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Illumina Body Map 2, young vs old

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Results for RFX5

Z-value: 0.60

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
ENSG00000143390.13 regulatory factor X5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319283_1513193140.411.8e-02Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_142020496 4.98 ENST00000390381.3
T cell receptor beta variable 5-1
chr6_-_32784687 4.59 ENST00000447394.1
ENST00000438763.2
major histocompatibility complex, class II, DO beta
chr22_+_44576770 4.56 ENST00000444313.3
ENST00000416291.1
parvin, gamma
chr6_-_32731243 4.10 ENST00000427449.1
ENST00000411527.1
major histocompatibility complex, class II, DQ beta 2
chr6_-_32498046 3.89 ENST00000374975.3
major histocompatibility complex, class II, DR beta 5
chr22_+_44577237 3.59 ENST00000415224.1
ENST00000417767.1
parvin, gamma
chr6_-_32634425 3.58 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
major histocompatibility complex, class II, DQ beta 1
chr6_-_32731299 3.56 ENST00000435145.2
ENST00000437316.2
major histocompatibility complex, class II, DQ beta 2
chr6_-_32908765 2.86 ENST00000416244.2
major histocompatibility complex, class II, DM beta
chr6_-_32908792 2.76 ENST00000418107.2
major histocompatibility complex, class II, DM beta
chr6_+_33043703 2.72 ENST00000418931.2
ENST00000535465.1
major histocompatibility complex, class II, DP beta 1
chr6_-_32557610 2.71 ENST00000360004.5
major histocompatibility complex, class II, DR beta 1
chr5_-_149792295 2.59 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_30658745 2.58 ENST00000376420.5
ENST00000376421.5
nurim (nuclear envelope membrane protein)
chr6_-_32920794 2.48 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr6_-_133079022 2.34 ENST00000525289.1
ENST00000326499.6
vanin 2
chr6_+_32812568 2.25 ENST00000414474.1
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32821599 2.25 ENST00000354258.4
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_+_26383318 2.24 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
butyrophilin, subfamily 2, member A2
chr6_+_26383404 2.13 ENST00000416795.2
ENST00000494184.1
butyrophilin, subfamily 2, member A2
chr2_-_242088850 2.09 ENST00000358649.4
ENST00000452907.1
ENST00000403638.3
ENST00000539818.1
ENST00000415234.1
ENST00000234040.4
PAS domain containing serine/threonine kinase
chr6_-_32812420 1.92 ENST00000374881.2
proteasome (prosome, macropain) subunit, beta type, 8
chr6_+_32821924 1.80 ENST00000374859.2
ENST00000453265.2
proteasome (prosome, macropain) subunit, beta type, 9
chr13_-_47012325 1.65 ENST00000409879.2
KIAA0226-like
chr15_+_45003675 1.56 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
beta-2-microglobulin
chr6_+_26458171 1.47 ENST00000493173.1
ENST00000541522.1
ENST00000429381.1
ENST00000469185.1
butyrophilin, subfamily 2, member A1
chr4_-_143227088 1.45 ENST00000511838.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr19_+_19496624 1.42 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATA zinc finger domain containing 2A
chr6_+_26458152 1.42 ENST00000312541.5
butyrophilin, subfamily 2, member A1
chr4_-_143226979 1.41 ENST00000514525.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr1_+_181003067 1.28 ENST00000434571.2
ENST00000367579.3
ENST00000282990.6
ENST00000367580.5
major histocompatibility complex, class I-related
chr6_+_26365443 1.20 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
butyrophilin, subfamily 3, member A2
chr19_-_49118067 1.08 ENST00000593772.1
family with sequence similarity 83, member E
chr3_+_196466710 1.08 ENST00000327134.3
p21 protein (Cdc42/Rac)-activated kinase 2
chr6_+_26365387 1.03 ENST00000532865.1
ENST00000530653.1
ENST00000527417.1
butyrophilin, subfamily 3, member A2
chr11_-_6640585 1.01 ENST00000533371.1
ENST00000528657.1
ENST00000436873.2
ENST00000299427.6
tripeptidyl peptidase I
chr19_+_19496728 0.96 ENST00000537887.1
ENST00000417582.2
GATA zinc finger domain containing 2A
chr6_+_26440700 0.92 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
butyrophilin, subfamily 3, member A3
chr3_+_43328004 0.92 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNF related kinase
chr11_+_8008867 0.92 ENST00000309828.4
ENST00000449102.2
eukaryotic translation initiation factor 3, subunit F
chr1_+_249132462 0.90 ENST00000306562.3
zinc finger protein 672
chr1_-_53608249 0.89 ENST00000371494.4
solute carrier family 1 (glutamate transporter), member 7
chr11_-_85430088 0.81 ENST00000533057.1
ENST00000533892.1
synaptotagmin-like 2
chr19_-_51014345 0.72 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
Josephin domain containing 2
chr11_+_111385497 0.68 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
chromosome 11 open reading frame 88
chr8_+_101170257 0.65 ENST00000251809.3
sperm associated antigen 1
chr1_+_114473350 0.61 ENST00000503968.1
homeodomain interacting protein kinase 1
chr1_+_249132512 0.61 ENST00000505503.1
zinc finger protein 672
chr16_+_67381263 0.53 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
leucine rich repeat containing 36
chr17_+_27052892 0.50 ENST00000579671.1
ENST00000579060.1
NIMA-related kinase 8
chr19_-_6057282 0.50 ENST00000592281.1
regulatory factor X, 2 (influences HLA class II expression)
chr9_+_43135095 0.48 ENST00000377437.2
Uncharacterized protein
chr5_+_119799927 0.46 ENST00000407149.2
ENST00000379551.2
proline rich 16
chr19_+_36103631 0.40 ENST00000203166.5
ENST00000379045.2
HAUS augmin-like complex, subunit 5
chr1_-_208417620 0.33 ENST00000367033.3
plexin A2
chr7_+_766320 0.29 ENST00000297440.6
ENST00000313147.5
HEAT repeat containing 2
chr16_+_67381289 0.28 ENST00000435835.3
leucine rich repeat containing 36
chr9_-_67925210 0.27 ENST00000543078.1
Uncharacterized protein
chr4_+_88529681 0.27 ENST00000399271.1
dentin sialophosphoprotein
chr5_-_55412774 0.25 ENST00000434982.2
ankyrin repeat domain 55
chr3_+_9851384 0.19 ENST00000419081.1
ENST00000438596.1
ENST00000417065.1
ENST00000439814.1
ENST00000418745.1
tubulin tyrosine ligase-like family, member 3
chr12_-_123565834 0.13 ENST00000546049.1
phosphatidylinositol transfer protein, membrane-associated 2
chr10_+_82116529 0.12 ENST00000411538.1
ENST00000256039.2
DPY30 domain containing 2
chr8_-_99306611 0.11 ENST00000341166.3
NIPA-like domain containing 2
chr10_+_14880287 0.07 ENST00000437161.2
heat shock 70kDa protein 14
chr17_+_30348024 0.06 ENST00000327564.7
ENST00000584368.1
ENST00000394713.3
ENST00000341671.7
leucine rich repeat containing 37B
chr7_-_15014398 0.06 ENST00000437998.1
diacylglycerol kinase, beta 90kDa
chr10_+_14880157 0.01 ENST00000378372.3
heat shock 70kDa protein 14
chr22_-_30987837 0.01 ENST00000335214.6
pescadillo ribosomal biogenesis factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 10.8 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.5 4.6 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.8 1.6 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
0.6 2.2 GO:0046967 cytosol to ER transport(GO:0046967)
0.5 2.6 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.3 2.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.2 4.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 1.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 2.3 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 17.8 GO:0031295 T cell costimulation(GO:0031295)
0.1 0.3 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.1 2.2 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 0.8 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.1 5.8 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.6 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.9 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 2.9 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 1.3 GO:0032620 interleukin-17 production(GO:0032620)
0.0 7.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.5 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 0.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.5 GO:0001675 acrosome assembly(GO:0001675)
0.0 2.4 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 1.0 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.7 GO:0048741 skeletal muscle fiber development(GO:0048741)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 35.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.7 6.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 2.2 GO:0042825 TAP complex(GO:0042825)
0.3 1.6 GO:0031905 early endosome lumen(GO:0031905)
0.2 0.5 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 1.3 GO:0042611 MHC protein complex(GO:0042611)
0.1 0.9 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 2.4 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 2.6 GO:0005637 nuclear inner membrane(GO:0005637)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 15.8 GO:0032395 MHC class II receptor activity(GO:0032395)
0.5 2.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.5 2.9 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.4 2.3 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.3 11.6 GO:0042605 peptide antigen binding(GO:0042605)
0.3 8.1 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 6.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.0 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 1.3 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 0.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.8 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.9 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.1 PID MYC PATHWAY C-MYC pathway
0.0 2.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 9.3 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 1.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 2.9 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 8.1 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 15.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.8 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)