2 GO:0000322 storage vacuole(GO:0000322)
0.1 0.7 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.2 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.1 1.0 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.8 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.5 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.2 GO:0008091 spectrin(GO:0008091)
0.1 0.4 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 1.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.8 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.0 1.6 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 3.5 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 8.8 GO:0072562 blood microparticle(GO:0072562)
0.0 1.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 1.6 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 3.4 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.1 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.0 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 2.2 GO:0016235 aggresome(GO:0016235)
0.0 0.8 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 2.0 GO:0001533 cornified envelope(GO:0001533)
0.0 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.0 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 1.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.7 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.9 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 2.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.6 GO:0016459 myosin complex(GO:0016459)
0.0 8.7 GO:0016607 nuclear speck(GO:0016607)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 15.1 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.4 GO:0002080 acrosomal membrane(GO:0002080)
0.0 3.0 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 4.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.4 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.8 2.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.5 1.6 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.5 9.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.5 1.4 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.4 1.6 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.4 1.1 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.3 5.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.3 1.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.3 1.9 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.3 2.5 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.3 1.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.3 1.5 GO:0004914 interleukin-3 receptor activity(GO:0004912) interleukin-5 receptor activity(GO:0004914)
0.3 1.8 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.2 0.7 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.2 1.5 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 2.1 GO:0045545 syndecan binding(GO:0045545)
0.2 0.7 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 1.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.2 0.5 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.1 2.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 2.8 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.6 GO:0004641 phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.1 2.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 1.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.4 GO:0035005 lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.0 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 1.5 GO:0051525 NFAT protein binding(GO:0051525)
0.1 32.2 GO:0003823 antigen binding(GO:0003823)
0.1 5.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.0 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 2.7 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 0.8 GO:1990254 keratin filament binding(GO:1990254)
0.1 1.2 GO:0042731 PH domain binding(GO:0042731)
0.1 1.2 GO:0016015 morphogen activity(GO:0016015)
0.1 0.6 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 1.5 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 1.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.0 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.7 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.1 1.5 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.1 4.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 4.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.9 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 1.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 2.7 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.6 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 2.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
0.1 0.3 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1 2.2 GO:0070628 proteasome binding(GO:0070628)
0.1 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 1.0 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.5 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.4 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 2.0 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.7 GO:0004849 uridine kinase activity(GO:0004849)
0.1 2.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 2.1 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.8 GO:0035497 cAMP response element binding(GO:0035497)
0.0 3.3 GO:0050699 WW domain binding(GO:0050699)
0.0 2.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.0 GO:0070330 aromatase activity(GO:0070330)
0.0 0.7 GO:0048185 activin binding(GO:0048185)
0.0 1.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.0 0.3 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.4 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 1.1 GO:0008009 chemokine activity(GO:0008009)
0.0 0.4 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.3 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.5 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.7 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.0 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.0 0.5 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 3.4 GO:0005179 hormone activity(GO:0005179)
0.0 1.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 2.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 0.8 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.5 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.4 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 2.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.4 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.2 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 1.8 GO:0051117 ATPase binding(GO:0051117)
0.0 0.8 GO:0043022 ribosome binding(GO:0043022)
0.0 2.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 5.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.0 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.2 GO:0001055 RNA polymerase I activity(GO:0001054) RNA polymerase II activity(GO:0001055)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 10.6 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.8 GO:0002020 protease binding(GO:0002020)
0.0 0.3 GO:0019841 retinol binding(GO:0019841)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 20.0 PID CD40 PATHWAY CD40/CD40L signaling
0.2 5.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 2.3 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 5.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.7 PID IL23 PATHWAY IL23-mediated signaling events
0.1 2.9 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 2.6 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 1.5 PID IL5 PATHWAY IL5-mediated signaling events
0.1 2.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.9 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 2.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 2.0 PID IL27 PATHWAY IL27-mediated signaling events
0.1 3.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 2.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 3.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 2.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.6 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 2.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 2.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 3.9 PID AP1 PATHWAY AP-1 transcription factor network
0.0 2.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.3 PID BMP PATHWAY BMP receptor signaling
0.0 0.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.0 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.8 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 4.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 4.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 3.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 5.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 3.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 8.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.4 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1 3.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.1 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 2.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 0.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.7 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 1.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 2.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.0 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.9 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 1.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 2.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 2.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.0 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 2.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.4 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 1.3 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.7 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 1.2 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling