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Illumina Body Map 2, young vs old

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Results for ZNF423

Z-value: 0.10

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Transcription factors associated with ZNF423

Gene Symbol Gene ID Gene Info
ZNF423
ENSG00000102935.7 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v2_chr16_-_49890016_498900460.485.4e-03Click!

Activity profile of ZNF423 motif

Sorted Z-values of ZNF423 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_71392616 4.78 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chr11_-_61062762 3.35 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr5_+_150400124 2.67 ENST00000388825.4
ENST00000521650.1
ENST00000517973.1
GPX3
glutathione peroxidase 3 (plasma)
chr14_+_100204027 2.44 ENST00000554479.1
ENST00000555145.1
EML1
echinoderm microtubule associated protein like 1
chr11_-_47207950 2.25 ENST00000298838.6
ENST00000531226.1
ENST00000524509.1
ENST00000528201.1
ENST00000530513.1
PACSIN3
protein kinase C and casein kinase substrate in neurons 3
chr17_+_77020325 2.03 ENST00000311661.4
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr10_+_88428206 2.02 ENST00000429277.2
ENST00000458213.2
ENST00000352360.5
LDB3
LIM domain binding 3
chr17_+_77020224 2.00 ENST00000339142.2
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr10_+_88428370 1.96 ENST00000372066.3
ENST00000263066.6
ENST00000372056.4
ENST00000310944.6
ENST00000361373.4
ENST00000542786.1
LDB3
LIM domain binding 3
chr7_-_27219849 1.93 ENST00000396344.4
HOXA10
homeobox A10
chr17_+_77020146 1.85 ENST00000579760.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr19_-_15311713 1.77 ENST00000601011.1
ENST00000263388.2
NOTCH3
notch 3
chr9_-_124976185 1.76 ENST00000464484.2
LHX6
LIM homeobox 6
chr11_+_60691924 1.74 ENST00000544065.1
ENST00000453848.2
ENST00000005286.4
TMEM132A
transmembrane protein 132A
chr9_-_124976154 1.68 ENST00000482062.1
LHX6
LIM homeobox 6
chr6_+_168841817 1.66 ENST00000356284.2
ENST00000354536.5
SMOC2
SPARC related modular calcium binding 2
chr1_-_33366931 1.61 ENST00000373463.3
ENST00000329151.5
TMEM54
transmembrane protein 54
chr8_-_80680078 1.53 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr15_-_74044719 1.48 ENST00000559817.1
C15orf59
chromosome 15 open reading frame 59
chr19_+_6740888 1.48 ENST00000596673.1
TRIP10
thyroid hormone receptor interactor 10
chr1_+_27719148 1.45 ENST00000374024.3
GPR3
G protein-coupled receptor 3
chr8_+_30241995 1.37 ENST00000397323.4
ENST00000339877.4
ENST00000320203.4
ENST00000287771.5
RBPMS
RNA binding protein with multiple splicing
chr10_-_118032979 1.31 ENST00000355422.6
GFRA1
GDNF family receptor alpha 1
chr7_-_44265492 1.23 ENST00000425809.1
CAMK2B
calcium/calmodulin-dependent protein kinase II beta
chr8_+_30241934 1.21 ENST00000538486.1
RBPMS
RNA binding protein with multiple splicing
chrX_+_152760397 1.11 ENST00000331595.4
ENST00000431891.1
BGN
biglycan
chr11_+_73019282 1.09 ENST00000263674.3
ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr20_+_44462430 1.03 ENST00000462307.1
SNX21
sorting nexin family member 21
chr6_+_151186554 1.03 ENST00000367321.3
ENST00000367307.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr1_-_165414414 1.03 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr10_+_85933494 1.01 ENST00000372126.3
C10orf99
chromosome 10 open reading frame 99
chr7_-_27219632 1.00 ENST00000470747.4
RP1-170O19.20
Uncharacterized protein
chr20_+_44462749 0.99 ENST00000372541.1
SNX21
sorting nexin family member 21
chr13_+_96743093 0.97 ENST00000376705.2
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr10_-_75255724 0.96 ENST00000342558.3
ENST00000360663.5
ENST00000394829.2
ENST00000394828.2
ENST00000394822.2
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr20_-_36794938 0.92 ENST00000453095.1
TGM2
transglutaminase 2
chr20_-_36794902 0.88 ENST00000373403.3
TGM2
transglutaminase 2
chr20_+_44462481 0.88 ENST00000491381.1
ENST00000342644.5
ENST00000372542.1
SNX21
sorting nexin family member 21
chr1_+_53527854 0.88 ENST00000371500.3
ENST00000395871.2
ENST00000312553.5
PODN
podocan
chr12_-_125348448 0.87 ENST00000339570.5
SCARB1
scavenger receptor class B, member 1
chr2_+_62932779 0.86 ENST00000427809.1
ENST00000405482.1
ENST00000431489.1
EHBP1
EH domain binding protein 1
chr12_-_125348329 0.85 ENST00000546215.1
ENST00000415380.2
ENST00000261693.6
ENST00000376788.1
ENST00000545493.1
SCARB1
scavenger receptor class B, member 1
chr10_-_100027943 0.85 ENST00000260702.3
LOXL4
lysyl oxidase-like 4
chr1_-_102462565 0.85 ENST00000370103.4
OLFM3
olfactomedin 3
chr3_+_6902794 0.82 ENST00000357716.4
ENST00000486284.1
ENST00000389336.4
ENST00000403881.1
ENST00000402647.2
GRM7
glutamate receptor, metabotropic 7
chr9_+_112542591 0.79 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
PALM2
PALM2-AKAP2
AKAP2
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr11_-_61659006 0.79 ENST00000278829.2
FADS3
fatty acid desaturase 3
chr16_+_333152 0.78 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
PDIA2
protein disulfide isomerase family A, member 2
chr2_+_14772810 0.77 ENST00000295092.2
ENST00000331243.4
FAM84A
family with sequence similarity 84, member A
chr12_+_7037461 0.77 ENST00000396684.2
ATN1
atrophin 1
chr11_-_61658853 0.74 ENST00000525588.1
ENST00000540820.1
FADS3
fatty acid desaturase 3
chr22_-_38484922 0.74 ENST00000428572.1
BAIAP2L2
BAI1-associated protein 2-like 2
chr10_-_75255668 0.73 ENST00000545874.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr19_-_5292781 0.72 ENST00000586065.1
PTPRS
protein tyrosine phosphatase, receptor type, S
chr12_+_54410664 0.70 ENST00000303406.4
HOXC4
homeobox C4
chrX_-_48827976 0.69 ENST00000218176.3
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr8_+_22422749 0.69 ENST00000523900.1
SORBS3
sorbin and SH3 domain containing 3
chr9_-_39239171 0.67 ENST00000358144.2
CNTNAP3
contactin associated protein-like 3
chr5_-_172756506 0.65 ENST00000265087.4
STC2
stanniocalcin 2
chr8_+_22022223 0.64 ENST00000306385.5
BMP1
bone morphogenetic protein 1
chr9_-_130659569 0.60 ENST00000542456.1
ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr6_-_31080336 0.60 ENST00000259870.3
C6orf15
chromosome 6 open reading frame 15
chr11_-_44972390 0.59 ENST00000395648.3
ENST00000531928.2
TP53I11
tumor protein p53 inducible protein 11
chr11_-_68748455 0.59 ENST00000309106.3
MRGPRD
MAS-related GPR, member D
chr7_-_100491854 0.59 ENST00000426415.1
ENST00000430554.1
ENST00000412389.1
ACHE
acetylcholinesterase (Yt blood group)
chr11_-_44972476 0.59 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr19_+_14544099 0.58 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
PKN1
protein kinase N1
chr11_-_44971702 0.58 ENST00000533940.1
ENST00000533937.1
TP53I11
tumor protein p53 inducible protein 11
chr2_+_46770531 0.58 ENST00000482449.2
RHOQ
ras homolog family member Q
chr11_-_44972299 0.57 ENST00000528473.1
TP53I11
tumor protein p53 inducible protein 11
chr9_-_130659679 0.57 ENST00000373141.1
ST6GALNAC6
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chr11_-_44972418 0.56 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
TP53I11
tumor protein p53 inducible protein 11
chr17_+_36584662 0.56 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr7_+_20370300 0.55 ENST00000537992.1
ITGB8
integrin, beta 8
chr11_-_1036706 0.55 ENST00000421673.2
MUC6
mucin 6, oligomeric mucus/gel-forming
chr9_+_139249228 0.55 ENST00000392944.1
GPSM1
G-protein signaling modulator 1
chr13_+_21277482 0.55 ENST00000304920.3
IL17D
interleukin 17D
chr19_-_57183114 0.54 ENST00000537055.2
ENST00000601659.1
ZNF835
zinc finger protein 835
chr20_-_25062767 0.53 ENST00000429762.3
ENST00000444511.2
ENST00000376707.3
VSX1
visual system homeobox 1
chr9_-_16870704 0.53 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2
basonuclin 2
chr20_+_43029911 0.52 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4, alpha
chr5_+_154181816 0.51 ENST00000518677.1
LARP1
La ribonucleoprotein domain family, member 1
chr11_-_6495101 0.50 ENST00000528227.1
ENST00000359518.3
ENST00000345851.3
ENST00000537602.1
TRIM3
tripartite motif containing 3
chr4_-_20985632 0.49 ENST00000359001.5
KCNIP4
Kv channel interacting protein 4
chr9_+_130160440 0.49 ENST00000439597.1
ENST00000423934.1
SLC2A8
solute carrier family 2 (facilitated glucose transporter), member 8
chr22_-_43045574 0.48 ENST00000352397.5
CYB5R3
cytochrome b5 reductase 3
chr5_+_78407602 0.48 ENST00000274353.5
ENST00000524080.1
BHMT
betaine--homocysteine S-methyltransferase
chr15_-_83316711 0.48 ENST00000568128.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr10_-_76859247 0.47 ENST00000472493.2
ENST00000605915.1
ENST00000478873.2
DUSP13
dual specificity phosphatase 13
chr3_+_9958758 0.46 ENST00000383812.4
ENST00000438091.1
ENST00000295981.3
ENST00000436503.1
ENST00000403601.3
ENST00000416074.2
ENST00000455057.1
IL17RC
interleukin 17 receptor C
chr7_-_23053693 0.46 ENST00000409763.1
ENST00000409923.1
FAM126A
family with sequence similarity 126, member A
chr11_-_64013663 0.46 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr14_-_77608121 0.46 ENST00000319374.4
ZDHHC22
zinc finger, DHHC-type containing 22
chr8_-_133493200 0.45 ENST00000388996.4
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3
chr4_+_71570430 0.45 ENST00000417478.2
RUFY3
RUN and FYVE domain containing 3
chr3_+_9958870 0.44 ENST00000413608.1
IL17RC
interleukin 17 receptor C
chr8_+_22423219 0.43 ENST00000523965.1
ENST00000521554.1
SORBS3
sorbin and SH3 domain containing 3
chr9_+_112542572 0.43 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr12_+_7342178 0.42 ENST00000266563.5
ENST00000543974.1
PEX5
peroxisomal biogenesis factor 5
chr16_-_2162831 0.40 ENST00000483024.1
PKD1
polycystic kidney disease 1 (autosomal dominant)
chr17_+_7341586 0.40 ENST00000575235.1
FGF11
fibroblast growth factor 11
chr15_+_100106670 0.40 ENST00000559903.1
MEF2A
myocyte enhancer factor 2A
chr18_+_77867177 0.39 ENST00000560752.1
ADNP2
ADNP homeobox 2
chr7_+_20370746 0.39 ENST00000222573.4
ITGB8
integrin, beta 8
chr5_+_141303373 0.38 ENST00000432126.2
ENST00000194118.4
KIAA0141
KIAA0141
chr6_-_35480705 0.37 ENST00000229771.6
TULP1
tubby like protein 1
chr3_+_180630319 0.37 ENST00000491674.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr8_+_22423168 0.36 ENST00000518912.1
ENST00000428103.1
SORBS3
sorbin and SH3 domain containing 3
chr2_+_46769798 0.36 ENST00000238738.4
RHOQ
ras homolog family member Q
chr7_-_23053719 0.35 ENST00000432176.2
ENST00000440481.1
FAM126A
family with sequence similarity 126, member A
chrX_-_1572629 0.35 ENST00000534940.1
ASMTL
acetylserotonin O-methyltransferase-like
chr12_+_57522439 0.33 ENST00000338962.4
LRP1
low density lipoprotein receptor-related protein 1
chr17_+_6347761 0.33 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
FAM64A
family with sequence similarity 64, member A
chr19_-_56110859 0.32 ENST00000221665.3
ENST00000592585.1
FIZ1
FLT3-interacting zinc finger 1
chr4_-_166034029 0.31 ENST00000306480.6
TMEM192
transmembrane protein 192
chr12_+_57522692 0.31 ENST00000554174.1
LRP1
low density lipoprotein receptor-related protein 1
chr3_+_180630444 0.30 ENST00000491062.1
ENST00000468861.1
ENST00000445140.2
ENST00000484958.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr12_+_7342271 0.29 ENST00000434354.2
ENST00000544456.1
ENST00000545574.1
ENST00000420616.2
PEX5
peroxisomal biogenesis factor 5
chr19_+_45971246 0.29 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr5_+_141303461 0.29 ENST00000508751.1
KIAA0141
KIAA0141
chr8_+_22022653 0.27 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1
bone morphogenetic protein 1
chr15_-_75660919 0.27 ENST00000569482.1
ENST00000565683.1
ENST00000561615.1
ENST00000563622.1
ENST00000568374.1
ENST00000566256.1
ENST00000267978.5
MAN2C1
mannosidase, alpha, class 2C, member 1
