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Illumina Body Map 2, young vs old

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Results for TBX5

Z-value: 0.85

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Transcription factors associated with TBX5

Gene Symbol Gene ID Gene Info
TBX5
ENSG00000089225.15 T-box transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX5hg19_v2_chr12_-_114841703_1148417260.251.7e-01Click!

Activity profile of TBX5 motif

Sorted Z-values of TBX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_39108643 2.93 ENST00000396857.2
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr14_+_98602380 2.78 ENST00000557072.1
RP11-61O1.2
RP11-61O1.2
chr19_-_39108568 2.66 ENST00000586296.1
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr19_-_39108552 2.65 ENST00000591517.1
MAP4K1
mitogen-activated protein kinase kinase kinase kinase 1
chr2_+_7865923 2.32 ENST00000417930.1
AC092580.4
AC092580.4
chr7_+_80231466 1.90 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr19_-_45826125 1.88 ENST00000221476.3
CKM
creatine kinase, muscle
chr11_+_1940786 1.84 ENST00000278317.6
ENST00000381561.4
ENST00000381548.3
ENST00000360603.3
ENST00000381549.3
TNNT3
troponin T type 3 (skeletal, fast)
chr11_-_107590383 1.81 ENST00000525934.1
ENST00000531293.1
SLN
sarcolipin
chr5_+_82767583 1.74 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
VCAN
versican
chr6_-_6225026 1.73 ENST00000445223.1
F13A1
coagulation factor XIII, A1 polypeptide
chr21_+_30503282 1.73 ENST00000399925.1
MAP3K7CL
MAP3K7 C-terminal like
chr20_+_816695 1.72 ENST00000246100.3
FAM110A
family with sequence similarity 110, member A
chr12_+_81101277 1.72 ENST00000228641.3
MYF6
myogenic factor 6 (herculin)
chr1_-_169680745 1.71 ENST00000236147.4
SELL
selectin L
chr7_-_142181009 1.66 ENST00000390368.2
TRBV6-5
T cell receptor beta variable 6-5
chr19_-_42721819 1.66 ENST00000336034.4
ENST00000598200.1
ENST00000598727.1
ENST00000596251.1
DEDD2
death effector domain containing 2
chrY_+_15016725 1.64 ENST00000336079.3
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr11_+_1860200 1.63 ENST00000381911.1
TNNI2
troponin I type 2 (skeletal, fast)
chr11_+_1940925 1.62 ENST00000453458.1
ENST00000381557.2
ENST00000381589.3
ENST00000381579.3
ENST00000381563.4
ENST00000344578.4
TNNT3
troponin T type 3 (skeletal, fast)
chr14_+_75746781 1.59 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr21_+_30502806 1.55 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr11_+_35198118 1.52 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44
CD44 molecule (Indian blood group)
chr5_+_54320078 1.52 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr3_-_39234074 1.47 ENST00000340369.3
ENST00000421646.1
ENST00000396251.1
XIRP1
xin actin-binding repeat containing 1
chr5_-_100238918 1.45 ENST00000451528.2
ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr20_+_30407105 1.44 ENST00000375994.2
MYLK2
myosin light chain kinase 2
chr20_+_30407151 1.42 ENST00000375985.4
MYLK2
myosin light chain kinase 2
chrX_-_70329118 1.39 ENST00000374188.3
IL2RG
interleukin 2 receptor, gamma
chr1_-_11042094 1.36 ENST00000377004.4
ENST00000377008.4
C1orf127
chromosome 1 open reading frame 127
chr5_+_82767487 1.33 ENST00000343200.5
ENST00000342785.4
VCAN
versican
chr6_-_45983549 1.32 ENST00000544153.1
CLIC5
chloride intracellular channel 5
chr18_+_32073253 1.31 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
DTNA
dystrobrevin, alpha
chrY_+_15016013 1.30 ENST00000360160.4
ENST00000454054.1
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr1_-_157670647 1.30 ENST00000368184.3
FCRL3
Fc receptor-like 3
chr5_+_82767284 1.28 ENST00000265077.3
VCAN
versican
chr14_+_22748980 1.27 ENST00000390465.2
TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr14_-_23904861 1.27 ENST00000355349.3
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr17_+_68164752 1.27 ENST00000535240.1
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr2_-_152589670 1.26 ENST00000604864.1
ENST00000603639.1
NEB
nebulin
chr5_-_100238956 1.26 ENST00000231461.5
ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr10_-_125853200 1.25 ENST00000421115.1
CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr19_-_42636543 1.24 ENST00000528894.4
ENST00000560804.2
ENST00000560558.1
ENST00000560398.1
ENST00000526816.2
POU2F2
POU class 2 homeobox 2
chr1_+_101702417 1.24 ENST00000305352.6
S1PR1
sphingosine-1-phosphate receptor 1
chr1_-_157670528 1.23 ENST00000368186.5
ENST00000496769.1
FCRL3
Fc receptor-like 3
chr12_+_65672702 1.22 ENST00000538045.1
ENST00000535239.1
MSRB3
methionine sulfoxide reductase B3
chr22_-_51016433 1.22 ENST00000405237.3
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr19_+_7741968 1.22 ENST00000597445.1
C19orf59
chromosome 19 open reading frame 59
chr17_-_3819751 1.20 ENST00000225538.3
P2RX1
purinergic receptor P2X, ligand-gated ion channel, 1
chr18_+_32073839 1.20 ENST00000590412.1
DTNA
dystrobrevin, alpha
chr3_-_42744130 1.19 ENST00000417472.1
ENST00000442469.1
HHATL
hedgehog acyltransferase-like
chr1_-_27961720 1.19 ENST00000545953.1
ENST00000374005.3
FGR
feline Gardner-Rasheed sarcoma viral oncogene homolog
chr1_-_25256368 1.18 ENST00000308873.6
RUNX3
runt-related transcription factor 3
chr10_-_99531709 1.18 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr19_+_7733929 1.16 ENST00000221515.2
RETN
resistin
chr1_-_153518270 1.16 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr22_-_31688431 1.14 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr6_-_45983581 1.14 ENST00000339561.6
CLIC5
chloride intracellular channel 5
chr7_-_142120321 1.14 ENST00000390377.1
TRBV7-7
T cell receptor beta variable 7-7
chr1_+_228395755 1.13 ENST00000284548.11
ENST00000570156.2
ENST00000422127.1
ENST00000366707.4
ENST00000366709.4
OBSCN
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr11_-_47470591 1.12 ENST00000524487.1
RAPSN
receptor-associated protein of the synapse
chr22_-_36013368 1.09 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
MB
myoglobin
chr14_+_72399114 1.07 ENST00000553525.1
ENST00000555571.1
RGS6
regulator of G-protein signaling 6
chr11_-_47470703 1.06 ENST00000298854.2
RAPSN
receptor-associated protein of the synapse
chr1_-_6269448 1.05 ENST00000465335.1
RPL22
ribosomal protein L22
chr7_+_143013198 1.05 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr6_+_108977520 1.05 ENST00000540898.1
FOXO3
forkhead box O3
chr4_+_37962018 1.04 ENST00000504686.1
PTTG2
pituitary tumor-transforming 2
chr1_+_47901689 1.04 ENST00000334793.5
FOXD2
forkhead box D2
chr6_+_34204642 1.04 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr7_-_142131914 1.03 ENST00000390375.2
TRBV5-6
T cell receptor beta variable 5-6
chr22_-_31688381 1.03 ENST00000487265.2
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr19_-_42636617 1.03 ENST00000529067.1
ENST00000529952.1
ENST00000533720.1
ENST00000389341.5
ENST00000342301.4
POU2F2
POU class 2 homeobox 2
chr11_-_47470682 1.03 ENST00000529341.1
ENST00000352508.3
RAPSN
receptor-associated protein of the synapse
chr19_-_46526304 1.01 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr14_+_22520762 1.00 ENST00000390449.3
TRAV21
T cell receptor alpha variable 21
chr11_+_122709200 1.00 ENST00000227348.4
CRTAM
cytotoxic and regulatory T cell molecule
chr19_-_10450328 0.99 ENST00000160262.5
ICAM3
intercellular adhesion molecule 3
chr6_+_41021027 0.99 ENST00000244669.2
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr3_-_18466026 0.99 ENST00000417717.2
SATB1
SATB homeobox 1
chr15_+_81489213 0.98 ENST00000559383.1
ENST00000394660.2
IL16
interleukin 16
chr1_-_207095324 0.97 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr5_-_88119580 0.97 ENST00000539796.1
MEF2C
myocyte enhancer factor 2C
chr13_+_30510003 0.97 ENST00000400540.1
LINC00544
long intergenic non-protein coding RNA 544
chr4_+_78079570 0.95 ENST00000509972.1
CCNG2
cyclin G2
chr1_+_158325684 0.93 ENST00000368162.2
CD1E
CD1e molecule
chr22_-_51016846 0.93 ENST00000312108.7
ENST00000395650.2
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr6_-_41168920 0.93 ENST00000483722.1
TREML2
triggering receptor expressed on myeloid cells-like 2
chr16_-_50715196 0.93 ENST00000423026.2
SNX20
sorting nexin 20
chr19_-_51875894 0.91 ENST00000600427.1
ENST00000595217.1
ENST00000221978.5
NKG7
natural killer cell group 7 sequence
chr2_+_174219548 0.91 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
CDCA7
cell division cycle associated 7
chr15_+_89182178 0.91 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_-_72748140 0.90 ENST00000434200.1
NEGR1
neuronal growth regulator 1
chr12_+_65672423 0.90 ENST00000355192.3
ENST00000308259.5
ENST00000540804.1
ENST00000535664.1
ENST00000541189.1
MSRB3
methionine sulfoxide reductase B3
chr6_-_31560729 0.89 ENST00000340027.5
ENST00000376073.4
ENST00000376072.3
NCR3
natural cytotoxicity triggering receptor 3
chr13_+_28195988 0.88 ENST00000399697.3
ENST00000399696.1
POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr9_+_125137565 0.88 ENST00000373698.5
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr22_-_30662828 0.87 ENST00000403463.1
ENST00000215781.2
OSM
oncostatin M
chr20_+_48884002 0.86 ENST00000425497.1
ENST00000445003.1
RP11-290F20.3
RP11-290F20.3
chr16_-_50715239 0.84 ENST00000330943.4
ENST00000300590.3
SNX20
sorting nexin 20
chr18_-_52969844 0.84 ENST00000561831.3
TCF4
transcription factor 4
chr3_+_45986511 0.84 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr17_+_34430980 0.84 ENST00000250151.4
CCL4
chemokine (C-C motif) ligand 4
chr19_+_39786962 0.83 ENST00000333625.2
IFNL1
interferon, lambda 1
chr22_+_38597889 0.83 ENST00000338483.2
ENST00000538320.1
ENST00000538999.1
ENST00000441709.1
MAFF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr6_+_83073952 0.81 ENST00000543496.1
TPBG
trophoblast glycoprotein
chr17_+_68165657 0.81 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr16_+_30675654 0.81 ENST00000287468.5
ENST00000395073.2
FBRS
fibrosin
chr19_+_51358191 0.81 ENST00000593997.1
ENST00000595952.1
ENST00000360617.3
ENST00000598145.1
KLK3
kallikrein-related peptidase 3
chr2_+_29336855 0.81 ENST00000404424.1
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr14_-_23877474 0.80 ENST00000405093.3
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr1_+_165513231 0.80 ENST00000294818.1
LRRC52
leucine rich repeat containing 52
chr4_-_102268708 0.80 ENST00000525819.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr6_-_130182410 0.80 ENST00000368143.1
TMEM244
transmembrane protein 244
chr15_+_89182156 0.79 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr19_-_10450287 0.79 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3
intercellular adhesion molecule 3
chr5_+_110559312 0.79 ENST00000508074.1
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr1_-_205290865 0.78 ENST00000367157.3
NUAK2
NUAK family, SNF1-like kinase, 2
chr19_+_51358166 0.77 ENST00000601503.1
ENST00000326003.2
ENST00000597286.1
ENST00000597483.1
KLK3
kallikrein-related peptidase 3
chr1_-_153917700 0.76 ENST00000368646.2
DENND4B
DENN/MADD domain containing 4B
chr15_+_89181974 0.76 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_86685227 0.75 ENST00000441037.2
AGBL1
ATP/GTP binding protein-like 1
chrX_+_95939711 0.75 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr5_-_176936844 0.74 ENST00000510380.1
ENST00000510898.1
ENST00000357198.4
DOK3
docking protein 3
chr12_+_58148842 0.73 ENST00000266643.5
MARCH9
membrane-associated ring finger (C3HC4) 9
chr5_-_88120151 0.73 ENST00000506716.1
MEF2C
myocyte enhancer factor 2C
chrX_-_106959631 0.71 ENST00000486554.1
ENST00000372390.4
TSC22D3
TSC22 domain family, member 3
chr11_-_46142948 0.71 ENST00000257821.4
PHF21A
PHD finger protein 21A
chr9_+_125133467 0.71 ENST00000426608.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr13_-_79177673 0.70 ENST00000377208.5
POU4F1
POU class 4 homeobox 1
chr2_-_109605663 0.70 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
EDAR
ectodysplasin A receptor
chr19_+_55085248 0.70 ENST00000391738.3
ENST00000251376.3
ENST00000391737.1
ENST00000396321.2
ENST00000418536.2
ENST00000448689.1
LILRA2
LILRB1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr19_+_41856816 0.70 ENST00000539627.1
TMEM91
transmembrane protein 91
chr9_+_125133315 0.69 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_+_201994042 0.68 ENST00000417748.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr17_+_37821593 0.68 ENST00000578283.1
TCAP
titin-cap
chr2_-_89521942 0.68 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chr11_+_46354455 0.68 ENST00000343674.6
DGKZ
diacylglycerol kinase, zeta
chr1_-_235116495 0.68 ENST00000549744.1
RP11-443B7.3
RP11-443B7.3
chr14_+_75745477 0.68 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr19_-_47734448 0.67 ENST00000439096.2
BBC3
BCL2 binding component 3
chr2_+_68962014 0.67 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr5_-_142784888 0.67 ENST00000514699.1
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr6_+_167536230 0.67 ENST00000341935.5
ENST00000349984.4
CCR6
chemokine (C-C motif) receptor 6
chr18_+_54318893 0.67 ENST00000593058.1
WDR7
WD repeat domain 7
chr19_+_51376505 0.66 ENST00000325321.3
ENST00000600690.1
ENST00000391810.2
ENST00000358049.4
KLK2
kallikrein-related peptidase 2
chr3_+_63897605 0.65 ENST00000487717.1
ATXN7
ataxin 7
chr1_-_6269304 0.65 ENST00000471204.1
RPL22
ribosomal protein L22
chr12_+_56511943 0.65 ENST00000257940.2
ENST00000552345.1
ENST00000551880.1
ENST00000546903.1
ENST00000551790.1
ZC3H10
ESYT1
zinc finger CCCH-type containing 10
extended synaptotagmin-like protein 1
chr5_-_74348371 0.65 ENST00000503568.1
RP11-229C3.2
RP11-229C3.2
chrX_+_95939638 0.65 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chr22_+_40441456 0.64 ENST00000402203.1
TNRC6B
trinucleotide repeat containing 6B
chr8_-_27336747 0.64 ENST00000240132.2
ENST00000407991.1
CHRNA2
cholinergic receptor, nicotinic, alpha 2 (neuronal)
chr14_-_91526462 0.64 ENST00000536315.2
RPS6KA5
ribosomal protein S6 kinase, 90kDa, polypeptide 5
chr3_+_167453026 0.63 ENST00000472941.1
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr11_-_3147835 0.63 ENST00000525498.1
OSBPL5
oxysterol binding protein-like 5
chr17_-_1588101 0.63 ENST00000577001.1
ENST00000572621.1
ENST00000304992.6
PRPF8
pre-mRNA processing factor 8
chr5_-_180229791 0.62 ENST00000504671.1
ENST00000507384.1
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr2_-_163099546 0.61 ENST00000447386.1
FAP
fibroblast activation protein, alpha
chr8_-_144654918 0.61 ENST00000529971.1
MROH6
maestro heat-like repeat family member 6
chr2_+_68961934 0.61 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr17_-_61959202 0.61 ENST00000449787.2
ENST00000456543.2
ENST00000423893.2
ENST00000332800.7
GH2
growth hormone 2
chr19_-_42931567 0.61 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr19_-_41934635 0.60 ENST00000321702.2
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr2_+_191334212 0.60 ENST00000444317.1
ENST00000535751.1
MFSD6
major facilitator superfamily domain containing 6
chr12_-_116714564 0.60 ENST00000548743.1
MED13L
mediator complex subunit 13-like
chr6_+_45389893 0.60 ENST00000371432.3
RUNX2
runt-related transcription factor 2
chr4_-_102268628 0.59 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr15_+_91416092 0.59 ENST00000559353.1
FURIN
furin (paired basic amino acid cleaving enzyme)
chr5_-_145562147 0.59 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
LARS
leucyl-tRNA synthetase
chr17_+_74372662 0.58 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr10_-_131762105 0.58 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr20_+_57875457 0.58 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3
endothelin 3
chr15_+_81589254 0.57 ENST00000394652.2
IL16
interleukin 16
chr2_+_89998789 0.57 ENST00000453166.2
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr2_+_68961905 0.57 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr17_-_7297519 0.57 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr19_+_38794797 0.57 ENST00000301246.5
ENST00000588605.1
C19orf33
chromosome 19 open reading frame 33
chr22_+_38609538 0.57 ENST00000407965.1
MAFF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr8_+_123793633 0.56 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr17_+_34431212 0.56 ENST00000394495.1
CCL4
chemokine (C-C motif) ligand 4
chr3_+_35722844 0.56 ENST00000436702.1
ENST00000438071.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr17_-_37934466 0.56 ENST00000583368.1
IKZF3
IKAROS family zinc finger 3 (Aiolos)
chr6_+_292253 0.55 ENST00000603453.1
ENST00000605315.1
ENST00000603881.1
DUSP22
dual specificity phosphatase 22
chr22_-_51017084 0.55 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr4_+_81118647 0.54 ENST00000415738.2
PRDM8
PR domain containing 8
chr5_-_176936817 0.54 ENST00000502885.1
ENST00000506493.1
DOK3
docking protein 3
chr17_-_61973929 0.54 ENST00000329882.8
ENST00000453363.3
ENST00000316193.8
CSH1
chorionic somatomammotropin hormone 1 (placental lactogen)
chr21_+_17214724 0.54 ENST00000449491.1
USP25
ubiquitin specific peptidase 25
chr5_-_88120083 0.53 ENST00000509373.1
MEF2C
myocyte enhancer factor 2C
chr14_+_90864504 0.53 ENST00000544280.2
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr10_-_31320860 0.53 ENST00000436087.2
ENST00000442986.1
ENST00000413025.1
ENST00000452305.1
ZNF438
zinc finger protein 438
chr17_-_7297833 0.53 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr13_+_24844979 0.53 ENST00000454083.1
SPATA13
spermatogenesis associated 13
chr3_+_167453493 0.53 ENST00000295777.5
ENST00000472747.2
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr6_-_130536774 0.53 ENST00000532763.1
SAMD3
sterile alpha motif domain containing 3
chr3_+_49726932 0.53 ENST00000327697.6
ENST00000432042.1
ENST00000454491.1
RNF123
ring finger protein 123
chrX_+_123097014 0.52 ENST00000394478.1
STAG2
stromal antigen 2
chr7_+_16700806 0.51 ENST00000446596.1
ENST00000438834.1
BZW2
basic leucine zipper and W2 domains 2
chr7_+_139529085 0.51 ENST00000539806.1
TBXAS1
thromboxane A synthase 1 (platelet)

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 1.3 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724)
1.1 3.2 GO:1900073 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
0.6 1.8 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.5 2.5 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.5 1.8 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.4 2.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.4 2.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.4 1.2 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.4 2.9 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.4 1.2 GO:2000870 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.4 2.6 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.4 1.4 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
0.3 1.0 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.3 1.0 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
0.3 0.6 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.3 1.2 GO:0060262 regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
0.3 0.9 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.3 0.8 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)
0.3 1.8 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.3 1.3 GO:0007525 somatic muscle development(GO:0007525)
0.2 8.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 1.0 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.2 2.2 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 1.2 GO:0002351 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.2 0.7 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.2 1.0 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.2 0.6 GO:1902362 melanocyte apoptotic process(GO:1902362)
0.2 0.6 GO:0019082 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.2 0.6 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 1.1 GO:0036309 protein localization to M-band(GO:0036309)
0.2 0.5 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.2 0.7 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.2 0.7 GO:0002290 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.2 1.4 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.2 1.9 GO:2000332 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2 1.5 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 1.2 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.2 0.5 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.2 2.1 GO:0030091 protein repair(GO:0030091)
