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Illumina Body Map 2, young vs old

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Results for ZFHX3

Z-value: 0.31

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ZFHX3
ENSG00000140836.10 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73082274_73082274-0.691.3e-05Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_63063152 9.58 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr4_-_155511887 9.00 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr17_-_64225508 7.13 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr1_+_159557607 6.66 ENST00000255040.2
APCS
amyloid P component, serum
chr2_+_234621551 5.61 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr14_+_95027772 5.53 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr17_-_26697304 5.24 ENST00000536498.1
VTN
vitronectin
chr1_-_159684371 5.11 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr17_+_41052808 5.07 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC
glucose-6-phosphatase, catalytic subunit
chr6_+_161123270 4.75 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr2_+_234637754 4.18 ENST00000482026.1
ENST00000609767.1
UGT1A3
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr2_+_234627424 4.18 ENST00000373409.3
UGT1A4
UDP glucuronosyltransferase 1 family, polypeptide A4
chr6_+_50061315 4.10 ENST00000415106.1
RP11-397G17.1
RP11-397G17.1
chr4_+_74347400 3.91 ENST00000226355.3
AFM
afamin
chr19_-_36304201 3.86 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr11_+_22696314 3.58 ENST00000532398.1
ENST00000433790.1
GAS2
growth arrest-specific 2
chr9_-_123812542 3.36 ENST00000223642.1
C5
complement component 5
chr20_-_7921090 3.29 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr19_-_58864848 3.25 ENST00000263100.3
A1BG
alpha-1-B glycoprotein
chr15_+_58724184 3.19 ENST00000433326.2
LIPC
lipase, hepatic
chr4_+_100495864 3.09 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr17_+_4692230 3.01 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr2_+_88047606 2.81 ENST00000359481.4
PLGLB2
plasminogen-like B2
chr6_+_25754927 2.73 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr7_-_44580861 2.43 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1
NPC1-like 1
chr6_-_161085291 2.34 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr1_-_197036364 2.04 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr2_-_87248975 2.04 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr4_+_3443614 1.98 ENST00000382774.3
ENST00000511533.1
HGFAC
HGF activator
chr3_+_46919235 1.90 ENST00000449590.1
PTH1R
parathyroid hormone 1 receptor
chr20_+_42187682 1.81 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr11_-_111649074 1.72 ENST00000534218.1
RP11-108O10.2
RP11-108O10.2
chr20_+_42187608 1.69 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chrX_-_32173579 1.65 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr7_-_7575477 1.49 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chrM_+_8527 1.49 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6
chrX_-_15288154 1.40 ENST00000380483.3
ENST00000380485.3
ENST00000380488.4
ASB9
ankyrin repeat and SOCS box containing 9
chr1_-_150944411 1.28 ENST00000368949.4
CERS2
ceramide synthase 2
chrM_-_14670 1.27 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr14_-_104408645 1.23 ENST00000557640.1
RD3L
retinal degeneration 3-like
chrM_+_10464 1.20 ENST00000361335.1
MT-ND4L
mitochondrially encoded NADH dehydrogenase 4L
chr20_-_33735070 1.19 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr5_-_125930929 1.14 ENST00000553117.1
ENST00000447989.2
ENST00000409134.3
ALDH7A1
aldehyde dehydrogenase 7 family, member A1
chrM_+_9207 1.11 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr4_-_22444733 1.09 ENST00000508133.1
GPR125
G protein-coupled receptor 125
chr5_-_115890554 1.08 ENST00000509665.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr9_-_95298314 1.04 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr16_-_69385681 1.01 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr15_-_76352069 0.99 ENST00000305435.10
ENST00000563910.1
NRG4
neuregulin 4
chr1_-_153585539 0.94 ENST00000368706.4
S100A16
S100 calcium binding protein A16
chrM_+_14741 0.94 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chr8_-_145754428 0.93 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
C8orf82
chromosome 8 open reading frame 82
chr12_-_7818474 0.92 ENST00000229304.4
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr7_+_150725510 0.83 ENST00000461373.1
ENST00000358849.4
ENST00000297504.6
ENST00000542328.1
ENST00000498578.1
ENST00000356058.4
ENST00000477719.1
ENST00000477092.1
ABCB8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr4_-_152149033 0.81 ENST00000514152.1
SH3D19
SH3 domain containing 19
chr12_+_59989791 0.80 ENST00000552432.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr5_+_95066823 0.77 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr12_+_59989918 0.77 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr8_-_18541603 0.73 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chrX_-_110655306 0.64 ENST00000371993.2
DCX
doublecortin
chr11_-_58378759 0.62 ENST00000601906.1
AP001350.1
Uncharacterized protein
chr9_-_95298254 0.56 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr11_-_559377 0.53 ENST00000486629.1
C11orf35
chromosome 11 open reading frame 35
chr3_+_77088989 0.52 ENST00000461745.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chrX_+_84258832 0.50 ENST00000373173.2
APOOL
apolipoprotein O-like
chr11_-_61687739 0.49 ENST00000531922.1
ENST00000301773.5
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr12_-_131200810 0.46 ENST00000536002.1
ENST00000544034.1
RIMBP2
RP11-662M24.2
RIMS binding protein 2
RP11-662M24.2
chrM_+_10053 0.43 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr1_+_212475148 0.38 ENST00000537030.3
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr10_-_74283694 0.38 ENST00000398763.4
ENST00000418483.2
ENST00000489666.2
MICU1
mitochondrial calcium uptake 1
chr12_+_80750134 0.35 ENST00000546620.1
OTOGL
otogelin-like
chr1_-_227505289 0.35 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr7_+_130126165 0.33 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST
mesoderm specific transcript
chr7_+_130126012 0.33 ENST00000341441.5
MEST
mesoderm specific transcript
chr4_-_69111401 0.30 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr5_+_60933634 0.29 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr14_+_39703112 0.29 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr17_-_39156138 0.27 ENST00000391587.1
KRTAP3-2
keratin associated protein 3-2
chr2_+_105050794 0.26 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr6_-_31681839 0.25 ENST00000409239.1
ENST00000461287.1
LY6G6E
XXbac-BPG32J3.20
lymphocyte antigen 6 complex, locus G6E (pseudogene)
Uncharacterized protein
chr20_-_21494654 0.25 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr3_-_114477787 0.21 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr14_-_83262540 0.19 ENST00000554451.1
RP11-11K13.1
RP11-11K13.1
chr8_+_104831440 0.17 ENST00000515551.1
RIMS2
regulating synaptic membrane exocytosis 2
chr1_+_192544857 0.17 ENST00000367459.3
ENST00000469578.2
RGS1
regulator of G-protein signaling 1
chr22_-_30642728 0.15 ENST00000403987.3
LIF
leukemia inhibitory factor
chr11_+_71934962 0.14 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr11_+_5410607 0.14 ENST00000328611.3
OR51M1
olfactory receptor, family 51, subfamily M, member 1
chr7_-_71868354 0.13 ENST00000412588.1
CALN1
calneuron 1
chr11_+_57559005 0.13 ENST00000534647.1
CTNND1
catenin (cadherin-associated protein), delta 1
chr4_-_149365827 0.12 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr2_-_40680578 0.11 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr11_-_111649015 0.10 ENST00000529841.1
RP11-108O10.2
RP11-108O10.2
chr12_+_53835539 0.09 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
PRR13
proline rich 13
chr1_-_47017199 0.08 ENST00000481882.2
KNCN
kinocilin
chr10_+_118083919 0.06 ENST00000333254.3
CCDC172
coiled-coil domain containing 172
chr1_-_158369256 0.06 ENST00000334438.1
OR10T2
olfactory receptor, family 10, subfamily T, member 2
chr12_-_101801505 0.05 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
ARL1
ADP-ribosylation factor-like 1
chr8_-_141774467 0.04 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
PTK2
protein tyrosine kinase 2
chr18_+_20494078 0.04 ENST00000579124.1
ENST00000577588.1
ENST00000582354.1
ENST00000581819.1
RBBP8
retinoblastoma binding protein 8
chr8_-_9762871 0.01 ENST00000521242.1
LINC00599
long intergenic non-protein coding RNA 599
chr5_-_35195338 0.01 ENST00000509839.1
PRLR
prolactin receptor

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 14.0 GO:0006789 bilirubin conjugation(GO:0006789)
1.2 4.7 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.0 9.6 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
1.0 6.7 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.9 5.5 GO:0061107 seminal vesicle development(GO:0061107)
0.6 9.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.6 10.2 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.6 3.4 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.6 3.9 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.4 5.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.4 3.3 GO:0009441 glycolate metabolic process(GO:0009441)
0.3 1.3 GO:0014011 Schwann cell proliferation involved in axon regeneration(GO:0014011) negative regulation of Schwann cell migration(GO:1900148) regulation of Schwann cell proliferation involved in axon regeneration(GO:1905044) negative regulation of Schwann cell proliferation involved in axon regeneration(GO:1905045)
0.3 0.9 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.3 1.1 GO:0019285 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
0.3 5.5 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.3 5.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 5.1 GO:0008228 opsonization(GO:0008228) positive regulation of superoxide anion generation(GO:0032930)
0.2 1.2 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.2 1.6 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.2 2.4 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.1 1.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 2.7 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.1 0.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925) apoptotic process involved in luteolysis(GO:0061364)
0.1 0.2 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 1.9 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.1 3.8 GO:0051180 vitamin transport(GO:0051180)
0.1 0.4 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.1 0.4 GO:0019566 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 1.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 1.5 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 1.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.5 GO:0042407 cristae formation(GO:0042407)
0.0 2.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.2 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 3.5 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 0.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 3.2 GO:0002576 platelet degranulation(GO:0002576)
0.0 3.6 GO:0008360 regulation of cell shape(GO:0008360)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.5 GO:0036024 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
1.3 5.2 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.6 9.0 GO:0005577 fibrinogen complex(GO:0005577)
0.5 4.7 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.4 7.1 GO:0031089 platelet dense granule lumen(GO:0031089)
0.4 9.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.4 3.4 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.6 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 0.5 GO:0061617 MICOS complex(GO:0061617)
0.1 5.5 GO:0034358 plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777)
0.1 1.5 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.4 GO:1990246 uniplex complex(GO:1990246)
0.1 1.1 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 13.8 GO:0072562 blood microparticle(GO:0072562)
0.1 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.8 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 3.3 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 4.2 GO:0031526 brush border membrane(GO:0031526)
0.0 2.9 GO:0070469 respiratory chain(GO:0070469)
0.0 1.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 5.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 9.5 GO:0030027 lamellipodium(GO:0030027)
0.0 3.6 GO:0005884 actin filament(GO:0005884)
0.0 0.5 GO:0045202 synapse(GO:0045202)
0.0 0.1 GO:0032437 cuticular plate(GO:0032437)
0.0 0.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.5 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:1904854 proteasome core complex binding(GO:1904854)
1.3 5.1 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.2 11.8 GO:0001849 complement component C1q binding(GO:0001849)
1.1 3.3 GO:0052853 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
1.0 7.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
1.0 3.9 GO:0008431 vitamin E binding(GO:0008431)
1.0 3.9 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.6 5.5 GO:0032190 acrosin binding(GO:0032190)
0.4 1.6 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.4 1.9 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.3 1.6 GO:0070052 collagen V binding(GO:0070052)
0.3 9.6 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.3 14.0 GO:0001972 retinoic acid binding(GO:0001972)
0.2 5.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 5.2 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 2.7 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 0.9 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 3.5 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.9 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 1.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 2.4 GO:0031489 myosin V binding(GO:0031489)
0.1 3.4 GO:0008009 chemokine activity(GO:0008009)
0.1 1.6 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.1 0.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.4 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.1 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.0 2.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 3.1 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 1.1 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.1 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 8.5 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 1.4 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 18.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 5.5 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 9.6 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 3.2 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 1.5 NABA COLLAGENS Genes encoding collagen proteins
0.1 5.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.3 ST GA13 PATHWAY G alpha 13 Pathway
0.0 2.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 3.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 11.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.5 14.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.4 5.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 6.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 4.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.3 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.1 3.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 3.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 1.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 6.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 5.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 1.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 4.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 4.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade