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Illumina Body Map 2, young vs old

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Results for SIX6

Z-value: 0.32

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Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
SIX6
ENSG00000184302.6 SIX homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX6hg19_v2_chr14_+_60975644_60975673-0.183.2e-01Click!

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_88427568 11.73 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chr1_-_161193349 6.30 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr9_-_100707116 6.12 ENST00000259456.3
HEMGN
hemogen
chr4_-_155511887 5.92 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr19_-_16008880 5.10 ENST00000011989.7
ENST00000221700.6
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr3_+_151531859 4.49 ENST00000488869.1
AADAC
arylacetamide deacetylase
chr1_+_159557607 3.40 ENST00000255040.2
APCS
amyloid P component, serum
chr6_+_37012607 3.19 ENST00000423336.1
COX6A1P2
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr2_+_34935472 3.19 ENST00000604250.1
AC073218.2
AC073218.2
chr3_+_151531810 3.19 ENST00000232892.7
AADAC
arylacetamide deacetylase
chr8_+_67405438 3.16 ENST00000305454.3
C8orf46
chromosome 8 open reading frame 46
chr13_-_46679185 3.15 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr1_+_86934526 3.06 ENST00000394711.1
CLCA1
chloride channel accessory 1
chr3_+_186742464 3.04 ENST00000416235.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr1_+_63063152 3.03 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr15_+_58430368 2.95 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr13_-_46679144 2.87 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr16_+_72090053 2.84 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
HP
haptoglobin
chr15_+_58430567 2.80 ENST00000536493.1
AQP9
aquaporin 9
chr1_-_159684371 2.76 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr7_+_117251671 2.76 ENST00000468795.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr12_-_14849470 2.66 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr6_+_25727046 2.46 ENST00000274764.2
HIST1H2BA
histone cluster 1, H2ba
chr1_+_21880560 2.45 ENST00000425315.2
ALPL
alkaline phosphatase, liver/bone/kidney
chr4_-_71532668 1.75 ENST00000510437.1
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr6_-_25726781 1.70 ENST00000297012.3
HIST1H2AA
histone cluster 1, H2aa
chr4_-_71532601 1.69 ENST00000510614.1
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr7_-_92855762 1.58 ENST00000453812.2
ENST00000394468.2
HEPACAM2
HEPACAM family member 2
chr22_+_18721427 1.57 ENST00000342888.3
AC008132.1
Uncharacterized protein
chr8_+_101170134 1.56 ENST00000520643.1
SPAG1
sperm associated antigen 1
chr16_-_20364030 1.49 ENST00000396134.2
ENST00000573567.1
ENST00000570757.1
ENST00000424589.1
ENST00000302509.4
ENST00000571174.1
ENST00000576688.1
UMOD
uromodulin
chr15_-_80263506 1.47 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr15_+_69857515 1.46 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chr4_-_184241927 1.42 ENST00000323319.5
CLDN22
claudin 22
chr10_-_14614311 1.35 ENST00000479731.1
ENST00000468492.1
FAM107B
family with sequence similarity 107, member B
chr22_+_18043133 1.33 ENST00000327451.6
ENST00000399813.1
SLC25A18
solute carrier family 25 (glutamate carrier), member 18
chr8_+_101170257 1.33 ENST00000251809.3
SPAG1
sperm associated antigen 1
chr19_-_14628645 1.29 ENST00000598235.1
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr6_-_108145499 1.29 ENST00000369020.3
ENST00000369022.2
SCML4
sex comb on midleg-like 4 (Drosophila)
chr5_-_66492562 1.28 ENST00000256447.4
CD180
CD180 molecule
chr4_+_74347400 1.27 ENST00000226355.3
AFM
afamin
chr16_-_20364122 1.26 ENST00000396138.4
ENST00000577168.1
UMOD
uromodulin
chrX_+_12809463 1.23 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr18_+_55018044 1.22 ENST00000324000.3
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr11_+_126262027 1.22 ENST00000526311.1
ST3GAL4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr14_+_20937538 1.21 ENST00000361505.5
ENST00000553591.1
PNP
purine nucleoside phosphorylase
chr9_-_23821842 1.13 ENST00000544538.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr19_+_9203855 1.10 ENST00000429566.3
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr2_+_21444025 1.08 ENST00000435237.1
ENST00000457901.1
AC067959.1
AC067959.1
chr2_-_239140011 1.07 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
AC016757.3
Protein LOC151174
chr14_+_83108955 0.99 ENST00000555798.1
ENST00000553760.1
ENST00000555150.1
ENST00000556970.1
RP11-406A9.2
RP11-406A9.2
chr13_-_62001982 0.98 ENST00000409186.1
PCDH20
protocadherin 20
chr2_+_210636697 0.94 ENST00000439458.1
ENST00000272845.6
UNC80
unc-80 homolog (C. elegans)
chr12_+_10705960 0.92 ENST00000544591.1
RP11-291B21.2
RP11-291B21.2
chr11_-_45307817 0.91 ENST00000020926.3
SYT13
synaptotagmin XIII
chrY_-_16098393 0.91 ENST00000250825.4
VCY
variable charge, Y-linked
chr18_+_50278430 0.86 ENST00000578080.1
ENST00000582875.1
ENST00000412726.1
DCC
deleted in colorectal carcinoma
chr12_-_87232771 0.86 ENST00000550014.1
RP11-202H2.1
RP11-202H2.1
chr16_-_52119019 0.85 ENST00000561513.1
ENST00000565742.1
LINC00919
long intergenic non-protein coding RNA 919
chr3_+_125694347 0.84 ENST00000505382.1
ENST00000511082.1
ROPN1B
rhophilin associated tail protein 1B
chr14_+_21152259 0.80 ENST00000555835.1
ENST00000336811.6
RNASE4
ANG
ribonuclease, RNase A family, 4
angiogenin, ribonuclease, RNase A family, 5
chrY_+_16168097 0.79 ENST00000250823.4
VCY1B
variable charge, Y-linked 1B
chr8_+_24241789 0.76 ENST00000256412.4
ENST00000538205.1
ADAMDEC1
ADAM-like, decysin 1
chrX_+_142113704 0.73 ENST00000446864.1
ENST00000370504.3
SPANXN4
SPANX family, member N4
chr19_-_53794875 0.72 ENST00000426466.1
BIRC8
baculoviral IAP repeat containing 8
chr1_+_40942887 0.72 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr6_-_8102279 0.70 ENST00000488226.2
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr16_+_19467772 0.70 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
TMC5
transmembrane channel-like 5
chrX_+_8433376 0.67 ENST00000440654.2
ENST00000381029.4
VCX3B
variable charge, X-linked 3B
chr11_+_59807748 0.64 ENST00000278855.2
ENST00000532905.1
PLAC1L
oocyte secreted protein 2
chr8_+_24241969 0.64 ENST00000522298.1
ADAMDEC1
ADAM-like, decysin 1
chr5_-_83016632 0.63 ENST00000515590.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr2_-_134326009 0.62 ENST00000409261.1
ENST00000409213.1
NCKAP5
NCK-associated protein 5
chr22_-_17302589 0.61 ENST00000331428.5
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr17_-_42327236 0.59 ENST00000399246.2
AC003102.1
AC003102.1
chr12_-_121477039 0.58 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr20_-_4990931 0.58 ENST00000379333.1
SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chrX_-_77225135 0.57 ENST00000458128.1
PGAM4
phosphoglycerate mutase family member 4
chr7_-_141957847 0.56 ENST00000552471.1
ENST00000547058.2
PRSS58
protease, serine, 58
chr4_-_42154895 0.55 ENST00000502486.1
ENST00000504360.1
BEND4
BEN domain containing 4
chr8_+_32579341 0.53 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr6_+_80816342 0.51 ENST00000369760.4
ENST00000356489.5
ENST00000320393.6
BCKDHB
branched chain keto acid dehydrogenase E1, beta polypeptide
chrX_-_18238999 0.50 ENST00000380033.4
ENST00000380030.3
BEND2
BEN domain containing 2
chr12_+_65277536 0.50 ENST00000540024.1
RP11-766N7.3
RP11-766N7.3
chr4_-_71532339 0.49 ENST00000254801.4
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr19_+_46000479 0.48 ENST00000456399.2
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr8_-_82598067 0.48 ENST00000523942.1
ENST00000522997.1
IMPA1
inositol(myo)-1(or 4)-monophosphatase 1
chr1_+_112016414 0.48 ENST00000343534.5
ENST00000369718.3
C1orf162
chromosome 1 open reading frame 162
chr7_+_6121296 0.48 ENST00000428901.1
AC004895.4
AC004895.4
chr2_-_77749387 0.47 ENST00000409884.1
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr6_+_12718497 0.46 ENST00000379348.2
PHACTR1
phosphatase and actin regulator 1
chr3_-_107596910 0.45 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
LINC00635
long intergenic non-protein coding RNA 635
chr5_+_171621176 0.44 ENST00000398186.4
EFCAB9
EF-hand calcium binding domain 9
chr12_+_19282643 0.43 ENST00000317589.4
ENST00000355397.3
ENST00000359180.3
ENST00000309364.4
ENST00000540972.1
ENST00000429027.2
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr12_-_87232644 0.42 ENST00000549405.2
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_+_53308398 0.41 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chr3_-_146323019 0.40 ENST00000492200.1
ENST00000482567.1
PLSCR5
phospholipid scramblase family, member 5
chr8_-_110660975 0.40 ENST00000528045.1
SYBU
syntabulin (syntaxin-interacting)
chr19_-_44031375 0.40 ENST00000292147.2
ETHE1
ethylmalonic encephalopathy 1
chr9_-_99382065 0.39 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
CDC14B
cell division cycle 14B
chr2_-_197457335 0.39 ENST00000260983.3
HECW2
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
chr12_+_103545593 0.39 ENST00000547418.1
RP11-552I14.1
Uncharacterized protein
chr1_-_161015752 0.38 ENST00000435396.1
ENST00000368021.3
USF1
upstream transcription factor 1
chr16_-_87350970 0.38 ENST00000567970.1
C16orf95
chromosome 16 open reading frame 95
chr1_-_182369751 0.37 ENST00000367565.1
TEDDM1
transmembrane epididymal protein 1
chr5_+_140201183 0.37 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
PCDHA5
protocadherin alpha 5
chr4_-_13546632 0.36 ENST00000382438.5
NKX3-2
NK3 homeobox 2
chr11_-_102496063 0.36 ENST00000260228.2
MMP20
matrix metallopeptidase 20
chr17_+_61271355 0.36 ENST00000583356.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr11_+_124789146 0.36 ENST00000408930.5
HEPN1
hepatocellular carcinoma, down-regulated 1
chr15_+_63414760 0.34 ENST00000557972.1
LACTB
lactamase, beta
chr8_+_67104323 0.34 ENST00000518412.1
ENST00000518035.1
ENST00000517725.1
LINC00967
long intergenic non-protein coding RNA 967
chr6_-_6711235 0.33 ENST00000432823.2
RP1-80N2.2
RP1-80N2.2
chr6_+_47749718 0.33 ENST00000489301.2
ENST00000371211.2
ENST00000393699.2
OPN5
opsin 5
chr6_-_26189304 0.33 ENST00000340756.2
HIST1H4D
histone cluster 1, H4d
chr12_-_122018346 0.31 ENST00000377069.4
KDM2B
lysine (K)-specific demethylase 2B
chr4_-_139051839 0.31 ENST00000514600.1
ENST00000513895.1
ENST00000512536.1
LINC00616
long intergenic non-protein coding RNA 616
chr14_+_21525981 0.31 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr22_-_19137796 0.29 ENST00000086933.2
GSC2
goosecoid homeobox 2
chr4_+_57396766 0.29 ENST00000512175.2
THEGL
theg spermatid protein-like
chr2_-_77749336 0.29 ENST00000409282.1
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr12_-_498620 0.28 ENST00000399788.2
ENST00000382815.4
KDM5A
lysine (K)-specific demethylase 5A
chr12_-_121476959 0.27 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr1_-_13673511 0.27 ENST00000344998.3
ENST00000334600.6
PRAMEF14
PRAME family member 14
chr17_+_7788104 0.27 ENST00000380358.4
CHD3
chromodomain helicase DNA binding protein 3
chr4_+_189321881 0.26 ENST00000512839.1
ENST00000513313.1
LINC01060
long intergenic non-protein coding RNA 1060
chr1_-_67142710 0.25 ENST00000502413.2
AL139147.1
Uncharacterized protein
chr6_+_167562968 0.25 ENST00000486697.2
TCP10L2
t-complex 10-like 2
chrY_-_24038660 0.25 ENST00000382677.3
RBMY1D
RNA binding motif protein, Y-linked, family 1, member D
chr5_+_115420688 0.24 ENST00000274458.4
COMMD10
COMM domain containing 10
chr5_-_78281775 0.24 ENST00000396151.3
ENST00000565165.1
ARSB
arylsulfatase B
chr6_+_127898312 0.24 ENST00000329722.7
C6orf58
chromosome 6 open reading frame 58
chr13_+_34392185 0.23 ENST00000380071.3
RFC3
replication factor C (activator 1) 3, 38kDa
chrY_+_23698778 0.21 ENST00000303902.5
RBMY1A1
RNA binding motif protein, Y-linked, family 1, member A1
chr2_-_220197351 0.21 ENST00000392083.1
RESP18
regulated endocrine-specific protein 18
chr1_-_10003372 0.21 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
LZIC
leucine zipper and CTNNBIP1 domain containing
chr21_+_22519416 0.20 ENST00000535285.1
NCAM2
neural cell adhesion molecule 2
chr17_-_5342380 0.19 ENST00000225698.4
C1QBP
complement component 1, q subcomponent binding protein
chr5_+_161277603 0.19 ENST00000519621.1
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr1_+_156119466 0.18 ENST00000414683.1
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr3_+_259218 0.18 ENST00000449294.2
CHL1
cell adhesion molecule L1-like
chr10_-_61720640 0.18 ENST00000521074.1
ENST00000444900.1
C10orf40
chromosome 10 open reading frame 40
chr8_-_128231299 0.18 ENST00000500112.1
CCAT1
colon cancer associated transcript 1 (non-protein coding)
chr22_-_17702729 0.17 ENST00000449907.2
ENST00000441548.1
ENST00000399839.1
CECR1
cat eye syndrome chromosome region, candidate 1
chr4_-_123377880 0.17 ENST00000226730.4
IL2
interleukin 2
chr6_+_146348782 0.16 ENST00000361719.2
ENST00000392299.2
GRM1
glutamate receptor, metabotropic 1
chr11_+_33902189 0.14 ENST00000330381.2
AC132216.1
HCG1785179; PRO1787; Uncharacterized protein
chr8_+_107593198 0.14 ENST00000517686.1
OXR1
oxidation resistance 1
chr11_+_6149840 0.14 ENST00000316517.2
OR56B3P
olfactory receptor, family 56, subfamily B, member 3 pseudogene
chr3_+_40141502 0.13 ENST00000539167.1
MYRIP
myosin VIIA and Rab interacting protein
chr1_-_36235559 0.13 ENST00000251195.5
CLSPN
claspin
chr2_-_58468437 0.11 ENST00000403676.1
ENST00000427708.2
ENST00000403295.3
ENST00000446381.1
ENST00000417361.1
ENST00000233741.4
ENST00000402135.3
ENST00000540646.1
ENST00000449070.1
FANCL
Fanconi anemia, complementation group L
chr1_-_161015663 0.10 ENST00000534633.1
USF1
upstream transcription factor 1
chr12_+_122018697 0.10 ENST00000541574.1
RP13-941N14.1
RP13-941N14.1
chr8_+_32579271 0.09 ENST00000518084.1
NRG1
neuregulin 1
chr6_+_146348810 0.09 ENST00000492807.2
GRM1
glutamate receptor, metabotropic 1
chr2_-_77749474 0.09 ENST00000409093.1
ENST00000409088.3
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr1_+_234509186 0.09 ENST00000366615.4
COA6
cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
chr2_+_181988560 0.08 ENST00000424170.1
ENST00000435411.1
AC104820.2
AC104820.2
chr12_-_122018859 0.07 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
KDM2B
lysine (K)-specific demethylase 2B
chr17_+_60501228 0.06 ENST00000311506.5
METTL2A
methyltransferase like 2A
chr1_+_179263308 0.06 ENST00000426956.1
SOAT1
sterol O-acyltransferase 1
chr2_+_177134201 0.05 ENST00000452865.1
MTX2
metaxin 2
chr2_+_177134134 0.05 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
MTX2
metaxin 2
chr19_+_31658405 0.05 ENST00000589511.1
CTC-439O9.3
CTC-439O9.3
chr2_-_89266286 0.04 ENST00000464162.1
IGKV1-6
immunoglobulin kappa variable 1-6
chr13_-_20080080 0.03 ENST00000400103.2
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
chr4_+_74301880 0.02 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr14_+_22948510 0.02 ENST00000390483.1
TRAJ56
T cell receptor alpha joining 56
chr9_-_21142144 0.02 ENST00000380229.2
IFNW1
interferon, omega 1
chr5_+_120649672 0.01 ENST00000609647.1
CTC-546K23.1
CTC-546K23.1
chr20_+_54987305 0.00 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
1.7 5.1 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
1.5 6.0 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
1.0 5.7 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.9 2.8 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.8 2.5 GO:0071529 cementum mineralization(GO:0071529)
0.7 11.7 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.7 2.8 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.6 7.7 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.5 2.7 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.5 3.4 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.4 5.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.4 1.2 GO:0070638 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.4 3.0 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.2 2.5 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 1.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 2.7 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.2 0.9 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.2 0.6 GO:0015993 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.2 1.3 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.2 0.8 GO:0032431 activation of phospholipase A2 activity(GO:0032431)
0.1 2.8 GO:0008228 opsonization(GO:0008228) positive regulation of superoxide anion generation(GO:0032930)
0.1 0.6 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 3.0 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 0.2 GO:0061580 colon epithelial cell migration(GO:0061580)
0.1 1.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.4 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.3 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.1 0.5 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.1 2.9 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 0.4 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.1 0.4 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 2.4 GO:0097503 sialylation(GO:0097503)
0.1 0.6 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.1 0.5 GO:0006021 inositol biosynthetic process(GO:0006021)
0.1 0.3 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.2 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 1.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 1.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 1.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.8 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.7 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.7 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.4 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 5.6 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.0 0.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 3.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.9 GO:0051180 vitamin transport(GO:0051180)
0.0 0.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 1.7 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.4 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.7 11.7 GO:0045179 apical cortex(GO:0045179)
0.5 2.8 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.4 5.9 GO:0005577 fibrinogen complex(GO:0005577)
0.4 6.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.3 1.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.3 2.5 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.2 3.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.2 2.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.8 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 2.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.5 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1 0.3 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.0 0.5 GO:0016589 NURF complex(GO:0016589)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 3.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 2.7 GO:0060170 ciliary membrane(GO:0060170)
0.0 4.1 GO:0072562 blood microparticle(GO:0072562)
0.0 0.9 GO:0000786 nucleosome(GO:0000786)
0.0 0.6 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.1 GO:0097259 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
1.7 11.7 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.6 6.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.1 5.7 GO:0015254 glycerol channel activity(GO:0015254)
0.7 2.8 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.6 6.4 GO:0001849 complement component C1q binding(GO:0001849)
0.5 2.8 GO:0030492 hemoglobin binding(GO:0030492)
0.4 1.2 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.3 1.3 GO:0008431 vitamin E binding(GO:0008431)
0.3 2.5 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.3 3.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 0.9 GO:0005042 netrin receptor activity(GO:0005042)
0.2 7.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 0.6 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.2 1.2 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.2 0.5 GO:0003826 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.2 1.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 6.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.7 GO:0019864 IgG binding(GO:0019864)
0.1 0.6 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 1.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 1.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 2.7 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.3 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.1 3.0 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 0.5 GO:0031403 lithium ion binding(GO:0031403)
0.1 3.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.3 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 1.5 GO:0051400 BH domain binding(GO:0051400)
0.1 0.8 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.2 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.1 0.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.4 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.4 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.4 GO:0098960 postsynaptic neurotransmitter receptor activity(GO:0098960)
0.0 1.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134) glycosphingolipid binding(GO:0043208)
0.0 0.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.8 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 2.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 2.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.5 PID BCR 5PATHWAY BCR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 5.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 6.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 2.8 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 4.7 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 5.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 0.9 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 10.0 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 3.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 0.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)