0.2 3.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.6 GO:1904379 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.2 0.5 GO:0060032 notochord regression(GO:0060032)
0.2 0.5 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.2 0.3 GO:0007518 myoblast fate determination(GO:0007518)
0.2 2.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.2 4.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 1.6 GO:0002775 antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778)
0.1 0.4 GO:0061386 closure of optic fissure(GO:0061386)
0.1 0.4 GO:0090222 centrosome-templated microtubule nucleation(GO:0090222)
0.1 1.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 0.7 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.1 0.4 GO:0021586 pons maturation(GO:0021586) superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 1.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.4 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.1 2.7 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.1 0.5 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.1 0.6 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.4 GO:0021934 medulla oblongata development(GO:0021550) hindbrain tangential cell migration(GO:0021934) lateral line system development(GO:0048925)
0.1 0.6 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 1.0 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1 2.0 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 1.9 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.3 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 0.1 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.1 1.2 GO:0045345 positive regulation of MHC class I biosynthetic process(GO:0045345)
0.1 0.4 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.1 0.7 GO:0014826 cellular magnesium ion homeostasis(GO:0010961) vein smooth muscle contraction(GO:0014826)
0.1 1.0 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.1 1.0 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.1 0.3 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.1 0.7 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.8 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.2 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.1 0.7 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.5 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.1 0.6 GO:0019075 virus maturation(GO:0019075)
0.1 1.0 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 1.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 5.1 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 0.4 GO:0060005 vestibular reflex(GO:0060005)
0.1 0.4 GO:0021778 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.5 GO:0006740 NADPH regeneration(GO:0006740)
0.1 1.5 GO:0033005 positive regulation of mast cell activation(GO:0033005) positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.1 0.9 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 3.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.4 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 1.8 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 0.2 GO:0061366 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.3 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.1 0.4 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.4 GO:0051541 elastin metabolic process(GO:0051541)
0.1 1.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.6 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 2.3 GO:0002335 mature B cell differentiation(GO:0002335)
0.1 0.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.5 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.1 0.3 GO:0046778 modification by virus of host mRNA processing(GO:0046778)
0.1 0.2 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.1 1.4 GO:0006853 carnitine shuttle(GO:0006853)
0.1 0.6 GO:0038129 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.1 0.4 GO:0071233 cellular response to leucine(GO:0071233)
0.1 0.2 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.1 1.3 GO:0003323 type B pancreatic cell development(GO:0003323)
0.1 0.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.2 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.3 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 0.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.0 0.8 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.8 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.6 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 1.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.3 GO:0060154 response to cycloheximide(GO:0046898) cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 1.1 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.1 GO:0045720 negative regulation of integrin biosynthetic process(GO:0045720)
0.0 0.3 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.7 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.7 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 1.3 GO:0007567 parturition(GO:0007567)
0.0 0.3 GO:0046984 regulation of hemoglobin biosynthetic process(GO:0046984)
0.0 0.3 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 3.3 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.2 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.0 0.3 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.8 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 0.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.5 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 2.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.8 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.5 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.1 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.2 GO:0042335 cuticle development(GO:0042335)
0.0 0.4 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.2 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.5 GO:1904293 negative regulation of ERAD pathway(GO:1904293)
0.0 0.1 GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902177)
0.0 2.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.7 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 1.3 GO:0033198 response to ATP(GO:0033198)
0.0 0.1 GO:0014908 myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.6 GO:0007379 segment specification(GO:0007379)
0.0 0.6 GO:0048757 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 0.3 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 0.1 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.1 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.5 GO:0097264 self proteolysis(GO:0097264)
0.0 0.2 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.7 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:0035627 ceramide transport(GO:0035627)
0.0 0.4 GO:0015671 oxygen transport(GO:0015671)
0.0 0.2 GO:0060052 positive regulation of axon regeneration(GO:0048680) neurofilament cytoskeleton organization(GO:0060052)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.6 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.0 0.1 GO:1902564 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) negative regulation of neutrophil activation(GO:1902564)
0.0 0.3 GO:0051693 actin filament capping(GO:0051693)
0.0 0.2 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 1.0 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.0 0.7 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.7 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.5 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0039019 pronephric nephron development(GO:0039019)
0.0 0.5 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.7 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.1 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 2.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0070602 regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0 0.1 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.2 GO:0030497 fatty acid elongation(GO:0030497)
0.0 1.8 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.2 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.5 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.2 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.3 GO:0006914 autophagy(GO:0006914)
0.0 0.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.4 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 1.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0030238 male sex determination(GO:0030238)
0.0 0.2 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.4 GO:0051904 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 1.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.1 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.6 GO:0009790 embryo development(GO:0009790)
0.0 0.5 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.5 GO:0010165 response to X-ray(GO:0010165)
0.0 0.3 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.2 GO:1903830 magnesium ion transmembrane transport(GO:1903830)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.3 2.3 GO:0035976 AP1 complex(GO:0035976)
0.2 5.1 GO:0005861 troponin complex(GO:0005861)
0.2 1.1 GO:0031904 endosome lumen(GO:0031904)
0.2 1.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 3.1 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.2 1.8 GO:0005955 calcineurin complex(GO:0005955)
0.2 0.5 GO:0070195 growth hormone receptor complex(GO:0070195)
0.2 0.7 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 1.0 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.1 1.6 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.5 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 1.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 2.1 GO:0032982 myosin filament(GO:0032982)
0.1 0.4 GO:0005899 insulin receptor complex(GO:0005899)
0.1 1.4 GO:0031264 death-inducing signaling complex(GO:0031264)
0.1 0.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.3 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.7 GO:0031931 TORC1 complex(GO:0031931)
0.0 1.0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 1.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.1 GO:0034515 proteasome storage granule(GO:0034515)
0.0 0.8 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.6 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.6 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0000799 nuclear condensin complex(GO:0000799)
0.0 3.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 2.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 5.3 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)
0.0 1.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.7 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.6 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.4 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 1.2 GO:0031941 filamentous actin(GO:0031941)
0.0 1.3 GO:0031430 M band(GO:0031430)
0.0 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 7.2 GO:0030016 myofibril(GO:0030016)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 4.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.5 GO:0046930 pore complex(GO:0046930)
0.0 0.8 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 1.0 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.3 GO:0034709 methylosome(GO:0034709)
0.0 0.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.5 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 1.0 GO:0097542 ciliary tip(GO:0097542)
0.0 1.2 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.0 GO:0002947 tumor necrosis factor receptor superfamily complex(GO:0002947)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 1.6 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.4 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.7 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.1 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.8 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.5 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.8 2.5 GO:0008859 exoribonuclease II activity(GO:0008859)
0.7 2.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.5 2.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 1.3 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.3 1.4 GO:0004913 interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917)
0.3 2.7 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.3 1.3 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.3 1.0 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
0.3 8.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.3 2.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.3 2.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.3 1.9 GO:0004111 creatine kinase activity(GO:0004111)
0.3 1.0 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.2 1.2 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.2 2.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.2 1.7 GO:0043208 glycosphingolipid binding(GO:0043208)
0.2 0.6 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 1.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.2 1.1 GO:0051373 FATZ binding(GO:0051373)
0.2 0.5 GO:0005148 prolactin receptor binding(GO:0005148)
0.2 0.7 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.2 1.9 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 1.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 1.2 GO:0046625 sphingolipid binding(GO:0046625)
0.1 0.4 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.4 GO:0035034 histone acetyltransferase regulator activity(GO:0035034)
0.1 0.3 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.7 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.5 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 0.4 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.4 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.1 2.9 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.2 GO:0043426 MRF binding(GO:0043426)
0.1 1.8 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.4 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 3.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 1.6 GO:0031014 troponin T binding(GO:0031014)
0.1 1.0 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 1.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 5.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.0 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.4 GO:0001632 leukotriene B4 receptor activity(GO:0001632)
0.1 0.5 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 1.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.6 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.5 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.9 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 0.8 GO:0017018 myosin phosphatase activity(GO:0017018)
0.1 2.0 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.1 0.6 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 1.7 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.4 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1 0.7 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 3.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.4 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 0.8 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.3 GO:0008518 reduced folate carrier activity(GO:0008518)
0.1 1.6 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 1.2 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 0.4 GO:0070513 death domain binding(GO:0070513)
0.1 0.2 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 1.6 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.8 GO:0016494 C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958)
0.1 1.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.6 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 1.1 GO:0031432 titin binding(GO:0031432)
0.0 0.4 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 1.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.2 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.2 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 2.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.5 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 2.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.5 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 1.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.0 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 1.7 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.4 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 1.0 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.4 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.1 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 2.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.8 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0032190 acrosin binding(GO:0032190)
0.0 0.3 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 2.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.9 GO:0008009 chemokine activity(GO:0008009)
0.0 0.4 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.1 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.0 0.1 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.6 GO:0001221 transcription cofactor binding(GO:0001221)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 4.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 3.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 3.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 2.5 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 3.2 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.0 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.0 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 3.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 2.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 3.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 4.7 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 3.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.8 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.8 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 1.1 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.2 PID EPO PATHWAY EPO signaling pathway
0.0 0.9 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.4 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.6 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.4 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.6 PID ENDOTHELIN PATHWAY Endothelins
0.0 2.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.6 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 1.0 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 0.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 1.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 4.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.4 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.1 1.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.6 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 5.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 2.6 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 2.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 2.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.8 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.6 REACTOME PI3K EVENTS IN ERBB4 SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.0 1.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.7 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.0 1.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 2.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME PI3K AKT ACTIVATION Genes involved in PI3K/AKT activation
0.0 1.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 2.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 2.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.0 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.3 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.3 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.1 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 2.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.3 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.1 REACTOME TRANSCRIPTION COUPLED NER TC NER Genes involved in Transcription-coupled NER (TC-NER)
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling