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Illumina Body Map 2, young vs old

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Results for ZBTB49

Z-value: 1.34

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Transcription factors associated with ZBTB49

Gene Symbol Gene ID Gene Info
ZBTB49
ENSG00000168826.11 zinc finger and BTB domain containing 49

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZBTB49hg19_v2_chr4_+_4291924_4292011-0.038.7e-01Click!

Activity profile of ZBTB49 motif

Sorted Z-values of ZBTB49 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_95691445 1.68 ENST00000353004.3
ENST00000354078.3
ENST00000349807.3
MAL
mal, T-cell differentiation protein
chr15_+_90728145 1.60 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr2_+_95691417 1.46 ENST00000309988.4
MAL
mal, T-cell differentiation protein
chr19_-_6481776 1.40 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chr8_-_82024290 1.29 ENST00000220597.4
PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr19_-_6481759 1.25 ENST00000588421.1
DENND1C
DENN/MADD domain containing 1C
chr12_+_40618764 1.24 ENST00000343742.2
LRRK2
leucine-rich repeat kinase 2
chr1_+_26869597 1.23 ENST00000530003.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr12_+_40618873 1.19 ENST00000298910.7
LRRK2
leucine-rich repeat kinase 2
chr11_+_117857063 1.18 ENST00000227752.3
ENST00000541785.1
ENST00000545409.1
IL10RA
interleukin 10 receptor, alpha
chr15_+_31508174 1.11 ENST00000559292.2
ENST00000557928.1
RP11-16E12.1
RP11-16E12.1
chr9_-_97401782 1.06 ENST00000375326.4
FBP1
fructose-1,6-bisphosphatase 1
chr16_-_28621353 0.92 ENST00000567512.1
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr18_+_32558380 0.81 ENST00000588349.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr3_-_172428842 0.78 ENST00000424772.1
NCEH1
neutral cholesterol ester hydrolase 1
chr17_+_54671047 0.77 ENST00000332822.4
NOG
noggin
chrX_-_153210107 0.77 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
RENBP
renin binding protein
chr2_+_30670209 0.74 ENST00000497423.1
ENST00000476535.1
LCLAT1
lysocardiolipin acyltransferase 1
chr3_-_172428959 0.72 ENST00000475381.1
ENST00000538775.1
ENST00000273512.3
ENST00000543711.1
NCEH1
neutral cholesterol ester hydrolase 1
chr2_+_89890533 0.71 ENST00000429992.2
IGKV2D-40
immunoglobulin kappa variable 2D-40
chr16_+_10972818 0.68 ENST00000576601.1
CIITA
class II, major histocompatibility complex, transactivator
chr18_+_32558208 0.66 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr6_-_6320875 0.63 ENST00000451619.1
F13A1
coagulation factor XIII, A1 polypeptide
chr11_+_108094786 0.63 ENST00000601453.1
ATM
ataxia telangiectasia mutated
chr3_-_196242233 0.62 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr9_-_123676827 0.62 ENST00000546084.1
TRAF1
TNF receptor-associated factor 1
chr4_+_128886424 0.60 ENST00000398965.1
C4orf29
chromosome 4 open reading frame 29
chr12_+_83080724 0.59 ENST00000548305.1
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr6_-_159240415 0.57 ENST00000367075.3
EZR
ezrin
chr3_+_196669494 0.55 ENST00000602845.1
NCBP2-AS2
NCBP2 antisense RNA 2 (head to head)
chrX_-_131623874 0.53 ENST00000436215.1
MBNL3
muscleblind-like splicing regulator 3
chr14_+_35591509 0.52 ENST00000604073.1
KIAA0391
KIAA0391
chr18_+_43753500 0.51 ENST00000587591.1
ENST00000588730.1
C18orf25
chromosome 18 open reading frame 25
chr14_-_93673353 0.50 ENST00000556566.1
ENST00000306954.4
C14orf142
chromosome 14 open reading frame 142
chr2_-_61244550 0.48 ENST00000421319.1
PUS10
pseudouridylate synthase 10
chr8_+_24151553 0.46 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr2_+_30670127 0.45 ENST00000540623.1
ENST00000476038.1
LCLAT1
lysocardiolipin acyltransferase 1
chr3_+_52232102 0.44 ENST00000469224.1
ENST00000394965.2
ENST00000310271.2
ENST00000484952.1
ALAS1
aminolevulinate, delta-, synthase 1
chr22_-_29196511 0.43 ENST00000344347.5
XBP1
X-box binding protein 1
chr3_-_184971817 0.43 ENST00000440662.1
ENST00000456310.1
EHHADH
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
chr14_+_35591858 0.42 ENST00000603544.1
KIAA0391
KIAA0391
chr1_+_79115503 0.41 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr2_-_179659669 0.40 ENST00000436599.1
TTN
titin
chrX_+_64887512 0.39 ENST00000360270.5
MSN
moesin
chr12_+_50505762 0.39 ENST00000550487.1
ENST00000317943.2
COX14
cytochrome c oxidase assembly homolog 14 (S. cerevisiae)
chr10_+_90750493 0.38 ENST00000357339.2
ENST00000355279.2
FAS
Fas cell surface death receptor
chr14_+_35591928 0.38 ENST00000605870.1
ENST00000557404.3
KIAA0391
KIAA0391
chr1_-_151319283 0.37 ENST00000392746.3
RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr12_+_83080659 0.37 ENST00000321196.3
TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr5_+_154238096 0.36 ENST00000517568.1
ENST00000524105.1
ENST00000285896.6
CNOT8
CCR4-NOT transcription complex, subunit 8
chr8_+_99129513 0.36 ENST00000522319.1
ENST00000401707.2
POP1
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chrX_+_9431324 0.35 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr2_+_30670077 0.35 ENST00000466477.1
ENST00000465200.1
ENST00000379509.3
ENST00000319406.4
ENST00000488144.1
ENST00000465538.1
ENST00000309052.4
ENST00000359433.1
LCLAT1
lysocardiolipin acyltransferase 1
chr20_-_25320367 0.35 ENST00000450393.1
ENST00000491682.1
ABHD12
abhydrolase domain containing 12
chrX_+_101854426 0.33 ENST00000536530.1
ENST00000473968.1
ENST00000604957.1
ENST00000477663.1
ENST00000479502.1
ARMCX5
armadillo repeat containing, X-linked 5
chr6_-_49604545 0.33 ENST00000371175.4
ENST00000229810.7
RHAG
Rh-associated glycoprotein
chr12_+_53835539 0.32 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
PRR13
proline rich 13
chrX_+_101854096 0.32 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
ARMCX5
armadillo repeat containing, X-linked 5
chr22_-_29196030 0.31 ENST00000405219.3
XBP1
X-box binding protein 1
chr2_-_27498208 0.31 ENST00000424577.1
ENST00000426569.1
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr10_+_81466084 0.31 ENST00000342531.2
NUTM2B
NUT family member 2B
chr4_-_53525406 0.29 ENST00000451218.2
ENST00000441222.3
USP46
ubiquitin specific peptidase 46
chr12_+_53835425 0.28 ENST00000549924.1
PRR13
proline rich 13
chr10_-_46641003 0.28 ENST00000395721.2
ENST00000374218.2
ENST00000395725.3
ENST00000374346.3
ENST00000417004.1
PTPN20A
protein tyrosine phosphatase, non-receptor type 20A
chr14_+_35591735 0.28 ENST00000604948.1
ENST00000605201.1
ENST00000250377.7
ENST00000321130.10
ENST00000534898.4
KIAA0391
KIAA0391
chr5_+_154237778 0.28 ENST00000523698.1
ENST00000517876.1
ENST00000520472.1
CNOT8
CCR4-NOT transcription complex, subunit 8
chr5_+_154238149 0.27 ENST00000519430.1
ENST00000520671.1
ENST00000521583.1
ENST00000518028.1
ENST00000519404.1
ENST00000519394.1
ENST00000518775.1
CNOT8
CCR4-NOT transcription complex, subunit 8
chr15_-_25684110 0.27 ENST00000232165.3
UBE3A
ubiquitin protein ligase E3A
chr16_+_2533020 0.26 ENST00000562105.1
TBC1D24
TBC1 domain family, member 24
chr8_-_42396632 0.26 ENST00000520179.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr2_-_27498186 0.25 ENST00000447008.2
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr22_-_20255212 0.25 ENST00000416372.1
RTN4R
reticulon 4 receptor
chr16_+_30406423 0.24 ENST00000524644.1
ZNF48
zinc finger protein 48
chr2_+_95873257 0.24 ENST00000425953.1
AC092835.2
AC092835.2
chr12_+_53835508 0.24 ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
ENST00000541275.1
PRR13
PCBP2
proline rich 13
poly(rC) binding protein 2
chr8_-_99129338 0.24 ENST00000520507.1
HRSP12
heat-responsive protein 12
chr7_+_99006232 0.23 ENST00000403633.2
BUD31
BUD31 homolog (S. cerevisiae)
chr2_-_85555086 0.23 ENST00000444342.2
ENST00000409232.3
ENST00000409015.1
TGOLN2
trans-golgi network protein 2
chr22_-_29196546 0.23 ENST00000403532.3
ENST00000216037.6
XBP1
X-box binding protein 1
chr11_+_63993738 0.22 ENST00000441250.2
ENST00000279206.3
NUDT22
nudix (nucleoside diphosphate linked moiety X)-type motif 22
chr5_+_154238042 0.22 ENST00000519211.1
ENST00000522458.1
ENST00000519903.1
ENST00000521450.1
ENST00000403027.2
CNOT8
CCR4-NOT transcription complex, subunit 8
chr19_-_54567035 0.22 ENST00000366170.2
ENST00000425006.2
VSTM1
V-set and transmembrane domain containing 1
chr12_+_53835383 0.22 ENST00000429243.2
PRR13
proline rich 13
chr8_-_99129384 0.21 ENST00000521560.1
ENST00000254878.3
HRSP12
heat-responsive protein 12
chr7_+_148936732 0.21 ENST00000335870.2
ZNF212
zinc finger protein 212
chr19_+_17862274 0.21 ENST00000596536.1
ENST00000593870.1
ENST00000598086.1
ENST00000598932.1
ENST00000595023.1
ENST00000594068.1
ENST00000596507.1
ENST00000595033.1
ENST00000597718.1
FCHO1
FCH domain only 1
chr12_-_120241187 0.21 ENST00000392520.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr1_-_151319318 0.21 ENST00000436271.1
ENST00000450506.1
ENST00000422595.1
RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr14_-_74485960 0.21 ENST00000556242.1
ENST00000334696.6
ENTPD5
ectonucleoside triphosphate diphosphohydrolase 5
chr16_+_30406721 0.19 ENST00000320159.2
ZNF48
zinc finger protein 48
chr20_-_33735070 0.19 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr22_-_42017021 0.19 ENST00000263256.6
DESI1
desumoylating isopeptidase 1
chr19_+_29097595 0.18 ENST00000587961.1
AC079466.1
AC079466.1
chr2_-_85555355 0.17 ENST00000282120.2
ENST00000398263.2
TGOLN2
trans-golgi network protein 2
chr16_-_18937480 0.17 ENST00000532700.2
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr22_-_20256054 0.17 ENST00000043402.7
RTN4R
reticulon 4 receptor
chr5_-_77590480 0.17 ENST00000519295.1
ENST00000255194.6
AP3B1
adaptor-related protein complex 3, beta 1 subunit
chr7_-_44613494 0.17 ENST00000431640.1
ENST00000258772.5
DDX56
DEAD (Asp-Glu-Ala-Asp) box helicase 56
chr4_+_144312659 0.16 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chr12_+_104324112 0.16 ENST00000299767.5
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr1_+_182808474 0.15 ENST00000367549.3
DHX9
DEAH (Asp-Glu-Ala-His) box helicase 9
chr1_+_24117627 0.15 ENST00000400061.1
LYPLA2
lysophospholipase II
chr5_-_180229833 0.14 ENST00000307826.4
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr16_-_18937726 0.14 ENST00000389467.3
ENST00000446231.2
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr1_-_151319654 0.12 ENST00000430227.1
ENST00000412774.1
RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr19_-_4182530 0.12 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
SIRT6
sirtuin 6
chr19_-_51611623 0.11 ENST00000421832.2
CTU1
cytosolic thiouridylase subunit 1
chr10_+_64893039 0.09 ENST00000277746.6
ENST00000435510.2
NRBF2
nuclear receptor binding factor 2
chr14_-_23446900 0.09 ENST00000556731.1
AJUBA
ajuba LIM protein
chr21_-_26979786 0.08 ENST00000419219.1
ENST00000352957.4
ENST00000307301.7
MRPL39
mitochondrial ribosomal protein L39
chr20_+_5731083 0.08 ENST00000445603.1
ENST00000442185.1
C20orf196
chromosome 20 open reading frame 196
chr22_+_21996549 0.06 ENST00000248958.4
SDF2L1
stromal cell-derived factor 2-like 1
chr14_-_35591679 0.06 ENST00000557278.1
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr7_-_12443501 0.06 ENST00000275358.3
VWDE
von Willebrand factor D and EGF domains
chr1_+_8021954 0.06 ENST00000377491.1
ENST00000377488.1
PARK7
parkinson protein 7
chr3_+_196594727 0.06 ENST00000445299.2
ENST00000323460.5
ENST00000419026.1
SENP5
SUMO1/sentrin specific peptidase 5
chr19_-_51466681 0.06 ENST00000456750.2
KLK6
kallikrein-related peptidase 6
chr17_+_74734052 0.06 ENST00000590514.1
MFSD11
major facilitator superfamily domain containing 11
chr11_+_43702322 0.05 ENST00000395700.4
HSD17B12
hydroxysteroid (17-beta) dehydrogenase 12
chr14_-_35591433 0.05 ENST00000261475.5
ENST00000555644.1
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr8_-_59572093 0.04 ENST00000427130.2
NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr11_-_63993690 0.04 ENST00000394546.2
ENST00000541278.1
TRPT1
tRNA phosphotransferase 1
chr14_-_35591156 0.04 ENST00000554361.1
PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr4_+_53525573 0.02 ENST00000503051.1
USP46-AS1
USP46 antisense RNA 1
chr6_-_109776901 0.01 ENST00000431946.1
MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr1_-_36863481 0.00 ENST00000315732.2
LSM10
LSM10, U7 small nuclear RNA associated

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB49

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:1903217 negative regulation of late endosome to lysosome transport(GO:1902823) regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.3 1.0 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690) epithelial cell maturation involved in salivary gland development(GO:0060691) regulation of plasma cell differentiation(GO:1900098) positive regulation of plasma cell differentiation(GO:1900100) positive regulation of lactation(GO:1903489)
0.3 1.1 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.2 3.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 1.5 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.2 0.8 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.2 0.8 GO:0006051 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.1 1.0 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 0.6 GO:1904882 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 1.2 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 1.6 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.3 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.1 0.3 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.7 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.1 0.1 GO:1990619 histone H3-K9 deacetylation(GO:1990619)
0.1 0.4 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.1 0.4 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.1 0.2 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.4 GO:0016078 tRNA catabolic process(GO:0016078)
0.0 0.5 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.2 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.9 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.5 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.2 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.2 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549)
0.0 0.4 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.2 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.0 1.1 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.4 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.3 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.3 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 1.6 GO:0050919 negative chemotaxis(GO:0050919)
0.0 1.5 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.0 0.1 GO:0034227 tRNA thio-modification(GO:0034227)
0.0 0.4 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.6 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.2 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.0 0.4 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.5 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0044753 amphisome(GO:0044753)
0.2 1.6 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.1 0.6 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.1 1.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 1.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.4 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.4 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.3 GO:0000502 proteasome complex(GO:0000502)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.3 1.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.2 1.5 GO:0004771 sterol esterase activity(GO:0004771)
0.2 0.6 GO:0015633 zinc transporting ATPase activity(GO:0015633)
0.2 3.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.4 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 0.4 GO:0038131 neuregulin receptor activity(GO:0038131)
0.1 0.9 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.1 1.2 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 0.3 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.1 2.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 0.4 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 0.6 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 0.4 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.1 0.2 GO:0033677 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) DNA/RNA helicase activity(GO:0033677) triplex DNA binding(GO:0045142)
0.0 1.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 1.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 1.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.0 0.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.0 0.6 GO:0031996 thioesterase binding(GO:0031996)
0.0 1.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.8 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.2 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 2.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.4 GO:0031433 telethonin binding(GO:0031433)
0.0 0.5 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 1.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.6 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.0 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 0.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.3 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.2 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.0 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.6 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 1.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 2.2 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis