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Illumina Body Map 2, young vs old

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Results for SOX7

Z-value: 0.46

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Transcription factors associated with SOX7

Gene Symbol Gene ID Gene Info
SOX7
ENSG00000171056.6 SRY-box transcription factor 7
SOX7
ENSG00000258724.1 SRY-box transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX7hg19_v2_chr8_-_10697281_10697365-0.392.8e-02Click!

Activity profile of SOX7 motif

Sorted Z-values of SOX7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_20364030 7.19 ENST00000396134.2
ENST00000573567.1
ENST00000570757.1
ENST00000424589.1
ENST00000302509.4
ENST00000571174.1
ENST00000576688.1
UMOD
uromodulin
chr16_-_20364122 6.29 ENST00000396138.4
ENST00000577168.1
UMOD
uromodulin
chr1_-_26394114 4.68 ENST00000374272.3
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase
chr4_-_177190364 3.35 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chr6_-_46048116 2.14 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr10_-_61495760 2.14 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr4_+_76995855 1.73 ENST00000355810.4
ENST00000349321.3
ART3
ADP-ribosyltransferase 3
chr1_-_186430222 1.58 ENST00000391997.2
PDC
phosducin
chr1_-_43751276 1.43 ENST00000423420.1
C1orf210
chromosome 1 open reading frame 210
chr6_+_150690089 1.36 ENST00000392256.2
IYD
iodotyrosine deiodinase
chr10_+_5005445 1.35 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chr6_+_150690028 1.32 ENST00000229447.5
ENST00000344419.3
IYD
iodotyrosine deiodinase
chr3_+_167584414 1.29 ENST00000475324.1
RP11-298O21.2
RP11-298O21.2
chr8_+_12803176 1.23 ENST00000524591.2
KIAA1456
KIAA1456
chr6_+_140175987 1.21 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
RP5-899B16.1
chr12_-_58027138 1.16 ENST00000341156.4
B4GALNT1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr14_+_95048217 1.14 ENST00000557598.1
ENST00000556064.1
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_-_47983519 1.10 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
CNGA1
cyclic nucleotide gated channel alpha 1
chr5_-_95158375 1.09 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr17_-_28661065 1.03 ENST00000328886.4
ENST00000538566.2
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr1_-_43751230 0.98 ENST00000523677.1
C1orf210
chromosome 1 open reading frame 210
chr19_+_37837218 0.96 ENST00000591134.1
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr5_-_95158644 0.91 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr10_+_24738355 0.77 ENST00000307544.6
KIAA1217
KIAA1217
chr10_-_5046042 0.75 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr9_-_70465758 0.73 ENST00000489273.1
CBWD5
COBW domain containing 5
chr6_+_150690133 0.67 ENST00000392255.3
ENST00000500320.3
IYD
iodotyrosine deiodinase
chr12_-_56693758 0.66 ENST00000547298.1
ENST00000551936.1
ENST00000551253.1
ENST00000551473.1
CS
citrate synthase
chr19_-_22379753 0.64 ENST00000397121.2
ZNF676
zinc finger protein 676
chr14_-_102771462 0.63 ENST00000522874.1
MOK
MOK protein kinase
chr14_+_50291993 0.57 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr17_-_66951382 0.56 ENST00000586539.1
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr19_-_5784610 0.55 ENST00000390672.2
ENST00000419421.2
PRR22
proline rich 22
chr19_+_37837185 0.53 ENST00000541583.2
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr15_+_25068773 0.50 ENST00000400100.1
ENST00000400098.1
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr10_+_122610687 0.45 ENST00000263461.6
WDR11
WD repeat domain 11
chr18_+_32820990 0.45 ENST00000601719.1
ENST00000591206.1
ENST00000330501.7
ENST00000261333.6
ENST00000355632.4
ENST00000585800.1
ZNF397
zinc finger protein 397
chr6_+_144164455 0.44 ENST00000367576.5
LTV1
LTV1 homolog (S. cerevisiae)
chr15_+_75639372 0.43 ENST00000566313.1
ENST00000568059.1
ENST00000568881.1
NEIL1
nei endonuclease VIII-like 1 (E. coli)
chr14_+_60712463 0.42 ENST00000325642.3
ENST00000529574.1
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr14_+_101361107 0.42 ENST00000553584.1
ENST00000554852.1
MEG8
maternally expressed 8 (non-protein coding)
chr6_-_3195981 0.41 ENST00000425384.2
ENST00000435043.2
RP1-40E16.9
RP1-40E16.9
chr4_-_39034542 0.38 ENST00000344606.6
TMEM156
transmembrane protein 156
chr12_-_57328187 0.37 ENST00000293502.1
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr16_-_21442874 0.37 ENST00000534903.1
NPIPB3
nuclear pore complex interacting protein family, member B3
chr8_-_82359662 0.36 ENST00000519260.1
ENST00000256103.2
PMP2
peripheral myelin protein 2
chr16_-_28303360 0.34 ENST00000501520.1
RP11-57A19.2
RP11-57A19.2
chr11_+_7618413 0.33 ENST00000528883.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_+_3011093 0.31 ENST00000332881.2
AC131971.1
HCG1782999; PRO0943; Uncharacterized protein
chr16_+_28303804 0.31 ENST00000341901.4
SBK1
SH3 domain binding kinase 1
chr1_+_156698743 0.30 ENST00000524343.1
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr17_-_66951474 0.30 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr15_+_66585950 0.30 ENST00000525109.1
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr19_-_2783363 0.29 ENST00000221566.2
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr10_-_17243579 0.28 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr5_+_175511859 0.28 ENST00000503724.2
ENST00000253490.4
FAM153B
family with sequence similarity 153, member B
chr16_+_22518495 0.27 ENST00000541154.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr1_+_100598691 0.27 ENST00000370143.1
ENST00000370141.2
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr10_-_71169031 0.27 ENST00000373307.1
TACR2
tachykinin receptor 2
chr19_-_21950332 0.26 ENST00000598026.1
ZNF100
zinc finger protein 100
chr10_-_12084770 0.25 ENST00000357604.5
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr10_-_5652705 0.25 ENST00000425246.1
RP11-336A10.5
RP11-336A10.5
chr4_-_4544061 0.25 ENST00000507908.1
STX18
syntaxin 18
chr7_-_33148975 0.22 ENST00000297157.3
RP9
retinitis pigmentosa 9 (autosomal dominant)
chr6_+_80129989 0.21 ENST00000429444.1
RP1-232L24.3
RP1-232L24.3
chr1_+_156698708 0.18 ENST00000519086.1
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr2_+_87144738 0.18 ENST00000559485.1
RGPD1
RANBP2-like and GRIP domain containing 1
chr19_-_2783255 0.18 ENST00000589251.1
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr17_-_39623681 0.16 ENST00000225899.3
KRT32
keratin 32
chr12_+_64173583 0.15 ENST00000261234.6
TMEM5
transmembrane protein 5
chr12_+_55886147 0.15 ENST00000379662.1
ENST00000548615.1
OR6C68
olfactory receptor, family 6, subfamily C, member 68
chr1_+_100598742 0.15 ENST00000370139.1
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr15_+_63414760 0.14 ENST00000557972.1
LACTB
lactamase, beta
chr17_-_56082455 0.13 ENST00000578794.1
RP11-159D12.5
Uncharacterized protein
chr16_-_279405 0.10 ENST00000430864.1
ENST00000293872.8
ENST00000337351.4
ENST00000397783.1
LUC7L
LUC7-like (S. cerevisiae)
chr13_-_28024681 0.09 ENST00000381116.1
ENST00000381120.3
ENST00000431572.2
MTIF3
mitochondrial translational initiation factor 3
chr12_-_123728548 0.09 ENST00000545406.1
MPHOSPH9
M-phase phosphoprotein 9
chr10_-_96829246 0.08 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr12_-_39734783 0.08 ENST00000552961.1
KIF21A
kinesin family member 21A
chr4_+_69313145 0.07 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr8_-_19459993 0.06 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr3_-_122694215 0.05 ENST00000449546.1
SEMA5B
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
chr7_-_143966381 0.04 ENST00000487179.1
CTAGE8
CTAGE family, member 8
chr14_-_31856397 0.04 ENST00000538864.2
ENST00000550366.1
HEATR5A
HEAT repeat containing 5A
chr2_-_152118276 0.02 ENST00000409092.1
RBM43
RNA binding motif protein 43

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 13.5 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.9 4.7 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.3 1.6 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.3 2.1 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.2 3.4 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 1.1 GO:0061107 seminal vesicle development(GO:0061107)
0.1 2.1 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 2.1 GO:0046415 urate metabolic process(GO:0046415)
0.1 0.5 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.1 1.2 GO:0030259 lipid glycosylation(GO:0030259)
0.1 1.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 0.9 GO:0042908 xenobiotic transport(GO:0042908)
0.1 2.0 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.1 0.3 GO:0035106 negative regulation of luteinizing hormone secretion(GO:0033685) operant conditioning(GO:0035106)
0.1 0.4 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 0.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.2 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 1.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.4 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 1.1 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.5 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.7 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.0 0.7 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.1 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 0.3 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.2 GO:0035269 protein O-linked mannosylation(GO:0035269)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0036024 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 14.6 GO:0060170 ciliary membrane(GO:0060170)
0.1 4.7 GO:0031430 M band(GO:0031430)
0.1 0.4 GO:0034448 EGO complex(GO:0034448)
0.0 1.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.5 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.2 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.6 GO:0097546 ciliary base(GO:0097546)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 13.5 GO:0019864 IgG binding(GO:0019864)
0.5 3.4 GO:0004447 iodide peroxidase activity(GO:0004447)
0.3 2.1 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.3 1.6 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.2 1.2 GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.2 0.7 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.2 4.7 GO:0031432 titin binding(GO:0031432)
0.2 1.7 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1 2.0 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 1.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 1.1 GO:0032190 acrosin binding(GO:0032190)
0.1 0.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 1.1 GO:0005221 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 0.9 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 0.5 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.3 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.1 0.3 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 2.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 2.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.4 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.4 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 2.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 7.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.9 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1