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Illumina Body Map 2, young vs old

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Results for SRF

Z-value: 0.19

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Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
ENSG00000112658.6 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg19_v2_chr6_+_43140095_431401450.799.4e-08Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_45826125 44.49 ENST00000221476.3
creatine kinase, muscle
chr15_-_35088340 30.34 ENST00000290378.4
actin, alpha, cardiac muscle 1
chr1_-_229569834 25.22 ENST00000366684.3
ENST00000366683.2
actin, alpha 1, skeletal muscle
chr19_+_11650709 23.86 ENST00000586059.1
calponin 1, basic, smooth muscle
chr20_+_35169885 18.59 ENST00000279022.2
ENST00000346786.2
myosin, light chain 9, regulatory
chr14_-_94443065 18.21 ENST00000555287.1
ankyrin repeat and SOCS box containing 2
chr14_-_94443105 17.53 ENST00000555019.1
ankyrin repeat and SOCS box containing 2
chr19_-_36247910 15.58 ENST00000587965.1
ENST00000004982.3
heat shock protein, alpha-crystallin-related, B6
chr2_+_74120094 15.37 ENST00000409731.3
ENST00000345517.3
ENST00000409918.1
ENST00000442912.1
ENST00000409624.1
actin, gamma 2, smooth muscle, enteric
chr6_-_123958141 14.84 ENST00000334268.4
triadin
chr17_+_33474826 13.19 ENST00000268876.5
ENST00000433649.1
ENST00000378449.1
unc-45 homolog B (C. elegans)
chr2_+_88367299 12.82 ENST00000419482.2
ENST00000444564.2
SET and MYND domain containing 1
chr10_+_88428370 12.67 ENST00000372066.3
ENST00000263066.6
ENST00000372056.4
ENST00000310944.6
ENST00000361373.4
ENST00000542786.1
LIM domain binding 3
chr17_+_33474860 12.43 ENST00000394570.2
unc-45 homolog B (C. elegans)
chr3_+_187930491 12.30 ENST00000443217.1
LIM domain containing preferred translocation partner in lipoma
chr10_-_29923893 12.13 ENST00000355867.4
supervillin
chr3_-_52486841 12.01 ENST00000496590.1
troponin C type 1 (slow)
chr6_-_123957942 11.68 ENST00000398178.3
triadin
chr6_-_123958051 11.60 ENST00000546248.1
triadin
chr9_-_35691017 11.55 ENST00000378292.3
tropomyosin 2 (beta)
chr2_+_88367368 11.53 ENST00000438570.1
SET and MYND domain containing 1
chr17_-_41132088 10.94 ENST00000591916.1
ENST00000451885.2
ENST00000454303.1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr6_-_105585022 10.48 ENST00000314641.5
blood vessel epicardial substance
chr6_-_123958111 10.48 ENST00000542443.1
triadin
chr14_-_23877474 10.11 ENST00000405093.3
myosin, heavy chain 6, cardiac muscle, alpha
chr1_-_208084387 9.79 ENST00000537704.1
CD34 molecule
chr10_+_88428206 9.74 ENST00000429277.2
ENST00000458213.2
ENST00000352360.5
LIM domain binding 3
chr2_-_106015491 9.68 ENST00000408995.1
ENST00000393353.3
ENST00000322142.8
four and a half LIM domains 2
chr1_-_208084729 9.64 ENST00000310833.7
ENST00000356522.4
CD34 molecule
chr17_-_42875115 9.56 ENST00000591137.1
CTC-296K1.4
chr2_-_106054952 9.47 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
four and a half LIM domains 2
chr2_-_106015527 8.92 ENST00000344213.4
ENST00000358129.4
four and a half LIM domains 2
chr7_-_44180884 8.41 ENST00000458240.1
ENST00000223364.3
myosin, light chain 7, regulatory
chr18_-_3219847 8.36 ENST00000261606.7
myomesin 1
chr3_+_187930429 8.26 ENST00000420410.1
LIM domain containing preferred translocation partner in lipoma
chr3_-_46904946 8.06 ENST00000292327.4
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr3_-_46904918 7.85 ENST00000395869.1
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr7_-_44180673 7.79 ENST00000457314.1
ENST00000447951.1
ENST00000431007.1
myosin, light chain 7, regulatory
chr10_+_123922941 7.70 ENST00000360561.3
transforming, acidic coiled-coil containing protein 2
chr18_-_3220106 7.69 ENST00000356443.4
ENST00000400569.3
myomesin 1
chr16_+_30383613 7.62 ENST00000568749.1
myosin light chain, phosphorylatable, fast skeletal muscle
chr9_+_124088860 7.27 ENST00000373806.1
gelsolin
chr3_-_99594948 7.23 ENST00000471562.1
ENST00000495625.2
filamin A interacting protein 1-like
chr17_-_27949911 6.98 ENST00000492276.2
ENST00000345068.5
ENST00000584602.1
coronin 6
chr3_-_99595037 6.83 ENST00000383694.2
filamin A interacting protein 1-like
chr2_-_128432639 6.67 ENST00000545738.2
ENST00000355119.4
ENST00000409808.2
LIM and senescent cell antigen-like domains 2
chr1_+_16085263 6.66 ENST00000483633.2
ENST00000502739.1
ENST00000431771.2
filamin binding LIM protein 1
chr2_-_161056802 6.50 ENST00000283249.2
ENST00000409872.1
integrin, beta 6
chr8_+_1993152 5.59 ENST00000262113.4
myomesin 2
chr8_-_37189432 5.41 ENST00000518765.1
RP11-527N22.1
chr1_-_11907829 5.25 ENST00000376480.3
natriuretic peptide A
chr15_+_96873921 5.22 ENST00000394166.3
nuclear receptor subfamily 2, group F, member 2
chr16_+_66413128 5.13 ENST00000563425.2
cadherin 5, type 2 (vascular endothelium)
chr19_+_13135439 4.88 ENST00000586873.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_-_161056762 4.80 ENST00000428609.2
ENST00000409967.2
integrin, beta 6
chr10_+_75757863 4.76 ENST00000372755.3
ENST00000211998.4
ENST00000417648.2
vinculin
chr5_-_33892118 4.63 ENST00000515401.1
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr8_+_1993173 4.59 ENST00000523438.1
myomesin 2
chr7_-_27183263 4.52 ENST00000222726.3
homeobox A5
chrX_-_153602991 4.50 ENST00000369850.3
ENST00000422373.1
filamin A, alpha
chr10_-_90712520 4.50 ENST00000224784.6
actin, alpha 2, smooth muscle, aorta
chr19_+_13135386 4.44 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_+_117070037 4.44 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
transgelin
chr5_+_137774706 4.43 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
receptor accessory protein 2
chr5_-_33892204 4.36 ENST00000504830.1
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr5_-_169816638 4.36 ENST00000521859.1
ENST00000274629.4
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr10_-_17659357 4.13 ENST00000326961.6
ENST00000361271.3
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr4_+_87928140 4.04 ENST00000307808.6
AF4/FMR2 family, member 1
chr15_+_74218787 3.91 ENST00000261921.7
lysyl oxidase-like 1
chr5_-_58295712 3.90 ENST00000317118.8
phosphodiesterase 4D, cAMP-specific
chr11_+_86667117 3.90 ENST00000531827.1
RP11-736K20.6
chr11_-_47374246 3.87 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
myosin binding protein C, cardiac
chr1_+_16085244 3.87 ENST00000400773.1
filamin binding LIM protein 1
chr8_-_97398865 3.83 ENST00000523862.1
KB-1448A5.1
chr22_+_36784632 3.71 ENST00000424761.1
RP4-633O19__A.1
chr5_-_176923846 3.71 ENST00000506537.1
PDZ and LIM domain 7 (enigma)
chr18_+_61143994 3.65 ENST00000382771.4
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr7_-_559853 3.59 ENST00000405692.2
platelet-derived growth factor alpha polypeptide
chr7_-_107643567 3.51 ENST00000393559.1
ENST00000439976.1
ENST00000393560.1
laminin, beta 1
chr16_-_3350614 3.45 ENST00000268674.2
tigger transposable element derived 7
chr4_+_186064395 3.43 ENST00000281456.6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr5_+_66254698 3.43 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
microtubule associated serine/threonine kinase family member 4
chr5_-_176923803 3.43 ENST00000506161.1
PDZ and LIM domain 7 (enigma)
chr17_+_50939459 3.34 ENST00000412360.1
Uncharacterized protein
chr4_+_87928353 3.28 ENST00000511722.1
AF4/FMR2 family, member 1
chr10_+_31610064 3.26 ENST00000446923.2
ENST00000559476.1
zinc finger E-box binding homeobox 1
chr4_+_87928413 3.23 ENST00000544085.1
AF4/FMR2 family, member 1
chr3_+_187930719 3.23 ENST00000312675.4
LIM domain containing preferred translocation partner in lipoma
chr10_-_17659234 3.19 ENST00000466335.1
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr5_-_33892046 3.14 ENST00000352040.3
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr11_-_65667884 3.09 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOS-like antigen 1
chr5_+_150404904 3.09 ENST00000521632.1
glutathione peroxidase 3 (plasma)
chr11_-_2162468 3.06 ENST00000434045.2
insulin-like growth factor 2 (somatomedin A)
chr11_-_65667997 3.05 ENST00000312562.2
ENST00000534222.1
FOS-like antigen 1
chr7_-_107643674 3.03 ENST00000222399.6
laminin, beta 1
chr19_+_13134772 2.97 ENST00000587760.1
ENST00000585575.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_+_96077888 2.94 ENST00000509259.1
ENST00000503828.1
calpastatin
chr1_+_167599532 2.92 ENST00000537350.1
RCSD domain containing 1
chr22_+_45714672 2.86 ENST00000424557.1
family with sequence similarity 118, member A
chr12_+_52445191 2.81 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
nuclear receptor subfamily 4, group A, member 1
chr7_+_114055052 2.71 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
forkhead box P2
chr20_+_4702548 2.69 ENST00000305817.2
prion protein 2 (dublet)
chr6_+_151561085 2.63 ENST00000402676.2
A kinase (PRKA) anchor protein 12
chr16_-_11375179 2.59 ENST00000312511.3
protamine 1
chr22_-_36850991 2.53 ENST00000442579.1
RP5-1119A7.14
chr7_+_149416439 2.53 ENST00000497895.1
KRAB-A domain containing 1
chr1_+_167599330 2.52 ENST00000367854.3
ENST00000361496.3
RCSD domain containing 1
chr16_+_86229728 2.44 ENST00000601250.1
long intergenic non-protein coding RNA 1082
chr19_+_54372693 2.38 ENST00000391768.2
myeloid-associated differentiation marker
chr6_+_151561506 2.36 ENST00000253332.1
A kinase (PRKA) anchor protein 12
chr17_-_10560619 2.32 ENST00000583535.1
myosin, heavy chain 3, skeletal muscle, embryonic
chr8_-_22550815 2.29 ENST00000317216.2
early growth response 3
chr19_+_54372639 2.29 ENST00000391769.2
myeloid-associated differentiation marker
chrX_-_11284095 2.28 ENST00000303025.6
ENST00000534860.1
Rho GTPase activating protein 6
chr11_-_2162162 2.26 ENST00000381389.1
insulin-like growth factor 2 (somatomedin A)
chr22_-_36357671 2.26 ENST00000408983.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_+_101179152 2.25 ENST00000264254.6
phosducin-like 3
chr8_-_22550691 2.20 ENST00000519492.1
early growth response 3
chr1_+_113263199 2.16 ENST00000361886.3
family with sequence similarity 19 (chemokine (C-C motif)-like), member A3
chr12_+_54426637 2.05 ENST00000312492.2
homeobox C5
chr16_+_30077055 2.05 ENST00000564595.2
ENST00000569798.1
aldolase A, fructose-bisphosphate
chr9_-_79520989 2.00 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
prune homolog 2 (Drosophila)
chr19_+_16177826 1.93 ENST00000589897.1
tropomyosin 4
chr19_+_57901208 1.92 ENST00000366197.5
ENST00000596282.1
ENST00000597400.1
ENST00000598895.1
ENST00000336128.7
ENST00000596617.1
zinc finger protein 548
Uncharacterized protein
chr6_+_43139037 1.91 ENST00000265354.4
serum response factor (c-fos serum response element-binding transcription factor)
chr1_-_168106536 1.90 ENST00000537209.1
ENST00000361697.2
ENST00000546300.1
ENST00000367835.1
G protein-coupled receptor 161
chr2_+_87769459 1.89 ENST00000414030.1
ENST00000437561.1
long intergenic non-protein coding RNA 152
chr16_+_30077098 1.88 ENST00000395240.3
ENST00000566846.1
aldolase A, fructose-bisphosphate
chr7_-_94285511 1.87 ENST00000265735.7
sarcoglycan, epsilon
chr7_-_94285472 1.86 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
sarcoglycan, epsilon
chr7_-_94285402 1.80 ENST00000428696.2
ENST00000445866.2
sarcoglycan, epsilon
chr19_+_35861831 1.74 ENST00000454971.1
G protein-coupled receptor 42 (gene/pseudogene)
chr17_-_41132410 1.72 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr12_+_4382917 1.65 ENST00000261254.3
cyclin D2
chr19_+_45971246 1.57 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FBJ murine osteosarcoma viral oncogene homolog B
chr1_+_113263041 1.53 ENST00000369630.3
family with sequence similarity 19 (chemokine (C-C motif)-like), member A3
chr1_-_89591749 1.43 ENST00000370466.3
guanylate binding protein 2, interferon-inducible
chr1_+_223889310 1.36 ENST00000434648.1
calpain 2, (m/II) large subunit
chr5_+_40679584 1.29 ENST00000302472.3
prostaglandin E receptor 4 (subtype EP4)
chr22_+_38004723 1.28 ENST00000381756.5
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr3_-_123339418 1.27 ENST00000583087.1
myosin light chain kinase
chr15_+_83776324 1.24 ENST00000379390.6
ENST00000379386.4
ENST00000565774.1
ENST00000565982.1
transmembrane 6 superfamily member 1
chr4_+_189321881 1.21 ENST00000512839.1
ENST00000513313.1
long intergenic non-protein coding RNA 1060
chr1_+_206858328 1.21 ENST00000367103.3
mitogen-activated protein kinase-activated protein kinase 2
chr22_+_45714301 1.17 ENST00000427777.1
family with sequence similarity 118, member A
chr19_+_1026298 1.13 ENST00000263097.4
calponin 2
chr19_+_54372877 1.11 ENST00000414489.1
myeloid-associated differentiation marker
chr15_+_33603147 1.10 ENST00000415757.3
ENST00000389232.4
ryanodine receptor 3
chr3_-_71294304 1.10 ENST00000498215.1
forkhead box P1
chr2_-_139259244 1.07 ENST00000414911.1
ENST00000431985.1
AC097721.2
chr10_-_16859361 1.04 ENST00000377921.3
Ras suppressor protein 1
chr9_+_92219919 1.00 ENST00000252506.6
ENST00000375769.1
growth arrest and DNA-damage-inducible, gamma
chr7_+_107531580 0.99 ENST00000537148.1
ENST00000440410.1
ENST00000437604.2
dihydrolipoamide dehydrogenase
chr3_-_157221380 0.99 ENST00000468233.1
ventricular zone expressed PH domain-containing 1
chr14_+_105266933 0.97 ENST00000555360.1
zinc finger and BTB domain containing 42
chr12_-_125398850 0.92 ENST00000535859.1
ENST00000546271.1
ENST00000540700.1
ENST00000546120.1
ubiquitin C
chr10_-_16859442 0.91 ENST00000602389.1
ENST00000345264.5
Ras suppressor protein 1
chr3_-_9834463 0.87 ENST00000439043.1
transcriptional adaptor 3
chr3_-_157221357 0.86 ENST00000494677.1
ventricular zone expressed PH domain-containing 1
chr22_+_38004832 0.86 ENST00000405147.3
ENST00000429218.1
ENST00000325180.8
ENST00000337437.4
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr18_-_54318353 0.84 ENST00000590954.1
ENST00000540155.1
thioredoxin-like 1
chr2_-_96811170 0.84 ENST00000288943.4
dual specificity phosphatase 2
chr13_+_27825706 0.80 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
ribosomal protein L21
chr5_-_142000883 0.77 ENST00000359370.6
fibroblast growth factor 1 (acidic)
chr3_-_123339343 0.72 ENST00000578202.1
myosin light chain kinase
chr17_+_42634844 0.70 ENST00000315323.3
frizzled family receptor 2
chr14_+_22992573 0.66 ENST00000390516.1
T cell receptor alpha joining 21
chr5_-_124080203 0.65 ENST00000504926.1
zinc finger protein 608
chr19_+_1026566 0.65 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
calponin 2
chr2_-_208031943 0.58 ENST00000421199.1
ENST00000457962.1
Kruppel-like factor 7 (ubiquitous)
chr19_+_52102540 0.56 ENST00000601315.1
AC018755.17
chr2_-_161264385 0.52 ENST00000409972.1
RNA binding motif, single stranded interacting protein 1
chr2_+_56179262 0.47 ENST00000606639.1
RP11-481J13.1
chr22_+_38004473 0.44 ENST00000414350.3
ENST00000343632.4
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr14_+_74034310 0.42 ENST00000538782.1
acyl-CoA thioesterase 2
chr13_+_42614176 0.38 ENST00000540693.1
diacylglycerol kinase, eta
chr12_-_50616122 0.38 ENST00000552823.1
ENST00000552909.1
LIM domain and actin binding 1
chr2_+_191792376 0.34 ENST00000409428.1
ENST00000409215.1
glutaminase
chr2_-_231989808 0.34 ENST00000258400.3
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr7_+_143078379 0.33 ENST00000449630.1
ENST00000457235.1
zyxin
chr1_+_11994715 0.32 ENST00000449038.1
ENST00000376369.3
ENST00000429000.2
ENST00000196061.4
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr19_+_16178317 0.31 ENST00000344824.6
ENST00000538887.1
tropomyosin 4
chr22_+_45714361 0.30 ENST00000452238.1
family with sequence similarity 118, member A
chr17_-_55911970 0.30 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
chr17_-_46671323 0.30 ENST00000239151.5
homeobox B5
chr2_+_26915584 0.28 ENST00000302909.3
potassium channel, subfamily K, member 3
chr17_+_73452695 0.28 ENST00000582186.1
ENST00000582455.1
ENST00000581252.1
ENST00000579208.1
KIAA0195
chr3_-_9834375 0.26 ENST00000343450.2
ENST00000301964.2
transcriptional adaptor 3
chr22_-_36784035 0.24 ENST00000216181.5
myosin, heavy chain 9, non-muscle
chr17_-_4890649 0.23 ENST00000361571.5
calmodulin binding transcription activator 2
chr22_-_50216853 0.23 ENST00000342989.5
ENST00000542442.1
bromodomain containing 1
chrX_-_103499602 0.21 ENST00000372588.4
ESX homeobox 1
chr4_-_10118469 0.21 ENST00000499869.2
WD repeat domain 1
chr7_+_112120908 0.19 ENST00000439068.2
ENST00000312849.4
ENST00000429049.1
leucine-rich single-pass membrane protein 1
chr12_-_50616382 0.16 ENST00000552783.1
LIM domain and actin binding 1
chr11_-_71823715 0.16 ENST00000545944.1
ENST00000502597.2
anaphase promoting complex subunit 15
chrX_-_101694853 0.15 ENST00000372749.1
nuclear RNA export factor 2B
chr17_-_4890919 0.13 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
calmodulin binding transcription activator 2
chr11_+_59807748 0.13 ENST00000278855.2
ENST00000532905.1
oocyte secreted protein 2
chr8_+_97597148 0.09 ENST00000521590.1
syndecan 2

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
12.6 75.4 GO:0090131 mesenchyme migration(GO:0090131)
12.1 48.6 GO:1901846 positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
6.5 19.4 GO:0072011 mesangial cell-matrix adhesion(GO:0035759) glomerular endothelium development(GO:0072011)
4.0 12.1 GO:1902203 negative regulation of hepatocyte growth factor receptor signaling pathway(GO:1902203) regulation of cellular response to hepatocyte growth factor stimulus(GO:2001112) negative regulation of cellular response to hepatocyte growth factor stimulus(GO:2001113)
3.5 10.5 GO:0060931 sinoatrial node cell development(GO:0060931)
3.1 28.1 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
3.0 12.0 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
2.6 26.2 GO:0002074 extraocular skeletal muscle development(GO:0002074)
2.6 44.5 GO:0006600 creatine metabolic process(GO:0006600)
1.5 4.5 GO:0060435 bronchiole development(GO:0060435)
1.5 4.5 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
1.5 4.4 GO:1903413 cellular response to bile acid(GO:1903413)
1.5 7.3 GO:0044856 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
1.3 6.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.3 5.2 GO:0009956 radial pattern formation(GO:0009956)
1.3 3.9 GO:0032971 regulation of muscle filament sliding(GO:0032971)
1.2 3.7 GO:1903980 positive regulation of microglial cell activation(GO:1903980)
1.1 5.3 GO:1902304 positive regulation of potassium ion export(GO:1902304)
1.0 3.9 GO:0018277 protein deamination(GO:0018277)
1.0 23.9 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.9 11.3 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.9 10.1 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.8 6.1 GO:0007296 vitellogenesis(GO:0007296)
0.7 4.4 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.7 5.8 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.7 2.7 GO:0098582 innate vocalization behavior(GO:0098582)
0.6 24.3 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.6 1.9 GO:1900222 bronchus cartilage development(GO:0060532) lung smooth muscle development(GO:0061145) negative regulation of beta-amyloid clearance(GO:1900222)
0.6 3.6 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.6 3.4 GO:0015853 adenine transport(GO:0015853)
0.6 11.8 GO:0033623 regulation of integrin activation(GO:0033623)
0.6 6.7 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.5 4.5 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.5 5.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.5 2.3 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.4 3.1 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.4 5.1 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.4 32.0 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.4 15.6 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.4 3.9 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.4 5.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.3 1.0 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.3 2.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 3.3 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.3 16.1 GO:0045214 sarcomere organization(GO:0045214)
0.3 35.7 GO:0045445 myoblast differentiation(GO:0045445)
0.2 5.4 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.2 2.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 2.8 GO:0061469 response to corticotropin-releasing hormone(GO:0043435) regulation of type B pancreatic cell proliferation(GO:0061469) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.2 3.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 18.6 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.2 2.9 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.2 24.6 GO:0002088 lens development in camera-type eye(GO:0002088)
0.2 12.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.2 1.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 4.8 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.2 0.7 GO:0060022 hard palate development(GO:0060022)
0.2 1.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.2 0.8 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 2.7 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 0.2 GO:1903921 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.1 1.1 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.1 1.1 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.1 1.9 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 1.6 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 3.6 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.1 1.2 GO:0044351 macropinocytosis(GO:0044351)
0.1 0.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 7.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 0.3 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 2.6 GO:0030261 chromosome condensation(GO:0030261)
0.1 0.3 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.1 2.3 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 1.3 GO:0051412 response to corticosterone(GO:0051412)
0.0 23.8 GO:0006936 muscle contraction(GO:0006936)
0.0 1.1 GO:0016540 protein autoprocessing(GO:0016540)
0.0 5.9 GO:0003012 muscle system process(GO:0003012)
0.0 2.6 GO:1901998 toxin transport(GO:1901998)
0.0 6.4 GO:0021987 cerebral cortex development(GO:0021987)
0.0 0.9 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 1.8 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 2.3 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 8.0 GO:0006260 DNA replication(GO:0006260)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 30.5 GO:0042643 actomyosin, actin portion(GO:0042643)
5.0 19.9 GO:0005863 striated muscle myosin thick filament(GO:0005863)
3.8 11.3 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
3.7 48.6 GO:0030314 junctional membrane complex(GO:0030314)
3.6 35.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
2.2 6.5 GO:0043257 laminin-8 complex(GO:0043257)
2.0 12.0 GO:1990584 cardiac Troponin complex(GO:1990584)
1.6 15.6 GO:0032982 myosin filament(GO:0032982)
1.5 64.7 GO:0005859 muscle myosin complex(GO:0005859)
1.1 4.5 GO:0031523 Myb complex(GO:0031523)
0.8 4.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.7 39.0 GO:0036379 myofilament(GO:0036379)
0.7 12.1 GO:0036449 microtubule minus-end(GO:0036449)
0.7 23.5 GO:0031143 pseudopodium(GO:0031143)
0.7 32.0 GO:0031430 M band(GO:0031430)
0.6 19.4 GO:0046930 pore complex(GO:0046930)
0.6 16.2 GO:0031672 A band(GO:0031672)
0.6 5.5 GO:0016012 sarcoglycan complex(GO:0016012)
0.5 7.3 GO:0030478 actin cap(GO:0030478)
0.3 1.0 GO:0043159 acrosomal matrix(GO:0043159)
0.3 4.8 GO:0005916 fascia adherens(GO:0005916)
0.2 1.6 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 10.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 17.9 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 5.3 GO:0042629 mast cell granule(GO:0042629)
0.1 10.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 8.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 5.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 7.7 GO:0005884 actin filament(GO:0005884)
0.1 1.1 GO:0000124 SAGA complex(GO:0000124) STAGA complex(GO:0030914)
0.0 4.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 5.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 6.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 33.7 GO:0005925 focal adhesion(GO:0005925)
0.0 2.6 GO:0000786 nucleosome(GO:0000786)
0.0 3.8 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 3.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 3.9 GO:0005604 basement membrane(GO:0005604)
0.0 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 11.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 44.5 GO:0004111 creatine kinase activity(GO:0004111)
3.2 15.9 GO:0032038 myosin II heavy chain binding(GO:0032038)
1.5 22.5 GO:0032036 myosin heavy chain binding(GO:0032036)
1.4 19.4 GO:0043199 sulfate binding(GO:0043199)
1.4 12.4 GO:0017018 myosin phosphatase activity(GO:0017018)
1.4 48.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
1.1 12.0 GO:0031013 troponin I binding(GO:0031013)
0.9 3.4 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.7 7.3 GO:0045159 myosin II binding(GO:0045159)
0.6 4.5 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.5 50.6 GO:0017022 myosin binding(GO:0017022)
0.5 15.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 1.9 GO:0010736 serum response element binding(GO:0010736)
0.4 2.3 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.4 1.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.4 24.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.4 10.5 GO:0031005 filamin binding(GO:0031005)
0.3 3.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 31.9 GO:0050681 androgen receptor binding(GO:0050681)
0.3 24.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.3 0.8 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.3 2.9 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.2 5.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 4.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.2 21.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 14.4 GO:0030552 cAMP binding(GO:0030552)
0.2 2.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 47.0 GO:0044325 ion channel binding(GO:0044325)
