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Illumina Body Map 2, young vs old
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Results for STAT6
Z-value: 0.28
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Transcription factors associated with STAT6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT6 | hg19_v2_chr12_-_57504975_57505019 | 0.13 | 4.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.7 | GO:0002925 | positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) |
| 1.1 | 4.2 | GO:2000349 | negative regulation of CD40 signaling pathway(GO:2000349) |
| 0.5 | 3.4 | GO:0010387 | COP9 signalosome assembly(GO:0010387) |
| 0.4 | 2.8 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.3 | 2.4 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.0 | 2.1 | GO:0019835 | cytolysis(GO:0019835) |
| 0.3 | 1.9 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.0 | 1.9 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.6 | 1.7 | GO:0045556 | TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556) |
| 0.2 | 1.6 | GO:0044245 | polysaccharide digestion(GO:0044245) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 3.9 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 3.7 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 3.4 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 2.8 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 2.0 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 1.6 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 1.6 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.4 | 1.5 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
| 0.0 | 1.5 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.9 | GO:0019863 | IgE binding(GO:0019863) |
| 0.3 | 2.4 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.0 | 2.3 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 1.9 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 1.9 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 1.7 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 1.6 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.1 | 1.5 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.1 | 1.5 | GO:0015250 | water channel activity(GO:0015250) |
| 0.0 | 1.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.7 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 2.4 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.5 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.3 | PID CD40 PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 3.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 2.8 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 2.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 2.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.9 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 1.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.5 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 1.5 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.4 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |