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Illumina Body Map 2, young vs old

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Results for SMAD3

Z-value: 0.12

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Transcription factors associated with SMAD3

Gene Symbol Gene ID Gene Info
SMAD3
ENSG00000166949.11 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD3hg19_v2_chr15_+_67358163_673581920.144.3e-01Click!

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_142428476 3.36 ENST00000390400.2
TRBV28
T cell receptor beta variable 28
chr7_+_142028105 3.23 ENST00000390353.2
TRBV6-1
T cell receptor beta variable 6-1
chr7_-_142247606 2.95 ENST00000390361.3
TRBV7-3
T cell receptor beta variable 7-3
chr1_-_160832642 2.76 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr1_-_160832490 2.66 ENST00000322302.7
ENST00000368033.3
CD244
CD244 molecule, natural killer cell receptor 2B4
chr11_+_60869980 2.49 ENST00000544014.1
CD5
CD5 molecule
chr7_+_50348268 2.46 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr11_+_60869867 2.44 ENST00000347785.3
CD5
CD5 molecule
chr1_-_156399184 2.43 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
C1orf61
chromosome 1 open reading frame 61
chr1_-_160832670 2.38 ENST00000368032.2
CD244
CD244 molecule, natural killer cell receptor 2B4
chr17_-_34195862 2.28 ENST00000592980.1
ENST00000587626.1
C17orf66
chromosome 17 open reading frame 66
chr17_-_34195889 2.25 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chr7_+_142364193 2.14 ENST00000390397.2
TRBV24-1
T cell receptor beta variable 24-1
chr16_-_52119019 2.00 ENST00000561513.1
ENST00000565742.1
LINC00919
long intergenic non-protein coding RNA 919
chr6_-_25726781 1.97 ENST00000297012.3
HIST1H2AA
histone cluster 1, H2aa
chr7_+_142012967 1.85 ENST00000390357.3
TRBV4-1
T cell receptor beta variable 4-1
chr2_-_239140011 1.83 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
AC016757.3
Protein LOC151174
chr17_+_30813576 1.75 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr6_+_25727046 1.69 ENST00000274764.2
HIST1H2BA
histone cluster 1, H2ba
chr17_-_39093672 1.68 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr16_+_30484021 1.64 ENST00000358164.5
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr16_+_30483962 1.53 ENST00000356798.6
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr16_+_30484054 1.46 ENST00000564118.1
ENST00000454514.2
ENST00000433423.2
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr1_-_9129631 1.46 ENST00000377414.3
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr3_+_51741072 1.45 ENST00000395052.3
GRM2
glutamate receptor, metabotropic 2
chr12_-_9913489 1.38 ENST00000228434.3
ENST00000536709.1
CD69
CD69 molecule
chr6_-_26216872 1.38 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr5_-_127674883 1.37 ENST00000507835.1
FBN2
fibrillin 2
chr14_-_24551137 1.37 ENST00000396995.1
NRL
neural retina leucine zipper
chr1_-_226129189 1.36 ENST00000366820.5
LEFTY2
left-right determination factor 2
chr3_+_126243126 1.36 ENST00000319340.2
CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr1_-_226129083 1.34 ENST00000420304.2
LEFTY2
left-right determination factor 2
chr7_+_139528952 1.32 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr14_-_107179265 1.30 ENST00000390634.2
IGHV2-70
immunoglobulin heavy variable 2-70
chr2_+_204732487 1.29 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr7_+_139529040 1.26 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr15_+_81591757 1.24 ENST00000558332.1
IL16
interleukin 16
chr6_+_146920097 1.20 ENST00000397944.3
ENST00000522242.1
ADGB
androglobin
chr14_-_24551195 1.19 ENST00000560550.1
NRL
neural retina leucine zipper
chr4_-_39033963 1.17 ENST00000381938.3
TMEM156
transmembrane protein 156
chr6_+_116937636 1.15 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A
radial spoke head 4 homolog A (Chlamydomonas)
chr11_-_107729287 1.13 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr9_+_44867571 1.13 ENST00000377548.2
RP11-160N1.10
RP11-160N1.10
chr22_+_23089870 1.12 ENST00000390311.2
IGLV3-16
immunoglobulin lambda variable 3-16
chr11_-_107729504 1.11 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr1_-_60539422 1.10 ENST00000371201.3
C1orf87
chromosome 1 open reading frame 87
chr1_-_9129598 1.09 ENST00000535586.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chrX_-_27999566 1.08 ENST00000441525.1
DCAF8L1
DDB1 and CUL4 associated factor 8-like 1
chr16_-_31076332 1.06 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr6_+_146920116 1.05 ENST00000367493.3
ADGB
androglobin
chr7_-_142251148 1.05 ENST00000390360.3
TRBV6-4
T cell receptor beta variable 6-4
chrX_-_101410762 1.04 ENST00000543160.1
ENST00000333643.3
BEX5
brain expressed, X-linked 5
chr6_+_27775899 1.03 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr3_-_126277796 1.03 ENST00000318225.2
C3orf22
chromosome 3 open reading frame 22
chr19_-_55691472 1.00 ENST00000537500.1
SYT5
synaptotagmin V
chr2_+_204732666 1.00 ENST00000295854.6
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr2_-_49381572 0.99 ENST00000454032.1
ENST00000304421.4
FSHR
follicle stimulating hormone receptor
chr1_-_60539405 0.99 ENST00000450089.2
C1orf87
chromosome 1 open reading frame 87
chr19_-_55691377 0.99 ENST00000589172.1
SYT5
synaptotagmin V
chr20_+_55926625 0.98 ENST00000452119.1
RAE1
ribonucleic acid export 1
chr4_-_157563459 0.97 ENST00000504237.1
ENST00000511399.1
RP11-171N4.2
Uncharacterized protein
chr1_-_9129895 0.96 ENST00000473209.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr8_+_10530133 0.94 ENST00000304519.5
C8orf74
chromosome 8 open reading frame 74
chr11_+_45376922 0.93 ENST00000524410.1
ENST00000524488.1
ENST00000524565.1
RP11-430H10.1
RP11-430H10.1
chr14_+_93389425 0.90 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr2_-_49381646 0.90 ENST00000346173.3
ENST00000406846.2
FSHR
follicle stimulating hormone receptor
chr4_-_103940791 0.89 ENST00000510559.1
ENST00000394789.3
ENST00000296422.7
SLC9B1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr16_-_3306587 0.88 ENST00000541159.1
ENST00000536379.1
ENST00000219596.1
ENST00000339854.4
MEFV
Mediterranean fever
chr6_+_26217159 0.87 ENST00000303910.2
HIST1H2AE
histone cluster 1, H2ae
chr7_+_31726822 0.87 ENST00000409146.3
PPP1R17
protein phosphatase 1, regulatory subunit 17
chr9_+_136399929 0.85 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chr14_-_106494587 0.84 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr9_+_100069933 0.83 ENST00000529487.1
CCDC180
coiled-coil domain containing 180
chrX_-_48328631 0.83 ENST00000429543.1
ENST00000317669.5
SLC38A5
solute carrier family 38, member 5
chr17_-_56621665 0.81 ENST00000321691.3
C17orf47
chromosome 17 open reading frame 47
chr19_-_11688447 0.81 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant
chr4_-_177116772 0.80 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr20_-_43280361 0.80 ENST00000372874.4
ADA
adenosine deaminase
chr11_+_124824000 0.79 ENST00000529051.1
ENST00000344762.5
CCDC15
coiled-coil domain containing 15
chrX_-_48328551 0.79 ENST00000376876.3
SLC38A5
solute carrier family 38, member 5
chr19_+_18283959 0.78 ENST00000597802.2
IFI30
interferon, gamma-inducible protein 30
chr6_-_27100529 0.78 ENST00000607124.1
ENST00000339812.2
ENST00000541790.1
HIST1H2BJ
histone cluster 1, H2bj
chr15_-_83316254 0.77 ENST00000567678.1
ENST00000450751.2
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr15_-_83316711 0.77 ENST00000568128.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr20_-_43280325 0.75 ENST00000537820.1
ADA
adenosine deaminase
chr11_-_46142615 0.75 ENST00000529734.1
ENST00000323180.6
PHF21A
PHD finger protein 21A
chr20_-_60795296 0.74 ENST00000340177.5
HRH3
histamine receptor H3
chr13_-_21918947 0.74 ENST00000423575.1
LINC00539
LINC00539
chr11_-_107729887 0.74 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr12_+_65563329 0.74 ENST00000308330.2
LEMD3
LEM domain containing 3
chr6_+_27114861 0.74 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chr17_-_39465505 0.72 ENST00000391352.1
KRTAP16-1
keratin associated protein 16-1
chr12_+_110906169 0.71 ENST00000377673.5
FAM216A
family with sequence similarity 216, member A
chr2_-_239140276 0.71 ENST00000334973.4
AC016757.3
Protein LOC151174
chr9_-_136451319 0.70 ENST00000496132.1
FAM163B
family with sequence similarity 163, member B
chr6_-_27806117 0.68 ENST00000330180.2
HIST1H2AK
histone cluster 1, H2ak
chr4_-_90759440 0.66 ENST00000336904.3
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr20_-_60795316 0.66 ENST00000317393.6
HRH3
histamine receptor H3
chr16_-_58328923 0.64 ENST00000567164.1
ENST00000219301.4
ENST00000569727.1
PRSS54
protease, serine, 54
chr2_-_220110187 0.63 ENST00000295759.7
ENST00000392089.2
GLB1L
galactosidase, beta 1-like
chr19_+_36132631 0.62 ENST00000379026.2
ENST00000379023.4
ENST00000402764.2
ENST00000479824.1
ETV2
ets variant 2
chr12_+_67663056 0.62 ENST00000545606.1
CAND1
cullin-associated and neddylation-dissociated 1
chr16_-_3350614 0.62 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr15_-_82338460 0.61 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr4_-_38666430 0.61 ENST00000436901.1
AC021860.1
Uncharacterized protein
chr1_+_90287480 0.60 ENST00000394593.3
LRRC8D
leucine rich repeat containing 8 family, member D
chr15_+_63796779 0.58 ENST00000561442.1
ENST00000560070.1
ENST00000540797.1
ENST00000380324.3
ENST00000268049.7
ENST00000536001.1
ENST00000539772.1
USP3
ubiquitin specific peptidase 3
chr15_-_22473353 0.58 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr2_+_96991033 0.56 ENST00000420176.1
ENST00000536814.1
ENST00000439118.2
ITPRIPL1
inositol 1,4,5-trisphosphate receptor interacting protein-like 1
chr20_+_55926566 0.56 ENST00000411894.1
ENST00000429339.1
RAE1
ribonucleic acid export 1
chr1_+_153388993 0.56 ENST00000368729.4
S100A7A
S100 calcium binding protein A7A
chrX_-_153523462 0.56 ENST00000361930.3
ENST00000369926.1
TEX28
testis expressed 28
chr16_-_30773372 0.55 ENST00000545825.1
ENST00000541260.1
C16orf93
chromosome 16 open reading frame 93
chr12_-_323689 0.55 ENST00000428720.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr16_-_58328884 0.55 ENST00000569079.1
PRSS54
protease, serine, 54
chr1_-_9129735 0.53 ENST00000377424.4
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr16_-_31076273 0.51 ENST00000426488.2
ZNF668
zinc finger protein 668
chr7_+_39125365 0.51 ENST00000559001.1
ENST00000464276.2
POU6F2
POU class 6 homeobox 2
chr3_+_125687987 0.51 ENST00000514116.1
ENST00000251776.4
ENST00000504401.1
ENST00000513830.1
ENST00000508088.1
ROPN1B
rhophilin associated tail protein 1B
chrX_-_62571187 0.51 ENST00000335144.3
SPIN4
spindlin family, member 4
chr3_-_112565703 0.50 ENST00000488794.1
CD200R1L
CD200 receptor 1-like
chr15_-_83315874 0.49 ENST00000569257.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr2_+_16080659 0.49 ENST00000281043.3
MYCN
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr6_+_26273144 0.49 ENST00000377733.2
HIST1H2BI
histone cluster 1, H2bi
chrX_-_62571220 0.48 ENST00000374884.2
SPIN4
spindlin family, member 4
chr10_+_94451574 0.48 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr6_-_27782548 0.47 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr8_-_101118439 0.46 ENST00000519408.1
RGS22
regulator of G-protein signaling 22
chrX_-_46618490 0.45 ENST00000328306.4
SLC9A7
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
chr15_-_83316087 0.45 ENST00000568757.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr9_+_21967137 0.45 ENST00000441769.2
C9orf53
chromosome 9 open reading frame 53
chr1_+_66797687 0.44 ENST00000371045.5
ENST00000531025.1
ENST00000526197.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr16_-_58328870 0.44 ENST00000543437.1
PRSS54
protease, serine, 54
chr3_+_102153859 0.44 ENST00000306176.1
ENST00000466937.1
ZPLD1
zona pellucida-like domain containing 1
chr17_-_39165366 0.44 ENST00000391588.1
KRTAP3-1
keratin associated protein 3-1
chr12_+_49212514 0.43 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr3_-_123710893 0.43 ENST00000467907.1
ENST00000459660.1
ENST00000495093.1
ENST00000460743.1
ENST00000405845.3
ENST00000484329.1
ENST00000479867.1
ENST00000496145.1
ROPN1
rhophilin associated tail protein 1
chr11_-_72145426 0.42 ENST00000535990.1
ENST00000437826.2
ENST00000340729.5
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr2_-_45162783 0.41 ENST00000432125.2
RP11-89K21.1
RP11-89K21.1
chr19_+_51728316 0.40 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33
CD33 molecule
chr15_-_23414193 0.40 ENST00000558241.1
RP11-467N20.5
Protein LOC440233
chr7_-_19813192 0.40 ENST00000422233.1
ENST00000433641.1
TMEM196
transmembrane protein 196
chr6_+_139349903 0.40 ENST00000461027.1
ABRACL
ABRA C-terminal like
chr1_+_153190053 0.39 ENST00000368744.3
PRR9
proline rich 9
chr19_-_42724261 0.39 ENST00000595337.1
DEDD2
death effector domain containing 2
chr6_-_27114577 0.38 ENST00000356950.1
ENST00000396891.4
HIST1H2BK
histone cluster 1, H2bk
chr6_+_139349817 0.37 ENST00000367660.3
ABRACL
ABRA C-terminal like
chr13_-_114898016 0.37 ENST00000542651.1
ENST00000334062.7
RASA3
RAS p21 protein activator 3
chr13_-_60738003 0.36 ENST00000400330.1
ENST00000400324.4
DIAPH3
diaphanous-related formin 3
chr19_-_51192661 0.36 ENST00000391813.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr20_+_55926274 0.35 ENST00000371242.2
ENST00000527947.1
RAE1
ribonucleic acid export 1
chr11_+_35222629 0.35 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chrX_+_47444613 0.34 ENST00000445623.1
TIMP1
TIMP metallopeptidase inhibitor 1
chr15_+_68117872 0.34 ENST00000380035.2
ENST00000389002.1
SKOR1
SKI family transcriptional corepressor 1
chr6_+_292051 0.34 ENST00000344450.5
DUSP22
dual specificity phosphatase 22
chr20_+_55926583 0.33 ENST00000395840.2
RAE1
ribonucleic acid export 1
chr19_+_41594377 0.33 ENST00000330436.3
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chrX_-_48931648 0.33 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr16_-_20681177 0.32 ENST00000524149.1
ACSM1
acyl-CoA synthetase medium-chain family member 1
chr8_-_101118210 0.32 ENST00000360863.6
RGS22
regulator of G-protein signaling 22
chr6_+_27861190 0.31 ENST00000303806.4
HIST1H2BO
histone cluster 1, H2bo
chr15_+_68117844 0.31 ENST00000554054.1
SKOR1
SKI family transcriptional corepressor 1
chr8_-_101117847 0.31 ENST00000523287.1
ENST00000519092.1
RGS22
regulator of G-protein signaling 22
chr11_-_83435965 0.30 ENST00000434967.1
ENST00000530800.1
DLG2
discs, large homolog 2 (Drosophila)
chr12_+_96588143 0.30 ENST00000228741.3
ENST00000547249.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr15_+_22736484 0.29 ENST00000560659.2
GOLGA6L1
golgin A6 family-like 1
chr6_+_12008986 0.28 ENST00000491710.1
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chr1_-_89357179 0.28 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
GTF2B
general transcription factor IIB
chr6_+_27100811 0.26 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr6_+_27791862 0.26 ENST00000355057.1
HIST1H4J
histone cluster 1, H4j
chr8_-_9761693 0.25 ENST00000521863.1
LINC00599
long intergenic non-protein coding RNA 599
chr8_-_101118185 0.25 ENST00000523437.1
RGS22
regulator of G-protein signaling 22
chr1_+_25757376 0.24 ENST00000399766.3
ENST00000399763.3
ENST00000374343.4
TMEM57
transmembrane protein 57
chr15_+_22736246 0.24 ENST00000316397.3
GOLGA6L1
golgin A6 family-like 1
chr15_-_43785274 0.23 ENST00000413546.1
TP53BP1
tumor protein p53 binding protein 1
chr17_-_982198 0.23 ENST00000571945.1
ENST00000536794.2
ABR
active BCR-related
chr5_+_55147205 0.23 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr2_-_220110111 0.23 ENST00000428427.1
ENST00000356283.3
ENST00000432839.1
ENST00000424620.1
GLB1L
galactosidase, beta 1-like
chr2_-_128784846 0.22 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
SAP130
Sin3A-associated protein, 130kDa
chr12_+_50135588 0.22 ENST00000423828.1
ENST00000550445.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr21_+_46077849 0.22 ENST00000397907.1
KRTAP12-3
keratin associated protein 12-3
chrX_+_49832231 0.21 ENST00000376108.3
CLCN5
chloride channel, voltage-sensitive 5
chr1_+_207038699 0.21 ENST00000367098.1
IL20
interleukin 20
chr3_+_97868170 0.21 ENST00000437310.1
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr6_+_26124373 0.21 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr6_-_26124138 0.20 ENST00000314332.5
ENST00000396984.1
HIST1H2BC
histone cluster 1, H2bc
chr20_+_24449821 0.20 ENST00000376862.3
SYNDIG1
synapse differentiation inducing 1
chr5_+_140566 0.20 ENST00000502646.1
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr11_+_35211511 0.20 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr6_-_66417107 0.20 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr6_+_27782788 0.20 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr5_+_171200656 0.18 ENST00000524175.1
CTB-78H18.1
Uncharacterized protein
chr1_+_201159914 0.17 ENST00000335211.4
ENST00000451870.2
ENST00000295591.8
IGFN1
immunoglobulin-like and fibronectin type III domain containing 1
chr17_-_38928414 0.15 ENST00000335552.4
KRT26
keratin 26
chrX_-_110513703 0.15 ENST00000324068.1
CAPN6
calpain 6
chr6_-_27841289 0.15 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l
chr10_+_129796390 0.15 ENST00000455661.1
PTPRE
protein tyrosine phosphatase, receptor type, E
chr18_+_13611763 0.15 ENST00000585931.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr22_-_41677625 0.14 ENST00000452543.1
ENST00000418067.1
RANGAP1
Ran GTPase activating protein 1
chr4_+_40337340 0.14 ENST00000310169.2
CHRNA9
cholinergic receptor, nicotinic, alpha 9 (neuronal)

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.8 GO:0071613 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.6 2.6 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.6 1.8 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.6 4.0 GO:0098704 fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.5 1.6 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.5 1.9 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.5 2.3 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.3 1.4 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.3 0.9 GO:0061110 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.2 4.6 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.2 0.5 GO:0061010 gall bladder development(GO:0061010)
0.2 0.6 GO:0060796 regulation of transcription involved in primary germ layer cell fate commitment(GO:0060796)
0.2 1.7 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 2.2 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 2.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.7 GO:2000470 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.1 0.8 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1 1.4 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 0.4 GO:0050894 determination of affect(GO:0050894)
0.1 2.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.8 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.1 0.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.5 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.1 0.3 GO:0018874 benzoate metabolic process(GO:0018874)
0.1 1.4 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1 1.4 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 1.2 GO:0015816 glycine transport(GO:0015816)
0.1 0.7 GO:0034398 telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 0.6 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 0.5 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.3 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 1.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.3 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.5 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.1 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.0 2.7 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.3 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.3 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.0 0.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 2.1 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 1.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 4.0 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.6 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.6 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 3.1 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.5 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.2 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.4 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.0 0.1 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.6 GO:0016578 histone deubiquitination(GO:0016578)
0.0 1.2 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.4 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.3 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 2.1 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.3 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.4 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.9 GO:0030317 sperm motility(GO:0030317)
0.0 0.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.0 GO:0038188 cholecystokinin signaling pathway(GO:0038188)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.4 4.6 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.4 1.2 GO:0001534 radial spoke(GO:0001534)
0.3 2.1 GO:1990769 proximal neuron projection(GO:1990769)
0.1 2.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 1.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 2.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 4.2 GO:0000786 nucleosome(GO:0000786)
0.1 0.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 2.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 1.4 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.0 0.9 GO:0042583 chromaffin granule(GO:0042583)
0.0 17.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.6 GO:0070938 contractile ring(GO:0070938)
0.0 0.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.7 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 4.0 GO:0035579 specific granule membrane(GO:0035579)
0.0 3.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.9 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.4 GO:0045095 keratin filament(GO:0045095)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.6 1.8 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.6 4.0 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.5 1.9 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.4 4.6 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.2 1.4 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.2 1.4 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.2 7.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 1.4 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 0.8 GO:0050436 microfibril binding(GO:0050436)
0.1 0.7 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.4 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 2.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.4 GO:0004969 histamine receptor activity(GO:0004969)
0.1 2.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.6 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 1.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.2 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.1 0.6 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.1 1.3 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.1 0.9 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 2.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 4.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.8 GO:0008199 ferric iron binding(GO:0008199)
0.0 1.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.3 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 2.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.0 0.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 1.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.9 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.8 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.3 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.4 GO:0015278 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 3.3 GO:0003823 antigen binding(GO:0003823)
0.0 2.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.0 GO:0004951 cholecystokinin receptor activity(GO:0004951)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 4.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.5 PID AURORA A PATHWAY Aurora A signaling
0.0 1.3 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.9 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 5.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 1.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 2.3 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.9 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 2.2 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 2.9 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 4.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 2.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 2.2 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.0 0.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events