0.2 3.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 3.9 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.2 5.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 3.1 GO:0008430 selenium binding(GO:0008430)
0.1 1.3 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 5.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 4.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 2.6 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.1 1.0 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 5.2 GO:0001972 retinoic acid binding(GO:0001972)
0.1 11.3 GO:0001618 virus receptor activity(GO:0001618)
0.1 33.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 0.3 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 0.8 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 12.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 1.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 7.7 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.1 9.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 14.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 3.3 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.0 5.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 1.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 2.7 GO:0005507 copper ion binding(GO:0005507)
0.0 6.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.3 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 6.0 GO:0051015 actin filament binding(GO:0051015)
0.0 3.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 4.4 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 5.2 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 28.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 46.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.3 11.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3 29.1 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.3 26.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 26.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.2 6.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 6.8 PID AP1 PATHWAY AP-1 transcription factor network
0.2 7.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 7.1 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 4.9 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 6.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 14.0 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 13.1 PID CMYB PATHWAY C-MYB transcription factor network
0.1 5.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 5.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 3.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 1.6 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 3.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 3.6 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 2.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 15.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.2 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 3.9 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 2.0 PID AURORA B PATHWAY Aurora B signaling
0.0 0.9 PID FGF PATHWAY FGF signaling pathway
0.0 1.4 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 59.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.7 40.4 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.7 5.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 12.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 5.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 7.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 19.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 45.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 17.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 26.0 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 35.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 5.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 4.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 3.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 3.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 3.4 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 2.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.8 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.8 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.2 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 3.6 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels