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Illumina Body Map 2, young vs old

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Results for ZKSCAN3

Z-value: 0.12

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.9 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg19_v2_chr6_+_28317685_28317761-0.281.2e-01Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_100867486 2.57 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr12_+_100867694 2.36 ENST00000392986.3
ENST00000549996.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr12_+_100867733 2.11 ENST00000546380.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr19_+_39786962 1.28 ENST00000333625.2
IFNL1
interferon, lambda 1
chr18_-_74728998 1.20 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
MBP
myelin basic protein
chr2_-_61244550 1.02 ENST00000421319.1
PUS10
pseudouridylate synthase 10
chr7_+_155089486 0.98 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
INSIG1
insulin induced gene 1
chr19_+_49258775 0.98 ENST00000593756.1
FGF21
fibroblast growth factor 21
chr5_+_65018017 0.97 ENST00000380985.5
ENST00000502464.1
NLN
neurolysin (metallopeptidase M3 family)
chr21_+_39668831 0.96 ENST00000419868.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_+_156123359 0.93 ENST00000368284.1
ENST00000368286.2
ENST00000438830.1
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr21_+_39668478 0.90 ENST00000398927.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_+_156123318 0.88 ENST00000368285.3
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr1_+_226250379 0.85 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr14_-_22103096 0.84 ENST00000542433.1
OR10G2
olfactory receptor, family 10, subfamily G, member 2
chr1_+_114473350 0.78 ENST00000503968.1
HIPK1
homeodomain interacting protein kinase 1
chr7_+_155090271 0.78 ENST00000476756.1
INSIG1
insulin induced gene 1
chr16_-_28506840 0.74 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chr1_+_114472992 0.65 ENST00000514621.1
HIPK1
homeodomain interacting protein kinase 1
chr9_+_127023704 0.65 ENST00000373596.1
ENST00000425237.1
NEK6
NIMA-related kinase 6
chr2_-_61244308 0.63 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr7_-_155089251 0.49 ENST00000609974.1
AC144652.1
AC144652.1
chr1_-_19811132 0.48 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr1_-_19811996 0.47 ENST00000264203.3
ENST00000401084.2
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr6_-_35656712 0.45 ENST00000357266.4
ENST00000542713.1
FKBP5
FK506 binding protein 5
chr11_-_64013663 0.43 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr16_-_745946 0.42 ENST00000562563.1
FBXL16
F-box and leucine-rich repeat protein 16
chr1_+_66258846 0.41 ENST00000341517.4
PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_19811962 0.36 ENST00000375142.1
ENST00000264202.6
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr16_-_4039001 0.36 ENST00000576936.1
ADCY9
adenylate cyclase 9
chr14_+_94492674 0.33 ENST00000203664.5
ENST00000553723.1
OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr17_+_36908984 0.32 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr8_+_123793633 0.32 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr22_+_50312379 0.32 ENST00000407217.3
ENST00000403427.3
CRELD2
cysteine-rich with EGF-like domains 2
chr11_-_64013288 0.31 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr22_+_50312274 0.30 ENST00000404488.3
CRELD2
cysteine-rich with EGF-like domains 2
chr11_-_67272794 0.30 ENST00000436757.2
ENST00000356404.3
PITPNM1
phosphatidylinositol transfer protein, membrane-associated 1
chr22_+_50312316 0.29 ENST00000328268.4
CRELD2
cysteine-rich with EGF-like domains 2
chr16_-_832054 0.28 ENST00000543963.1
MSLNL
mesothelin-like
chr1_-_28415204 0.28 ENST00000373871.3
EYA3
eyes absent homolog 3 (Drosophila)
chr17_-_62499334 0.27 ENST00000579996.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr15_+_74610894 0.27 ENST00000558821.1
ENST00000268082.4
CCDC33
coiled-coil domain containing 33
chr1_-_28415075 0.27 ENST00000373863.3
ENST00000436342.2
ENST00000540618.1
ENST00000545175.1
EYA3
eyes absent homolog 3 (Drosophila)
chr5_-_65017921 0.26 ENST00000381007.4
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr16_-_832926 0.24 ENST00000293892.3
MSLNL
mesothelin-like
chr17_-_60142609 0.23 ENST00000397786.2
MED13
mediator complex subunit 13
chr6_+_116850174 0.23 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
FAM26D
family with sequence similarity 26, member D
chr6_+_32936353 0.20 ENST00000374825.4
BRD2
bromodomain containing 2
chr3_+_50316458 0.19 ENST00000316436.3
LSMEM2
leucine-rich single-pass membrane protein 2
chr15_+_41624892 0.18 ENST00000260359.6
ENST00000450318.1
ENST00000450592.2
ENST00000559596.1
ENST00000414849.2
ENST00000560747.1
ENST00000560177.1
NUSAP1
nucleolar and spindle associated protein 1
chr10_+_21823079 0.18 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr19_-_4182530 0.18 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
SIRT6
sirtuin 6
chrX_+_153775869 0.16 ENST00000424839.1
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr11_-_111320706 0.16 ENST00000531398.1
POU2AF1
POU class 2 associating factor 1
chrX_+_153775821 0.15 ENST00000263518.6
ENST00000470142.1
ENST00000393549.2
ENST00000455588.2
ENST00000369602.3
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr7_+_150782945 0.15 ENST00000463381.1
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr12_+_113796347 0.15 ENST00000545182.2
ENST00000280800.3
PLBD2
phospholipase B domain containing 2
chr19_-_4182497 0.14 ENST00000597896.1
SIRT6
sirtuin 6
chr12_-_3982511 0.12 ENST00000427057.2
ENST00000228820.4
PARP11
poly (ADP-ribose) polymerase family, member 11
chr3_-_122512619 0.12 ENST00000383659.1
ENST00000306103.2
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr5_-_114598548 0.12 ENST00000379615.3
ENST00000419445.1
PGGT1B
protein geranylgeranyltransferase type I, beta subunit
chr12_-_113573495 0.11 ENST00000446861.3
RASAL1
RAS protein activator like 1 (GAP1 like)
chr5_-_180235755 0.11 ENST00000502678.1
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr6_-_31508304 0.10 ENST00000376177.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr22_-_50312052 0.10 ENST00000330817.6
ALG12
ALG12, alpha-1,6-mannosyltransferase
chr19_+_54372639 0.10 ENST00000391769.2
MYADM
myeloid-associated differentiation marker
chr15_-_41624685 0.09 ENST00000560640.1
ENST00000220514.3
OIP5
Opa interacting protein 5
chr10_+_21823243 0.08 ENST00000307729.7
ENST00000377091.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chrX_+_85403445 0.08 ENST00000373131.1
DACH2
dachshund homolog 2 (Drosophila)
chr12_+_109535923 0.07 ENST00000336865.2
UNG
uracil-DNA glycosylase
chr5_+_140079919 0.06 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chrX_+_85403487 0.06 ENST00000373125.4
DACH2
dachshund homolog 2 (Drosophila)
chr12_-_3982548 0.06 ENST00000397096.2
ENST00000447133.3
ENST00000450737.2
PARP11
poly (ADP-ribose) polymerase family, member 11
chr19_-_39735646 0.05 ENST00000413851.2
IFNL3
interferon, lambda 3
chr1_-_99470368 0.05 ENST00000263177.4
LPPR5
Lipid phosphate phosphatase-related protein type 5
chr1_-_115259337 0.04 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chrX_-_153775760 0.03 ENST00000440967.1
ENST00000393564.2
ENST00000369620.2
G6PD
glucose-6-phosphate dehydrogenase
chr1_-_99470558 0.03 ENST00000370188.3
LPPR5
Lipid phosphate phosphatase-related protein type 5
chr2_+_191221240 0.01 ENST00000409027.1
ENST00000458193.1
INPP1
inositol polyphosphate-1-phosphatase

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.0 GO:0072615 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.6 1.8 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 1.0 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.2 1.3 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.2 0.8 GO:0060623 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.2 1.2 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.2 1.0 GO:1904640 response to methionine(GO:1904640)
0.2 0.7 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 1.6 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 1.3 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.1 1.4 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 0.3 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619)
0.0 1.8 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 1.9 GO:0010107 potassium ion import(GO:0010107)
0.0 0.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.3 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.4 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.1 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.6 GO:2000772 regulation of cellular senescence(GO:2000772)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.4 1.3 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.2 1.3 GO:0071203 WASH complex(GO:0071203)
0.1 7.0 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 0.8 GO:0001740 Barr body(GO:0001740)
0.1 1.2 GO:0033269 internode region of axon(GO:0033269)
0.1 0.3 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.0 0.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.0 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.1 0.3 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.1 1.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 1.9 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.7 GO:0019888 protein phosphatase inhibitor activity(GO:0004864) phosphatase regulator activity(GO:0019208) phosphatase inhibitor activity(GO:0019212) protein phosphatase regulator activity(GO:0019888)
0.1 0.3 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 1.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0 0.3 GO:0035500 MH2 domain binding(GO:0035500)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.5 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 0.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.9 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening