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Illumina Body Map 2, young vs old

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Results for TBX20

Z-value: 1.73

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Transcription factors associated with TBX20

Gene Symbol Gene ID Gene Info
TBX20
ENSG00000164532.10 T-box transcription factor 20

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX20hg19_v2_chr7_-_35293740_35293758-0.232.0e-01Click!

Activity profile of TBX20 motif

Sorted Z-values of TBX20 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_57662419 12.35 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
GPR56
G protein-coupled receptor 56
chr16_+_57662527 9.50 ENST00000563374.1
ENST00000568234.1
ENST00000565770.1
ENST00000564338.1
ENST00000566164.1
GPR56
G protein-coupled receptor 56
chr16_+_57662596 8.47 ENST00000567397.1
ENST00000568979.1
GPR56
G protein-coupled receptor 56
chr17_-_7080227 4.42 ENST00000574330.1
ASGR1
asialoglycoprotein receptor 1
chr17_-_3599327 2.98 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr17_-_3599492 2.95 ENST00000435558.1
ENST00000345901.3
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr7_-_142099977 2.63 ENST00000390359.3
TRBV7-8
T cell receptor beta variable 7-8
chr7_-_142207004 2.44 ENST00000426318.2
TRBV10-2
T cell receptor beta variable 10-2
chr17_-_3599696 2.33 ENST00000225328.5
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr8_+_27183033 2.25 ENST00000420218.2
PTK2B
protein tyrosine kinase 2 beta
chr8_+_27182862 2.24 ENST00000521164.1
ENST00000346049.5
PTK2B
protein tyrosine kinase 2 beta
chrX_+_78200913 2.22 ENST00000171757.2
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chrX_+_78200829 2.02 ENST00000544091.1
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr12_+_15475331 1.80 ENST00000281171.4
PTPRO
protein tyrosine phosphatase, receptor type, O
chr12_+_15475462 1.72 ENST00000543886.1
ENST00000348962.2
PTPRO
protein tyrosine phosphatase, receptor type, O
chr15_-_22448819 1.72 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr13_-_30948036 1.46 ENST00000447147.1
ENST00000444319.1
LINC00426
long intergenic non-protein coding RNA 426
chr5_+_133861339 1.31 ENST00000282605.4
ENST00000361895.2
ENST00000402835.1
PHF15
jade family PHD finger 2
chr2_+_61108771 1.28 ENST00000394479.3
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr6_-_2842219 1.19 ENST00000380739.5
SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr1_-_158300747 1.18 ENST00000451207.1
CD1B
CD1b molecule
chr19_-_4540486 1.16 ENST00000306390.6
LRG1
leucine-rich alpha-2-glycoprotein 1
chr6_-_2842087 1.16 ENST00000537185.1
SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr14_+_77228532 1.14 ENST00000167106.4
ENST00000554237.1
VASH1
vasohibin 1
chr2_+_61108650 1.02 ENST00000295025.8
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr7_-_139763521 0.94 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr12_-_121477039 0.83 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr12_-_121476959 0.81 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr5_+_135394840 0.80 ENST00000503087.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr4_+_160025300 0.79 ENST00000505478.1
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr3_-_183273477 0.76 ENST00000341319.3
KLHL6
kelch-like family member 6
chr3_+_161214596 0.74 ENST00000327928.4
OTOL1
otolin 1
chr3_+_186915274 0.72 ENST00000312295.4
RTP1
receptor (chemosensory) transporter protein 1
chrX_+_67913471 0.69 ENST00000374597.3
STARD8
StAR-related lipid transfer (START) domain containing 8
chr5_+_161494521 0.68 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr19_+_7745708 0.67 ENST00000596148.1
ENST00000317378.5
ENST00000426877.2
TRAPPC5
trafficking protein particle complex 5
chr6_-_90062543 0.64 ENST00000435041.2
UBE2J1
ubiquitin-conjugating enzyme E2, J1
chr1_+_87797351 0.63 ENST00000370542.1
LMO4
LIM domain only 4
chr12_-_121476750 0.55 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr17_-_76824975 0.51 ENST00000586066.2
USP36
ubiquitin specific peptidase 36
chr22_-_46283597 0.51 ENST00000451118.1
WI2-85898F10.1
WI2-85898F10.1
chr3_-_187694195 0.41 ENST00000446091.1
RP11-132N15.3
RP11-132N15.3
chr7_+_30185496 0.37 ENST00000455738.1
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr6_-_107077347 0.36 ENST00000369063.3
ENST00000539449.1
RTN4IP1
reticulon 4 interacting protein 1
chr21_-_45960078 0.35 ENST00000400375.1
KRTAP10-1
keratin associated protein 10-1
chr19_+_35810164 0.32 ENST00000598537.1
CD22
CD22 molecule
chr19_-_10213335 0.30 ENST00000592641.1
ENST00000253109.4
ANGPTL6
angiopoietin-like 6
chr14_-_106453155 0.30 ENST00000390594.2
IGHV1-2
immunoglobulin heavy variable 1-2
chr20_+_44509857 0.30 ENST00000372523.1
ENST00000372520.1
ZSWIM1
zinc finger, SWIM-type containing 1
chr15_-_38519066 0.29 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chr11_-_17410629 0.29 ENST00000526912.1
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr21_-_46000481 0.28 ENST00000400372.1
KRTAP10-5
keratin associated protein 10-5
chr4_-_26492076 0.26 ENST00000295589.3
CCKAR
cholecystokinin A receptor
chr1_+_147013182 0.25 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr19_-_9325542 0.24 ENST00000308682.2
OR7D4
olfactory receptor, family 7, subfamily D, member 4
chr1_-_11118896 0.23 ENST00000465788.1
SRM
spermidine synthase
chr15_-_74421477 0.23 ENST00000514871.1
RP11-247C2.2
HCG2004779; Uncharacterized protein
chr20_-_48782639 0.21 ENST00000435301.2
RP11-112L6.3
RP11-112L6.3
chr10_+_88414338 0.14 ENST00000241891.5
ENST00000443292.1
OPN4
opsin 4
chr22_+_38219389 0.14 ENST00000249041.2
GALR3
galanin receptor 3
chrX_-_16881144 0.13 ENST00000416035.1
RBBP7
retinoblastoma binding protein 7
chr10_+_88414298 0.12 ENST00000372071.2
OPN4
opsin 4
chr7_+_30185406 0.12 ENST00000324489.5
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr5_-_89825328 0.10 ENST00000500869.2
ENST00000315948.6
ENST00000509384.1
LYSMD3
LysM, putative peptidoglycan-binding, domain containing 3
chr2_+_207630081 0.10 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr19_+_17579556 0.07 ENST00000442725.1
SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr7_-_33140498 0.06 ENST00000448915.1
RP9
retinitis pigmentosa 9 (autosomal dominant)
chr8_+_142264664 0.06 ENST00000518520.1
RP11-10J21.3
Uncharacterized protein
chr3_-_50396978 0.00 ENST00000266025.3
TMEM115
transmembrane protein 115

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX20

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.6 4.5 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.3 1.1 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.3 12.5 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.1 0.8 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1 2.3 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 1.2 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.2 GO:0014908 myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
0.1 0.6 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 4.4 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.6 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.2 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.7 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.2 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.8 GO:0002467 germinal center formation(GO:0002467)
0.0 0.1 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.0 1.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0071316 cellular response to nicotine(GO:0071316)
0.0 2.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0 0.1 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.3 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.2 4.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 2.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.7 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 1.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 3.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.2 GO:1904724 tertiary granule lumen(GO:1904724)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.7 8.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.5 4.4 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.2 2.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2 4.2 GO:0001614 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.1 1.2 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 0.7 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 3.5 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.2 GO:0004766 spermidine synthase activity(GO:0004766)
0.1 0.8 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.7 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 2.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 2.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 3.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.1 4.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 2.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 2.3 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation