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Illumina Body Map 2, young vs old

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Results for SREBF2

Z-value: 0.16

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_422291460.154.1e-01Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_56150184 4.76 ENST00000394554.1
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr12_-_53343602 4.03 ENST00000546897.1
ENST00000552551.1
KRT8
keratin 8
chr6_+_151561085 3.37 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr12_-_53343633 3.26 ENST00000546826.1
KRT8
keratin 8
chr9_+_96928516 3.16 ENST00000602703.1
RP11-2B6.3
RP11-2B6.3
chr12_-_91505608 3.01 ENST00000266718.4
LUM
lumican
chr12_-_53343560 2.91 ENST00000548998.1
KRT8
keratin 8
chr7_-_84816122 2.78 ENST00000444867.1
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr19_+_55591743 2.68 ENST00000588359.1
ENST00000245618.5
EPS8L1
EPS8-like 1
chr6_-_32152064 2.51 ENST00000375076.4
ENST00000375070.3
AGER
advanced glycosylation end product-specific receptor
chr6_-_32152020 2.47 ENST00000375055.2
AGER
advanced glycosylation end product-specific receptor
chr15_+_47476275 2.43 ENST00000558014.1
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr6_-_32151999 2.38 ENST00000375069.3
ENST00000538695.1
ENST00000438221.2
ENST00000375065.5
ENST00000450110.1
ENST00000375067.3
ENST00000375056.2
AGER
advanced glycosylation end product-specific receptor
chr19_-_11308190 2.11 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
KANK2
KN motif and ankyrin repeat domains 2
chr5_-_149535421 2.10 ENST00000261799.4
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr2_-_219925189 1.80 ENST00000295731.6
IHH
indian hedgehog
chr16_+_2083265 1.74 ENST00000565855.1
ENST00000566198.1
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr6_+_41604747 1.74 ENST00000419164.1
ENST00000373051.2
MDFI
MyoD family inhibitor
chr17_-_15168624 1.70 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
PMP22
peripheral myelin protein 22
chr6_-_39902160 1.60 ENST00000340692.5
MOCS1
molybdenum cofactor synthesis 1
chr5_+_137774706 1.55 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr9_-_117267717 1.53 ENST00000374057.3
DFNB31
deafness, autosomal recessive 31
chr1_+_33219592 1.49 ENST00000373481.3
KIAA1522
KIAA1522
chr8_-_17579726 1.46 ENST00000381861.3
MTUS1
microtubule associated tumor suppressor 1
chr6_+_41604620 1.41 ENST00000432027.1
MDFI
MyoD family inhibitor
chr15_+_33010175 1.40 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1
gremlin 1, DAN family BMP antagonist
chr5_+_159656437 1.35 ENST00000402432.3
FABP6
fatty acid binding protein 6, ileal
chr6_+_43968306 1.30 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr5_-_149535190 1.28 ENST00000517488.1
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr3_-_160117301 1.19 ENST00000326448.7
ENST00000498409.1
ENST00000475677.1
ENST00000478536.1
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr16_+_22103828 1.15 ENST00000567131.1
ENST00000568328.1
ENST00000389398.5
ENST00000389397.4
VWA3A
von Willebrand factor A domain containing 3A
chr19_+_11200038 1.12 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chr8_+_21882244 1.06 ENST00000289820.6
ENST00000381530.5
NPM2
nucleophosmin/nucleoplasmin 2
chr6_-_52860171 1.06 ENST00000370963.4
GSTA4
glutathione S-transferase alpha 4
chr6_-_52859968 0.85 ENST00000370959.1
GSTA4
glutathione S-transferase alpha 4
chrX_-_153236819 0.83 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_-_232571621 0.82 ENST00000595658.1
MGC4771
MGC4771
chr3_-_98620500 0.79 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr12_-_48398104 0.79 ENST00000337299.6
ENST00000380518.3
COL2A1
collagen, type II, alpha 1
chr3_-_171527560 0.76 ENST00000331659.2
PP13439
PP13439
chr5_-_43313574 0.75 ENST00000325110.6
ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr1_+_55505184 0.74 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr6_+_69942298 0.72 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr12_+_50344516 0.71 ENST00000199280.3
ENST00000550862.1
AQP2
aquaporin 2 (collecting duct)
chrX_-_153237258 0.68 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr16_+_66914264 0.66 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
PDP2
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr4_+_185909970 0.64 ENST00000505053.1
RP11-386B13.4
RP11-386B13.4
chr5_-_43313269 0.54 ENST00000511774.1
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chrX_-_103087136 0.51 ENST00000243298.2
RAB9B
RAB9B, member RAS oncogene family
chr19_+_36266433 0.50 ENST00000314737.5
ARHGAP33
Rho GTPase activating protein 33
chr19_+_36266417 0.46 ENST00000378944.5
ENST00000007510.4
ARHGAP33
Rho GTPase activating protein 33
chr1_+_39796810 0.45 ENST00000289893.4
MACF1
microtubule-actin crosslinking factor 1
chr4_+_75230853 0.44 ENST00000244869.2
EREG
epiregulin
chr19_-_46285646 0.42 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr5_-_139283982 0.42 ENST00000340391.3
NRG2
neuregulin 2
chr6_-_53213780 0.42 ENST00000304434.6
ENST00000370918.4
ELOVL5
ELOVL fatty acid elongase 5
chr14_-_35183886 0.41 ENST00000298159.6
CFL2
cofilin 2 (muscle)
chr7_-_44580861 0.37 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr11_+_22688150 0.36 ENST00000454584.2
GAS2
growth arrest-specific 2
chr3_-_16554403 0.32 ENST00000449415.1
ENST00000441460.1
RFTN1
raftlin, lipid raft linker 1
chr2_+_232572361 0.26 ENST00000409321.1
PTMA
prothymosin, alpha
chr19_-_46285736 0.22 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase
chrX_+_27826107 0.22 ENST00000356790.2
MAGEB10
melanoma antigen family B, 10
chr6_-_53213587 0.21 ENST00000542638.1
ENST00000370913.5
ENST00000541407.1
ELOVL5
ELOVL fatty acid elongase 5
chr9_+_126131131 0.21 ENST00000373629.2
CRB2
crumbs homolog 2 (Drosophila)
chr6_-_32083106 0.21 ENST00000442721.1
TNXB
tenascin XB
chrX_-_153236620 0.19 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr4_+_718896 0.19 ENST00000433814.1
PCGF3
polycomb group ring finger 3
chr8_+_26434578 0.18 ENST00000493789.2
DPYSL2
dihydropyrimidinase-like 2
chr11_+_65479462 0.17 ENST00000377046.3
ENST00000352980.4
ENST00000341318.4
KAT5
K(lysine) acetyltransferase 5
chr3_+_5020801 0.14 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chr8_+_104513086 0.11 ENST00000406091.3
RIMS2
regulating synaptic membrane exocytosis 2
chr2_+_232573222 0.10 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chr11_+_2923499 0.08 ENST00000449793.2
SLC22A18
solute carrier family 22, member 18
chr11_+_2923423 0.05 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr11_+_65479702 0.05 ENST00000530446.1
ENST00000534104.1
ENST00000530605.1
ENST00000528198.1
ENST00000531880.1
ENST00000534650.1
KAT5
K(lysine) acetyltransferase 5
chr3_+_46742823 0.05 ENST00000326431.3
TMIE
transmembrane inner ear
chr9_-_99381660 0.04 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B
chr3_+_188889737 0.03 ENST00000345063.3
TPRG1
tumor protein p63 regulated 1
chr8_+_26435359 0.02 ENST00000311151.5
DPYSL2
dihydropyrimidinase-like 2
chr3_+_160117418 0.02 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
SMC4
structural maintenance of chromosomes 4
chr13_+_24844857 0.01 ENST00000409126.1
ENST00000343003.6
SPATA13
spermatogenesis associated 13
chr3_-_171528227 0.00 ENST00000356327.5
ENST00000342215.6
ENST00000340989.4
ENST00000351298.4
PLD1
phospholipase D1, phosphatidylcholine-specific

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:1904603 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
1.1 3.4 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
0.7 2.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.6 1.8 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.6 10.2 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.5 4.8 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.5 1.4 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.4 1.7 GO:0019046 release from viral latency(GO:0019046)
0.3 3.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.3 1.1 GO:1903979 negative regulation of microglial cell activation(GO:1903979)
0.3 1.5 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.2 0.7 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.2 3.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.2 2.7 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.2 0.7 GO:0071288 cellular response to mercury ion(GO:0071288)
0.1 0.4 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.1 1.6 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.1 3.2 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.1 1.3 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 0.8 GO:0060174 limb bud formation(GO:0060174)
0.1 1.7 GO:0032060 bleb assembly(GO:0032060)
0.1 0.6 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.1 0.6 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 1.1 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836)
0.0 2.4 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 1.9 GO:1901685 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.0 2.8 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.2 GO:0014028 notochord formation(GO:0014028)
0.0 0.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 1.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.4 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0 0.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:0046618 drug export(GO:0046618)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.5 1.6 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.4 1.1 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.3 4.0 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 10.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 0.6 GO:0097447 dendritic tree(GO:0097447)
0.1 1.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.7 GO:0043218 compact myelin(GO:0043218)
0.0 1.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 5.4 GO:0001650 fibrillar center(GO:0001650)
0.0 0.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.7 GO:0043202 lysosomal lumen(GO:0043202)
0.0 2.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 6.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:1904599 advanced glycation end-product binding(GO:1904599)
1.0 4.8 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.8 3.4 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
0.4 1.3 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.2 1.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.2 0.7 GO:0070326 very-low-density lipoprotein particle binding(GO:0034189) very-low-density lipoprotein particle receptor binding(GO:0070326)
0.2 2.7 GO:0042608 T cell receptor binding(GO:0042608)
0.2 3.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.8 GO:0005113 patched binding(GO:0005113)
0.1 1.4 GO:0016015 morphogen activity(GO:0016015)
0.1 1.7 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 2.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.8 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.7 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 2.8 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.7 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 10.2 GO:0097110 scaffold protein binding(GO:0097110)
0.1 1.3 GO:0032052 bile acid binding(GO:0032052)
0.1 0.6 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 1.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 3.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.1 GO:0043426 MRF binding(GO:0043426)
0.0 1.7 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.4 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 7.4 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 3.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 6.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.7 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 6.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.7 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.8 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 3.0 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 2.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.6 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 4.2 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 1.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)