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Illumina Body Map 2, young vs old

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Results for TFAP2E

Z-value: 0.18

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
TFAP2E
ENSG00000116819.6 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFAP2Ehg19_v2_chr1_+_36038971_36038971-0.241.8e-01Click!

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_115152651 3.21 ENST00000250535.4
CDO1
cysteine dioxygenase type 1
chr11_+_116700600 2.78 ENST00000227667.3
APOC3
apolipoprotein C-III
chr11_+_116700614 2.75 ENST00000375345.1
APOC3
apolipoprotein C-III
chr14_+_24837226 2.43 ENST00000554050.1
ENST00000554903.1
ENST00000554779.1
ENST00000250373.4
ENST00000553708.1
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr11_-_61062762 1.75 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr12_+_53443963 1.62 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr3_+_52813932 1.52 ENST00000537050.1
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr9_+_136501478 1.39 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr3_+_50192833 1.38 ENST00000426511.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr12_-_15942503 1.33 ENST00000281172.5
EPS8
epidermal growth factor receptor pathway substrate 8
chr17_+_72428218 1.32 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr19_-_35981358 1.31 ENST00000484218.2
ENST00000338897.3
KRTDAP
keratinocyte differentiation-associated protein
chr2_-_133429091 1.25 ENST00000345008.6
LYPD1
LY6/PLAUR domain containing 1
chr14_-_25519095 1.22 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
STXBP6
syntaxin binding protein 6 (amisyn)
chrX_+_128872918 1.19 ENST00000371105.3
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr12_-_75784669 1.10 ENST00000552497.1
ENST00000551829.1
ENST00000436898.1
ENST00000442339.2
CAPS2
calcyphosine 2
chr1_+_214163033 1.08 ENST00000607425.1
PROX1
prospero homeobox 1
chr12_+_72666407 1.07 ENST00000261180.4
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr1_+_233749739 1.04 ENST00000366621.3
KCNK1
potassium channel, subfamily K, member 1
chr14_+_21214039 1.04 ENST00000326842.2
EDDM3A
epididymal protein 3A
chr17_-_39769005 1.00 ENST00000301653.4
ENST00000593067.1
KRT16
keratin 16
chr12_-_15942309 0.98 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr17_+_40932610 0.91 ENST00000246914.5
WNK4
WNK lysine deficient protein kinase 4
chr2_-_45236540 0.89 ENST00000303077.6
SIX2
SIX homeobox 2
chr3_+_110790590 0.88 ENST00000485303.1
PVRL3
poliovirus receptor-related 3
chr11_+_118478313 0.87 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr14_-_25519317 0.86 ENST00000323944.5
STXBP6
syntaxin binding protein 6 (amisyn)
chr15_+_23810903 0.85 ENST00000564592.1
MKRN3
makorin ring finger protein 3
chr15_-_65503801 0.84 ENST00000261883.4
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr3_+_49591881 0.84 ENST00000296452.4
BSN
bassoon presynaptic cytomatrix protein
chr12_+_72667203 0.83 ENST00000547300.1
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr4_-_101439148 0.82 ENST00000511970.1
ENST00000502569.1
ENST00000305864.3
EMCN
endomucin
chr8_+_22250334 0.81 ENST00000520832.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr9_-_34662651 0.77 ENST00000259631.4
CCL27
chemokine (C-C motif) ligand 27
chr4_-_101439242 0.76 ENST00000296420.4
EMCN
endomucin
chr11_-_35441524 0.75 ENST00000395750.1
ENST00000449068.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr17_+_36584662 0.75 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr2_+_241375069 0.73 ENST00000264039.2
GPC1
glypican 1
chr22_+_29601840 0.72 ENST00000334018.6
ENST00000429226.1
ENST00000404755.3
ENST00000404820.3
ENST00000430127.1
EMID1
EMI domain containing 1
chr20_+_55205825 0.70 ENST00000544508.1
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chrX_+_128872998 0.70 ENST00000371106.3
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr11_+_64009072 0.69 ENST00000535135.1
ENST00000394540.3
FKBP2
FK506 binding protein 2, 13kDa
chr2_-_241831424 0.69 ENST00000402775.2
ENST00000307486.8
C2orf54
chromosome 2 open reading frame 54
chr11_-_35440796 0.66 ENST00000278379.3
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_-_231175964 0.64 ENST00000366654.4
FAM89A
family with sequence similarity 89, member A
chr3_-_48632593 0.62 ENST00000454817.1
ENST00000328333.8
COL7A1
collagen, type VII, alpha 1
chr7_+_100464760 0.61 ENST00000200457.4
TRIP6
thyroid hormone receptor interactor 6
chr10_+_102505954 0.59 ENST00000556085.1
ENST00000427256.1
PAX2
paired box 2
chr16_+_56623433 0.58 ENST00000570176.1
MT3
metallothionein 3
chr11_+_66045634 0.55 ENST00000528852.1
ENST00000311445.6
CNIH2
cornichon family AMPA receptor auxiliary protein 2
chr3_+_155860751 0.54 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr6_+_99282570 0.52 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chr1_+_152943122 0.52 ENST00000328051.2
SPRR4
small proline-rich protein 4
chr19_-_39264072 0.51 ENST00000599035.1
ENST00000378626.4
LGALS7
lectin, galactoside-binding, soluble, 7
chr1_-_63782888 0.51 ENST00000436475.2
LINC00466
long intergenic non-protein coding RNA 466
chr11_-_66056596 0.49 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr4_-_82393052 0.49 ENST00000335927.7
ENST00000504863.1
ENST00000264400.2
RASGEF1B
RasGEF domain family, member 1B
chr11_-_66056478 0.48 ENST00000431556.2
ENST00000528575.1
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr4_-_82393009 0.47 ENST00000436139.2
RASGEF1B
RasGEF domain family, member 1B
chr3_-_55521323 0.47 ENST00000264634.4
WNT5A
wingless-type MMTV integration site family, member 5A
chr17_+_37824411 0.46 ENST00000269582.2
PNMT
phenylethanolamine N-methyltransferase
chr15_+_27112251 0.46 ENST00000400081.3
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr10_-_108924284 0.45 ENST00000344440.6
ENST00000263054.6
SORCS1
sortilin-related VPS10 domain containing receptor 1
chr19_-_11039261 0.44 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2
Yip1 domain family, member 2
chr19_-_11039188 0.44 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr17_+_37824217 0.43 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr17_-_31620006 0.41 ENST00000225823.2
ASIC2
acid-sensing (proton-gated) ion channel 2
chrX_+_51636629 0.40 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
MAGED1
melanoma antigen family D, 1
chr15_+_27112058 0.40 ENST00000355395.5
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr22_+_31644309 0.37 ENST00000425203.1
LIMK2
LIM domain kinase 2
chr1_+_35225339 0.36 ENST00000339480.1
GJB4
gap junction protein, beta 4, 30.3kDa
chr2_+_74741569 0.33 ENST00000233638.7
TLX2
T-cell leukemia homeobox 2
chr12_+_57984965 0.32 ENST00000540759.2
ENST00000551772.1
ENST00000550465.1
ENST00000354947.5
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr12_+_75784850 0.31 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr17_+_37824700 0.31 ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr15_+_27112380 0.31 ENST00000554596.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr19_-_54676884 0.31 ENST00000376591.4
TMC4
transmembrane channel-like 4
chr1_+_9599540 0.30 ENST00000302692.6
SLC25A33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr15_+_27112194 0.30 ENST00000555182.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr2_+_38893047 0.27 ENST00000272252.5
GALM
galactose mutarotase (aldose 1-epimerase)
chr19_-_54676846 0.26 ENST00000301187.4
TMC4
transmembrane channel-like 4
chr1_-_154531095 0.25 ENST00000292211.4
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr2_+_155555201 0.25 ENST00000544049.1
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr15_+_27112296 0.25 ENST00000554038.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr4_-_85419603 0.23 ENST00000295886.4
NKX6-1
NK6 homeobox 1
chr11_-_113345995 0.23 ENST00000355319.2
ENST00000542616.1
DRD2
dopamine receptor D2
chr1_-_32801825 0.22 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr16_+_69599861 0.22 ENST00000354436.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr6_-_49917157 0.22 ENST00000398721.2
DEFB133
defensin, beta 133
chr8_-_11853819 0.20 ENST00000526438.1
ENST00000382205.4
DEFB134
defensin, beta 134
chr2_+_38893208 0.20 ENST00000410063.1
GALM
galactose mutarotase (aldose 1-epimerase)
chr16_-_72698834 0.20 ENST00000570152.1
ENST00000561611.2
ENST00000570035.1
AC004158.2
AC004158.2
chr5_+_176237478 0.19 ENST00000329542.4
UNC5A
unc-5 homolog A (C. elegans)
chrX_+_152783131 0.19 ENST00000349466.2
ENST00000370186.1
ATP2B3
ATPase, Ca++ transporting, plasma membrane 3
chr14_-_60952739 0.18 ENST00000555476.1
ENST00000321731.3
C14orf39
chromosome 14 open reading frame 39
chr12_+_108168162 0.18 ENST00000342331.4
ASCL4
achaete-scute family bHLH transcription factor 4
chr19_+_54960358 0.17 ENST00000439657.1
ENST00000376514.2
ENST00000376526.4
ENST00000436479.1
LENG8
leukocyte receptor cluster (LRC) member 8
chr1_+_228194693 0.17 ENST00000284523.1
ENST00000366753.2
WNT3A
wingless-type MMTV integration site family, member 3A
chr9_-_86432547 0.17 ENST00000376365.3
ENST00000376371.2
GKAP1
G kinase anchoring protein 1
chr3_-_170459154 0.16 ENST00000473110.1
RP11-373E16.4
RP11-373E16.4
chr2_-_177502254 0.14 ENST00000339037.3
AC017048.3
long intergenic non-protein coding RNA 1116
chrX_-_124097620 0.13 ENST00000371130.3
ENST00000422452.2
TENM1
teneurin transmembrane protein 1
chr3_+_4535155 0.13 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr17_+_3627185 0.13 ENST00000325418.4
GSG2
germ cell associated 2 (haspin)
chr19_+_36195467 0.12 ENST00000426659.2
ZBTB32
zinc finger and BTB domain containing 32
chr16_+_69600058 0.12 ENST00000393742.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chrX_+_115567767 0.10 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr2_+_239335449 0.10 ENST00000264607.4
ASB1
ankyrin repeat and SOCS box containing 1
chr19_+_49458107 0.10 ENST00000539787.1
ENST00000345358.7
ENST00000391871.3
ENST00000415969.2
ENST00000354470.3
ENST00000506183.1
ENST00000293288.8
BAX
BCL2-associated X protein
chr5_+_133984462 0.10 ENST00000398844.2
ENST00000322887.4
SEC24A
SEC24 family member A
chr10_-_112678692 0.08 ENST00000605742.1
BBIP1
BBSome interacting protein 1
chr1_+_182584314 0.08 ENST00000566297.1
RP11-317P15.4
RP11-317P15.4
chr3_+_32280159 0.08 ENST00000458535.2
ENST00000307526.3
CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr3_+_105086056 0.07 ENST00000472644.2
ALCAM
activated leukocyte cell adhesion molecule
chr1_+_901847 0.07 ENST00000379410.3
ENST00000379409.2
ENST00000379407.3
PLEKHN1
pleckstrin homology domain containing, family N member 1
chr6_+_37787262 0.06 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr6_+_7107999 0.06 ENST00000491191.1
ENST00000379938.2
ENST00000471433.1
RREB1
ras responsive element binding protein 1
chr6_+_150070831 0.05 ENST00000367380.5
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr15_+_23810853 0.05 ENST00000568252.1
MKRN3
makorin ring finger protein 3
chr3_-_136471204 0.04 ENST00000480733.1
ENST00000383202.2
ENST00000236698.5
ENST00000434713.2
STAG1
stromal antigen 1
chr6_+_150070857 0.03 ENST00000544496.1
PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr17_+_74070853 0.03 ENST00000329003.3
GALR2
galanin receptor 2
chr1_-_151778630 0.02 ENST00000368820.3
LINGO4
leucine rich repeat and Ig domain containing 4
chr14_+_77607026 0.02 ENST00000600936.1
AC007375.1
Uncharacterized protein; cDNA FLJ43210 fis, clone FEBRA2020582
chr22_+_35653445 0.02 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr1_-_11865982 0.01 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr3_+_51428704 0.01 ENST00000323686.4
RBM15B
RNA binding motif protein 15B
chr7_-_129251459 0.01 ENST00000608694.1
RP11-448A19.1
RP11-448A19.1
chr10_-_112678904 0.00 ENST00000423273.1
ENST00000436562.1
ENST00000447005.1
ENST00000454061.1
BBIP1
BBSome interacting protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0060621 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.6 3.2 GO:0042412 taurine biosynthetic process(GO:0042412)
0.5 2.4 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.4 1.1 GO:0002194 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.3 1.2 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.3 2.3 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.2 1.4 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.2 0.6 GO:0035566 regulation of metanephros size(GO:0035566)
0.2 0.6 GO:0097212 cadmium ion homeostasis(GO:0055073) lysosomal membrane organization(GO:0097212) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374)
0.2 0.9 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.6 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.1 0.9 GO:0072156 distal tubule morphogenesis(GO:0072156)
0.1 2.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 1.4 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.6 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 0.5 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.5 GO:0061354 chemoattraction of serotonergic neuron axon(GO:0036517) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) chemoattraction of axon(GO:0061642) negative regulation of cell proliferation in midbrain(GO:1904934) planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation(GO:1904955)
0.1 0.7 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.1 0.3 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 1.4 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.1 1.0 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.1 0.2 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.1 0.8 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 1.0 GO:0007320 insemination(GO:0007320)
0.1 0.5 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.1 0.4 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.2 GO:0061184 positive regulation of cell fate specification(GO:0042660) positive regulation of dermatome development(GO:0061184) regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012)
0.1 1.0 GO:0051546 keratinocyte migration(GO:0051546)
0.0 0.9 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.8 GO:1903874 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 3.0 GO:0002209 behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.0 0.2 GO:0051586 glial cell-derived neurotrophic factor secretion(GO:0044467) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.0 0.1 GO:0046666 B cell negative selection(GO:0002352) retinal cell programmed cell death(GO:0046666) post-embryonic camera-type eye morphogenesis(GO:0048597) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.0 1.9 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.5 GO:0060539 diaphragm development(GO:0060539) negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.4 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.3 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.0 0.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 1.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.3 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.3 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.3 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.4 GO:0061213 positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 1.7 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.5 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 1.0 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.6 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.6 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.6 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.1 1.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 2.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.5 GO:1990635 proximal dendrite(GO:1990635)
0.0 2.1 GO:0000145 exocyst(GO:0000145)
0.0 0.9 GO:0045180 basal cortex(GO:0045180)
0.0 1.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.3 GO:0042599 lamellar body(GO:0042599)
0.0 0.2 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 1.4 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.5 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.4 1.2 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.3 1.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 0.8 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.2 1.4 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 1.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.6 GO:0005110 frizzled-2 binding(GO:0005110)
0.1 3.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.1 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.3 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1 0.8 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 3.2 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.3 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.9 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.1 0.4 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 1.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.8 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 0.6 GO:0046870 cadmium ion binding(GO:0046870)
0.1 1.4 GO:0045499 chemorepellent activity(GO:0045499)
0.1 1.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 1.7 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.3 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.5 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 2.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.7 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.5 GO:0070402 NADPH binding(GO:0070402)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 2.3 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.9 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 4.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 3.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.0 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.5 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines