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Illumina Body Map 2, young vs old

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Results for VAX1_GSX2

Z-value: 0.37

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Transcription factors associated with VAX1_GSX2

Gene Symbol Gene ID Gene Info
ENSG00000148704.8 ventral anterior homeobox 1
ENSG00000180613.6 GS homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
VAX1hg19_v2_chr10_-_118897806_1188978170.421.8e-02Click!
GSX2hg19_v2_chr4_+_54966198_549663400.411.9e-02Click!

Activity profile of VAX1_GSX2 motif

Sorted Z-values of VAX1_GSX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_26593779 2.13 ENST00000529533.1
mucin 15, cell surface associated
chr11_-_26593677 1.96 ENST00000527569.1
mucin 15, cell surface associated
chr1_-_190446759 1.85 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr12_+_10163231 1.85 ENST00000396502.1
ENST00000338896.5
C-type lectin domain family 12, member B
chr11_-_26593649 1.82 ENST00000455601.2
mucin 15, cell surface associated
chr18_-_44181442 1.80 ENST00000398722.4
lipoxygenase homology domains 1
chr1_+_192778161 1.64 ENST00000235382.5
regulator of G-protein signaling 2, 24kDa
chr13_+_32313658 1.64 ENST00000380314.1
ENST00000298386.2
relaxin/insulin-like family peptide receptor 2
chr1_-_185597619 1.61 ENST00000608417.1
ENST00000436955.1
GS1-204I12.1
chr17_+_61151306 1.55 ENST00000580068.1
ENST00000580466.1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr11_+_65554493 1.51 ENST00000335987.3
ovo-like zinc finger 1
chr3_-_164796269 1.44 ENST00000264382.3
sucrase-isomaltase (alpha-glucosidase)
chr9_+_125132803 1.33 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_-_164534657 1.25 ENST00000339875.5
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr9_+_125133467 1.25 ENST00000426608.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_+_125133315 1.21 ENST00000223423.4
ENST00000362012.2
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr14_+_20187174 1.15 ENST00000557414.1
olfactory receptor, family 4, subfamily N, member 2
chr7_-_88425025 1.11 ENST00000297203.2
chromosome 7 open reading frame 62
chr1_+_40713573 1.11 ENST00000372766.3
transmembrane and coiled-coil domains 2
chr2_-_40680578 1.11 ENST00000455476.1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr4_-_25865159 1.07 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr15_+_84115868 1.00 ENST00000427482.2
SH3-domain GRB2-like 3
chr13_+_78315295 0.99 ENST00000351546.3
SLAIN motif family, member 1
chr1_-_92952433 0.99 ENST00000294702.5
growth factor independent 1 transcription repressor
chr6_+_78400375 0.97 ENST00000602452.2
meiosis-specific 4 homolog (S. cerevisiae)
chr3_+_111717511 0.96 ENST00000478951.1
ENST00000393917.2
transgelin 3
chrX_+_107288280 0.95 ENST00000458383.1
V-set and immunoglobulin domain containing 1
chrX_-_70326455 0.89 ENST00000374251.5
chromosome X open reading frame 65
chr4_-_66536057 0.89 ENST00000273854.3
EPH receptor A5
chr7_-_81399355 0.88 ENST00000457544.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr3_+_108541545 0.84 ENST00000295756.6
T cell receptor associated transmembrane adaptor 1
chr17_+_73539339 0.84 ENST00000581713.1
lethal giant larvae homolog 2 (Drosophila)
chr4_-_109541610 0.84 ENST00000510212.1
RPL34 antisense RNA 1 (head to head)
chr3_-_191000172 0.82 ENST00000427544.2
urotensin 2B
chr3_+_111718036 0.80 ENST00000455401.2
transgelin 3
chr5_+_142286887 0.78 ENST00000451259.1
Rho GTPase activating protein 26
chr4_-_66536196 0.77 ENST00000511294.1
EPH receptor A5
chr3_+_108541608 0.77 ENST00000426646.1
T cell receptor associated transmembrane adaptor 1
chr20_-_50419055 0.77 ENST00000217086.4
spalt-like transcription factor 4
chr11_+_60163775 0.77 ENST00000300187.6
ENST00000395005.2
membrane-spanning 4-domains, subfamily A, member 14
chr3_+_111717600 0.75 ENST00000273368.4
transgelin 3
chr4_+_66536248 0.75 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
chr7_+_37723336 0.73 ENST00000450180.1
G protein-coupled receptor 141
chr20_+_31805131 0.72 ENST00000375454.3
ENST00000375452.3
BPI fold containing family A, member 3
chr12_+_8666126 0.68 ENST00000299665.2
C-type lectin domain family 4, member D
chr9_-_5339873 0.67 ENST00000223862.1
ENST00000223858.4
relaxin 1
chr4_-_159956333 0.66 ENST00000434826.2
chromosome 4 open reading frame 45
chr2_-_101925055 0.65 ENST00000295317.3
ring finger protein 149
chr7_-_121944491 0.65 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZ family zinc finger 1
chr6_-_49931818 0.65 ENST00000322066.3
defensin, beta 114
chr12_+_15699286 0.63 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
protein tyrosine phosphatase, receptor type, O
chr15_+_58430567 0.63 ENST00000536493.1
aquaporin 9
chr13_+_78315348 0.60 ENST00000441784.1
SLAIN motif family, member 1
chr7_+_99202003 0.60 ENST00000609449.1
GS1-259H13.2
chr9_+_111624577 0.59 ENST00000333999.3
actin-like 7A
chr9_-_5304432 0.58 ENST00000416837.1
ENST00000308420.3
relaxin 2
chr1_+_53925063 0.58 ENST00000371445.3
DMRT-like family B with proline-rich C-terminal, 1
chr2_+_78143006 0.57 ENST00000443419.1
AC073628.1
chrX_+_107288239 0.56 ENST00000217957.5
V-set and immunoglobulin domain containing 1
chr11_+_45376922 0.55 ENST00000524410.1
ENST00000524488.1
ENST00000524565.1
RP11-430H10.1
chr11_+_121447469 0.54 ENST00000532694.1
ENST00000534286.1
sortilin-related receptor, L(DLR class) A repeats containing
chr3_+_51851612 0.54 ENST00000456080.1
IQ motif containing F3
chr18_-_19997878 0.53 ENST00000391403.2
cutaneous T-cell lymphoma-associated antigen 1
chr12_-_112123524 0.53 ENST00000327551.6
BRCA1 associated protein
chr5_+_110559312 0.53 ENST00000508074.1
calcium/calmodulin-dependent protein kinase IV
chr22_+_40297105 0.52 ENST00000540310.1
GRB2-related adaptor protein 2
chr7_+_156433573 0.52 ENST00000311822.8
ring finger protein 32
chr6_-_33860521 0.52 ENST00000525746.1
ENST00000531046.1
long intergenic non-protein coding RNA 1016
chr3_+_111718173 0.52 ENST00000494932.1
transgelin 3
chr4_-_36245561 0.52 ENST00000506189.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr22_+_40297079 0.51 ENST00000344138.4
ENST00000543252.1
GRB2-related adaptor protein 2
chr7_-_81399438 0.51 ENST00000222390.5
hepatocyte growth factor (hepapoietin A; scatter factor)
chrX_+_107288197 0.49 ENST00000415430.3
V-set and immunoglobulin domain containing 1
chr19_-_52307357 0.49 ENST00000594900.1
formyl peptide receptor 1
chrX_-_18690210 0.48 ENST00000379984.3
retinoschisin 1
chr2_-_73520667 0.48 ENST00000545030.1
ENST00000436467.2
early growth response 4
chr15_+_63188009 0.48 ENST00000557900.1
RP11-1069G10.2
chr15_+_75491203 0.48 ENST00000562637.1
chromosome 15 open reading frame 39
chr3_+_44840679 0.47 ENST00000425755.1
kinesin family member 15
chr5_-_96478466 0.47 ENST00000274382.4
Lix1 homolog (chicken)
chr18_-_67624160 0.47 ENST00000581982.1
ENST00000280200.4
CD226 molecule
chr2_-_166930131 0.46 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
sodium channel, voltage-gated, type I, alpha subunit
chr20_-_50418972 0.46 ENST00000395997.3
spalt-like transcription factor 4
chr3_+_111393501 0.45 ENST00000393934.3
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr6_+_155538093 0.44 ENST00000462408.2
T-cell lymphoma invasion and metastasis 2
chr7_-_81399329 0.44 ENST00000453411.1
ENST00000444829.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr11_-_102651343 0.44 ENST00000279441.4
ENST00000539681.1
matrix metallopeptidase 10 (stromelysin 2)
chr7_-_81399411 0.43 ENST00000423064.2
hepatocyte growth factor (hepapoietin A; scatter factor)
chr10_-_92681033 0.43 ENST00000371697.3
ankyrin repeat domain 1 (cardiac muscle)
chr14_+_39944025 0.43 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
chr21_-_15918618 0.42 ENST00000400564.1
ENST00000400566.1
SAM domain, SH3 domain and nuclear localization signals 1
chr16_+_58010339 0.41 ENST00000290871.5
ENST00000441824.2
testis, prostate and placenta expressed
chr14_+_72399833 0.41 ENST00000553530.1
ENST00000556437.1
regulator of G-protein signaling 6
chrX_+_106765680 0.40 ENST00000276185.4
FERM and PDZ domain containing 3
chr3_+_140396881 0.40 ENST00000286349.3
tripartite motif containing 42
chr4_-_112993808 0.40 ENST00000511219.1
RP11-269F21.3
chr9_+_95709733 0.40 ENST00000375482.3
FYVE, RhoGEF and PH domain containing 3
chr7_+_37723450 0.39 ENST00000447769.1
G protein-coupled receptor 141
chr10_+_91461413 0.39 ENST00000447580.1
kinesin family member 20B
chr6_-_87804815 0.39 ENST00000369582.2
glycoprotein hormones, alpha polypeptide
chr6_+_127898312 0.39 ENST00000329722.7
chromosome 6 open reading frame 58
chr7_-_35013217 0.38 ENST00000446375.1
dpy-19-like 1 (C. elegans)
chr10_-_28571015 0.38 ENST00000375719.3
ENST00000375732.1
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr2_+_3800169 0.38 ENST00000399143.3
doublecortin domain containing 2C
chr5_+_148443049 0.38 ENST00000515304.1
ENST00000507318.1
CTC-529P8.1
chr1_+_152974218 0.38 ENST00000331860.3
ENST00000443178.1
ENST00000295367.4
small proline-rich protein 3
chr12_+_96196875 0.38 ENST00000553095.1
Uncharacterized protein
chr16_-_52061283 0.38 ENST00000566314.1
chromosome 16 open reading frame 97
chr1_-_67266939 0.38 ENST00000304526.2
insulin-like 5
chr14_+_32798547 0.37 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr12_-_10607084 0.37 ENST00000408006.3
ENST00000544822.1
ENST00000536188.1
killer cell lectin-like receptor subfamily C, member 1
chr20_-_56647116 0.37 ENST00000441277.2
ENST00000452842.1
RP13-379L11.1
chr11_+_59824060 0.36 ENST00000395032.2
ENST00000358152.2
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr12_-_10282742 0.36 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
C-type lectin domain family 7, member A
chr14_+_22564294 0.36 ENST00000390452.2
T cell receptor delta variable 1
chr22_+_24990746 0.36 ENST00000456869.1
ENST00000411974.1
gamma-glutamyltransferase 1
chr5_-_96478457 0.36 ENST00000512378.1
Lix1 homolog (chicken)
chr13_-_41593425 0.36 ENST00000239882.3
E74-like factor 1 (ets domain transcription factor)
chr11_-_36619771 0.36 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
recombination activating gene 2
chr3_+_62304648 0.35 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
chromosome 3 open reading frame 14
chr21_-_22175341 0.35 ENST00000416768.1
ENST00000452561.1
ENST00000419299.1
ENST00000437238.1
long intergenic non-protein coding RNA 320
chr7_-_92777606 0.35 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
sterile alpha motif domain containing 9-like
chr14_+_105864847 0.35 ENST00000451127.2
testis expressed 22
chr5_-_147286065 0.35 ENST00000318315.4
ENST00000515291.1
chromosome 5 open reading frame 46
chr3_+_62304712 0.35 ENST00000494481.1
chromosome 3 open reading frame 14
chr15_-_75748115 0.35 ENST00000360439.4
SIN3 transcription regulator family member A
chr19_+_17638059 0.35 ENST00000599164.1
ENST00000449408.2
ENST00000600871.1
ENST00000599124.1
family with sequence similarity 129, member C
chr6_+_13272904 0.35 ENST00000379335.3
ENST00000379329.1
phosphatase and actin regulator 1
chr14_-_57272366 0.34 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
orthodenticle homeobox 2
chr11_-_27722021 0.34 ENST00000356660.4
ENST00000418212.1
ENST00000533246.1
brain-derived neurotrophic factor
chr2_-_203735484 0.33 ENST00000420558.1
ENST00000418208.1
islet cell autoantigen 1,69kDa-like
chr9_-_5830768 0.32 ENST00000381506.3
endoplasmic reticulum metallopeptidase 1
chr6_-_89927151 0.32 ENST00000454853.2
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr8_-_94179079 0.32 ENST00000521906.1
chromosome 8 open reading frame 87
chr8_+_27238147 0.32 ENST00000412793.1
protein tyrosine kinase 2 beta
chr2_-_50201327 0.32 ENST00000412315.1
neurexin 1
chr15_-_64665911 0.32 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
Uncharacterized protein
chr1_-_68698197 0.32 ENST00000370973.2
ENST00000370971.1
wntless Wnt ligand secretion mediator
chr11_-_133826852 0.31 ENST00000533871.2
ENST00000321016.8
immunoglobulin superfamily, member 9B
chr14_+_22465771 0.31 ENST00000390445.2
T cell receptor alpha variable 17
chr6_+_46761118 0.31 ENST00000230588.4
meprin A, alpha (PABA peptide hydrolase)
chr17_-_73663245 0.31 ENST00000584999.1
ENST00000317905.5
ENST00000420326.2
ENST00000340830.5
RecQ protein-like 5
chr17_-_29645836 0.31 ENST00000578584.1
CTD-2370N5.3
chr18_+_22040620 0.30 ENST00000426880.2
histamine receptor H4
chr12_-_10282836 0.30 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
C-type lectin domain family 7, member A
chr2_-_166060382 0.30 ENST00000409101.3
sodium channel, voltage-gated, type III, alpha subunit
chrY_+_24454970 0.30 ENST00000414629.2
ENST00000445779.2
RNA binding motif protein, Y-linked, family 1, member J
chr11_-_13517565 0.29 ENST00000282091.1
ENST00000529816.1
parathyroid hormone
chr1_-_197115818 0.29 ENST00000367409.4
ENST00000294732.7
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr19_-_7764960 0.29 ENST00000593418.1
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr17_-_57229155 0.29 ENST00000584089.1
spindle and kinetochore associated complex subunit 2
chr9_+_90112767 0.28 ENST00000408954.3
death-associated protein kinase 1
chr18_-_67624412 0.28 ENST00000580335.1
CD226 molecule
chr3_-_112565703 0.28 ENST00000488794.1
CD200 receptor 1-like
chr20_-_50418947 0.28 ENST00000371539.3
spalt-like transcription factor 4
chr3_-_151034734 0.27 ENST00000260843.4
G protein-coupled receptor 87
chrX_-_77225135 0.27 ENST00000458128.1
phosphoglycerate mutase family member 4
chr4_-_110736505 0.27 ENST00000609440.1
RP11-602N24.3
chr4_+_48492269 0.27 ENST00000327939.4
zygote arrest 1
chr15_+_75491213 0.27 ENST00000360639.2
chromosome 15 open reading frame 39
chr1_-_205325850 0.27 ENST00000537168.1
kelch domain containing 8A
chr12_+_29376592 0.27 ENST00000182377.4
fatty acyl CoA reductase 2
chr2_+_210518057 0.27 ENST00000452717.1
microtubule-associated protein 2
chr6_-_110501126 0.27 ENST00000368938.1
WAS protein family, member 1
chr1_+_117544366 0.27 ENST00000256652.4
ENST00000369470.1
CD101 molecule
chr17_-_38956205 0.26 ENST00000306658.7
keratin 28
chr8_-_86253888 0.26 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
carbonic anhydrase I
chr2_+_210517895 0.26 ENST00000447185.1
microtubule-associated protein 2
chr10_-_135379132 0.26 ENST00000343131.5
synaptonemal complex central element protein 1
chr7_+_29186192 0.26 ENST00000539406.1
chimerin 2
chr2_-_205099700 0.26 ENST00000419860.1
AC009498.1
chr18_-_67623906 0.26 ENST00000583955.1
CD226 molecule
chr12_+_66582919 0.26 ENST00000545837.1
ENST00000457197.2
interleukin-1 receptor-associated kinase 3
chr12_+_29376673 0.25 ENST00000547116.1
fatty acyl CoA reductase 2
chr5_+_174151536 0.25 ENST00000239243.6
ENST00000507785.1
msh homeobox 2
chr2_+_169757750 0.25 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
glucose-6-phosphatase, catalytic, 2
chr20_+_42523336 0.25 ENST00000428529.1
RP5-1030M6.3
chr5_+_173930676 0.25 ENST00000504512.1
RP11-267A15.1
chr1_-_68698222 0.25 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
wntless Wnt ligand secretion mediator
chr12_-_10605929 0.24 ENST00000347831.5
ENST00000359151.3
killer cell lectin-like receptor subfamily C, member 1
chr9_+_5450503 0.24 ENST00000381573.4
ENST00000381577.3
CD274 molecule
chr6_+_34204642 0.24 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chr5_-_55412774 0.24 ENST00000434982.2
ankyrin repeat domain 55
chr1_+_28199047 0.24 ENST00000373925.1
ENST00000328928.7
ENST00000373927.3
ENST00000427466.1
ENST00000442118.1
ENST00000373921.3
thymocyte selection associated family member 2
chr1_+_84630645 0.24 ENST00000394839.2
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_49121213 0.24 ENST00000548380.1
long intergenic non-protein coding RNA 935
chr12_-_64062583 0.23 ENST00000542209.1
dpy-19-like 2 (C. elegans)
chrX_-_13835147 0.23 ENST00000493677.1
ENST00000355135.2
glycoprotein M6B
chr8_-_86290333 0.23 ENST00000521846.1
ENST00000523022.1
ENST00000524324.1
ENST00000519991.1
ENST00000520663.1
ENST00000517590.1
ENST00000522579.1
ENST00000522814.1
ENST00000522662.1
ENST00000523858.1
ENST00000519129.1
carbonic anhydrase I
chr11_-_795170 0.23 ENST00000481290.1
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr16_+_31885079 0.23 ENST00000300870.10
ENST00000394846.3
zinc finger protein 267
chr6_-_110501200 0.23 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
WAS protein family, member 1
chr8_+_75262612 0.23 ENST00000220822.7
ganglioside induced differentiation associated protein 1
chr17_+_12569472 0.23 ENST00000343344.4
myocardin
chr1_-_205325698 0.23 ENST00000460687.1
kelch domain containing 8A
chr11_+_115498761 0.23 ENST00000424313.2
AP000997.1
chr12_-_10282681 0.22 ENST00000533022.1
C-type lectin domain family 7, member A
chrX_+_37639264 0.22 ENST00000378588.4
cytochrome b-245, beta polypeptide
chr1_+_84630574 0.22 ENST00000413538.1
ENST00000417530.1
protein kinase, cAMP-dependent, catalytic, beta
chr9_+_33638033 0.22 ENST00000390389.3
T cell receptor beta variable 23/OR9-2 (non-functional)

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX1_GSX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.3 1.5 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.2 0.6 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 1.4 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 1.6 GO:0071877 regulation of adrenergic receptor signaling pathway(GO:0071877)
0.2 1.0 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.2 0.5 GO:1905246 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.2 1.6 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.2 0.5 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)
0.2 3.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 2.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.2 1.0 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.2 1.8 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.1 0.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.5 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.3 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.1 1.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 0.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 0.6 GO:0061760 antifungal innate immune response(GO:0061760)
0.1 0.6 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.1 0.5 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 0.6 GO:1903438 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
0.1 0.3 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.7 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.4 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.1 0.3 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.1 1.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 2.0 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 1.7 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.5 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1 0.4 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.1 0.2 GO:0090678 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.1 0.6 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 5.9 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.3 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.1 0.2 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.3 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0 0.2 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.5 GO:0097338 response to clozapine(GO:0097338)
0.0 0.3 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.2 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 1.6 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.4 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.3 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.0 0.2 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 0.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.4 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.8 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.4 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.5 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 1.8 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 0.1 GO:0045209 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.5 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.2 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 1.0 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.2 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0 0.2 GO:0034350 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.0 0.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.1 GO:1903936 response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.0 0.1 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 0.2 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.1 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.1 GO:0051549 elastin metabolic process(GO:0051541) positive regulation of keratinocyte migration(GO:0051549)
0.0 0.2 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.1 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.5 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.3 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.3 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.7 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.1 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0 0.8 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.1 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.1 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.4 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 1.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.6 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 1.0 GO:0000800 lateral element(GO:0000800)
0.0 5.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0000801 central element(GO:0000801)
0.0 0.6 GO:0070938 contractile ring(GO:0070938)
0.0 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 4.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.2 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.5 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.2 GO:0071547 piP-body(GO:0071547)
0.0 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 1.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 1.5 GO:0000792 heterochromatin(GO:0000792)
0.0 2.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.8 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 1.4 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.2 1.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 0.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 1.7 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.6 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.3 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.6 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 0.5 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 1.8 GO:0030547 receptor inhibitor activity(GO:0030547)
0.1 1.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.2 GO:0016768 spermine synthase activity(GO:0016768)
0.1 0.3 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.2 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.5 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.5 GO:0005124 N-formyl peptide receptor activity(GO:0004982) scavenger receptor binding(GO:0005124)
0.1 0.2 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.1 1.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 1.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.5 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.3 GO:0019863 IgE binding(GO:0019863)
0.0 2.2 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 0.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 2.0 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.1 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.3 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.2 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 3.1 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.7 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.6 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 3.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 9.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.7 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.4 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.5 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.5 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.5 PID IL3 PATHWAY IL3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.9 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.0 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.6 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 2.3 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.2 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.2 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.7 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.7 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 1.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.0 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 2.4 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins