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Illumina Body Map 2, young vs old

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Results for UUGUUCG

Z-value: 0.37

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miRNA associated with seed UUGUUCG

NamemiRBASE accession
hsa-miR-375
MIMAT0000728

Activity profile of UUGUUCG motif

Sorted Z-values of UUGUUCG motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_38599693 0.57 ENST00000542955.1
ENST00000269593.4
IGFBP4
insulin-like growth factor binding protein 4
chr18_+_19749386 0.42 ENST00000269216.3
GATA6
GATA binding protein 6
chr1_+_110009215 0.35 ENST00000369872.3
SYPL2
synaptophysin-like 2
chr11_+_101981169 0.35 ENST00000526343.1
ENST00000282441.5
ENST00000537274.1
ENST00000345877.2
YAP1
Yes-associated protein 1
chr8_+_120220561 0.32 ENST00000276681.6
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chrX_+_73641286 0.30 ENST00000587091.1
SLC16A2
solute carrier family 16, member 2 (thyroid hormone transporter)
chr1_-_57045228 0.28 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr18_+_18943554 0.27 ENST00000580732.2
GREB1L
growth regulation by estrogen in breast cancer-like
chr12_+_20522179 0.27 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr3_-_114790179 0.26 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr11_+_68080077 0.26 ENST00000294304.7
LRP5
low density lipoprotein receptor-related protein 5
chr11_-_115375107 0.25 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1
cell adhesion molecule 1
chr2_-_228028829 0.24 ENST00000396625.3
ENST00000329662.7
COL4A4
collagen, type IV, alpha 4
chr11_+_12695944 0.23 ENST00000361905.4
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr2_+_204192942 0.23 ENST00000295851.5
ENST00000261017.5
ABI2
abl-interactor 2
chr14_-_30396948 0.22 ENST00000331968.5
PRKD1
protein kinase D1
chr9_-_16870704 0.22 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2
basonuclin 2
chr10_-_63213177 0.21 ENST00000399298.3
ENST00000399293.1
TMEM26
transmembrane protein 26
chr11_-_86666427 0.19 ENST00000531380.1
FZD4
frizzled family receptor 4
chr8_-_65711310 0.18 ENST00000310193.3
CYP7B1
cytochrome P450, family 7, subfamily B, polypeptide 1
chr7_-_27183263 0.18 ENST00000222726.3
HOXA5
homeobox A5
chr9_-_127533519 0.18 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr10_+_102505468 0.16 ENST00000361791.3
ENST00000355243.3
ENST00000428433.1
ENST00000370296.2
PAX2
paired box 2
chr22_+_40390930 0.16 ENST00000333407.6
FAM83F
family with sequence similarity 83, member F
chr8_+_106330920 0.16 ENST00000407775.2
ZFPM2
zinc finger protein, FOG family member 2
chr12_-_120806960 0.16 ENST00000257552.2
MSI1
musashi RNA-binding protein 1
chr10_-_131762105 0.15 ENST00000368648.3
ENST00000355311.5
EBF3
early B-cell factor 3
chr1_-_240775447 0.14 ENST00000318160.4
GREM2
gremlin 2, DAN family BMP antagonist
chr3_-_151176497 0.14 ENST00000282466.3
IGSF10
immunoglobulin superfamily, member 10
chr1_-_225840747 0.13 ENST00000366843.2
ENST00000366844.3
ENAH
enabled homolog (Drosophila)
chr1_+_61547894 0.13 ENST00000403491.3
NFIA
nuclear factor I/A
chr1_+_199996702 0.13 ENST00000367362.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr18_+_13218769 0.13 ENST00000399848.3
ENST00000361205.4
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr4_+_184020398 0.13 ENST00000403733.3
ENST00000378925.3
WWC2
WW and C2 domain containing 2
chr17_+_27369918 0.12 ENST00000323372.4
PIPOX
pipecolic acid oxidase
chr22_+_51112800 0.12 ENST00000414786.2
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr2_+_179345173 0.12 ENST00000234453.5
PLEKHA3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr9_-_38069208 0.12 ENST00000377707.3
ENST00000377700.4
SHB
Src homology 2 domain containing adaptor protein B
chr12_-_76425368 0.12 ENST00000602540.1
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr2_+_133174147 0.12 ENST00000329321.3
GPR39
G protein-coupled receptor 39
chr4_+_72204755 0.12 ENST00000512686.1
ENST00000340595.3
SLC4A4
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr17_+_55162453 0.12 ENST00000575322.1
ENST00000337714.3
ENST00000314126.3
AKAP1
A kinase (PRKA) anchor protein 1
chr4_-_40631859 0.12 ENST00000295971.7
ENST00000319592.4
RBM47
RNA binding motif protein 47
chr1_+_2985760 0.12 ENST00000378391.2
ENST00000514189.1
ENST00000270722.5
PRDM16
PR domain containing 16
chr20_+_306221 0.11 ENST00000342665.2
SOX12
SRY (sex determining region Y)-box 12
chr9_+_26956371 0.11 ENST00000380062.5
ENST00000518614.1
IFT74
intraflagellar transport 74 homolog (Chlamydomonas)
chr17_+_77751931 0.10 ENST00000310942.4
ENST00000269399.5
CBX2
chromobox homolog 2
chr14_+_67707826 0.09 ENST00000261681.4
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr4_-_157892498 0.09 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr10_-_735553 0.09 ENST00000280886.6
ENST00000423550.1
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr15_+_36887069 0.09 ENST00000566807.1
ENST00000567389.1
ENST00000562877.1
C15orf41
chromosome 15 open reading frame 41
chr14_+_101359265 0.08 ENST00000599197.1
AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr3_+_197687071 0.08 ENST00000482695.1
ENST00000330198.4
ENST00000419117.1
ENST00000420910.2
ENST00000332636.5
LMLN
leishmanolysin-like (metallopeptidase M8 family)
chr16_+_86544113 0.08 ENST00000262426.4
FOXF1
forkhead box F1
chr1_+_233463507 0.08 ENST00000366623.3
ENST00000366624.3
MLK4
Mitogen-activated protein kinase kinase kinase MLK4
chr6_+_149068464 0.07 ENST00000367463.4
UST
uronyl-2-sulfotransferase
chr2_+_118846008 0.07 ENST00000245787.4
INSIG2
insulin induced gene 2
chr1_+_43148059 0.07 ENST00000321358.7
ENST00000332220.6
YBX1
Y box binding protein 1
chr17_-_7832753 0.07 ENST00000303790.2
KCNAB3
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr14_-_70883708 0.07 ENST00000256366.4
SYNJ2BP
synaptojanin 2 binding protein
chr1_+_180601139 0.07 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr13_+_73632897 0.07 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr14_+_74486043 0.07 ENST00000464394.1
ENST00000394009.3
CCDC176
coiled-coil domain containing 176
chr19_+_47421933 0.06 ENST00000404338.3
ARHGAP35
Rho GTPase activating protein 35
chr16_+_77822427 0.06 ENST00000302536.2
VAT1L
vesicle amine transport 1-like
chr12_+_19592602 0.06 ENST00000398864.3
ENST00000266508.9
AEBP2
AE binding protein 2
chr14_+_57735614 0.06 ENST00000261558.3
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chrX_-_100604184 0.06 ENST00000372902.3
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr17_+_14204389 0.06 ENST00000360954.2
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr15_-_72410109 0.06 ENST00000564571.1
MYO9A
myosin IXA
chr19_-_7293942 0.06 ENST00000341500.5
ENST00000302850.5
INSR
insulin receptor
chr18_+_42260861 0.06 ENST00000282030.5
SETBP1
SET binding protein 1
chr11_+_120207787 0.05 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr1_-_100231349 0.05 ENST00000287474.5
ENST00000414213.1
FRRS1
ferric-chelate reductase 1
chr8_-_122653630 0.05 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr8_-_38386175 0.05 ENST00000437935.2
ENST00000358138.1
C8orf86
chromosome 8 open reading frame 86
chr7_+_157318477 0.05 ENST00000444154.1
AC006372.1
AC006372.1
chr5_+_174905398 0.05 ENST00000321442.5
SFXN1
sideroflexin 1
chr9_+_15553055 0.05 ENST00000380701.3
CCDC171
coiled-coil domain containing 171
chr1_-_10856694 0.04 ENST00000377022.3
ENST00000344008.5
CASZ1
castor zinc finger 1
chr2_+_46926048 0.04 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chr12_+_56211703 0.04 ENST00000243045.5
ENST00000552672.1
ENST00000550836.1
ORMDL2
ORM1-like 2 (S. cerevisiae)
chr17_-_60142609 0.04 ENST00000397786.2
MED13
mediator complex subunit 13
chr15_+_57210818 0.04 ENST00000438423.2
ENST00000267811.5
ENST00000452095.2
ENST00000559609.1
ENST00000333725.5
TCF12
transcription factor 12
chr22_+_29168652 0.04 ENST00000249064.4
ENST00000444523.1
ENST00000448492.2
ENST00000421503.2
CCDC117
coiled-coil domain containing 117
chr2_-_178937478 0.04 ENST00000286063.6
PDE11A
phosphodiesterase 11A
chr5_-_56247935 0.04 ENST00000381199.3
ENST00000381226.3
ENST00000381213.3
MIER3
mesoderm induction early response 1, family member 3
chr5_-_76935513 0.04 ENST00000306422.3
OTP
orthopedia homeobox
chr2_-_172750733 0.03 ENST00000392592.4
ENST00000422440.2
SLC25A12
solute carrier family 25 (aspartate/glutamate carrier), member 12
chrX_+_154997474 0.03 ENST00000302805.2
SPRY3
sprouty homolog 3 (Drosophila)
chr22_-_42017021 0.03 ENST00000263256.6
DESI1
desumoylating isopeptidase 1
chr21_-_38362497 0.03 ENST00000427746.1
ENST00000336648.4
HLCS
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr12_+_50690489 0.03 ENST00000598429.1
AC140061.12
Uncharacterized protein
chr10_-_126849068 0.03 ENST00000494626.2
ENST00000337195.5
CTBP2
C-terminal binding protein 2
chr17_+_28804380 0.03 ENST00000225724.5
ENST00000451249.2
ENST00000467337.2
ENST00000581721.1
ENST00000414833.2
GOSR1
golgi SNAP receptor complex member 1
chr12_+_56401268 0.03 ENST00000262032.5
IKZF4
IKAROS family zinc finger 4 (Eos)
chr9_+_115983808 0.03 ENST00000374210.6
ENST00000374212.4
SLC31A1
solute carrier family 31 (copper transporter), member 1
chr17_-_27621125 0.03 ENST00000579665.1
ENST00000225388.4
NUFIP2
nuclear fragile X mental retardation protein interacting protein 2
chr6_+_4021554 0.03 ENST00000337659.6
PRPF4B
pre-mRNA processing factor 4B
chr2_+_223725652 0.02 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr10_-_89623194 0.02 ENST00000445946.3
KLLN
killin, p53-regulated DNA replication inhibitor
chr1_+_39456895 0.02 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr4_+_155665123 0.02 ENST00000336356.3
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr13_-_31736027 0.02 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chr1_-_149982624 0.02 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chr17_-_42143963 0.02 ENST00000585388.1
ENST00000293406.3
LSM12
LSM12 homolog (S. cerevisiae)
chr19_-_14316980 0.02 ENST00000361434.3
ENST00000340736.6
LPHN1
latrophilin 1
chr3_-_135914615 0.02 ENST00000309993.2
MSL2
male-specific lethal 2 homolog (Drosophila)
chr14_+_55493920 0.02 ENST00000395472.2
ENST00000555846.1
SOCS4
suppressor of cytokine signaling 4
chr14_-_55878538 0.02 ENST00000247178.5
ATG14
autophagy related 14
chr11_+_44117741 0.02 ENST00000395673.3
ENST00000343631.3
EXT2
exostosin glycosyltransferase 2
chr8_+_61591337 0.02 ENST00000423902.2
CHD7
chromodomain helicase DNA binding protein 7
chr20_-_524455 0.02 ENST00000349736.5
ENST00000217244.3
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chrX_+_56259316 0.02 ENST00000468660.1
KLF8
Kruppel-like factor 8
chr1_-_67896095 0.02 ENST00000370994.4
SERBP1
SERPINE1 mRNA binding protein 1
chr9_-_135819987 0.02 ENST00000298552.3
ENST00000403810.1
TSC1
tuberous sclerosis 1
chr9_+_4679555 0.02 ENST00000381858.1
ENST00000381854.3
CDC37L1
cell division cycle 37-like 1
chr2_+_242641442 0.02 ENST00000313552.6
ENST00000406941.1
ING5
inhibitor of growth family, member 5
chr19_+_16607122 0.02 ENST00000221671.3
ENST00000594035.1
ENST00000599550.1
ENST00000594813.1
C19orf44
chromosome 19 open reading frame 44
chr10_+_45455207 0.01 ENST00000334940.6
ENST00000374417.2
ENST00000340258.5
ENST00000427758.1
RASSF4
Ras association (RalGDS/AF-6) domain family member 4
chr1_+_15853308 0.01 ENST00000375838.1
ENST00000375847.3
ENST00000375849.1
DNAJC16
DnaJ (Hsp40) homolog, subfamily C, member 16
chr5_+_56111361 0.01 ENST00000399503.3
MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr9_+_140513438 0.01 ENST00000462484.1
ENST00000334856.6
ENST00000460843.1
EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr7_-_130080977 0.01 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr2_-_131850951 0.01 ENST00000409185.1
ENST00000389915.3
FAM168B
family with sequence similarity 168, member B
chr8_+_125551338 0.01 ENST00000276689.3
ENST00000518008.1
ENST00000522532.1
ENST00000517367.1
NDUFB9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
chr14_-_96830207 0.01 ENST00000359933.4
ATG2B
autophagy related 2B
chr7_-_105517021 0.01 ENST00000318724.4
ENST00000419735.3
ATXN7L1
ataxin 7-like 1
chr7_-_128695147 0.01 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
TNPO3
transportin 3
chr7_+_139044621 0.01 ENST00000354926.4
C7orf55-LUC7L2
C7orf55-LUC7L2 readthrough
chrX_+_69664706 0.00 ENST00000194900.4
ENST00000374360.3
DLG3
discs, large homolog 3 (Drosophila)
chr7_-_112579869 0.00 ENST00000297145.4
C7orf60
chromosome 7 open reading frame 60
chr14_-_68283291 0.00 ENST00000555452.1
ENST00000347230.4
ZFYVE26
zinc finger, FYVE domain containing 26
chr7_+_75831181 0.00 ENST00000388802.4
ENST00000326382.8
SRRM3
serine/arginine repetitive matrix 3

Network of associatons between targets according to the STRING database.

First level regulatory network of UUGUUCG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0007493 endodermal cell fate determination(GO:0007493)
0.1 0.5 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.1 0.2 GO:0060435 bronchiole development(GO:0060435)
0.1 0.2 GO:0035566 regulation of metanephros size(GO:0035566)
0.0 0.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0045210 FasL biosynthetic process(GO:0045210)
0.0 0.1 GO:0035750 protein localization to myelin sheath abaxonal region(GO:0035750)
0.0 0.2 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.1 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) right lung development(GO:0060458)
0.0 0.2 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0 0.2 GO:1901727 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) protein kinase D signaling(GO:0089700) positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.1 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773) positive regulation of long-term neuronal synaptic plasticity(GO:0048170) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0 0.3 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.3 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.6 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.0 0.1 GO:0060283 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0 0.2 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.2 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.1 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.1 GO:1990535 neuron projection maintenance(GO:1990535)
0.0 0.2 GO:0032836 glomerular basement membrane development(GO:0032836)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.3 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 0.3 GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928)
0.0 0.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.3 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID WNT SIGNALING PATHWAY Wnt signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression