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Illumina Body Map 2, young vs old

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Results for REST

Z-value: 0.28

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.183.2e-01Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_154862028 45.64 ENST00000287907.2
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
chr1_+_33352036 26.30 ENST00000373467.3
HPCA
hippocalcin
chr5_+_175298487 25.12 ENST00000393745.3
CPLX2
complexin 2
chr14_+_93389425 24.77 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr9_+_140033862 24.68 ENST00000350902.5
ENST00000371550.4
ENST00000371546.4
ENST00000371555.4
ENST00000371553.3
ENST00000371559.4
ENST00000371560.3
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr17_+_42385927 23.28 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
RUNDC3A
RUN domain containing 3A
chr18_-_40857493 23.17 ENST00000255224.3
SYT4
synaptotagmin IV
chr5_+_71014990 22.48 ENST00000296777.4
CARTPT
CART prepropeptide
chr18_-_40857447 21.25 ENST00000590752.1
ENST00000596867.1
SYT4
synaptotagmin IV
chr20_+_44657845 20.89 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr8_-_145559943 20.78 ENST00000332135.4
SCRT1
scratch family zinc finger 1
chr1_-_241520385 19.98 ENST00000366564.1
RGS7
regulator of G-protein signaling 7
chr20_+_5892037 18.96 ENST00000378961.4
CHGB
chromogranin B (secretogranin 1)
chr1_+_154540246 18.37 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr1_-_102462565 18.31 ENST00000370103.4
OLFM3
olfactomedin 3
chr10_+_26505594 18.27 ENST00000259271.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chrX_-_49056635 18.18 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP
synaptophysin
chr5_+_167956121 17.82 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr12_+_113229737 17.61 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr5_+_175298573 17.40 ENST00000512824.1
CPLX2
complexin 2
chr19_-_55691472 17.29 ENST00000537500.1
SYT5
synaptotagmin V
chr1_-_151689259 17.25 ENST00000420342.1
ENST00000290583.4
CELF3
CUGBP, Elav-like family member 3
chr20_+_5892147 17.14 ENST00000455042.1
CHGB
chromogranin B (secretogranin 1)
chr10_+_26505179 17.14 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr4_+_158141806 16.67 ENST00000393815.2
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr7_+_8474150 16.66 ENST00000602349.1
NXPH1
neurexophilin 1
chr19_-_40724246 16.66 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr15_-_83378638 16.57 ENST00000261722.3
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr4_+_158141899 16.35 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr20_+_44657807 16.10 ENST00000372315.1
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr19_+_4769117 15.95 ENST00000540211.1
ENST00000317292.3
ENST00000586721.1
ENST00000592709.1
ENST00000588711.1
ENST00000589639.1
ENST00000591008.1
ENST00000592663.1
ENST00000588758.1
MIR7-3HG
MIR7-3 host gene (non-protein coding)
chr2_+_115199876 15.95 ENST00000436732.1
ENST00000410059.1
DPP10
dipeptidyl-peptidase 10 (non-functional)
chr3_+_120626919 15.76 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L
syntaxin binding protein 5-like
chr10_+_60936921 15.72 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr4_+_158141843 15.53 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr2_-_51259528 15.52 ENST00000404971.1
NRXN1
neurexin 1
chr17_+_30813576 15.39 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr1_+_65775204 15.33 ENST00000371069.4
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr14_-_51562037 15.13 ENST00000338969.5
TRIM9
tripartite motif containing 9
chr14_-_105071083 14.97 ENST00000415614.2
TMEM179
transmembrane protein 179
chrX_-_153141302 14.84 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM
L1 cell adhesion molecule
chrX_-_47479246 14.75 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr12_+_113229452 14.49 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr18_-_40857329 14.44 ENST00000593720.1
SYT4
synaptotagmin IV
chr15_-_83378526 14.39 ENST00000535348.1
ENST00000535359.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr2_-_51259641 14.31 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr12_+_113229543 14.20 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr11_+_22359562 14.05 ENST00000263160.3
SLC17A6
solute carrier family 17 (vesicular glutamate transporter), member 6
chr1_-_175712665 13.97 ENST00000263525.2
TNR
tenascin R
chr8_-_91095099 13.92 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr14_-_51561784 13.83 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr10_+_99609996 13.81 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr3_+_9745487 13.76 ENST00000383832.3
CPNE9
copine family member IX
chr12_+_113229708 13.42 ENST00000550901.1
RPH3A
rabphilin 3A homolog (mouse)
chr6_+_153071925 13.40 ENST00000367244.3
ENST00000367243.3
VIP
vasoactive intestinal peptide
chr2_-_51259292 13.27 ENST00000401669.2
NRXN1
neurexin 1
chr12_+_119419294 13.27 ENST00000267260.4
SRRM4
serine/arginine repetitive matrix 4
chr3_+_9745510 13.05 ENST00000383831.3
CPNE9
copine family member IX
chr20_-_60795296 12.95 ENST00000340177.5
HRH3
histamine receptor H3
chr19_-_55691377 12.82 ENST00000589172.1
SYT5
synaptotagmin V
chr3_-_131753830 12.75 ENST00000429747.1
CPNE4
copine IV
chr2_-_51259229 12.70 ENST00000405472.3
NRXN1
neurexin 1
chr7_-_100808394 12.31 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr16_+_335680 12.24 ENST00000435833.1
PDIA2
protein disulfide isomerase family A, member 2
chr12_+_113229337 11.96 ENST00000552667.1
RPH3A
rabphilin 3A homolog (mouse)
chr14_+_93897199 11.95 ENST00000553484.1
UNC79
unc-79 homolog (C. elegans)
chr12_+_113229725 11.70 ENST00000551198.1
RPH3A
rabphilin 3A homolog (mouse)
chr3_+_62304712 11.63 ENST00000494481.1
C3orf14
chromosome 3 open reading frame 14
chr7_-_100808843 11.09 ENST00000249330.2
VGF
VGF nerve growth factor inducible
chr1_+_210111534 11.04 ENST00000422431.1
ENST00000534859.1
ENST00000399639.2
ENST00000537238.1
SYT14
synaptotagmin XIV
chr5_-_176037105 10.75 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr14_+_93897272 10.69 ENST00000393151.2
UNC79
unc-79 homolog (C. elegans)
chr10_+_26505662 10.61 ENST00000428517.2
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr5_+_175298674 10.59 ENST00000514150.1
CPLX2
complexin 2
chr10_-_50970382 10.59 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr20_-_60795316 10.57 ENST00000317393.6
HRH3
histamine receptor H3
chr8_-_57358432 10.54 ENST00000517415.1
ENST00000314922.3
PENK
proenkephalin
chr15_+_75287861 10.50 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
SCAMP5
secretory carrier membrane protein 5
chr17_-_27333311 10.49 ENST00000317338.12
ENST00000585644.1
SEZ6
seizure related 6 homolog (mouse)
chr2_+_215275771 10.45 ENST00000312504.5
ENST00000427124.1
VWC2L
von Willebrand factor C domain containing protein 2-like
chr3_+_62304648 10.39 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14
chromosome 3 open reading frame 14
chrX_-_153141434 10.18 ENST00000407935.2
ENST00000439496.1
L1CAM
L1 cell adhesion molecule
chr14_-_74892805 9.70 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr18_-_5197224 9.65 ENST00000434239.3
C18orf42
chromosome 18 open reading frame 42
chr12_-_12837423 9.53 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr11_-_75141206 9.53 ENST00000376292.4
KLHL35
kelch-like family member 35
chr10_-_50970322 9.43 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr20_+_30555805 9.29 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr17_-_27332931 9.17 ENST00000442608.3
ENST00000335960.6
SEZ6
seizure related 6 homolog (mouse)
chr19_-_55691614 9.03 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr6_+_110299501 8.92 ENST00000414000.2
GPR6
G protein-coupled receptor 6
chr16_+_5008290 8.88 ENST00000251170.7
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr15_-_27018884 8.54 ENST00000299267.4
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr18_-_5197501 8.50 ENST00000580650.1
C18orf42
chromosome 18 open reading frame 42
chr11_+_45907177 8.49 ENST00000241014.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr12_-_99288986 8.00 ENST00000552407.1
ENST00000551613.1
ENST00000548447.1
ENST00000546364.3
ENST00000552748.1
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr7_+_145813453 7.95 ENST00000361727.3
CNTNAP2
contactin associated protein-like 2
chr2_-_47798044 7.81 ENST00000327876.4
KCNK12
potassium channel, subfamily K, member 12
chr2_+_131513864 7.60 ENST00000458606.1
ENST00000423981.1
AMER3
APC membrane recruitment protein 3
chr1_+_210111570 7.57 ENST00000367019.1
ENST00000472886.1
SYT14
synaptotagmin XIV
chr5_+_63802109 7.52 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr19_+_41036371 7.32 ENST00000392023.1
SPTBN4
spectrin, beta, non-erythrocytic 4
chr9_+_138606400 7.25 ENST00000486577.2
KCNT1
potassium channel, subfamily T, member 1
chr3_+_75955817 7.02 ENST00000487694.3
ENST00000602589.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr3_-_48700310 6.90 ENST00000164024.4
ENST00000544264.1
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3
chr16_+_3019309 6.16 ENST00000576565.1
PAQR4
progestin and adipoQ receptor family member IV
chr2_-_30143525 6.13 ENST00000431873.1
ALK
anaplastic lymphoma receptor tyrosine kinase
chr17_-_27333163 6.08 ENST00000360295.9
SEZ6
seizure related 6 homolog (mouse)
chr16_+_3019246 5.91 ENST00000318782.8
ENST00000293978.8
PAQR4
progestin and adipoQ receptor family member IV
chr3_-_42743006 5.89 ENST00000310417.5
HHATL
hedgehog acyltransferase-like
chr15_-_79576156 5.88 ENST00000560452.1
ENST00000560872.1
ENST00000560732.1
ENST00000559979.1
ENST00000560533.1
ENST00000559225.1
RP11-17L5.4
RP11-17L5.4
chr10_-_102790852 5.82 ENST00000470414.1
ENST00000370215.3
PDZD7
PDZ domain containing 7
chr4_-_175750364 5.71 ENST00000340217.5
ENST00000274093.3
GLRA3
glycine receptor, alpha 3
chr4_+_96012614 5.60 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr12_+_175930 5.58 ENST00000538872.1
ENST00000326261.4
IQSEC3
IQ motif and Sec7 domain 3
chr19_+_39759154 5.39 ENST00000331982.5
IFNL2
interferon, lambda 2
chr11_-_66115032 5.31 ENST00000311181.4
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr4_+_96012585 5.21 ENST00000502683.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr7_+_150748288 5.06 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr12_-_99288536 4.95 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr17_+_72667239 4.86 ENST00000402449.4
RAB37
RAB37, member RAS oncogene family
chr9_-_74061751 4.86 ENST00000357533.2
ENST00000423814.3
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr20_-_62284766 4.37 ENST00000370053.1
STMN3
stathmin-like 3
chr15_-_32162833 4.32 ENST00000560598.1
OTUD7A
OTU domain containing 7A
chr6_+_154360357 4.23 ENST00000330432.7
ENST00000360422.4
OPRM1
opioid receptor, mu 1
chr9_+_138606271 4.13 ENST00000473941.1
KCNT1
potassium channel, subfamily T, member 1
chr6_+_25652432 3.94 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr12_-_57443886 3.87 ENST00000300119.3
MYO1A
myosin IA
chr10_-_79398127 3.69 ENST00000372443.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chrX_-_73061339 3.58 ENST00000602863.1
XIST
X inactive specific transcript (non-protein coding)
chr10_-_79398250 2.86 ENST00000286627.5
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr15_-_83378611 2.37 ENST00000542200.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr7_-_65113280 2.27 ENST00000593865.1
AC104057.1
Protein LOC100996407
chr7_+_63361201 2.27 ENST00000450544.1
RP11-340I6.8
RP11-340I6.8
chr20_+_62327996 2.27 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr6_+_25652501 2.24 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr6_+_35773070 2.09 ENST00000373853.1
ENST00000360215.1
LHFPL5
lipoma HMGIC fusion partner-like 5
chr19_-_39402798 1.80 ENST00000571838.1
CTC-360G5.1
coiled-coil glutamate-rich protein 2
chr15_-_79576229 1.73 ENST00000557790.1
ENST00000558297.1
RP11-17L5.4
RP11-17L5.4
chr12_+_71833756 1.53 ENST00000536515.1
ENST00000540815.2
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr8_+_6566206 1.31 ENST00000518327.1
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr15_+_68117872 1.27 ENST00000380035.2
ENST00000389002.1
SKOR1
SKI family transcriptional corepressor 1
chr5_+_33936491 0.69 ENST00000330120.3
RXFP3
relaxin/insulin-like family peptide receptor 3
chr12_+_71833550 0.68 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr9_-_123812542 0.54 ENST00000223642.1
C5
complement component 5
chr11_-_92931098 0.46 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr2_+_226264401 0.44 ENST00000431435.1
AC067961.1
AC067961.1
chr12_-_24737089 0.35 ENST00000483544.1
LINC00477
long intergenic non-protein coding RNA 477
chr1_+_171750776 0.22 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr12_+_52695617 0.22 ENST00000293525.5
KRT86
keratin 86
chr14_+_96039882 0.21 ENST00000556346.1
ENST00000553785.1
RP11-1070N10.4
RP11-1070N10.4
chr15_+_68117844 0.20 ENST00000554054.1
SKOR1
SKI family transcriptional corepressor 1
chr5_-_151304337 0.16 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
GLRA1
glycine receptor, alpha 1
chr20_+_36012051 0.14 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr10_+_102790980 0.06 ENST00000393459.1
ENST00000224807.5
SFXN3
sideroflexin 3

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
19.6 58.9 GO:0048174 negative regulation of short-term neuronal synaptic plasticity(GO:0048174)
12.3 37.0 GO:0040040 thermosensory behavior(GO:0040040)
9.1 45.6 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
8.3 24.8 GO:1901899 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
8.2 24.7 GO:0043449 cellular alkene metabolic process(GO:0043449)
7.5 22.5 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
7.2 29.0 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
6.6 46.0 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
6.2 55.8 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
5.9 17.8 GO:0034963 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
5.1 15.4 GO:0021586 pons maturation(GO:0021586)
4.6 18.4 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
3.8 26.3 GO:1902075 cellular response to salt(GO:1902075)
3.4 23.5 GO:0014050 negative regulation of glutamate secretion(GO:0014050) negative regulation of serotonin secretion(GO:0014063)
2.7 8.0 GO:0071109 superior temporal gyrus development(GO:0071109)
2.3 14.0 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
2.1 10.5 GO:0051866 general adaptation syndrome(GO:0051866)
1.9 53.1 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
1.9 13.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
1.5 13.9 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
1.5 10.8 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
1.5 6.1 GO:0036269 swimming behavior(GO:0036269)
1.5 141.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.5 5.9 GO:0060254 regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
1.5 23.3 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
1.4 14.1 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
1.4 15.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
1.2 26.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
1.2 18.2 GO:0016188 synaptic vesicle maturation(GO:0016188)
1.2 7.0 GO:0050925 negative regulation of negative chemotaxis(GO:0050925) apoptotic process involved in luteolysis(GO:0061364)
1.1 33.3 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.1 13.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
1.0 5.1 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
1.0 6.9 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
1.0 14.8 GO:0097091 synaptic vesicle clustering(GO:0097091)
1.0 13.4 GO:0070459 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) prolactin secretion(GO:0070459)
0.9 12.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.9 8.5 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.8 25.7 GO:0060074 synapse maturation(GO:0060074)
0.8 17.2 GO:0030575 nuclear body organization(GO:0030575)
0.8 48.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.7 6.5 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.7 23.4 GO:0002021 response to dietary excess(GO:0002021)
0.6 4.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.6 8.5 GO:0007258 JUN phosphorylation(GO:0007258)
0.6 5.9 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.6 15.5 GO:0048149 behavioral response to ethanol(GO:0048149)
0.5 7.9 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.5 7.3 GO:0010459 negative regulation of heart rate(GO:0010459)
0.4 10.5 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.4 4.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.4 8.9 GO:0090520 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.4 20.0 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.3 20.8 GO:2001222 regulation of neuron migration(GO:2001222)
0.3 7.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 18.3 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.3 15.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 15.9 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.2 14.0 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 5.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 4.9 GO:0016048 detection of temperature stimulus(GO:0016048)
0.2 11.9 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.2 2.2 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.2 5.4 GO:0002385 mucosal immune response(GO:0002385)
0.1 11.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 3.9 GO:0030033 microvillus assembly(GO:0030033)
0.1 0.5 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 4.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 6.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.2 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 20.0 GO:0006457 protein folding(GO:0006457)
0.0 0.1 GO:0086098 angiotensin-activated signaling pathway involved in heart process(GO:0086098)
0.0 0.5 GO:0015808 L-alanine transport(GO:0015808)
0.0 11.4 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 21.4 GO:0043687 post-translational protein modification(GO:0043687)
0.0 5.3 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 2.3 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
11.8 58.9 GO:0032127 dense core granule membrane(GO:0032127)
6.9 48.6 GO:0098843 postsynaptic endocytic zone(GO:0098843)
6.5 39.1 GO:1990769 proximal neuron projection(GO:1990769)
5.3 53.1 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
3.8 15.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
3.5 14.0 GO:0072534 perineuronal net(GO:0072534)
3.0 17.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
2.4 51.8 GO:0060077 inhibitory synapse(GO:0060077)
2.1 33.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
2.0 26.3 GO:0044327 dendritic spine head(GO:0044327)
1.9 5.8 GO:0002139 stereocilia coupling link(GO:0002139)
1.9 5.7 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
1.8 24.7 GO:0098839 postsynaptic density membrane(GO:0098839)
1.8 10.5 GO:0032280 symmetric synapse(GO:0032280)
1.7 20.0 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
1.1 24.8 GO:0042583 chromaffin granule(GO:0042583)
0.9 8.5 GO:0044294 dendritic growth cone(GO:0044294)
0.9 126.1 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.9 23.9 GO:0097440 apical dendrite(GO:0097440)
0.8 7.3 GO:0070852 cell body fiber(GO:0070852)
0.8 14.8 GO:0048786 presynaptic active zone(GO:0048786)
0.7 25.0 GO:0044295 axonal growth cone(GO:0044295)
0.7 10.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.7 13.8 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.7 18.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.7 28.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.5 37.0 GO:0043198 dendritic shaft(GO:0043198)
0.4 8.0 GO:0033010 paranodal junction(GO:0033010)
0.4 55.8 GO:0042734 presynaptic membrane(GO:0042734)
0.4 45.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 20.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 71.3 GO:0098793 presynapse(GO:0098793)
0.3 8.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 7.0 GO:0030673 axolemma(GO:0030673)
0.2 13.0 GO:0015030 Cajal body(GO:0015030)
0.1 2.1 GO:0032426 stereocilium tip(GO:0032426)
0.1 63.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 17.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 9.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 15.1 GO:0030426 growth cone(GO:0030426)
0.1 3.9 GO:0009925 basal plasma membrane(GO:0009925)
0.1 15.5 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 0.5 GO:0005579 membrane attack complex(GO:0005579)
0.1 6.2 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 29.6 GO:0016604 nuclear body(GO:0016604)
0.0 2.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 31.4 GO:0005886 plasma membrane(GO:0005886)
0.0 123.1 GO:0016021 integral component of membrane(GO:0016021)
0.0 10.2 GO:0030141 secretory granule(GO:0030141)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 17.8 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
5.8 46.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
5.4 58.9 GO:0030348 syntaxin-3 binding(GO:0030348)
5.1 15.4 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
4.1 24.7 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
4.0 83.4 GO:0008430 selenium binding(GO:0008430)
3.5 45.6 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
3.3 55.8 GO:0097109 neuroligin family protein binding(GO:0097109)
2.9 20.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
2.8 37.0 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
2.6 23.3 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
2.6 48.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
2.0 13.9 GO:0005499 vitamin D binding(GO:0005499)
1.8 23.5 GO:0004969 histamine receptor activity(GO:0004969)
1.8 66.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.4 17.2 GO:0097322 7SK snRNA binding(GO:0097322)
1.2 53.1 GO:0017075 syntaxin-1 binding(GO:0017075)
1.0 5.9 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
1.0 15.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.9 10.8 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.8 5.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.7 18.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.7 6.5 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.7 7.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.7 8.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.6 8.9 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.6 6.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.6 8.5 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.6 73.5 GO:0019905 syntaxin binding(GO:0019905)
0.6 12.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.5 29.0 GO:0000149 SNARE binding(GO:0000149)
0.4 14.1 GO:0015172 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.4 11.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.4 13.8 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.4 12.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.3 7.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.3 36.1 GO:0005179 hormone activity(GO:0005179)
0.2 18.3 GO:0042169 SH2 domain binding(GO:0042169)
0.2 13.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 4.9 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.2 7.3 GO:0030506 ankyrin binding(GO:0030506)
0.2 5.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 4.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.7 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.5 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 15.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 7.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 10.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 2.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 13.3 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 41.1 GO:0019900 kinase binding(GO:0019900)
0.0 13.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 39.2 GO:0005215 transporter activity(GO:0005215)
0.0 3.9 GO:0003774 motor activity(GO:0003774)
0.0 1.5 GO:0046332 SMAD binding(GO:0046332)
0.0 4.4 GO:0015631 tubulin binding(GO:0015631)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 48.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.4 23.9 PID REELIN PATHWAY Reelin signaling pathway
0.3 25.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 10.8 PID BMP PATHWAY BMP receptor signaling
0.1 12.2 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 10.5 PID AP1 PATHWAY AP-1 transcription factor network
0.0 14.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.8 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
2.9 45.6 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
1.7 73.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.0 18.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
1.0 46.0 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.6 32.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 15.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.4 14.5 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.3 15.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 14.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.3 39.1 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.3 51.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 13.4 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.2 10.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 5.3 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 7.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 29.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 16.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1