chr11_-_6495082 0.27 ENST00000536344.1
TRIM3
tripartite motif containing 3
chr7_-_100253993 0.26 ENST00000461605.1
ENST00000160382.5
ACTL6B
actin-like 6B
chrX_-_51239425 0.25 ENST00000375992.3
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr14_-_93582214 0.25 ENST00000556603.2
ENST00000354313.3
ITPK1
inositol-tetrakisphosphate 1-kinase
chr10_+_17271266 0.25 ENST00000224237.5
VIM
vimentin
chr4_-_166034004 0.25 ENST00000505095.1
TMEM192
transmembrane protein 192
chr6_-_35480640 0.24 ENST00000428978.1
ENST00000322263.4
TULP1
tubby like protein 1
chr19_+_41770236 0.23 ENST00000392006.3
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr9_+_131549610 0.22 ENST00000223865.8
TBC1D13
TBC1 domain family, member 13
chr3_-_195808980 0.22 ENST00000360110.4
TFRC
transferrin receptor
chr17_+_6347729 0.21 ENST00000572447.1
FAM64A
family with sequence similarity 64, member A
chr8_+_145065705 0.21 ENST00000533044.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr1_-_204121102 0.21 ENST00000367202.4
ETNK2
ethanolamine kinase 2
chr12_+_7342441 0.20 ENST00000412720.2
ENST00000396637.3
PEX5
peroxisomal biogenesis factor 5
chr6_-_91296602 0.20 ENST00000369325.3
ENST00000369327.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr17_-_71258491 0.19 ENST00000397671.1
CPSF4L
cleavage and polyadenylation specific factor 4-like
chr19_+_41770269 0.18 ENST00000378215.4
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr19_+_41770349 0.18 ENST00000602130.1
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr3_-_195808952 0.18 ENST00000540528.1
ENST00000392396.3
ENST00000535031.1
ENST00000420415.1
TFRC
transferrin receptor
chr6_+_142468361 0.16 ENST00000367630.4
VTA1
vesicle (multivesicular body) trafficking 1
chr1_-_204121298 0.16 ENST00000367199.2
ETNK2
ethanolamine kinase 2
chr15_-_59225758 0.15 ENST00000558486.1
ENST00000560682.1
ENST00000249736.7
ENST00000559880.1
ENST00000536328.1
SLTM
SAFB-like, transcription modulator
chr1_-_48462566 0.14 ENST00000606738.2
TRABD2B
TraB domain containing 2B
chr1_+_17914907 0.14 ENST00000375420.3
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr6_+_30130969 0.13 ENST00000376694.4
TRIM15
tripartite motif containing 15
chr9_-_99382065 0.13 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
CDC14B
cell division cycle 14B
chr9_+_139877445 0.13 ENST00000408973.2
LCNL1
lipocalin-like 1
chr8_-_103668114 0.13 ENST00000285407.6
KLF10
Kruppel-like factor 10
chr2_+_171785012 0.13 ENST00000234160.4
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr15_-_66649010 0.12 ENST00000367709.4
ENST00000261881.4
TIPIN
TIMELESS interacting protein
chr4_-_120548779 0.12 ENST00000264805.5
PDE5A
phosphodiesterase 5A, cGMP-specific
chr18_-_60985914 0.11 ENST00000589955.1
BCL2
B-cell CLL/lymphoma 2
chr4_+_128982416 0.10 ENST00000326639.6
LARP1B
La ribonucleoprotein domain family, member 1B
chr16_+_70148230 0.10 ENST00000398122.3
ENST00000568530.1
PDPR
pyruvate dehydrogenase phosphatase regulatory subunit
chr19_+_10531150 0.10 ENST00000352831.6
PDE4A
phosphodiesterase 4A, cAMP-specific
chr17_-_1029052 0.09 ENST00000574437.1
ABR
active BCR-related
chr5_+_72509751 0.08 ENST00000515556.1
ENST00000513379.1
ENST00000427584.2
RP11-60A8.1
RP11-60A8.1
chr8_+_145065521 0.08 ENST00000534791.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr4_+_152330409 0.07 ENST00000513086.1
FAM160A1
family with sequence similarity 160, member A1
chr5_+_169011033 0.07 ENST00000513795.1
SPDL1
spindle apparatus coiled-coil protein 1
chr15_+_41523417 0.07 ENST00000560397.1
CHP1
calcineurin-like EF-hand protein 1
chr22_+_39853258 0.07 ENST00000341184.6
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr1_-_35658736 0.06 ENST00000357214.5
SFPQ
splicing factor proline/glutamine-rich
chr3_+_196439170 0.05 ENST00000392391.3
ENST00000314118.4
PIGX
phosphatidylinositol glycan anchor biosynthesis, class X
chr15_-_59225844 0.05 ENST00000380516.2
SLTM
SAFB-like, transcription modulator
chr12_-_50101003 0.05 ENST00000550488.1
FMNL3
formin-like 3
chr6_-_91296737 0.05 ENST00000369332.3
ENST00000369329.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr19_-_23941680 0.03 ENST00000402377.3
ZNF681
zinc finger protein 681
chr14_-_93582148 0.03 ENST00000267615.6
ENST00000553452.1
ITPK1
inositol-tetrakisphosphate 1-kinase
chr2_+_12246664 0.03 ENST00000449986.1
AC096559.1
AC096559.1
chr20_-_62475273 0.02 ENST00000596861.1
AL158091.1
Protein LOC100509861
chr6_+_30131318 0.02 ENST00000376688.1
TRIM15
tripartite motif containing 15
chr18_-_5543338 0.01 ENST00000584015.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr1_+_155278625 0.01 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr9_-_99381660 0.01 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B
chr5_-_176057365 0.00 ENST00000310112.3
SNCB
synuclein, beta

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.9 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.6 1.7 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.4 1.5 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.4 2.7 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.4 1.8 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.2 3.4 GO:0021853 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 0.7 GO:0034164 negative regulation of toll-like receptor 9 signaling pathway(GO:0034164)
0.2 0.9 GO:1901091 regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094)
0.2 0.9 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.2 1.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 0.5 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.6 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.1 0.6 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 1.8 GO:0072104 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 0.8 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.1 1.7 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915) locomotion involved in locomotory behavior(GO:0031987)
0.1 2.6 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.1 2.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.4 GO:0072287 metanephric distal tubule morphogenesis(GO:0072287)
0.1 0.6 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.1 0.5 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.1 0.5 GO:0072752 cellular response to rapamycin(GO:0072752)
0.1 0.9 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.1 1.2 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.1 1.3 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 0.8 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 2.1 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 0.6 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.1 0.5 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 0.2 GO:0007500 mesodermal cell fate determination(GO:0007500) negative regulation of intracellular transport of viral material(GO:1901253)
0.0 1.9 GO:0060065 uterus development(GO:0060065)
0.0 0.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 1.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.3 GO:1901911 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 4.0 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.1 GO:1904808 regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808)
0.0 0.3 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 1.4 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.9 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.0 0.9 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0 0.5 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 2.4 GO:0007405 neuroblast proliferation(GO:0007405)
0.0 0.4 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 1.0 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.2 GO:0070307 Bergmann glial cell differentiation(GO:0060020) lens fiber cell development(GO:0070307)
0.0 0.5 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.5 GO:0043586 tongue development(GO:0043586)
0.0 0.7 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 0.7 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.8 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 1.5 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.5 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 0.2 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.5 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.9 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.4 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.3 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.2 1.7 GO:0005955 calcineurin complex(GO:0005955)
0.2 0.8 GO:0032279 asymmetric synapse(GO:0032279)
0.1 4.0 GO:0031143 pseudopodium(GO:0031143)
0.1 4.8 GO:0005921 gap junction(GO:0005921)
0.1 2.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.4 GO:0002133 polycystin complex(GO:0002133)
0.1 2.6 GO:0005685 U1 snRNP(GO:0005685)
0.1 2.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.7 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.7 GO:0071439 clathrin complex(GO:0071439)
0.0 0.6 GO:0043083 synaptic cleft(GO:0043083)
0.0 5.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.5 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.7 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.9 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.4 GO:0071437 invadopodium(GO:0071437)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 1.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.4 1.5 GO:0035939 microsatellite binding(GO:0035939)
0.4 2.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.3 1.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 1.0 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.2 0.9 GO:0032427 GBD domain binding(GO:0032427)
0.2 0.6 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.2 0.9 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.2 0.5 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.2 0.9 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.1 1.3 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 0.8 GO:0070905 serine binding(GO:0070905)
0.1 0.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 2.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.7 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 2.7 GO:0008430 selenium binding(GO:0008430)
0.1 0.6 GO:0070052 collagen V binding(GO:0070052)
0.1 0.6 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 1.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 1.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 4.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.6 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.3 GO:0052725 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.1 0.9 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 2.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.7 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 6.6 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0052844 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.0 0.8 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 1.5 GO:0017166 vinculin binding(GO:0017166)
0.0 0.2 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.5 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.8 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.3 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.5 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.3 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.5 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.3 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 13.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.5 GO:0005504 fatty acid binding(GO:0005504)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 2.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 5.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.2 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.1 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.8 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism