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Illumina Body Map 2, young vs old

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Results for RREB1

Z-value: 0.05

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Transcription factors associated with RREB1

Gene Symbol Gene ID Gene Info
RREB1
ENSG00000124782.15 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RREB1hg19_v2_chr6_+_7107830_71079930.412.0e-02Click!

Activity profile of RREB1 motif

Sorted Z-values of RREB1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_54447637 4.55 ENST00000609810.1
ENST00000430889.2
HOXC4
HOXC4
homeobox C4
Homeobox protein Hox-C4
chr4_-_154710210 3.55 ENST00000274063.4
SFRP2
secreted frizzled-related protein 2
chr11_+_1092184 3.52 ENST00000361558.6
MUC2
mucin 2, oligomeric mucus/gel-forming
chr11_+_1093318 3.50 ENST00000333592.6
MUC2
mucin 2, oligomeric mucus/gel-forming
chr12_+_54384370 3.35 ENST00000504315.1
HOXC6
homeobox C6
chr7_-_19157248 3.31 ENST00000242261.5
TWIST1
twist family bHLH transcription factor 1
chr19_+_35609380 3.29 ENST00000604621.1
FXYD3
FXYD domain containing ion transport regulator 3
chr3_+_192958914 2.94 ENST00000264735.2
ENST00000602513.1
HRASLS
HRAS-like suppressor
chrX_-_119249819 2.84 ENST00000217999.2
RHOXF1
Rhox homeobox family, member 1
chr12_-_53074182 2.78 ENST00000252244.3
KRT1
keratin 1
chr12_+_54378849 2.71 ENST00000515593.1
HOXC10
homeobox C10
chrX_+_151081351 2.57 ENST00000276344.2
MAGEA4
melanoma antigen family A, 4
chr1_+_170632250 2.55 ENST00000367760.3
PRRX1
paired related homeobox 1
chr17_+_41924511 2.52 ENST00000377203.4
ENST00000539718.1
ENST00000588884.1
ENST00000293396.8
ENST00000586233.1
CD300LG
CD300 molecule-like family member g
chr4_-_87374330 2.46 ENST00000511328.1
ENST00000503911.1
MAPK10
mitogen-activated protein kinase 10
chr12_-_8088773 2.41 ENST00000544291.1
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr19_+_51358166 2.40 ENST00000601503.1
ENST00000326003.2
ENST00000597286.1
ENST00000597483.1
KLK3
kallikrein-related peptidase 3
chr15_-_43513187 2.36 ENST00000540029.1
ENST00000441366.2
EPB42
erythrocyte membrane protein band 4.2
chr17_-_39677971 2.36 ENST00000393976.2
KRT15
keratin 15
chr16_+_28889801 2.27 ENST00000395503.4
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr17_-_46703826 2.25 ENST00000550387.1
ENST00000311177.5
HOXB9
homeobox B9
chr1_-_72748140 2.24 ENST00000434200.1
NEGR1
neuronal growth regulator 1
chr17_+_58499844 2.23 ENST00000269127.4
C17orf64
chromosome 17 open reading frame 64
chr16_+_28889703 2.22 ENST00000357084.3
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr19_+_51358191 2.19 ENST00000593997.1
ENST00000595952.1
ENST00000360617.3
ENST00000598145.1
KLK3
kallikrein-related peptidase 3
chr12_+_54402790 2.15 ENST00000040584.4
HOXC8
homeobox C8
chr8_-_75233563 2.14 ENST00000342232.4
JPH1
junctophilin 1
chr9_+_132427883 2.03 ENST00000372469.4
PRRX2
paired related homeobox 2
chr4_-_87374283 1.97 ENST00000361569.2
MAPK10
mitogen-activated protein kinase 10
chr9_+_96026230 1.93 ENST00000448251.1
WNK2
WNK lysine deficient protein kinase 2
chr19_-_51456344 1.91 ENST00000336334.3
ENST00000593428.1
KLK5
kallikrein-related peptidase 5
chr19_+_36157715 1.82 ENST00000379013.2
ENST00000222275.2
UPK1A
uroplakin 1A
chr17_+_41924536 1.79 ENST00000317310.4
CD300LG
CD300 molecule-like family member g
chr19_-_51456321 1.77 ENST00000391809.2
KLK5
kallikrein-related peptidase 5
chr8_+_37553261 1.77 ENST00000331569.4
ZNF703
zinc finger protein 703
chr4_-_13549417 1.76 ENST00000501050.1
AC006445.8
long intergenic non-protein coding RNA 1096
chr1_-_17307173 1.70 ENST00000438542.1
ENST00000375535.3
MFAP2
microfibrillar-associated protein 2
chr11_-_22881972 1.68 ENST00000532798.2
CCDC179
coiled-coil domain containing 179
chr7_-_27153454 1.64 ENST00000522456.1
HOXA3
homeobox A3
chr19_+_55999916 1.59 ENST00000587166.1
ENST00000389623.6
SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr12_-_8088871 1.58 ENST00000075120.7
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr17_+_58227287 1.52 ENST00000300900.4
ENST00000591725.1
CA4
carbonic anhydrase IV
chr19_+_55999771 1.48 ENST00000594321.1
SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr1_+_16083098 1.45 ENST00000496928.2
ENST00000508310.1
FBLIM1
filamin binding LIM protein 1
chr6_+_43112037 1.45 ENST00000473339.1
PTK7
protein tyrosine kinase 7
chr2_+_48757278 1.44 ENST00000404752.1
ENST00000406226.1
STON1
stonin 1
chrX_-_48693955 1.43 ENST00000218230.5
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr5_+_169758393 1.43 ENST00000521471.1
ENST00000518357.1
ENST00000436248.3
CTB-114C7.3
CTB-114C7.3
chr10_+_17271266 1.41 ENST00000224237.5
VIM
vimentin
chr20_+_57875457 1.39 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3
endothelin 3
chr12_-_6233828 1.39 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr15_+_21145765 1.38 ENST00000553416.1
CT60
cancer/testis antigen 60 (non-protein coding)
chr2_-_74645669 1.37 ENST00000518401.1
C2orf81
chromosome 2 open reading frame 81
chr11_-_89224488 1.35 ENST00000534731.1
ENST00000527626.1
NOX4
NADPH oxidase 4
chr16_-_1275257 1.35 ENST00000234798.4
TPSG1
tryptase gamma 1
chr12_-_16759711 1.33 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_58003935 1.32 ENST00000333972.7
ARHGEF25
Rho guanine nucleotide exchange factor (GEF) 25
chrX_+_151080929 1.32 ENST00000431963.1
MAGEA4
melanoma antigen family A, 4
chr20_+_4702548 1.32 ENST00000305817.2
PRND
prion protein 2 (dublet)
chrX_+_148863584 1.31 ENST00000439010.2
ENST00000298974.5
ENST00000522429.1
ENST00000519822.1
MAGEA9
melanoma antigen family A, 9
chr2_-_128432639 1.29 ENST00000545738.2
ENST00000355119.4
ENST00000409808.2
LIMS2
LIM and senescent cell antigen-like domains 2
chr12_+_49212514 1.29 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr15_+_76629064 1.27 ENST00000290759.4
ISL2
ISL LIM homeobox 2
chr16_+_21169976 1.27 ENST00000572258.1
ENST00000261388.3
ENST00000451578.2
ENST00000572599.1
ENST00000577162.1
TMEM159
transmembrane protein 159
chr8_-_22550815 1.26 ENST00000317216.2
EGR3
early growth response 3
chrX_+_151867214 1.23 ENST00000329342.5
ENST00000412733.1
ENST00000457643.1
MAGEA6
melanoma antigen family A, 6
chrX_-_152939252 1.22 ENST00000340888.3
PNCK
pregnancy up-regulated nonubiquitous CaM kinase
chr19_+_6135646 1.22 ENST00000588304.1
ENST00000588485.1
ENST00000588722.1
ENST00000591403.1
ENST00000586696.1
ENST00000589401.1
ENST00000252669.5
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr19_+_48867652 1.21 ENST00000344846.2
SYNGR4
synaptogyrin 4
chr5_-_148758839 1.19 ENST00000261796.3
IL17B
interleukin 17B
chr19_-_51071302 1.19 ENST00000389201.3
ENST00000600381.1
LRRC4B
leucine rich repeat containing 4B
chr14_-_105635090 1.18 ENST00000331782.3
ENST00000347004.2
JAG2
jagged 2
chr19_-_51456198 1.18 ENST00000594846.1
KLK5
kallikrein-related peptidase 5
chrX_-_148669116 1.18 ENST00000243314.5
MAGEA9B
melanoma antigen family A, 9B
chr19_-_47975417 1.18 ENST00000236877.6
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr2_-_85637459 1.17 ENST00000409921.1
CAPG
capping protein (actin filament), gelsolin-like
chr21_+_44073860 1.15 ENST00000335512.4
ENST00000539837.1
ENST00000291539.6
ENST00000380328.2
ENST00000398232.3
ENST00000398234.3
ENST00000398236.3
ENST00000328862.6
ENST00000335440.6
ENST00000398225.3
ENST00000398229.3
ENST00000398227.3
PDE9A
phosphodiesterase 9A
chr2_-_67442409 1.14 ENST00000414404.1
ENST00000433133.1
AC078941.1
AC078941.1
chr10_+_119302508 1.13 ENST00000442245.4
EMX2
empty spiracles homeobox 2
chr1_-_31712401 1.11 ENST00000373736.2
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr16_-_49890016 1.11 ENST00000563137.2
ZNF423
zinc finger protein 423
chr21_+_44073916 1.10 ENST00000349112.3
ENST00000398224.3
PDE9A
phosphodiesterase 9A
chr16_+_14396121 1.09 ENST00000570945.1
RP11-65J21.3
RP11-65J21.3
chr3_-_137834436 1.09 ENST00000327532.2
ENST00000467030.1
DZIP1L
DAZ interacting zinc finger protein 1-like
chr9_+_35906176 1.09 ENST00000354323.2
HRCT1
histidine rich carboxyl terminus 1
chr2_+_28618532 1.08 ENST00000545753.1
FOSL2
FOS-like antigen 2
chr12_-_16760021 1.07 ENST00000540445.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_+_7506837 1.07 ENST00000528758.1
OLFML1
olfactomedin-like 1
chrX_+_153813407 1.06 ENST00000443287.2
ENST00000333128.3
CTAG1A
cancer/testis antigen 1A
chr8_+_58106143 1.05 ENST00000521653.1
ENST00000518556.1
RP11-513O17.2
RP11-513O17.2
chrX_+_102585124 1.04 ENST00000332431.4
ENST00000372666.1
TCEAL7
transcription elongation factor A (SII)-like 7
chr3_+_8775466 1.04 ENST00000343849.2
ENST00000397368.2
CAV3
caveolin 3
chr19_-_47975106 1.03 ENST00000539381.1
ENST00000594353.1
ENST00000542837.1
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr1_+_164528866 1.03 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr10_+_127661942 1.02 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
FANK1
fibronectin type III and ankyrin repeat domains 1
chr17_+_58499066 1.02 ENST00000474834.1
C17orf64
chromosome 17 open reading frame 64
chr12_+_26348429 1.02 ENST00000242729.2
SSPN
sarcospan
chr13_-_72441315 1.02 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
DACH1
dachshund homolog 1 (Drosophila)
chr7_-_102257139 1.01 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RASA4
RAS p21 protein activator 4
chr22_-_44258360 1.01 ENST00000330884.4
ENST00000249130.5
SULT4A1
sulfotransferase family 4A, member 1
chr11_+_46402744 1.01 ENST00000533952.1
MDK
midkine (neurite growth-promoting factor 2)
chr12_+_26348246 1.01 ENST00000422622.2
SSPN
sarcospan
chr12_-_16760195 1.00 ENST00000546281.1
ENST00000537757.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr17_+_1958388 1.00 ENST00000399849.3
HIC1
hypermethylated in cancer 1
chr8_+_58106173 1.00 ENST00000523341.1
RP11-513O17.2
RP11-513O17.2
chrX_+_148864169 1.00 ENST00000523516.1
MAGEA9
melanoma antigen family A, 9
chr1_-_6240183 0.99 ENST00000262450.3
ENST00000378021.1
CHD5
chromodomain helicase DNA binding protein 5
chr4_+_123747834 0.99 ENST00000264498.3
FGF2
fibroblast growth factor 2 (basic)
chr6_+_151646800 0.99 ENST00000354675.6
AKAP12
A kinase (PRKA) anchor protein 12
chr10_+_115438920 0.98 ENST00000429617.1
ENST00000369331.4
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr20_+_34700333 0.97 ENST00000441639.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chrX_-_151922340 0.96 ENST00000370284.1
ENST00000543232.1
ENST00000393876.1
ENST00000393872.3
MAGEA2
melanoma antigen family A, 2
chr18_-_21242833 0.96 ENST00000586087.1
ENST00000592179.1
ANKRD29
ankyrin repeat domain 29
chrX_-_151938171 0.92 ENST00000393902.3
ENST00000417212.1
ENST00000370278.3
MAGEA3
melanoma antigen family A, 3
chr11_+_1897697 0.92 ENST00000432093.1
LSP1
lymphocyte-specific protein 1
chr7_+_75932863 0.92 ENST00000429938.1
HSPB1
heat shock 27kDa protein 1
chr19_-_18995029 0.91 ENST00000596048.1
CERS1
ceramide synthase 1
chrX_-_153847522 0.91 ENST00000328435.2
ENST00000359887.4
CTAG1B
cancer/testis antigen 1B
chr1_+_157963063 0.91 ENST00000360089.4
ENST00000368173.3
ENST00000392272.2
KIRREL
kin of IRRE like (Drosophila)
chr15_-_23692381 0.90 ENST00000567107.1
ENST00000345070.5
ENST00000312015.5
GOLGA6L2
golgin A6 family-like 2
chr19_-_9006766 0.89 ENST00000599436.1
MUC16
mucin 16, cell surface associated
chrX_-_70150939 0.89 ENST00000374299.3
ENST00000298085.4
SLC7A3
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
chr11_-_35547277 0.88 ENST00000527605.1
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr11_+_125034586 0.88 ENST00000298282.9
PKNOX2
PBX/knotted 1 homeobox 2
chr11_-_35547151 0.87 ENST00000378878.3
ENST00000529303.1
ENST00000278360.3
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr12_-_56101647 0.87 ENST00000347027.6
ENST00000257879.6
ENST00000257880.7
ENST00000394230.2
ENST00000394229.2
ITGA7
integrin, alpha 7
chr17_-_58499698 0.86 ENST00000590297.1
USP32
ubiquitin specific peptidase 32
chr17_-_62658186 0.85 ENST00000262435.9
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr11_+_7506584 0.85 ENST00000530135.1
OLFML1
olfactomedin-like 1
chr1_-_153538292 0.84 ENST00000497140.1
ENST00000368708.3
S100A2
S100 calcium binding protein A2
chr13_+_111972980 0.84 ENST00000283547.1
TEX29
testis expressed 29
chr4_-_77996032 0.83 ENST00000505609.1
CCNI
cyclin I
chr11_+_46403194 0.83 ENST00000395569.4
ENST00000395566.4
MDK
midkine (neurite growth-promoting factor 2)
chr15_+_75498739 0.82 ENST00000565074.1
C15orf39
chromosome 15 open reading frame 39
chr2_+_177001685 0.82 ENST00000432796.2
HOXD3
homeobox D3
chr11_+_46403303 0.81 ENST00000407067.1
ENST00000395565.1
MDK
midkine (neurite growth-promoting factor 2)
chr8_+_38261880 0.81 ENST00000527175.1
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr11_-_64703354 0.80 ENST00000532246.1
ENST00000279168.2
GPHA2
glycoprotein hormone alpha 2
chr17_+_38296576 0.80 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr2_+_28974531 0.79 ENST00000420282.1
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr8_+_95653840 0.79 ENST00000520385.1
ESRP1
epithelial splicing regulatory protein 1
chr20_+_23168759 0.77 ENST00000411595.1
RP4-737E23.2
RP4-737E23.2
chrX_-_8769378 0.75 ENST00000543214.1
ENST00000381003.3
FAM9A
family with sequence similarity 9, member A
chr17_-_41132088 0.75 ENST00000591916.1
ENST00000451885.2
ENST00000454303.1
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr12_-_48214345 0.74 ENST00000433685.1
ENST00000447463.1
ENST00000427332.2
HDAC7
histone deacetylase 7
chr19_-_44306590 0.74 ENST00000377950.3
LYPD5
LY6/PLAUR domain containing 5
chr1_-_228604328 0.73 ENST00000355586.4
ENST00000366698.2
ENST00000520264.1
ENST00000479800.1
ENST00000295033.3
TRIM17
tripartite motif containing 17
chr4_+_123747979 0.73 ENST00000608478.1
FGF2
fibroblast growth factor 2 (basic)
chr10_-_61122625 0.72 ENST00000468840.2
FAM13C
family with sequence similarity 13, member C
chr7_+_76101379 0.72 ENST00000429179.1
DTX2
deltex homolog 2 (Drosophila)
chr12_+_26348582 0.72 ENST00000535504.1
SSPN
sarcospan
chr18_+_77160282 0.71 ENST00000318065.5
ENST00000545796.1
ENST00000592223.1
ENST00000329101.4
ENST00000586434.1
NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr18_-_3874271 0.71 ENST00000400149.3
ENST00000400155.1
ENST00000400150.3
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr7_-_132262060 0.69 ENST00000359827.3
PLXNA4
plexin A4
chr11_-_71791726 0.69 ENST00000393695.3
NUMA1
nuclear mitotic apparatus protein 1
chrX_-_151903184 0.69 ENST00000357916.4
ENST00000393869.3
MAGEA12
melanoma antigen family A, 12
chr8_-_145578505 0.68 ENST00000526263.1
ENST00000398633.3
TMEM249
transmembrane protein 249
chr4_+_164265035 0.67 ENST00000338566.3
NPY5R
neuropeptide Y receptor Y5
chr19_-_3025614 0.67 ENST00000447365.2
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr9_+_93921855 0.67 ENST00000423719.2
ENST00000609752.1
LINC00484
long intergenic non-protein coding RNA 484
chr11_-_71791435 0.67 ENST00000351960.6
ENST00000541719.1
ENST00000535111.1
NUMA1
nuclear mitotic apparatus protein 1
chr11_+_7506713 0.67 ENST00000329293.3
ENST00000534244.1
OLFML1
olfactomedin-like 1
chr10_+_52751010 0.67 ENST00000373985.1
PRKG1
protein kinase, cGMP-dependent, type I
chrX_-_151306982 0.67 ENST00000444834.2
ENST00000579960.1
MAGEA10
melanoma antigen family A, 10
chrX_+_151883090 0.67 ENST00000370293.2
ENST00000423993.1
ENST00000447530.1
ENST00000458057.1
ENST00000331220.2
ENST00000422085.1
ENST00000453150.1
ENST00000409560.1
MAGEA2B
melanoma antigen family A, 2B
chr8_+_72755367 0.67 ENST00000537896.1
RP11-383H13.1
Protein LOC100132891; cDNA FLJ53548
chr2_+_105471969 0.66 ENST00000361360.2
POU3F3
POU class 3 homeobox 3
chrX_-_153881842 0.66 ENST00000369585.3
ENST00000247306.4
CTAG2
cancer/testis antigen 2
chr17_+_54671047 0.65 ENST00000332822.4
NOG
noggin
chr11_-_71791518 0.65 ENST00000537217.1
ENST00000366394.3
ENST00000358965.6
ENST00000546131.1
ENST00000543937.1
ENST00000368959.5
ENST00000541641.1
NUMA1
nuclear mitotic apparatus protein 1
chr2_+_106468204 0.64 ENST00000425756.1
ENST00000393349.2
NCK2
NCK adaptor protein 2
chr8_-_22550691 0.64 ENST00000519492.1
EGR3
early growth response 3
chr3_+_140660634 0.63 ENST00000446041.2
ENST00000507429.1
ENST00000324194.6
SLC25A36
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr20_+_55967129 0.61 ENST00000371219.2
RBM38
RNA binding motif protein 38
chr6_-_35480705 0.61 ENST00000229771.6
TULP1
tubby like protein 1
chr18_-_21242774 0.61 ENST00000322980.9
ANKRD29
ankyrin repeat domain 29
chr20_+_62697564 0.60 ENST00000458442.1
TCEA2
transcription elongation factor A (SII), 2
chr11_+_125034640 0.59 ENST00000542175.1
PKNOX2
PBX/knotted 1 homeobox 2
chr12_-_95044309 0.59 ENST00000261226.4
TMCC3
transmembrane and coiled-coil domain family 3
chr18_+_33877654 0.59 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3
formin homology 2 domain containing 3
chr12_-_57644952 0.59 ENST00000554578.1
ENST00000546246.2
ENST00000553489.1
ENST00000332782.2
STAC3
SH3 and cysteine rich domain 3
chr10_-_61122934 0.58 ENST00000512919.1
FAM13C
family with sequence similarity 13, member C
chr11_-_118789613 0.58 ENST00000532899.1
BCL9L
B-cell CLL/lymphoma 9-like
chr3_-_38991853 0.58 ENST00000456224.3
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr19_+_14544099 0.57 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
PKN1
protein kinase N1
chr6_-_35480640 0.55 ENST00000428978.1
ENST00000322263.4
TULP1
tubby like protein 1
chr19_-_44084586 0.54 ENST00000599693.1
ENST00000598165.1
XRCC1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr11_+_818902 0.54 ENST00000336615.4
PNPLA2
patatin-like phospholipase domain containing 2
chr7_+_95401851 0.54 ENST00000447467.2
DYNC1I1
dynein, cytoplasmic 1, intermediate chain 1
chr5_-_37835010 0.54 ENST00000510177.1
GDNF
glial cell derived neurotrophic factor
chr15_-_35088340 0.54 ENST00000290378.4
ACTC1
actin, alpha, cardiac muscle 1
chr3_+_57094469 0.53 ENST00000334325.1
SPATA12
spermatogenesis associated 12
chr1_+_110091189 0.53 ENST00000369851.4
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr14_-_69444957 0.53 ENST00000556571.1
ENST00000553659.1
ENST00000555616.1
ACTN1
actinin, alpha 1
chr10_+_102758105 0.53 ENST00000429732.1
LZTS2
leucine zipper, putative tumor suppressor 2
chr18_+_9334755 0.52 ENST00000262120.5
TWSG1
twisted gastrulation BMP signaling modulator 1
chr17_+_78193443 0.51 ENST00000577155.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chrX_-_151903101 0.51 ENST00000393900.3
MAGEA12
melanoma antigen family A, 12
chr3_+_53195517 0.51 ENST00000487897.1
PRKCD
protein kinase C, delta
chr12_-_62653903 0.51 ENST00000552075.1
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2

Network of associatons between targets according to the STRING database.

First level regulatory network of RREB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0031448 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
1.2 3.6 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
1.1 3.3 GO:2000276 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.9 9.5 GO:0002775 antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778)
0.8 4.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.6 1.7 GO:0042660 positive regulation of cell fate specification(GO:0042660)
0.5 3.1 GO:0042494 detection of bacterial lipoprotein(GO:0042494)
0.4 2.7 GO:0030421 defecation(GO:0030421)
0.4 4.3 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.3 1.0 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.3 1.3 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.3 4.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.3 0.9 GO:0072720 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.3 3.2 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.2 3.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.2 1.6 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.2 0.9 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.2 0.9 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.2 2.5 GO:0048664 neuron fate determination(GO:0048664)
0.2 2.7 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.2 3.1 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.2 2.0 GO:0032888 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.2 0.8 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.2 1.7 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.2 0.5 GO:1904875 regulation of DNA ligase activity(GO:1904875)
0.2 2.8 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 1.0 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 2.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 4.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 1.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.5 GO:0021784 postganglionic parasympathetic fiber development(GO:0021784)
0.1 0.7 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.1 0.7 GO:0060825 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.1 2.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.9 GO:1903401 L-lysine transmembrane transport(GO:1903401)
0.1 0.5 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 0.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1 1.1 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 1.0 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 1.0 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1 1.3 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 0.6 GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.1 1.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.5 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.1 1.4 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 2.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.4 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 0.7 GO:0014050 negative regulation of glutamate secretion(GO:0014050) negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.1 0.6 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.1 1.3 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.5 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.1 0.5 GO:0090131 mesenchyme migration(GO:0090131)
0.1 1.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.1 0.4 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.1 1.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.8 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.1 1.2 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 0.9 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.1 0.9 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 0.5 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.3 GO:0061150 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.3 GO:1901994 meiotic DNA integrity checkpoint(GO:0044778) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.1 1.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.3 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 1.2 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 0.9 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 1.3 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 1.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.7 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 0.9 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.4 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.4 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.5 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.1 0.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 2.1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.1 1.3 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.1 1.1 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 1.0 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.9 GO:0007512 adult heart development(GO:0007512)
0.0 5.2 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.4 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 1.0 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 1.1 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:1902869 regulation of amacrine cell differentiation(GO:1902869)
0.0 0.8 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.3 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952)
0.0 1.4 GO:0002021 response to dietary excess(GO:0002021)
0.0 0.2 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 11.7 GO:0009952 anterior/posterior pattern specification(GO:0009952)
0.0 1.3 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.3 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.2 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.4 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0 0.7 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 1.2 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.5 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396) tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.7 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.2 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.3 GO:1904970 brush border assembly(GO:1904970)
0.0 0.3 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 1.1 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 1.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.5 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.4 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.5 GO:0051601 exocyst localization(GO:0051601)
0.0 0.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 3.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.2 GO:0051461 positive regulation of corticotropin secretion(GO:0051461)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 1.2 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.5 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.2 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.9 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.6 GO:0050718 positive regulation of interleukin-1 beta secretion(GO:0050718)
0.0 0.8 GO:0051931 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0 1.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:2000322 regulation of glucocorticoid receptor signaling pathway(GO:2000322)
0.0 0.8 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 1.0 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 0.6 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.0 1.3 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 1.2 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.4 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293)
0.0 0.6 GO:0030488 tRNA methylation(GO:0030488)
0.0 1.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 2.5 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.0 0.9 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.0 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0 0.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.6 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.0 0.3 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.7 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 0.2 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.3 GO:0097320 membrane tubulation(GO:0097320)
0.0 1.0 GO:0071277 cellular response to calcium ion(GO:0071277)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 7.0 GO:0070702 inner mucus layer(GO:0070702) outer mucus layer(GO:0070703)
0.7 4.9 GO:0097209 epidermal lamellar body(GO:0097209)
0.3 0.8 GO:0044299 C-fiber(GO:0044299)
0.2 2.7 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.2 2.0 GO:0055028 cortical microtubule(GO:0055028)
0.2 2.1 GO:0030314 junctional membrane complex(GO:0030314)
0.2 4.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 4.7 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 0.5 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.1 2.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 0.5 GO:0042643 actomyosin, actin portion(GO:0042643)
0.1 0.6 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.1 2.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.9 GO:0070852 cell body fiber(GO:0070852)
0.1 1.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 1.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.5 GO:0070522 ERCC4-ERCC1 complex(GO:0070522)
0.1 1.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.8 GO:0042587 glycogen granule(GO:0042587)
0.1 0.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.6 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.5 GO:0044326 dendritic spine neck(GO:0044326)
0.1 0.9 GO:0071141 SMAD protein complex(GO:0071141)
0.0 1.2 GO:0000800 lateral element(GO:0000800)
0.0 0.2 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 1.7 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.5 GO:0042588 zymogen granule(GO:0042588)
0.0 0.1 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.1 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 3.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.7 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.8 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 3.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0051286 cell tip(GO:0051286)
0.0 0.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 4.5 GO:0043204 perikaryon(GO:0043204)
0.0 4.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 1.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 2.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.2 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.9 GO:1904115 axon cytoplasm(GO:1904115)
0.0 2.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0030904 retromer complex(GO:0030904)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.4 3.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.4 4.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3 1.0 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.3 1.6 GO:0031708 endothelin B receptor binding(GO:0031708)
0.3 9.4 GO:0071837 HMG box domain binding(GO:0071837)
0.3 0.8 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.2 1.0 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.2 1.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 0.9 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.2 0.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.6 GO:0032090 Pyrin domain binding(GO:0032090)
0.2 1.4 GO:1990254 keratin filament binding(GO:1990254)
0.2 2.8 GO:0019826 oxygen sensor activity(GO:0019826)
0.2 0.7 GO:0001601 peptide YY receptor activity(GO:0001601)
0.2 2.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 1.4 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.2 0.8 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.1 5.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 2.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 4.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.3 GO:0070984 SET domain binding(GO:0070984)
0.1 0.9 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.1 0.6 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 0.6 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 2.0 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 1.0 GO:0071253 connexin binding(GO:0071253)
0.1 1.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 2.5 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.7 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 3.8 GO:0043236 laminin binding(GO:0043236)
0.1 0.5 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 1.5 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 0.7 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 0.6 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 0.5 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 0.9 GO:0089720 caspase binding(GO:0089720)
0.1 1.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1 3.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 0.2 GO:0004641 phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.1 0.3 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.2 GO:0016731 ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731)
0.1 1.2 GO:0047617 very long-chain fatty acid-CoA ligase activity(GO:0031957) acyl-CoA hydrolase activity(GO:0047617)
0.0 1.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.0 1.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.4 GO:0031005 filamin binding(GO:0031005)
0.0 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250) ER retention sequence binding(GO:0046923)
0.0 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.0 3.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0016015 morphogen activity(GO:0016015)
0.0 1.1 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.9 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.5 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 1.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.5 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 1.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 4.7 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 1.0 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.5 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 1.0 GO:0017166 vinculin binding(GO:0017166)
0.0 2.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.2 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.7 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.5 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.4 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 1.0 GO:0030507 spectrin binding(GO:0030507)
0.0 2.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.0 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.3 GO:0005507 copper ion binding(GO:0005507)
0.0 0.8 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 1.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.3 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 1.1 GO:0017022 myosin binding(GO:0017022)
0.0 0.9 GO:0046332 SMAD binding(GO:0046332)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 8.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 5.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 4.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.9 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 4.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.9 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.7 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 1.6 PID BMP PATHWAY BMP receptor signaling
0.0 1.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.9 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 1.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.0 PID E2F PATHWAY E2F transcription factor network
0.0 1.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.7 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 3.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.8 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.5 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.2 7.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 7.0 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.2 4.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 4.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 4.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.7 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.0 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 3.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 1.3 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.9 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.5 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 2.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.0 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.0 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock