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Illumina Body Map 2, young vs old

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Results for SPI1

Z-value: 0.69

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Transcription factors associated with SPI1

Gene Symbol Gene ID Gene Info
SPI1
ENSG00000066336.7 Spi-1 proto-oncogene

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPI1hg19_v2_chr11_-_47400062_474000770.841.3e-09Click!

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_198607801 33.49 ENST00000367379.1
PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_198608146 29.37 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_-_167487808 27.34 ENST00000392122.3
CD247
CD247 molecule
chr1_+_198608292 27.25 ENST00000418674.1
PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_-_167487758 27.01 ENST00000362089.5
CD247
CD247 molecule
chr1_-_207095212 23.24 ENST00000420007.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr11_+_128563652 23.16 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr11_+_60223312 23.11 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr7_-_45018686 22.31 ENST00000258787.7
MYO1G
myosin IG
chr1_-_207095324 21.20 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr11_+_60223225 20.72 ENST00000524807.1
ENST00000345732.4
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr9_-_71161505 19.17 ENST00000446290.1
RP11-274B18.2
RP11-274B18.2
chr16_-_30393752 18.69 ENST00000566517.1
ENST00000605106.1
SEPT1
SEPT1
septin 1
Uncharacterized protein
chr2_+_233924548 18.66 ENST00000422935.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr19_+_42381173 18.26 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr6_-_32160622 18.12 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr5_+_57787254 17.84 ENST00000502276.1
ENST00000396776.2
ENST00000511930.1
GAPT
GRB2-binding adaptor protein, transmembrane
chr5_-_66492562 15.91 ENST00000256447.4
CD180
CD180 molecule
chr22_+_37678424 15.88 ENST00000248901.6
CYTH4
cytohesin 4
chr6_+_144980954 15.53 ENST00000367525.3
UTRN
utrophin
chr6_+_31553901 15.36 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr2_+_69002052 15.31 ENST00000497079.1
ARHGAP25
Rho GTPase activating protein 25
chr2_+_69001913 15.14 ENST00000409030.3
ENST00000409220.1
ARHGAP25
Rho GTPase activating protein 25
chr19_-_8642289 14.99 ENST00000596675.1
ENST00000338257.8
MYO1F
myosin IF
chr6_+_31553978 14.99 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr22_+_37678505 14.93 ENST00000402997.1
ENST00000405206.3
CYTH4
cytohesin 4
chr5_-_169725231 14.88 ENST00000046794.5
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_-_150738261 14.71 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr1_-_183560011 14.59 ENST00000367536.1
NCF2
neutrophil cytosolic factor 2
chr10_-_72362515 14.58 ENST00000373209.2
ENST00000441259.1
PRF1
perforin 1 (pore forming protein)
chr16_+_30484021 14.56 ENST00000358164.5
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr15_+_81589254 14.56 ENST00000394652.2
IL16
interleukin 16
chr12_+_54891495 14.46 ENST00000293373.6
NCKAP1L
NCK-associated protein 1-like
chr2_+_233925064 14.37 ENST00000359570.5
ENST00000538935.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr1_-_207096529 14.31 ENST00000525793.1
ENST00000529560.1
FAIM3
Fas apoptotic inhibitory molecule 3
chr2_+_233925038 14.14 ENST00000451407.1
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
chr16_+_30483962 14.12 ENST00000356798.6
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr6_+_31543334 14.08 ENST00000449264.2
TNF
tumor necrosis factor
chr11_-_118083600 13.98 ENST00000524477.1
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr1_-_161039456 13.95 ENST00000368016.3
ARHGAP30
Rho GTPase activating protein 30
chr2_+_204801471 13.67 ENST00000316386.6
ENST00000435193.1
ICOS
inducible T-cell co-stimulator
chr16_+_30484054 13.66 ENST00000564118.1
ENST00000454514.2
ENST00000433423.2
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr14_-_23284703 13.62 ENST00000555911.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr13_-_46756351 13.48 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr9_-_137809718 13.40 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr17_-_47287928 13.37 ENST00000507680.1
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chr16_-_30394143 13.33 ENST00000321367.3
ENST00000571393.1
SEPT1
septin 1
chr7_-_115670792 13.13 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chrX_+_128913906 13.07 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr9_+_95726243 13.04 ENST00000416701.2
FGD3
FYVE, RhoGEF and PH domain containing 3
chr11_-_3862059 13.01 ENST00000396978.1
RHOG
ras homolog family member G
chr4_-_153601136 12.92 ENST00000504064.1
ENST00000304385.3
TMEM154
transmembrane protein 154
chr11_+_118175596 12.87 ENST00000528600.1
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chrX_-_47489244 12.78 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
CFP
complement factor properdin
chr5_+_35856951 12.64 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr19_+_42381337 12.51 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr11_-_47400062 12.48 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr16_-_29757272 12.42 ENST00000329410.3
C16orf54
chromosome 16 open reading frame 54
chr17_+_43299156 12.25 ENST00000331495.3
FMNL1
formin-like 1
chr17_+_47287749 12.04 ENST00000419580.2
ABI3
ABI family, member 3
chr7_-_115670804 11.91 ENST00000320239.7
TFEC
transcription factor EC
chr1_-_183559693 11.91 ENST00000367535.3
ENST00000413720.1
ENST00000418089.1
NCF2
neutrophil cytosolic factor 2
chr19_-_6481776 11.86 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chr11_+_118175132 11.80 ENST00000361763.4
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr19_-_6481759 11.80 ENST00000588421.1
DENND1C
DENN/MADD domain containing 1C
chr11_+_67171548 11.77 ENST00000542590.1
TBC1D10C
TBC1 domain family, member 10C
chr11_+_67171391 11.76 ENST00000312390.5
TBC1D10C
TBC1 domain family, member 10C
chr11_-_47399942 11.61 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_+_67171358 11.56 ENST00000526387.1
TBC1D10C
TBC1 domain family, member 10C
chr1_-_25256368 11.54 ENST00000308873.6
RUNX3
runt-related transcription factor 3
chr17_+_43299241 11.49 ENST00000328118.3
FMNL1
formin-like 1
chr16_-_21663919 11.31 ENST00000569602.1
IGSF6
immunoglobulin superfamily, member 6
chr11_+_128563948 11.21 ENST00000534087.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr6_-_159466136 11.11 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr4_+_100737954 11.07 ENST00000296414.7
ENST00000512369.1
DAPP1
dual adaptor of phosphotyrosine and 3-phosphoinositides
chr4_+_68424434 10.82 ENST00000265404.2
ENST00000396225.1
STAP1
signal transducing adaptor family member 1
chr11_-_47400078 10.81 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr15_-_40600111 10.81 ENST00000543785.2
ENST00000260402.3
PLCB2
phospholipase C, beta 2
chr2_-_235405168 10.79 ENST00000339728.3
ARL4C
ADP-ribosylation factor-like 4C
chr16_+_28996114 10.78 ENST00000395461.3
LAT
linker for activation of T cells
chr12_+_7055767 10.70 ENST00000447931.2
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chrX_+_135730297 10.69 ENST00000370629.2
CD40LG
CD40 ligand
chr16_-_21663950 10.67 ENST00000268389.4
IGSF6
immunoglobulin superfamily, member 6
chr16_+_29674277 10.65 ENST00000395389.2
SPN
sialophorin
chr11_-_47400032 10.63 ENST00000533968.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr1_+_32716857 10.63 ENST00000482949.1
ENST00000495610.2
LCK
lymphocyte-specific protein tyrosine kinase
chr1_+_32716840 10.52 ENST00000336890.5
LCK
lymphocyte-specific protein tyrosine kinase
chr7_+_50344289 10.51 ENST00000413698.1
ENST00000359197.5
ENST00000331340.3
ENST00000357364.4
ENST00000343574.5
ENST00000349824.4
ENST00000346667.4
ENST00000440768.2
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr8_-_133772794 10.49 ENST00000519187.1
ENST00000523829.1
ENST00000356838.3
ENST00000377901.4
ENST00000519304.1
TMEM71
transmembrane protein 71
chr12_-_9760482 10.33 ENST00000229402.3
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr15_+_77287426 10.31 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr17_+_4618734 10.30 ENST00000571206.1
ARRB2
arrestin, beta 2
chr22_-_37545972 10.30 ENST00000216223.5
IL2RB
interleukin 2 receptor, beta
chr7_-_3083573 10.27 ENST00000396946.4
CARD11
caspase recruitment domain family, member 11
chr1_+_32739733 10.26 ENST00000333070.4
LCK
lymphocyte-specific protein tyrosine kinase
chr12_-_53601055 10.25 ENST00000552972.1
ENST00000422257.3
ENST00000267082.5
ITGB7
integrin, beta 7
chr6_-_6320875 10.24 ENST00000451619.1
F13A1
coagulation factor XIII, A1 polypeptide
chr11_+_60869867 10.23 ENST00000347785.3
CD5
CD5 molecule
chr2_+_182321925 10.17 ENST00000339307.4
ENST00000397033.2
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr1_+_32739714 10.13 ENST00000461712.2
ENST00000373562.3
ENST00000477031.2
ENST00000373557.2
LCK
lymphocyte-specific protein tyrosine kinase
chr17_-_37934466 10.10 ENST00000583368.1
IKZF3
IKAROS family zinc finger 3 (Aiolos)
chr22_+_44577237 10.06 ENST00000415224.1
ENST00000417767.1
PARVG
parvin, gamma
chr1_+_111415757 10.05 ENST00000429072.2
ENST00000271324.5
CD53
CD53 molecule
chr14_-_23284675 10.04 ENST00000555959.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr5_+_169064245 10.00 ENST00000256935.8
DOCK2
dedicator of cytokinesis 2
chr14_+_22554680 9.99 ENST00000390451.2
TRAV23DV6
T cell receptor alpha variable 23/delta variable 6
chr1_-_157522180 9.98 ENST00000356953.4
ENST00000368188.2
ENST00000368190.3
ENST00000368189.3
FCRL5
Fc receptor-like 5
chr16_+_28996364 9.96 ENST00000564277.1
LAT
linker for activation of T cells
chr16_+_28996572 9.93 ENST00000360872.5
ENST00000566177.1
ENST00000354453.4
LAT
linker for activation of T cells
chr12_-_53601000 9.92 ENST00000338737.4
ENST00000549086.2
ITGB7
integrin, beta 7
chr9_-_117150243 9.91 ENST00000374088.3
AKNA
AT-hook transcription factor
chr11_+_60869980 9.88 ENST00000544014.1
CD5
CD5 molecule
chr14_-_23285011 9.87 ENST00000397532.3
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr6_-_159466042 9.87 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chrX_+_78200913 9.84 ENST00000171757.2
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr14_-_23285069 9.84 ENST00000554758.1
ENST00000397528.4
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr16_+_28996416 9.79 ENST00000395456.2
ENST00000454369.2
LAT
linker for activation of T cells
chr4_-_109089573 9.76 ENST00000265165.1
LEF1
lymphoid enhancer-binding factor 1
chr11_+_60739115 9.74 ENST00000344028.5
ENST00000346437.4
CD6
CD6 molecule
chr8_-_133772870 9.74 ENST00000522334.1
ENST00000519016.1
TMEM71
transmembrane protein 71
chr10_-_6104253 9.72 ENST00000256876.6
ENST00000379954.1
ENST00000379959.3
IL2RA
interleukin 2 receptor, alpha
chrX_+_78200829 9.72 ENST00000544091.1
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr9_+_273038 9.68 ENST00000487230.1
ENST00000469391.1
DOCK8
dedicator of cytokinesis 8
chr1_-_161039753 9.67 ENST00000368015.1
ARHGAP30
Rho GTPase activating protein 30
chr11_+_60739249 9.60 ENST00000542157.1
ENST00000433107.2
ENST00000452451.2
ENST00000352009.5
CD6
CD6 molecule
chr22_-_30662828 9.59 ENST00000403463.1
ENST00000215781.2
OSM
oncostatin M
chr6_+_31554612 9.50 ENST00000211921.7
LST1
leukocyte specific transcript 1
chr19_+_49838653 9.50 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37
CD37 molecule
chr12_+_7055631 9.49 ENST00000543115.1
ENST00000399448.1
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_+_161676739 9.49 ENST00000236938.6
ENST00000367959.2
ENST00000546024.1
ENST00000540521.1
ENST00000367949.2
ENST00000350710.3
ENST00000540926.1
FCRLA
Fc receptor-like A
chr17_-_72527605 9.46 ENST00000392621.1
ENST00000314401.3
CD300LB
CD300 molecule-like family member b
chr11_+_65408273 9.46 ENST00000394227.3
SIPA1
signal-induced proliferation-associated 1
chrX_+_135730373 9.44 ENST00000370628.2
CD40LG
CD40 ligand
chr1_-_202129704 9.41 ENST00000476061.1
ENST00000544762.1
ENST00000467283.1
ENST00000464870.1
ENST00000435759.2
ENST00000486116.1
ENST00000543735.1
ENST00000308986.5
ENST00000477625.1
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr11_+_60739140 9.38 ENST00000313421.7
CD6
CD6 molecule
chr17_+_76126842 9.29 ENST00000590426.1
ENST00000590799.1
ENST00000318430.5
ENST00000589691.1
TMC8
transmembrane channel-like 8
chr1_-_161039647 9.28 ENST00000368013.3
ARHGAP30
Rho GTPase activating protein 30
chr17_+_72462525 9.26 ENST00000360141.3
CD300A
CD300a molecule
chrX_-_70331298 9.25 ENST00000456850.2
ENST00000473378.1
ENST00000487883.1
ENST00000374202.2
IL2RG
interleukin 2 receptor, gamma
chr7_-_27135591 9.17 ENST00000343060.4
ENST00000355633.5
HOXA1
homeobox A1
chr1_-_157522260 9.09 ENST00000368191.3
ENST00000361835.3
FCRL5
Fc receptor-like 5
chr3_-_183273477 9.09 ENST00000341319.3
KLHL6
kelch-like family member 6
chr17_-_38721711 9.08 ENST00000578085.1
ENST00000246657.2
CCR7
chemokine (C-C motif) receptor 7
chr6_+_45390222 9.05 ENST00000359524.5
RUNX2
runt-related transcription factor 2
chr1_+_153330322 9.04 ENST00000368738.3
S100A9
S100 calcium binding protein A9
chr15_-_40600026 9.03 ENST00000456256.2
ENST00000557821.1
PLCB2
phospholipase C, beta 2
chr17_+_7239904 8.95 ENST00000575425.1
ACAP1
ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr20_+_24929866 8.95 ENST00000480798.1
ENST00000376835.2
CST7
cystatin F (leukocystatin)
chr1_-_157746909 8.89 ENST00000392274.3
ENST00000361516.3
ENST00000368181.4
FCRL2
Fc receptor-like 2
chr6_+_31554826 8.87 ENST00000376089.2
ENST00000396112.2
LST1
leukocyte specific transcript 1
chr4_-_109088940 8.84 ENST00000438313.2
LEF1
lymphoid enhancer-binding factor 1
chr17_-_72619869 8.80 ENST00000392619.1
ENST00000426295.2
CD300E
CD300e molecule
chr1_+_9711781 8.79 ENST00000536656.1
ENST00000377346.4
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr6_+_31554456 8.77 ENST00000339530.4
LST1
leukocyte specific transcript 1
chr15_+_77287715 8.73 ENST00000559161.1
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr7_+_106505696 8.71 ENST00000440650.2
ENST00000496166.1
ENST00000473541.1
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr11_+_65407331 8.69 ENST00000527525.1
SIPA1
signal-induced proliferation-associated 1
chr19_-_36399149 8.64 ENST00000585901.2
ENST00000544690.2
ENST00000424586.3
ENST00000262629.4
ENST00000589517.1
TYROBP
TYRO protein tyrosine kinase binding protein
chr6_+_32811861 8.63 ENST00000453426.1
TAPSAR1
TAP1 and PSMB8 antisense RNA 1
chr9_+_120466610 8.56 ENST00000394487.4
TLR4
toll-like receptor 4
chr8_+_56792355 8.51 ENST00000519728.1
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr12_-_51718436 8.45 ENST00000544402.1
BIN2
bridging integrator 2
chr10_+_49892904 8.44 ENST00000360890.2
WDFY4
WDFY family member 4
chr11_-_3862206 8.43 ENST00000351018.4
RHOG
ras homolog family member G
chr20_-_50179368 8.40 ENST00000609943.1
ENST00000609507.1
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr2_+_68961934 8.39 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr15_-_80263506 8.37 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr12_-_57871620 8.30 ENST00000552604.1
ARHGAP9
Rho GTPase activating protein 9
chr3_-_46249878 8.29 ENST00000296140.3
CCR1
chemokine (C-C motif) receptor 1
chr12_-_57871567 8.25 ENST00000551452.1
ARHGAP9
Rho GTPase activating protein 9
chr1_-_168513229 8.24 ENST00000367819.2
XCL2
chemokine (C motif) ligand 2
chr12_-_15114603 8.21 ENST00000228945.4
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr17_+_7461613 8.21 ENST00000438470.1
ENST00000436057.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr16_-_89043377 8.19 ENST00000436887.2
ENST00000448839.1
ENST00000360302.2
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr1_+_159772121 8.18 ENST00000339348.5
ENST00000392235.3
ENST00000368106.3
FCRL6
Fc receptor-like 6
chr4_-_164534657 8.16 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr2_-_198175495 8.15 ENST00000409153.1
ENST00000409919.1
ENST00000539527.1
ANKRD44
ankyrin repeat domain 44
chr14_+_24783906 8.13 ENST00000396782.2
LTB4R
leukotriene B4 receptor
chr8_+_56792377 8.09 ENST00000520220.2
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chrX_-_153192211 8.09 ENST00000461052.1
ENST00000422091.1
ARHGAP4
Rho GTPase activating protein 4
chr12_-_15114658 8.04 ENST00000542276.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr12_-_57871825 8.03 ENST00000548139.1
ARHGAP9
Rho GTPase activating protein 9
chr17_+_72462766 7.97 ENST00000392625.3
ENST00000361933.3
ENST00000310828.5
CD300A
CD300a molecule
chr6_+_31554636 7.97 ENST00000433492.1
LST1
leukocyte specific transcript 1
chr14_-_35344093 7.96 ENST00000382422.2
BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr1_+_168545711 7.93 ENST00000367818.3
XCL1
chemokine (C motif) ligand 1
chr2_+_68961905 7.93 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr19_+_36393367 7.90 ENST00000246551.4
HCST
hematopoietic cell signal transducer
chr1_+_161677034 7.90 ENST00000349527.4
ENST00000309691.6
ENST00000294796.4
ENST00000367953.3
ENST00000367950.1
FCRLA
Fc receptor-like A
chr22_+_40322595 7.89 ENST00000420971.1
ENST00000544756.1
GRAP2
GRB2-related adaptor protein 2
chr22_-_37640277 7.83 ENST00000401529.3
ENST00000249071.6
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_-_92951607 7.76 ENST00000427103.1
GFI1
growth factor independent 1 transcription repressor
chr9_-_117150303 7.76 ENST00000312033.3
AKNA
AT-hook transcription factor
chr17_+_7461580 7.75 ENST00000483039.1
ENST00000396542.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr2_+_103035102 7.73 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chr9_+_120466650 7.71 ENST00000355622.6
TLR4
toll-like receptor 4
chr11_+_64107663 7.70 ENST00000356786.5
CCDC88B
coiled-coil domain containing 88B
chr1_+_27669719 7.68 ENST00000473280.1
SYTL1
synaptotagmin-like 1
chr2_-_175499294 7.64 ENST00000392547.2
WIPF1
WAS/WASL interacting protein family, member 1
chrX_-_153979315 7.64 ENST00000369575.3
ENST00000369568.4
ENST00000424127.2
GAB3
GRB2-associated binding protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
18.0 90.1 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
10.8 10.8 GO:1903970 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
9.4 47.2 GO:0045659 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
9.1 45.5 GO:0044027 hypermethylation of CpG island(GO:0044027)
8.6 17.2 GO:1902567 negative regulation of eosinophil activation(GO:1902567)
7.1 50.0 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
6.9 6.9 GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125)
6.5 19.6 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
6.1 30.3 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
5.5 16.6 GO:0070668 regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
4.9 24.7 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
4.7 14.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of translational initiation by iron(GO:0045994) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
4.5 18.2 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
4.5 13.5 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
4.5 22.3 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
4.3 43.4 GO:0000821 regulation of arginine metabolic process(GO:0000821)
4.0 28.1 GO:0071461 cellular response to redox state(GO:0071461)
3.9 27.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
3.8 11.4 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
3.7 11.0 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
3.7 29.3 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
3.6 18.2 GO:0042631 cellular response to water deprivation(GO:0042631)
3.6 36.3 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
3.6 14.5 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
3.3 10.0 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
3.3 6.6 GO:0002884 negative regulation of hypersensitivity(GO:0002884)
3.2 9.7 GO:0061485 memory T cell proliferation(GO:0061485)
3.0 9.0 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
2.9 20.4 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
2.8 19.8 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
2.7 18.6 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
2.7 15.9 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
2.6 49.9 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
2.6 7.8 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103) positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
2.5 17.3 GO:0061737 leukotriene signaling pathway(GO:0061737)
2.4 18.9 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
2.4 2.4 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
2.3 9.4 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
2.3 43.4 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
2.3 49.7 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
2.2 6.7 GO:0045083 negative regulation of interleukin-12 biosynthetic process(GO:0045083)
2.2 32.4 GO:0048290 isotype switching to IgA isotypes(GO:0048290)
2.1 12.6 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
2.1 10.3 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
1.9 7.6 GO:0051225 spindle assembly(GO:0051225)
1.9 1.9 GO:0002678 positive regulation of chronic inflammatory response(GO:0002678)
1.9 5.6 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
1.8 7.3 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
1.8 10.7 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
1.8 7.1 GO:1903445 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
1.7 7.0 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
1.7 5.1 GO:0002352 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
1.7 59.3 GO:0045730 respiratory burst(GO:0045730)
1.7 13.5 GO:0071802 negative regulation of podosome assembly(GO:0071802)
1.7 6.8 GO:0032661 regulation of interleukin-18 production(GO:0032661)
1.6 6.6 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
1.6 9.7 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
1.6 11.1 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
1.5 4.5 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
1.5 44.9 GO:0035855 megakaryocyte development(GO:0035855)
1.5 20.7 GO:1903715 regulation of aerobic respiration(GO:1903715)
1.5 4.4 GO:0001810 regulation of type I hypersensitivity(GO:0001810) positive regulation of type I hypersensitivity(GO:0001812) type I hypersensitivity(GO:0016068)
1.4 7.0 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.4 1.4 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
1.3 141.3 GO:0042100 B cell proliferation(GO:0042100)
1.3 29.0 GO:0002418 immune response to tumor cell(GO:0002418)
1.3 6.5 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
1.3 54.4 GO:0070207 protein homotrimerization(GO:0070207)
1.3 3.8 GO:0032497 detection of lipopolysaccharide(GO:0032497)
1.2 2.4 GO:0003274 endocardial cushion fusion(GO:0003274)
1.2 37.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
1.2 9.6 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
1.2 2.4 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
1.1 6.7 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
1.1 6.6 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.1 5.4 GO:0052056 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
1.1 3.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
1.1 13.7 GO:0002517 T cell tolerance induction(GO:0002517)
1.0 4.2 GO:1904059 regulation of locomotor rhythm(GO:1904059)
1.0 5.1 GO:0035984 response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984)
1.0 2.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
1.0 3.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
1.0 9.1 GO:0002467 germinal center formation(GO:0002467)
1.0 9.0 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
1.0 5.0 GO:0060010 Sertoli cell fate commitment(GO:0060010)
1.0 23.7 GO:0051014 actin filament severing(GO:0051014)
1.0 2.9 GO:1990637 response to prolactin(GO:1990637)
1.0 2.9 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
1.0 4.8 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
1.0 3.8 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.9 13.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.9 3.7 GO:0002384 hepatic immune response(GO:0002384)
0.9 12.8 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.9 3.7 GO:0061056 sclerotome development(GO:0061056)
0.9 4.5 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.9 0.9 GO:0003249 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250)
0.9 15.1 GO:0030220 platelet formation(GO:0030220)
0.9 7.9 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.9 4.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.9 5.2 GO:0071315 cellular response to morphine(GO:0071315) cellular response to isoquinoline alkaloid(GO:0071317)
0.9 2.6 GO:0060119 auditory receptor cell development(GO:0060117) inner ear receptor cell development(GO:0060119)
0.9 12.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.9 8.6 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.9 4.3 GO:0002347 response to tumor cell(GO:0002347)
0.9 4.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.8 1.7 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.8 3.3 GO:0001928 regulation of exocyst assembly(GO:0001928) regulation of exocyst localization(GO:0060178)
0.8 10.0 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.8 3.3 GO:0097045 phosphatidylserine exposure on blood platelet(GO:0097045)
0.8 12.4 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.8 4.9 GO:2000503 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) positive regulation of natural killer cell chemotaxis(GO:2000503)
0.8 4.8 GO:0002507 tolerance induction(GO:0002507)
0.8 19.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.8 1.6 GO:0045168 cell-cell signaling involved in cell fate commitment(GO:0045168) negative regulation of auditory receptor cell differentiation(GO:0045608)
0.8 17.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.8 7.7 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.8 10.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.8 43.0 GO:0002279 mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.8 1.5 GO:0007518 myoblast fate determination(GO:0007518)
0.8 1.5 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.7 9.0 GO:1902563 regulation of neutrophil activation(GO:1902563)
0.7 55.3 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.7 2.2 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.7 11.5 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.7 7.1 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.7 3.5 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.7 9.0 GO:0002051 osteoblast fate commitment(GO:0002051)
0.7 7.6 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.7 13.1 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.7 4.1 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.7 14.3 GO:0045576 mast cell activation(GO:0045576)
0.7 6.1 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.7 4.7 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.7 20.7 GO:0010447 response to acidic pH(GO:0010447)
0.7 2.7 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.7 7.3 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.7 3.9 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.7 4.6 GO:0006226 dUMP biosynthetic process(GO:0006226)
0.6 1.9 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.6 1.9 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.6 8.3 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.6 4.4 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.6 3.7 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.6 23.8 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.6 14.6 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.6 3.0 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.6 10.7 GO:0042832 defense response to protozoan(GO:0042832)
0.6 7.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.6 6.8 GO:0048194 Golgi vesicle budding(GO:0048194)
0.6 3.9 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.6 5.0 GO:0097324 melanocyte migration(GO:0097324) positive regulation of lens fiber cell differentiation(GO:1902748)
0.6 3.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.5 13.1 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.5 4.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.5 0.5 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.5 11.2 GO:0090520 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.5 37.1 GO:0072676 lymphocyte migration(GO:0072676)
0.5 10.0 GO:0038203 TORC2 signaling(GO:0038203)
0.5 2.1 GO:1905203 regulation of connective tissue replacement(GO:1905203) positive regulation of connective tissue replacement(GO:1905205)
0.5 22.5 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.5 3.1 GO:0032494 response to peptidoglycan(GO:0032494)
0.5 6.5 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.5 7.0 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.5 2.5 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.5 11.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.5 7.6 GO:0030225 macrophage differentiation(GO:0030225)
0.5 3.8 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.5 1.9 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416)
0.5 3.8 GO:0007296 vitellogenesis(GO:0007296)
0.5 3.3 GO:0090527 actin filament reorganization(GO:0090527)
0.5 5.1 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.5 2.7 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.4 14.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.4 38.0 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.4 0.9 GO:0071673 positive regulation of smooth muscle cell chemotaxis(GO:0071673)
0.4 3.8 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.4 7.6 GO:0090168 Golgi reassembly(GO:0090168)
0.4 4.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.4 3.8 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.4 4.1 GO:0001780 neutrophil homeostasis(GO:0001780)
0.4 2.0 GO:0010157 response to chlorate(GO:0010157)
0.4 5.3 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.4 1.6 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.4 4.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.4 2.8 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.4 1.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.4 6.4 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.4 0.8 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.4 7.9 GO:0071380 cellular response to prostaglandin E stimulus(GO:0071380)
0.4 0.8 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.4 19.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.4 12.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 6.9 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.4 2.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.4 1.9 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.4 15.7 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.4 2.2 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.4 3.0 GO:0006116 NADH oxidation(GO:0006116)
0.4 1.4 GO:0061743 motor learning(GO:0061743)
0.4 17.0 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.4 1.8 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.3 2.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.3 1.0 GO:0045575 histamine biosynthetic process(GO:0001694) basophil activation(GO:0045575)
0.3 1.7 GO:1904764 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.3 5.1 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.3 2.7 GO:0080009 mRNA methylation(GO:0080009)
0.3 10.1 GO:0032460 negative regulation of protein oligomerization(GO:0032460)
0.3 2.0 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.3 2.7 GO:0036337 Fas signaling pathway(GO:0036337) regulation of Fas signaling pathway(GO:1902044)
0.3 3.3 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.3 1.3 GO:0016094 polyprenol biosynthetic process(GO:0016094)
0.3 1.0 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381)
0.3 2.6 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.3 5.2 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.3 5.8 GO:2000587 regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.3 5.1 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.3 4.4 GO:0007144 female meiosis I(GO:0007144)
0.3 1.6 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.3 2.2 GO:0043316 cytotoxic T cell degranulation(GO:0043316)
0.3 8.5 GO:0097320 membrane tubulation(GO:0097320)
0.3 8.9 GO:0043101 purine-containing compound salvage(GO:0043101)
0.3 1.5 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.3 0.9 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008)
0.3 48.0 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.3 7.8 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.3 3.9 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)
0.3 160.8 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.3 2.7 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.3 1.7 GO:0021993 initiation of neural tube closure(GO:0021993)
0.3 1.5 GO:0090166 Golgi disassembly(GO:0090166)
0.3 1.4 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.3 0.5 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.3 1.9 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.3 1.9 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.3 1.9 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.3 3.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.3 0.3 GO:0015825 L-serine transport(GO:0015825)
0.3 1.1 GO:1900154 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.3 2.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 7.7 GO:0045332 phospholipid translocation(GO:0045332)
0.3 5.1 GO:0036065 fucosylation(GO:0036065)
0.3 2.0 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.3 6.5 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.2 1.2 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.2 2.5 GO:0034770 histone H4-K20 methylation(GO:0034770)
0.2 0.7 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.2 2.1 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.2 11.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.2 3.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.2 10.3 GO:0032456 endocytic recycling(GO:0032456)
0.2 0.9 GO:0072318 clathrin coat disassembly(GO:0072318) clathrin-coated pit assembly(GO:1905224)
0.2 3.9 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.2 1.4 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.2 5.4 GO:0001696 gastric acid secretion(GO:0001696)
0.2 1.3 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.2 6.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 2.9 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.2 2.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.2 1.5 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.2 3.8 GO:0021794 thalamus development(GO:0021794)
0.2 1.2 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 3.0 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 2.0 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 0.6 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.2 2.2 GO:0060613 fat pad development(GO:0060613)
0.2 1.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.2 1.4 GO:0072719 cellular response to cisplatin(GO:0072719)
0.2 2.9 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.2 5.3 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 2.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.2 5.9 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.2 0.9 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.2 6.7 GO:0006491 N-glycan processing(GO:0006491)
0.2 2.7 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.2 14.8 GO:0007602 phototransduction(GO:0007602)
0.2 27.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 3.8 GO:0070933 histone H4 deacetylation(GO:0070933)
0.2 0.9 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.2 2.4 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.2 2.7 GO:0097178 ruffle assembly(GO:0097178)
0.2 2.0 GO:0046085 adenosine metabolic process(GO:0046085)
0.2 1.0 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 1.2 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.2 1.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.2 1.4 GO:0035897 proteolysis in other organism(GO:0035897)
0.2 8.9 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.2 1.9 GO:0021759 globus pallidus development(GO:0021759)
0.2 0.3 GO:0008355 olfactory learning(GO:0008355)
0.2 26.0 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.2 8.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.2 0.9 GO:0072752 cellular response to rapamycin(GO:0072752)
0.2 19.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.2 0.9 GO:0035063 nuclear speck organization(GO:0035063)
0.2 3.4 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.2 7.1 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.1 2.4 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 2.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 1.9 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 2.7 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 4.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 5.6 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.1 0.8 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 1.7 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.1 2.5 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.1 3.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.5 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 0.4 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 1.0 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 2.6 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 0.5 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 0.9 GO:0007172 signal complex assembly(GO:0007172)
0.1 2.4 GO:0006853 carnitine shuttle(GO:0006853)
0.1 1.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 1.8 GO:0050880 regulation of tube size(GO:0035150) regulation of blood vessel size(GO:0050880)
0.1 3.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 2.5 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 1.0 GO:0071830 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.1 1.1 GO:0002438 acute inflammatory response to antigenic stimulus(GO:0002438)
0.1 0.4 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.1 14.0 GO:0006903 vesicle targeting(GO:0006903)
0.1 2.4 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.1 2.9 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 3.1 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 7.9 GO:0048678 response to axon injury(GO:0048678)
0.1 1.8 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 0.4 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.2 GO:1904995 negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.1 1.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 0.4 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.1 2.3 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.1 1.3 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 5.0 GO:0018146 keratan sulfate biosynthetic process(GO:0018146)
0.1 10.6 GO:0034605 cellular response to heat(GO:0034605)
0.1 0.5 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 1.5 GO:0034205 beta-amyloid formation(GO:0034205)
0.1 2.3 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 2.9 GO:0030728 ovulation(GO:0030728)
0.1 0.3 GO:2001140 regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
0.1 1.2 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.1 4.2 GO:0006298 mismatch repair(GO:0006298)
0.1 1.5 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043281)
0.1 3.7 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.1 4.5 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 0.7 GO:0016556 mRNA modification(GO:0016556) mRNA pseudouridine synthesis(GO:1990481)
0.1 2.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 7.0 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 0.4 GO:0098876 vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 1.6 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 51.2 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 0.6 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.9 GO:0048565 digestive tract development(GO:0048565)
0.1 1.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 1.5 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.1 3.0 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 1.0 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.6 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952)
0.1 4.8 GO:0030183 B cell differentiation(GO:0030183)
0.1 3.5 GO:0010830 regulation of myotube differentiation(GO:0010830)
0.1 0.6 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.1 2.1 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 8.2 GO:0030218 erythrocyte differentiation(GO:0030218)
0.1 1.3 GO:0045116 protein neddylation(GO:0045116)
0.1 1.4 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.1 0.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.7 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 1.3 GO:0002003 angiotensin maturation(GO:0002003)
0.1 1.7 GO:0060065 uterus development(GO:0060065)
0.1 0.2 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051) sperm ejaculation(GO:0042713)
0.1 2.4 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 7.3 GO:0006955 immune response(GO:0006955)
0.1 12.3 GO:0002576 platelet degranulation(GO:0002576)
0.1 0.8 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 4.6 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.1 1.9 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 1.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.4 GO:0052250 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 1.9 GO:0098751 bone cell development(GO:0098751)
0.1 1.7 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.1 0.7 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1 1.7 GO:0015671 oxygen transport(GO:0015671)
0.1 3.8 GO:0006968 cellular defense response(GO:0006968)
0.1 4.0 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.1 3.9 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.1 1.6 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.1 6.6 GO:0002377 immunoglobulin production(GO:0002377)
0.1 1.7 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 2.2 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.1 0.9 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.1 2.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 3.2 GO:0042113 B cell activation(GO:0042113)
0.1 1.3 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.1 0.2 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.1 3.0 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.1 0.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 5.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 0.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 3.0 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.1 2.5 GO:2000737 negative regulation of stem cell differentiation(GO:2000737)
0.1 1.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 0.9 GO:0043586 tongue development(GO:0043586)
0.1 0.8 GO:0010815 bradykinin catabolic process(GO:0010815)
0.1 0.1 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.1 3.2 GO:0006611 protein export from nucleus(GO:0006611)
0.1 0.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 0.5 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.0 GO:0016180 snRNA processing(GO:0016180)
0.1 1.2 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 3.2 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 1.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.6 GO:0015914 phospholipid transport(GO:0015914)
0.0 5.4 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 5.5 GO:2000117 negative regulation of cysteine-type endopeptidase activity(GO:2000117)
0.0 2.1 GO:0001824 blastocyst development(GO:0001824)
0.0 3.3 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 2.8 GO:0016266 O-glycan processing(GO:0016266)
0.0 2.0 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 1.7 GO:0046039 GTP metabolic process(GO:0046039)
0.0 1.3 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.6 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 3.6 GO:0045727 positive regulation of translation(GO:0045727)
0.0 6.9 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.1 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.6 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.6 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.4 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.0 1.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 2.4 GO:0050709 negative regulation of protein secretion(GO:0050709)
0.0 4.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0 3.2 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 3.7 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 0.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 3.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.3 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 1.2 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.4 GO:0032119 sequestering of zinc ion(GO:0032119)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 2.6 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 1.7 GO:0010107 potassium ion import(GO:0010107)
0.0 1.7 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 0.8 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.1 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 5.3 GO:0006333 chromatin assembly or disassembly(GO:0006333)
0.0 0.9 GO:0021983 pituitary gland development(GO:0021983)
0.0 0.3 GO:0031503 protein complex localization(GO:0031503) cellular protein complex localization(GO:0034629) exocyst localization(GO:0051601)
0.0 0.1 GO:1904693 midbrain morphogenesis(GO:1904693)
0.0 0.9 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.9 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.6 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015) inositol lipid-mediated signaling(GO:0048017)
0.0 0.4 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.7 GO:0030168 platelet activation(GO:0030168)
0.0 0.4 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 8.8 GO:0002275 myeloid cell activation involved in immune response(GO:0002275)
0.0 1.3 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.3 GO:0043928 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.3 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 99.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
6.1 30.3 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
4.4 30.8 GO:0019815 B cell receptor complex(GO:0019815)
4.3 47.6 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
4.1 40.7 GO:0032010 phagolysosome(GO:0032010)
4.0 15.9 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
3.0 14.9 GO:0036398 TCR signalosome(GO:0036398)
2.8 16.6 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
2.7 8.0 GO:0008623 CHRAC(GO:0008623)
2.5 10.1 GO:0036284 tubulobulbar complex(GO:0036284)
2.2 20.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
2.2 6.5 GO:0042022 interleukin-12 receptor complex(GO:0042022)
2.1 14.7 GO:0036021 endolysosome lumen(GO:0036021)
2.1 14.6 GO:0044194 cytolytic granule(GO:0044194)
2.0 46.6 GO:0042101 T cell receptor complex(GO:0042101)
1.9 13.4 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
1.8 63.5 GO:0001891 phagocytic cup(GO:0001891)
1.8 100.6 GO:0001772 immunological synapse(GO:0001772)
1.7 43.0 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
1.4 22.3 GO:0043020 NADPH oxidase complex(GO:0043020)
1.4 4.1 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
1.3 18.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.3 8.9 GO:1902560 GMP reductase complex(GO:1902560)
1.3 11.3 GO:1990111 spermatoproteasome complex(GO:1990111)
1.2 3.7 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.2 23.7 GO:0032059 bleb(GO:0032059)
1.1 20.1 GO:0031209 SCAR complex(GO:0031209)
1.1 16.9 GO:0070938 contractile ring(GO:0070938)
1.0 1.0 GO:0071159 NF-kappaB complex(GO:0071159)
0.9 29.3 GO:0031527 filopodium membrane(GO:0031527)
0.9 4.4 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.7 312.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.7 2.9 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.7 15.0 GO:0016461 unconventional myosin complex(GO:0016461)
0.7 13.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.7 2.7 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.7 6.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.7 6.6 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.6 1.9 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.6 2.4 GO:0048179 activin receptor complex(GO:0048179)
0.6 5.2 GO:0005577 fibrinogen complex(GO:0005577)
0.5 2.7 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.5 2.6 GO:0042643 actomyosin, actin portion(GO:0042643)
0.5 6.6 GO:0097524 sperm plasma membrane(GO:0097524)
0.5 2.9 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.5 3.7 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.5 2.8 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.4 0.9 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.4 43.1 GO:0035580 specific granule lumen(GO:0035580)
0.4 2.6 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.4 8.2 GO:0005916 fascia adherens(GO:0005916)
0.4 9.6 GO:0031528 microvillus membrane(GO:0031528)
0.4 10.6 GO:0031932 TORC2 complex(GO:0031932)
0.4 9.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.4 4.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.4 1.6 GO:0098839 postsynaptic density membrane(GO:0098839)
0.4 2.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.4 2.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.4 6.6 GO:0097433 dense body(GO:0097433)
0.4 27.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.4 2.3 GO:1990037 Lewy body core(GO:1990037)
0.4 1.5 GO:0016939 plus-end kinesin complex(GO:0005873) kinesin II complex(GO:0016939)
0.4 5.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 7.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 33.5 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.3 1.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.3 5.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.3 44.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 4.2 GO:0097470 ribbon synapse(GO:0097470)
0.3 24.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.3 2.1 GO:0070435 Shc-EGFR complex(GO:0070435)
0.3 2.7 GO:0033263 CORVET complex(GO:0033263)
0.3 14.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.3 2.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.3 24.0 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.3 2.0 GO:0044294 dendritic growth cone(GO:0044294)
0.2 3.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 5.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.2 5.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 2.0 GO:0016272 prefoldin complex(GO:0016272)
0.2 1.7 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.2 1.2 GO:0000125 PCAF complex(GO:0000125)
0.2 2.4 GO:0005884 actin filament(GO:0005884)
0.2 2.5 GO:0000322 storage vacuole(GO:0000322)
0.2 2.7 GO:0030870 Mre11 complex(GO:0030870)
0.2 1.6 GO:0097208 alveolar lamellar body(GO:0097208)
0.2 2.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 4.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.2 5.6 GO:0042627 chylomicron(GO:0042627)
0.2 4.5 GO:0043679 axon terminus(GO:0043679)
0.2 1.9 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.2 0.9 GO:0035061 interchromatin granule(GO:0035061)
0.2 0.7 GO:0055087 Ski complex(GO:0055087)
0.2 1.2 GO:0097427 microtubule bundle(GO:0097427)
0.2 1.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 1.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 86.6 GO:0000790 nuclear chromatin(GO:0000790)
0.2 72.4 GO:0034774 secretory granule lumen(GO:0034774)
0.2 1.0 GO:0030008 TRAPP complex(GO:0030008)
0.2 2.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.9 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.2 3.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 1.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 1.6 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.1 5.8 GO:0032590 dendrite membrane(GO:0032590)
0.1 3.2 GO:0000785 chromatin(GO:0000785)
0.1 0.5 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.1 1.1 GO:0016600 flotillin complex(GO:0016600)
0.1 2.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 11.1 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 10.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 16.8 GO:0005776 autophagosome(GO:0005776)
0.1 15.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 13.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 0.9 GO:0097452 GAIT complex(GO:0097452)
0.1 1.0 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.1 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 4.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.4 GO:0005588 collagen type V trimer(GO:0005588)
0.1 2.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 2.1 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.3 GO:0072487 MSL complex(GO:0072487)
0.1 2.0 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 7.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 2.2 GO:0071141 SMAD protein complex(GO:0071141)
0.1 7.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 3.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 20.2 GO:0001650 fibrillar center(GO:0001650)
0.1 6.8 GO:0030427 site of polarized growth(GO:0030427)
0.1 8.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.5 GO:0034457 Mpp10 complex(GO:0034457)
0.1 33.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 2.9 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 7.7 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 1.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 0.9 GO:0038201 TOR complex(GO:0038201)
0.1 103.9 GO:0000139 Golgi membrane(GO:0000139)
0.1 19.4 GO:0001726 ruffle(GO:0001726)
0.1 1.0 GO:0005955 calcineurin complex(GO:0005955)
0.1 23.6 GO:0030496 midbody(GO:0030496)
0.1 0.7 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 1.2 GO:1990909 Wnt signalosome(GO:1990909)
0.1 24.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 2.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 6.4 GO:0005802 trans-Golgi network(GO:0005802)
0.1 4.2 GO:0032155 cell division site(GO:0032153) cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610)
0.1 2.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 2.1 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 4.3 GO:0016235 aggresome(GO:0016235)
0.1 13.7 GO:0031252 cell leading edge(GO:0031252)
0.1 2.0 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 0.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 1.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.5 GO:1990246 uniplex complex(GO:1990246)
0.1 0.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 5.4 GO:0005902 microvillus(GO:0005902)
0.1 0.8 GO:0070187 telosome(GO:0070187)
0.1 3.5 GO:0043596 nuclear replication fork(GO:0043596)
0.1 1.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 10.5 GO:0016605 PML body(GO:0016605)
0.1 7.2 GO:0030175 filopodium(GO:0030175)
0.1 0.3 GO:0035748 Scrib-APC-beta-catenin complex(GO:0034750) myelin sheath abaxonal region(GO:0035748)
0.1 3.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 4.7 GO:0012505 endomembrane system(GO:0012505)
0.1 20.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 21.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 1.8 GO:0098791 Golgi subcompartment(GO:0098791)
0.1 0.4 GO:0032044 DSIF complex(GO:0032044)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 11.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.0 GO:0032039 integrator complex(GO:0032039)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.6 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.1 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.7 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 12.2 GO:0031965 nuclear membrane(GO:0031965)
0.1 1.8 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 1.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 6.0 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.0 0.2 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 22.2 GO:0005925 focal adhesion(GO:0005925)
0.0 1.1 GO:0031105 septin complex(GO:0031105)
0.0 1.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.1 GO:0097422 tubular endosome(GO:0097422)
0.0 0.2 GO:0098793 presynapse(GO:0098793)
0.0 0.2 GO:0005687 U4 snRNP(GO:0005687)
0.0 1.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 4.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.1 GO:0000814 ESCRT II complex(GO:0000814)
0.0 6.7 GO:0005741 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 7.9 GO:0016607 nuclear speck(GO:0016607)
0.0 7.3 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 1.3 GO:0030133 transport vesicle(GO:0030133)
0.0 174.2 GO:0005829 cytosol(GO:0005829)
0.0 1.1 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 0.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.8 GO:0005770 late endosome(GO:0005770)
0.0 0.0 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 2.7 GO:0044432 endoplasmic reticulum part(GO:0044432)
0.0 0.3 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0005657 replication fork(GO:0005657)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 1.6 GO:0044454 nuclear chromosome part(GO:0044454)
0.0 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 20.1 GO:0005174 CD40 receptor binding(GO:0005174)
6.3 12.6 GO:0004917 interleukin-7 receptor activity(GO:0004917)
5.9 47.2 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
5.9 29.3 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
4.8 76.2 GO:0042608 T cell receptor binding(GO:0042608)
4.5 13.5 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
4.0 47.6 GO:0030369 ICAM-3 receptor activity(GO:0030369)
3.6 29.0 GO:0043208 glycosphingolipid binding(GO:0043208)
3.5 45.5 GO:0051525 NFAT protein binding(GO:0051525)
3.4 10.3 GO:0031859 platelet activating factor receptor binding(GO:0031859)
3.2 28.7 GO:0070891 lipoteichoic acid binding(GO:0070891)
2.9 17.3 GO:0004974 leukotriene receptor activity(GO:0004974)
2.7 10.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
2.6 17.9 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
2.5 98.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
2.3 28.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
2.3 7.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
2.3 55.7 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
2.3 6.9 GO:0005136 interleukin-4 receptor binding(GO:0005136)
2.2 24.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
2.2 20.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
2.2 6.5 GO:0016517 interleukin-12 receptor activity(GO:0016517)
2.1 12.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
2.0 44.4 GO:0005522 profilin binding(GO:0005522)
1.9 5.6 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
1.8 7.3 GO:0004979 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
1.7 39.8 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
1.5 7.5 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
1.5 7.3 GO:0070051 fibrinogen binding(GO:0070051)
1.4 8.6 GO:0046624 sphingolipid transporter activity(GO:0046624)
1.4 4.3 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
1.4 24.0 GO:0019957 C-C chemokine binding(GO:0019957)
1.4 10.8 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
1.3 10.7 GO:0035800 deubiquitinase activator activity(GO:0035800)
1.3 6.6 GO:0019770 IgG receptor activity(GO:0019770)
1.3 9.0 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
1.3 8.9 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
1.2 45.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
1.2 3.7 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
1.2 44.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.2 27.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.1 17.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
1.1 4.6 GO:0004132 dCMP deaminase activity(GO:0004132)
1.1 5.6 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.1 4.4 GO:0019763 immunoglobulin receptor activity(GO:0019763)
1.1 12.6 GO:0019864 IgG binding(GO:0019864)
1.0 77.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
1.0 10.2 GO:1990405 protein antigen binding(GO:1990405)
1.0 3.0 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
1.0 18.6 GO:0030284 estrogen receptor activity(GO:0030284)
1.0 2.9 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.9 48.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.9 3.7 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.9 18.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.9 2.7 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.9 13.4 GO:0033691 sialic acid binding(GO:0033691)
0.9 3.5 GO:0061769 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.9 19.0 GO:0051400 BH domain binding(GO:0051400)
0.8 11.0 GO:0004969 histamine receptor activity(GO:0004969)
0.8 3.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.8 6.4 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.8 19.6 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.8 3.8 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.8 14.6 GO:0042609 CD4 receptor binding(GO:0042609)
0.8 3.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.8 5.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.7 21.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.7 3.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.7 3.5 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.7 2.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.7 27.2 GO:0017166 vinculin binding(GO:0017166)
0.7 23.1 GO:0071837 HMG box domain binding(GO:0071837)
0.7 2.0 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.7 2.0 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.7 2.0 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.7 4.0 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.7 7.9 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.6 1.9 GO:0036328 VEGF-C-activated receptor activity(GO:0036328)
0.6 5.0 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.6 4.4 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.6 92.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.6 9.5 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.6 22.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.6 13.3 GO:0050700 CARD domain binding(GO:0050700)
0.5 4.9 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.5 8.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.5 1.6 GO:0086040 sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086040)
0.5 5.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.5 55.0 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.5 1.5 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.5 2.5 GO:0023023 MHC protein complex binding(GO:0023023)
0.5 5.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.5 2.5 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.5 4.9 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.5 3.9 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.5 4.8 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.5 21.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.5 2.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.5 238.4 GO:0005096 GTPase activator activity(GO:0005096)
0.5 4.2 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.5 5.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.5 8.7 GO:0030957 Tat protein binding(GO:0030957)
0.4 2.7 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.4 0.9 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.4 2.2 GO:0035500 MH2 domain binding(GO:0035500)
0.4 14.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.4 4.2 GO:0004985 opioid receptor activity(GO:0004985)
0.4 7.0 GO:0050681 androgen receptor binding(GO:0050681)
0.4 1.6 GO:0098808 mRNA cap binding(GO:0098808)
0.4 4.8 GO:0008420 CTD phosphatase activity(GO:0008420)
0.4 2.0 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 2.0 GO:1990460 leptin receptor binding(GO:1990460)
0.4 19.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 10.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 19.7 GO:0042287 MHC protein binding(GO:0042287)
0.4 2.9 GO:0019826 oxygen sensor activity(GO:0019826)
0.4 12.4 GO:0022829 wide pore channel activity(GO:0022829)
0.4 11.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 7.6 GO:0043274 phospholipase binding(GO:0043274)
0.3 3.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.3 13.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 2.0 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.3 3.0 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.3 1.3 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.3 3.3 GO:0050542 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.3 2.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.3 9.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 2.8 GO:0043426 MRF binding(GO:0043426)
0.3 2.8 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.3 1.8 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.3 0.9 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.3 14.7 GO:0043236 laminin binding(GO:0043236)
0.3 1.5 GO:0033265 choline binding(GO:0033265)
0.3 2.7 GO:0070087 chromo shadow domain binding(GO:0070087)
0.3 5.0 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 2.7 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.3 21.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.3 2.0 GO:0004966 galanin receptor activity(GO:0004966)
0.3 2.0 GO:0005119 smoothened binding(GO:0005119)
0.3 5.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.3 2.2 GO:0004771 sterol esterase activity(GO:0004771)
0.3 1.6 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.3 4.3 GO:0045159 myosin II binding(GO:0045159)
0.3 2.2 GO:1990932 5.8S rRNA binding(GO:1990932)
0.3 1.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.3 3.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.3 6.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.3 0.8 GO:0015616 DNA translocase activity(GO:0015616)
0.3 9.0 GO:0008301 DNA binding, bending(GO:0008301)
0.3 2.9 GO:0070412 R-SMAD binding(GO:0070412)
0.3 9.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.3 12.0 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.3 3.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.3 1.3 GO:0008457 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.3 38.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 6.6 GO:0004697 protein kinase C activity(GO:0004697)
0.2 11.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.2 0.7 GO:0015057 thrombin receptor activity(GO:0015057)
0.2 1.6 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.2 2.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 4.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 2.7 GO:0034594 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.2 7.3 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 2.4 GO:0008607 cAMP-dependent protein kinase regulator activity(GO:0008603) phosphorylase kinase regulator activity(GO:0008607)
0.2 18.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.2 7.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 11.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 1.6 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.2 3.0 GO:0015925 galactosidase activity(GO:0015925)
0.2 1.4 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.2 8.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 4.0 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 1.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.2 12.9 GO:0003678 DNA helicase activity(GO:0003678)
0.2 3.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 0.7 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.2 1.7 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 6.2 GO:0016805 dipeptidase activity(GO:0016805)
0.2 8.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 18.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 3.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 1.9 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 8.0 GO:0008134 transcription factor binding(GO:0008134)
0.1 2.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 2.6 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.1 11.5 GO:0001618 virus receptor activity(GO:0001618)
0.1 5.1 GO:0005521 lamin binding(GO:0005521)
0.1 0.8 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 3.4 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 61.3 GO:0003924 GTPase activity(GO:0003924)
0.1 1.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.0 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 4.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.6 GO:0004348 glucosylceramidase activity(GO:0004348)
0.1 3.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 5.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 3.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 1.9 GO:0098847 sequence-specific single stranded DNA binding(GO:0098847)
0.1 4.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.6 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.1 4.3 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 3.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 1.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 3.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 2.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.9 GO:0032183 SUMO binding(GO:0032183)
0.1 2.1 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 6.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 4.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 1.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 4.0 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 5.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 7.9 GO:0035004 phosphatidylinositol 3-kinase activity(GO:0035004)
0.1 2.1 GO:0046961 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.1 GO:0017091 AU-rich element binding(GO:0017091)
0.1 4.1 GO:0030332 cyclin binding(GO:0030332)
0.1 2.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.8 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 0.9 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 3.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 3.6 GO:0070717 poly-purine tract binding(GO:0070717)
0.1 2.8 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.2 GO:0035326 enhancer binding(GO:0035326)
0.1 0.9 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 7.7 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 1.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 9.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 18.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.9 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 1.6 GO:0097602 cullin family protein binding(GO:0097602)
0.1 4.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 11.2 GO:0004386 helicase activity(GO:0004386)
0.1 1.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 2.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.5 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.8 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 0.6 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 3.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 19.0 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.9 GO:0008494 translation activator activity(GO:0008494)
0.1 0.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 8.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 1.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 1.0 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 2.5 GO:0005080 protein kinase C binding(GO:0005080)
0.1 11.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 1.8 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 3.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 3.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 1.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.5 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 1.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 1.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 2.1 GO:0042054 histone methyltransferase activity(GO:0042054)
0.0 1.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 1.9 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 10.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 4.1 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.4 GO:0034452 dynactin binding(GO:0034452)
0.0 3.5 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 4.8 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 1.4 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.3 GO:0000149 SNARE binding(GO:0000149)
0.0 0.4 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 3.4 GO:0005525 GTP binding(GO:0005525)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 7.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 2.7 GO:0003823 antigen binding(GO:0003823)
0.0 0.2 GO:0008009 chemokine activity(GO:0008009)
0.0 0.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 359.0 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
1.7 70.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
1.7 74.9 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
1.3 48.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.3 88.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.9 51.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.9 66.3 PID BCR 5PATHWAY BCR signaling pathway
0.9 25.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.9 45.2 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.9 15.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.9 62.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.9 31.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.8 21.5 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.8 108.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.7 79.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.7 2.9 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.6 12.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.6 59.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.6 21.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.6 15.4 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.5 2.4 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.5 58.8 PID CMYB PATHWAY C-MYB transcription factor network
0.5 12.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.5 10.1 PID IL2 1PATHWAY IL2-mediated signaling events
0.4 16.0 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.4 19.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.4 16.0 PID IL12 2PATHWAY IL12-mediated signaling events
0.4 4.9 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.4 63.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.4 13.5 PID IL3 PATHWAY IL3-mediated signaling events
0.4 29.4 PID AURORA B PATHWAY Aurora B signaling
0.4 7.1 PID S1P S1P2 PATHWAY S1P2 pathway
0.4 16.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.4 5.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.4 14.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.3 12.0 PID CONE PATHWAY Visual signal transduction: Cones
0.3 19.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3 2.7 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.3 20.8 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.3 29.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 8.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 8.7 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.2 10.9 PID ENDOTHELIN PATHWAY Endothelins
0.2 10.7 PID ARF6 PATHWAY Arf6 signaling events
0.2 5.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.2 17.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.2 5.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 4.2 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 2.0 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.2 3.3 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 6.8 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.1 0.7 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 1.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 8.6 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 1.7 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.1 1.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.8 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 0.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 2.3 PID RHOA PATHWAY RhoA signaling pathway
0.1 1.8 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 5.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.5 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 3.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 2.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 12.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 2.0 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.0 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 1.1 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 12.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.2 PID MYC PATHWAY C-MYC pathway
0.0 1.2 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.2 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.5 PID ATR PATHWAY ATR signaling pathway
0.0 0.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 230.5 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
4.9 14.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
2.4 94.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
2.2 20.2 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
1.9 1.9 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
1.6 187.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.5 19.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
1.3 27.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
1.3 87.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.1 35.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
1.1 59.5 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
1.1 20.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
1.0 58.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.9 20.6 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.9 5.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.9 48.2 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.9 27.6 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.9 19.6 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.8 12.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.8 13.2 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.7 10.9 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.7 13.8 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.7 19.7 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.6 11.0 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.6 6.9 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.6 46.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.6 0.6 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.6 163.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.6 14.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.6 6.7 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.5 5.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.5 10.3 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.5 2.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.5 13.8 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.5 25.6 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.4 21.8 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.4 4.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4 14.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.4 13.4 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.4 22.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.4 32.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.4 3.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.4 9.0 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.3 4.7 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.3 8.9 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.3 8.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.3 7.3 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.3 3.9 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.3 4.9 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 3.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.2 5.0 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 1.4 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.2 3.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 35.3 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2 5.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 6.0 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.2 9.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2 30.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 3.9 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.2 17.3 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.2 8.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 2.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 0.3 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.2 5.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.2 2.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 6.8 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 4.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 4.8 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 5.0 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 8.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.3 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 11.1 REACTOME MITOTIC G1 G1 S PHASES Genes involved in Mitotic G1-G1/S phases
0.1 3.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.0 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 0.6 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.5 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 23.0 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.1 2.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 7.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 0.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 10.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 2.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.4 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 1.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 5.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 2.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.8 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.9 REACTOME PURINE METABOLISM Genes involved in Purine metabolism
0.0 1.5 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 1.1 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.0 2.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.1 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 1.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.8 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.5 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.6 REACTOME TRANSLATION Genes involved in Translation
0.0 1.1 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 1.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 2.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.0 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 1.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.0 0.4 REACTOME METABOLISM OF NUCLEOTIDES Genes involved in Metabolism of nucleotides
0.0 0.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.2 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.2 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)