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Illumina Body Map 2, young vs old

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Results for ZNF274

Z-value: 0.04

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Transcription factors associated with ZNF274

Gene Symbol Gene ID Gene Info
ZNF274
ENSG00000171606.13 zinc finger protein 274

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF274hg19_v2_chr19_+_58694742_586948630.631.3e-04Click!

Activity profile of ZNF274 motif

Sorted Z-values of ZNF274 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_6713376 7.57 ENST00000399484.3
ENST00000544825.1
ENST00000401847.1
AC073343.1
Uncharacterized protein
chr14_+_22409308 4.77 ENST00000390441.2
TRAV9-2
T cell receptor alpha variable 9-2
chr7_+_6714599 3.68 ENST00000328239.7
ENST00000542006.1
AC073343.1
Uncharacterized protein
chr7_-_142240014 3.65 ENST00000390363.2
TRBV9
T cell receptor beta variable 9
chr20_-_1638408 2.29 ENST00000303415.3
ENST00000381583.2
SIRPG
signal-regulatory protein gamma
chr20_-_1638360 2.15 ENST00000216927.4
ENST00000344103.4
SIRPG
signal-regulatory protein gamma
chr14_-_64846033 2.02 ENST00000556556.1
CTD-2555O16.1
CTD-2555O16.1
chr2_-_89292422 1.86 ENST00000495489.1
IGKV1-8
immunoglobulin kappa variable 1-8
chr22_+_24038593 1.72 ENST00000452208.1
RGL4
ral guanine nucleotide dissociation stimulator-like 4
chr6_-_32784687 1.68 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr6_+_31553978 1.68 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr6_+_31553901 1.57 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr22_+_39353527 1.40 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr1_-_114414316 1.39 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr19_+_6887571 1.38 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr22_+_22453093 1.34 ENST00000390283.2
IGLV8-61
immunoglobulin lambda variable 8-61
chr16_+_31470143 1.15 ENST00000457010.2
ENST00000563544.1
ARMC5
armadillo repeat containing 5
chr19_-_56109119 1.12 ENST00000587678.1
FIZ1
FLT3-interacting zinc finger 1
chr14_-_24047965 1.07 ENST00000397118.3
ENST00000356300.4
JPH4
junctophilin 4
chr4_+_15704679 0.90 ENST00000382346.3
BST1
bone marrow stromal cell antigen 1
chr13_+_103459704 0.90 ENST00000602836.1
BIVM-ERCC5
BIVM-ERCC5 readthrough
chr1_-_206671061 0.87 ENST00000367119.1
C1orf147
chromosome 1 open reading frame 147
chr5_-_74162739 0.79 ENST00000513277.1
FAM169A
family with sequence similarity 169, member A
chr5_-_74162605 0.78 ENST00000389156.4
ENST00000510496.1
ENST00000380515.3
FAM169A
family with sequence similarity 169, member A
chr16_+_29819446 0.75 ENST00000568282.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr7_-_142143973 0.73 ENST00000390373.2
TRBV6-7
T cell receptor beta variable 6-7 (non-functional)
chr17_+_73028676 0.72 ENST00000581589.1
KCTD2
potassium channel tetramerization domain containing 2
chr16_+_29819096 0.71 ENST00000568411.1
ENST00000563012.1
ENST00000562557.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr12_+_113344755 0.71 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr16_+_29819372 0.70 ENST00000568544.1
ENST00000569978.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr17_+_41132564 0.69 ENST00000361677.1
ENST00000589705.1
RUNDC1
RUN domain containing 1
chr16_+_29818857 0.65 ENST00000567444.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr6_+_30687978 0.62 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr4_+_15704573 0.61 ENST00000265016.4
BST1
bone marrow stromal cell antigen 1
chr17_-_37322013 0.59 ENST00000269586.7
ARL5C
ADP-ribosylation factor-like 5C
chr12_-_49581152 0.56 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr8_-_4852218 0.52 ENST00000400186.3
ENST00000602723.1
CSMD1
CUB and Sushi multiple domains 1
chr16_+_31470179 0.52 ENST00000538189.1
ENST00000268314.4
ARMC5
armadillo repeat containing 5
chr2_-_96971259 0.52 ENST00000349783.5
SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr16_+_29127282 0.51 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chr15_+_89164520 0.50 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr15_+_89164560 0.48 ENST00000379231.3
ENST00000559528.1
AEN
apoptosis enhancing nuclease
chr8_-_4852494 0.46 ENST00000520002.1
ENST00000602557.1
CSMD1
CUB and Sushi multiple domains 1
chr17_-_7145106 0.44 ENST00000577035.1
GABARAP
GABA(A) receptor-associated protein
chr17_-_73636019 0.44 ENST00000580707.1
RECQL5
RecQ protein-like 5
chr6_+_36165133 0.40 ENST00000446974.1
ENST00000454960.1
BRPF3
bromodomain and PHD finger containing, 3
chr2_-_42991257 0.39 ENST00000378661.2
OXER1
oxoeicosanoid (OXE) receptor 1
chr8_-_19540086 0.38 ENST00000332246.6
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr2_+_11864458 0.37 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr8_-_19540266 0.34 ENST00000311540.4
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr12_-_89920030 0.34 ENST00000413530.1
ENST00000547474.1
GALNT4
POC1B-GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr20_+_60174827 0.32 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr3_-_137893721 0.28 ENST00000505015.2
ENST00000260803.4
DBR1
debranching RNA lariats 1
chr11_+_59705928 0.28 ENST00000398992.1
OOSP1
oocyte secreted protein 1
chrX_+_119737806 0.26 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr3_+_50284321 0.24 ENST00000451956.1
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr19_+_46498704 0.23 ENST00000595358.1
ENST00000594672.1
ENST00000536603.1
CCDC61
coiled-coil domain containing 61
chr2_+_178977143 0.23 ENST00000286070.5
RBM45
RNA binding motif protein 45
chr11_+_16760161 0.19 ENST00000524439.1
ENST00000422258.2
ENST00000528634.1
ENST00000525684.1
C11orf58
chromosome 11 open reading frame 58
chr12_-_89919965 0.19 ENST00000548729.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr3_+_37903432 0.16 ENST00000443503.2
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr19_-_19774473 0.16 ENST00000357324.6
ATP13A1
ATPase type 13A1
chr5_+_32531893 0.13 ENST00000512913.1
SUB1
SUB1 homolog (S. cerevisiae)
chr1_+_42928945 0.12 ENST00000428554.2
CCDC30
coiled-coil domain containing 30
chr1_-_54355430 0.11 ENST00000371399.1
ENST00000072644.1
ENST00000412288.1
YIPF1
Yip1 domain family, member 1
chr11_+_5757681 0.08 ENST00000317121.3
OR56B1
olfactory receptor, family 56, subfamily B, member 1
chr22_-_43036607 0.05 ENST00000505920.1
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr17_-_3461092 0.04 ENST00000301365.4
ENST00000572519.1
TRPV3
transient receptor potential cation channel, subfamily V, member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF274

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.3 1.4 GO:0070425 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.2 1.4 GO:0070383 DNA cytosine deamination(GO:0070383)
0.1 0.5 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.1 0.7 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 1.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.4 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 1.5 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.9 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 3.2 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0 5.7 GO:0002377 immunoglobulin production(GO:0002377)
0.0 2.8 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.4 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.2 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.0 4.4 GO:0050870 positive regulation of T cell activation(GO:0050870)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0030314 junctional membrane complex(GO:0030314)
0.1 1.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.4 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.4 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 1.6 GO:0005637 nuclear inner membrane(GO:0005637)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.3 1.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 0.7 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 1.7 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.7 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.4 GO:1901567 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0 0.7 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.6 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 2.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 3.2 GO:0003823 antigen binding(GO:0003823)
0.0 1.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.4 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE