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Illumina Body Map 2, young vs old

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Results for SMAD2

Z-value: 0.34

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Transcription factors associated with SMAD2

Gene Symbol Gene ID Gene Info
ENSG00000175387.11 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD2hg19_v2_chr18_-_45457478_454575170.212.4e-01Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_159141397 3.84 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
cell adhesion molecule 3
chr7_-_100493482 2.91 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
acetylcholinesterase (Yt blood group)
chr17_-_15165854 2.88 ENST00000395936.1
ENST00000395938.2
peripheral myelin protein 22
chr1_-_44482979 2.76 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_-_100493744 2.69 ENST00000428317.1
ENST00000441605.1
acetylcholinesterase (Yt blood group)
chr17_-_74533963 2.67 ENST00000293230.5
cytoglobin
chr20_+_43343886 2.65 ENST00000190983.4
WNT1 inducible signaling pathway protein 2
chr17_-_15165825 2.55 ENST00000426385.3
peripheral myelin protein 22
chr20_+_43343476 2.52 ENST00000372868.2
WNT1 inducible signaling pathway protein 2
chr1_+_160085567 2.52 ENST00000392233.3
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr8_+_106331769 2.51 ENST00000520492.1
zinc finger protein, FOG family member 2
chrX_+_38420783 2.48 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
tetraspanin 7
chr12_+_53443963 2.44 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
tensin like C1 domain containing phosphatase (tensin 2)
chrX_+_38420623 2.42 ENST00000378482.2
tetraspanin 7
chr1_+_160085501 2.40 ENST00000361216.3
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr11_-_107590383 2.39 ENST00000525934.1
ENST00000531293.1
sarcolipin
chr1_-_201915590 2.37 ENST00000367288.4
leiomodin 1 (smooth muscle)
chr8_+_94241867 2.22 ENST00000598428.1
Uncharacterized protein
chr19_-_46105411 2.20 ENST00000323040.4
ENST00000544371.1
G protein-coupled receptor 4
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr21_+_47401650 2.14 ENST00000361866.3
collagen, type VI, alpha 1
chr16_+_28889801 2.09 ENST00000395503.4
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr12_+_129178451 2.07 ENST00000537538.1
transmembrane protein 132C
chr22_+_22723969 1.99 ENST00000390295.2
immunoglobulin lambda variable 7-46 (gene/pseudogene)
chr22_+_23010756 1.99 ENST00000390304.2
immunoglobulin lambda variable 3-27
chr20_+_43343517 1.98 ENST00000372865.4
WNT1 inducible signaling pathway protein 2
chr2_-_72375167 1.89 ENST00000001146.2
cytochrome P450, family 26, subfamily B, polypeptide 1
chr11_-_107729887 1.84 ENST00000525815.1
solute carrier family 35, member F2
chr11_-_119211525 1.84 ENST00000528368.1
C1q and tumor necrosis factor related protein 5
chr16_+_28889703 1.81 ENST00000357084.3
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr14_-_106494587 1.80 ENST00000390597.2
immunoglobulin heavy variable 2-5
chr1_+_160097462 1.79 ENST00000447527.1
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr1_-_44497118 1.79 ENST00000537678.1
ENST00000466926.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr16_-_70719925 1.78 ENST00000338779.6
metastasis suppressor 1-like
chr7_-_102158157 1.77 ENST00000541662.1
ENST00000306682.6
ENST00000465829.1
RAS p21 protein activator 4B
chr9_+_71944241 1.76 ENST00000257515.8
family with sequence similarity 189, member A2
chr7_-_102257139 1.72 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RAS p21 protein activator 4
chr8_+_82192501 1.63 ENST00000297258.6
fatty acid binding protein 5 (psoriasis-associated)
chr11_-_107729287 1.61 ENST00000375682.4
solute carrier family 35, member F2
chr7_+_130020180 1.57 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
carboxypeptidase A1 (pancreatic)
chr19_-_44285401 1.48 ENST00000262888.3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr1_+_100111479 1.45 ENST00000263174.4
palmdelphin
chr3_+_123813509 1.41 ENST00000460856.1
ENST00000240874.3
kalirin, RhoGEF kinase
chr9_-_136006496 1.38 ENST00000372062.3
ral guanine nucleotide dissociation stimulator
chr11_-_107729504 1.38 ENST00000265836.7
solute carrier family 35, member F2
chr6_+_32132360 1.37 ENST00000333845.6
ENST00000395512.1
ENST00000432129.1
EGF-like-domain, multiple 8
chr20_+_30598231 1.31 ENST00000300415.8
ENST00000262659.8
cerebral cavernous malformation 2-like
chr14_+_31343747 1.29 ENST00000216361.4
ENST00000396618.3
ENST00000475087.1
cochlin
chr1_+_100111580 1.26 ENST00000605497.1
palmdelphin
chr12_+_53443680 1.25 ENST00000314250.6
ENST00000451358.1
tensin like C1 domain containing phosphatase (tensin 2)
chr12_-_10251539 1.25 ENST00000420265.2
C-type lectin domain family 1, member A
chr10_+_72972281 1.24 ENST00000335350.6
unc-5 homolog B (C. elegans)
chr22_+_22676808 1.24 ENST00000390290.2
immunoglobulin lambda variable 1-51
chr12_-_10251603 1.24 ENST00000457018.2
C-type lectin domain family 1, member A
chr3_-_79068138 1.24 ENST00000495273.1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr7_-_96654133 1.24 ENST00000486603.2
ENST00000222598.4
distal-less homeobox 5
chr12_-_22094336 1.23 ENST00000326684.4
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr14_-_106478603 1.20 ENST00000390596.2
immunoglobulin heavy variable 4-4
chr4_-_5890145 1.19 ENST00000397890.2
collapsin response mediator protein 1
chr22_+_23213658 1.16 ENST00000390318.2
immunoglobulin lambda variable 4-3
chr5_-_172755056 1.13 ENST00000520648.1
stanniocalcin 2
chr19_+_16999966 1.12 ENST00000599210.1
coagulation factor II (thrombin) receptor-like 3
chr19_+_35521699 1.12 ENST00000415950.3
sodium channel, voltage-gated, type I, beta subunit
chr7_+_130020932 1.07 ENST00000484324.1
carboxypeptidase A1 (pancreatic)
chr12_-_10251576 1.06 ENST00000315330.4
C-type lectin domain family 1, member A
chr7_-_559853 1.06 ENST00000405692.2
platelet-derived growth factor alpha polypeptide
chr22_+_22735135 1.04 ENST00000390297.2
immunoglobulin lambda variable 1-44
chr2_-_220174166 1.03 ENST00000409251.3
ENST00000451506.1
ENST00000295718.2
ENST00000446182.1
protein tyrosine phosphatase, receptor type, N
chr21_-_36259445 1.01 ENST00000399240.1
runt-related transcription factor 1
chr16_+_31483374 0.99 ENST00000394863.3
transforming growth factor beta 1 induced transcript 1
chr19_+_16999654 0.99 ENST00000248076.3
coagulation factor II (thrombin) receptor-like 3
chr12_-_29936731 0.98 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
transmembrane and tetratricopeptide repeat containing 1
chr22_-_24641027 0.97 ENST00000398292.3
ENST00000263112.7
ENST00000418439.2
ENST00000424217.1
ENST00000327365.4
gamma-glutamyltransferase 5
chr1_-_59249732 0.97 ENST00000371222.2
jun proto-oncogene
chr16_-_87417351 0.97 ENST00000311635.7
F-box protein 31
chr12_-_22094159 0.97 ENST00000538350.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr8_-_20161466 0.96 ENST00000381569.1
leucine zipper, putative tumor suppressor 1
chr22_+_22764088 0.95 ENST00000390299.2
immunoglobulin lambda variable 1-40
chr2_+_168725458 0.94 ENST00000392690.3
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr11_+_75273101 0.92 ENST00000533603.1
ENST00000358171.3
ENST00000526242.1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr11_-_75379612 0.92 ENST00000526740.1
microtubule-associated protein 6
chr17_-_10017864 0.89 ENST00000323816.4
growth arrest-specific 7
chr10_-_75193308 0.87 ENST00000299432.2
MSS51 mitochondrial translational activator
chr16_-_4987065 0.85 ENST00000590782.2
ENST00000345988.2
periplakin
chr12_+_7037461 0.83 ENST00000396684.2
atrophin 1
chrX_-_48328551 0.82 ENST00000376876.3
solute carrier family 38, member 5
chr4_+_39640787 0.82 ENST00000532680.1
RP11-539G18.2
chr11_-_75379479 0.80 ENST00000434603.2
microtubule-associated protein 6
chr19_+_13106383 0.79 ENST00000397661.2
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_-_108991812 0.78 ENST00000392806.3
ENST00000547567.1
transmembrane protein 119
chr10_-_14372870 0.78 ENST00000357447.2
FERM domain containing 4A
chr3_-_15374659 0.73 ENST00000426925.1
SH3-domain binding protein 5 (BTK-associated)
chr4_-_41216492 0.72 ENST00000503503.1
ENST00000509446.1
ENST00000503264.1
ENST00000508707.1
ENST00000508593.1
amyloid beta (A4) precursor protein-binding, family B, member 2
chr1_-_151119087 0.71 ENST00000341697.3
ENST00000368914.3
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
chrX_-_48328631 0.71 ENST00000429543.1
ENST00000317669.5
solute carrier family 38, member 5
chr4_-_819901 0.70 ENST00000304062.6
complexin 1
chr1_-_235813290 0.69 ENST00000391854.2
guanine nucleotide binding protein (G protein), gamma 4
chr12_+_101188718 0.68 ENST00000299222.9
ENST00000392977.3
anoctamin 4
chr5_+_140762268 0.68 ENST00000518325.1
protocadherin gamma subfamily A, 7
chr15_-_88799661 0.67 ENST00000360948.2
ENST00000357724.2
ENST00000355254.2
ENST00000317501.3
neurotrophic tyrosine kinase, receptor, type 3
chr6_+_39760129 0.66 ENST00000274867.4
dishevelled associated activator of morphogenesis 2
chr15_-_88799384 0.65 ENST00000540489.2
ENST00000557856.1
ENST00000558676.1
neurotrophic tyrosine kinase, receptor, type 3
chr12_+_47473369 0.65 ENST00000546455.1
PC-esterase domain containing 1B
chr3_-_195603566 0.65 ENST00000424563.1
ENST00000411741.1
tyrosine kinase, non-receptor, 2
chr4_-_41216619 0.65 ENST00000508676.1
ENST00000506352.1
ENST00000295974.8
amyloid beta (A4) precursor protein-binding, family B, member 2
chr19_-_46288917 0.64 ENST00000537879.1
ENST00000596586.1
ENST00000595946.1
dystrophia myotonica, WD repeat containing
Uncharacterized protein
chr9_+_34990219 0.63 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
DnaJ (Hsp40) homolog, subfamily B, member 5
chr7_-_130418888 0.63 ENST00000310992.4
Kruppel-like factor 14
chr12_-_8765446 0.63 ENST00000537228.1
ENST00000229335.6
activation-induced cytidine deaminase
chr17_+_3627185 0.63 ENST00000325418.4
germ cell associated 2 (haspin)
chr12_-_57410304 0.61 ENST00000441881.1
ENST00000458521.2
tachykinin 3
chr20_+_34680620 0.61 ENST00000430276.1
ENST00000373950.2
ENST00000452261.1
erythrocyte membrane protein band 4.1-like 1
chr7_+_143080063 0.59 ENST00000446634.1
zyxin
chr17_+_40440094 0.59 ENST00000546010.2
signal transducer and activator of transcription 5A
chr6_+_39760783 0.57 ENST00000398904.2
ENST00000538976.1
dishevelled associated activator of morphogenesis 2
chr20_-_56284816 0.57 ENST00000395819.3
ENST00000341744.3
prostate transmembrane protein, androgen induced 1
chr1_-_41707778 0.57 ENST00000337495.5
ENST00000372597.1
ENST00000372596.1
sex comb on midleg homolog 1 (Drosophila)
chr19_-_6481759 0.56 ENST00000588421.1
DENN/MADD domain containing 1C
chr7_+_149416439 0.56 ENST00000497895.1
KRAB-A domain containing 1
chr19_-_42636543 0.56 ENST00000528894.4
ENST00000560804.2
ENST00000560558.1
ENST00000560398.1
ENST00000526816.2
POU class 2 homeobox 2
chr20_-_36889127 0.56 ENST00000279024.4
KIAA1755
chr10_-_102989551 0.55 ENST00000370193.2
ladybird homeobox 1
chrX_+_153029633 0.55 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
plexin B3
chr16_-_54320675 0.53 ENST00000329734.3
iroquois homeobox 3
chr19_+_50148087 0.53 ENST00000601038.1
ENST00000595242.1
SR-related CTD-associated factor 1
chr13_-_80915059 0.53 ENST00000377104.3
sprouty homolog 2 (Drosophila)
chr4_-_41216473 0.51 ENST00000513140.1
amyloid beta (A4) precursor protein-binding, family B, member 2
chr11_-_1619524 0.51 ENST00000412090.1
keratin associated protein 5-2
chr1_+_185703513 0.48 ENST00000271588.4
ENST00000367492.2
hemicentin 1
chr11_-_33913708 0.48 ENST00000257818.2
LIM domain only 2 (rhombotin-like 1)
chr2_-_73053126 0.48 ENST00000272427.6
ENST00000410104.1
exocyst complex component 6B
chr20_+_42143053 0.48 ENST00000373135.3
ENST00000444063.1
l(3)mbt-like 1 (Drosophila)
chr12_+_122516626 0.47 ENST00000319080.7
MLX interacting protein
chr3_+_3841108 0.46 ENST00000319331.3
leucine rich repeat neuronal 1
chr11_-_101454658 0.45 ENST00000344327.3
transient receptor potential cation channel, subfamily C, member 6
chr2_+_113033164 0.44 ENST00000409871.1
ENST00000343936.4
zinc finger CCCH-type containing 6
chr2_-_220173685 0.44 ENST00000423636.2
ENST00000442029.1
ENST00000412847.1
protein tyrosine phosphatase, receptor type, N
chrX_-_151143140 0.44 ENST00000393914.3
ENST00000370328.3
ENST00000370325.1
gamma-aminobutyric acid (GABA) A receptor, epsilon
chr2_+_27237615 0.43 ENST00000458529.1
ENST00000402218.1
microtubule-associated protein, RP/EB family, member 3
chr19_-_49522727 0.43 ENST00000600007.1
CTB-60B18.10
chrX_+_24167828 0.43 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
zinc finger protein, X-linked
chr11_-_75380165 0.42 ENST00000304771.3
microtubule-associated protein 6
chr6_+_30852738 0.42 ENST00000508312.1
ENST00000512336.1
discoidin domain receptor tyrosine kinase 1
chr11_-_3859089 0.41 ENST00000396979.1
ras homolog family member G
chr12_+_101188547 0.40 ENST00000546991.1
ENST00000392979.3
anoctamin 4
chr5_-_151066514 0.40 ENST00000538026.1
ENST00000522348.1
ENST00000521569.1
secreted protein, acidic, cysteine-rich (osteonectin)
chr8_-_37411648 0.40 ENST00000519738.1
RP11-150O12.1
chr9_+_133569108 0.39 ENST00000372358.5
ENST00000546165.1
ENST00000372352.3
ENST00000372351.3
ENST00000372350.3
ENST00000495699.2
exosome component 2
chr19_-_42636617 0.38 ENST00000529067.1
ENST00000529952.1
ENST00000533720.1
ENST00000389341.5
ENST00000342301.4
POU class 2 homeobox 2
chr11_+_74951948 0.38 ENST00000562197.2
trophoblast glycoprotein-like
chr3_+_123813543 0.38 ENST00000360013.3
kalirin, RhoGEF kinase
chr7_-_69062391 0.37 ENST00000436600.2
RP5-942I16.1
chr1_+_226411319 0.37 ENST00000542034.1
ENST00000366810.5
Mix paired-like homeobox
chr7_-_100494222 0.37 ENST00000445236.1
acetylcholinesterase (Yt blood group)
chr13_-_88323514 0.37 ENST00000441617.1
MIR4500 host gene (non-protein coding)
chr9_-_73029540 0.37 ENST00000377126.2
Kruppel-like factor 9
chr10_+_99627889 0.36 ENST00000596005.1
Golgin subfamily A member 7B; cDNA FLJ43465 fis, clone OCBBF2036476
chr18_+_20715416 0.35 ENST00000580153.1
Cdk5 and Abl enzyme substrate 1
chr10_+_102821551 0.35 ENST00000370200.5
Kazal-type serine peptidase inhibitor domain 1
chr4_-_102268708 0.35 ENST00000525819.1
protein phosphatase 3, catalytic subunit, alpha isozyme
chr10_+_105314881 0.34 ENST00000437579.1
neuralized E3 ubiquitin protein ligase 1
chr11_-_117166201 0.34 ENST00000510915.1
beta-site APP-cleaving enzyme 1
chr20_-_48532019 0.33 ENST00000289431.5
spermatogenesis associated 2
chr16_-_67997947 0.33 ENST00000537830.2
solute carrier family 12 (potassium/chloride transporter), member 4
chr16_+_2286726 0.33 ENST00000382437.4
ENST00000569184.1
deoxyribonuclease I-like 2
chr4_-_103749179 0.32 ENST00000502690.1
ubiquitin-conjugating enzyme E2D 3
chr1_+_15783222 0.32 ENST00000359621.4
chymotrypsin-like elastase family, member 2A
chr20_+_34020827 0.31 ENST00000374375.1
growth differentiation factor 5 opposite strand
chr4_-_185139062 0.31 ENST00000296741.2
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr4_-_103749205 0.31 ENST00000508249.1
ubiquitin-conjugating enzyme E2D 3
chr4_+_102268904 0.30 ENST00000527564.1
ENST00000529296.1
Uncharacterized protein
chr4_-_84030996 0.30 ENST00000411416.2
placenta-specific 8
chr16_-_17564738 0.28 ENST00000261381.6
xylosyltransferase I
chr12_-_53207842 0.28 ENST00000458244.2
keratin 4
chr6_+_30689401 0.27 ENST00000396389.1
ENST00000396384.1
tubulin, beta class I
chrX_-_30595959 0.27 ENST00000378962.3
chromosome X open reading frame 21
chr12_+_3600356 0.26 ENST00000382622.3
protein arginine methyltransferase 8
chr6_+_30853002 0.26 ENST00000421124.2
ENST00000512725.1
discoidin domain receptor tyrosine kinase 1
chr3_-_71179699 0.25 ENST00000497355.1
forkhead box P1
chr4_-_114682719 0.25 ENST00000394522.3
calcium/calmodulin-dependent protein kinase II delta
chr7_+_102004322 0.25 ENST00000496391.1
PRKR interacting protein 1 (IL11 inducible)
chr11_-_18813353 0.24 ENST00000358540.2
ENST00000396171.4
ENST00000396167.2
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr4_-_114682597 0.24 ENST00000394524.3
calcium/calmodulin-dependent protein kinase II delta
chr17_+_30593195 0.24 ENST00000431505.2
ENST00000269051.4
ENST00000538145.1
rhomboid, veinlet-like 3 (Drosophila)
chr21_-_47706098 0.24 ENST00000426537.1
minichromosome maintenance complex component 3 associated protein
chr1_-_153508460 0.23 ENST00000462776.2
S100 calcium binding protein A6
chr12_-_56583243 0.23 ENST00000550164.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr19_-_57335682 0.22 ENST00000593931.1
zinc finger, imprinted 2
chr5_+_133861339 0.22 ENST00000282605.4
ENST00000361895.2
ENST00000402835.1
jade family PHD finger 2
chr5_-_43412418 0.21 ENST00000537013.1
ENST00000361115.4
chemokine (C-C motif) ligand 28
chr7_-_142724282 0.21 ENST00000350513.2
olfactory receptor, family 9, subfamily A, member 2
chr16_+_24621546 0.21 ENST00000566108.1
CTD-2540M10.1
chr8_+_75015699 0.19 ENST00000522498.1
RP11-6I2.4
chr11_-_74204692 0.19 ENST00000528085.1
lipoyl(octanoyl) transferase 2 (putative)
chr20_+_44098346 0.19 ENST00000372676.3
WAP four-disulfide core domain 2
chr11_-_34535297 0.19 ENST00000532417.1
E74-like factor 5 (ets domain transcription factor)
chr12_-_47473642 0.19 ENST00000266581.4
adhesion molecule with Ig-like domain 2
chr12_-_47473557 0.18 ENST00000321382.3
adhesion molecule with Ig-like domain 2
chr1_-_149783914 0.18 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
histone cluster 2, H2bf
chr12_+_68042517 0.18 ENST00000393555.3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr3_+_40547483 0.18 ENST00000420891.1
ENST00000314529.6
ENST00000418905.1
zinc finger protein 620

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:1903280 negative regulation of calcium:sodium antiporter activity(GO:1903280)
1.5 4.6 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.5 6.0 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
1.3 3.9 GO:0031448 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.8 2.4 GO:1901877 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.6 1.9 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.5 1.1 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.4 1.3 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.4 1.2 GO:1904530 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.4 2.7 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.4 1.5 GO:1990502 dense core granule maturation(GO:1990502)
0.4 2.5 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.3 1.3 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.3 1.2 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.3 1.2 GO:0060166 olfactory pit development(GO:0060166)
0.3 1.1 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.3 1.1 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.2 2.2 GO:0072144 glomerular mesangial cell development(GO:0072144)
0.2 1.8 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.2 0.4 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.2 2.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 0.6 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.2 0.6 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.2 5.4 GO:0032060 bleb assembly(GO:0032060)
0.2 1.0 GO:0035026 leading edge cell differentiation(GO:0035026)
0.2 1.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 0.4 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.1 0.5 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.1 0.6 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 1.0 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 1.9 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 0.5 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.1 1.5 GO:0015816 glycine transport(GO:0015816)
0.1 1.5 GO:0046541 saliva secretion(GO:0046541)
0.1 0.9 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.1 0.3 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.1 0.6 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 0.3 GO:0003335 corneocyte development(GO:0003335)
0.1 1.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.4 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.9 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 2.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.4 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.1 0.4 GO:0051414 response to cortisol(GO:0051414)
0.1 0.3 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 1.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.5 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.1 1.0 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 8.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 4.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.8 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.4 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.0 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 3.5 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.6 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 1.0 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 2.2 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.1 GO:0033037 polysaccharide localization(GO:0033037)
0.0 0.7 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.2 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.1 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 1.8 GO:0070206 protein trimerization(GO:0070206)
0.0 1.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.5 GO:1901725 regulation of histone deacetylase activity(GO:1901725)
0.0 0.9 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.4 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 1.0 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.3 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.1 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.0 0.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.6 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.7 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.6 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 1.8 GO:0032418 lysosome localization(GO:0032418)
0.0 1.8 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.0 4.1 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.2 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.9 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0 2.4 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.3 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 7.7 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway(GO:0038089) positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.2 GO:0017121 phospholipid scrambling(GO:0017121)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.0 GO:0043083 synaptic cleft(GO:0043083)
0.3 2.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 6.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 0.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 2.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 3.9 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 5.4 GO:0043218 compact myelin(GO:0043218)
0.1 3.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.6 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 1.0 GO:0035976 AP1 complex(GO:0035976)
0.1 0.3 GO:0036457 keratohyalin granule(GO:0036457)
0.1 0.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.3 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.0 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 4.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 0.6 GO:0010369 chromocenter(GO:0010369)
0.0 1.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.8 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.1 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.5 GO:0000145 exocyst(GO:0000145)
0.0 0.4 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.1 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 2.8 GO:0043197 dendritic spine(GO:0043197)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.0 GO:0003990 acetylcholinesterase activity(GO:0003990)
1.1 4.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.7 2.7 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.5 2.2 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.3 6.7 GO:1990239 steroid hormone binding(GO:1990239)
0.3 0.9 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.3 1.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.3 1.9 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.3 2.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.2 1.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 7.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 0.5 GO:0032093 SAM domain binding(GO:0032093)
0.2 3.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.0 GO:0048495 Roundabout binding(GO:0048495)
0.1 0.3 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 1.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
0.1 3.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.5 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 2.6 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.3 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.3 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.1 2.2 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 1.0 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 1.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 0.6 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 1.2 GO:0031005 filamin binding(GO:0031005)
0.0 10.8 GO:0003823 antigen binding(GO:0003823)
0.0 1.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.4 GO:0008312 7S RNA binding(GO:0008312)
0.0 1.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.9 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 1.5 GO:0030507 spectrin binding(GO:0030507)
0.0 2.6 GO:0005518 collagen binding(GO:0005518)
0.0 1.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.7 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 1.2 GO:0050699 WW domain binding(GO:0050699)
0.0 2.4 GO:0051117 ATPase binding(GO:0051117)
0.0 1.0 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 6.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 1.8 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 5.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.6 PID IL5 PATHWAY IL5-mediated signaling events
0.0 3.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 9.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.6 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.0 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 1.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.5 PID IFNG PATHWAY IFN-gamma pathway
0.0 1.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.1 PID BCR 5PATHWAY BCR signaling pathway
0.0 3.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.0 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 4.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 9.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.4 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 1.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 2.4 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 1.0 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 2.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 1.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 3.7 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.5 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus