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Illumina Body Map 2, young vs old

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Results for ZNF8

Z-value: 0.31

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Transcription factors associated with ZNF8

Gene Symbol Gene ID Gene Info
ZNF8
ENSG00000083842.8 zinc finger protein 8
ZNF8
ENSG00000273439.1 zinc finger protein 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF8hg19_v2_chr19_+_58790314_58790358-0.355.0e-02Click!

Activity profile of ZNF8 motif

Sorted Z-values of ZNF8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_55652290 1.96 ENST00000589745.1
TNNT1
troponin T type 1 (skeletal, slow)
chr12_-_46662888 0.70 ENST00000546893.1
SLC38A1
solute carrier family 38, member 1
chr22_-_37415475 0.58 ENST00000403892.3
ENST00000249042.3
ENST00000438203.1
TST
thiosulfate sulfurtransferase (rhodanese)
chr4_-_186347099 0.57 ENST00000505357.1
ENST00000264689.6
UFSP2
UFM1-specific peptidase 2
chr12_-_46662772 0.52 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
SLC38A1
solute carrier family 38, member 1
chr9_-_37576226 0.50 ENST00000432825.2
FBXO10
F-box protein 10
chr6_-_26056695 0.49 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr6_-_31763408 0.48 ENST00000444930.2
VARS
valyl-tRNA synthetase
chr1_+_6615241 0.45 ENST00000333172.6
ENST00000328191.4
ENST00000351136.3
TAS1R1
taste receptor, type 1, member 1
chr5_+_10353780 0.45 ENST00000449913.2
ENST00000503788.1
ENST00000274140.5
MARCH6
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
chr17_+_7517264 0.43 ENST00000593717.1
ENST00000572182.1
ENST00000574539.1
ENST00000576728.1
ENST00000575314.1
ENST00000570547.1
ENST00000572262.1
ENST00000576478.1
AC007421.1
SHBG
AC007421.1
sex hormone-binding globulin
chr9_+_96026230 0.41 ENST00000448251.1
WNK2
WNK lysine deficient protein kinase 2
chr17_+_34136459 0.40 ENST00000588240.1
ENST00000590273.1
ENST00000588441.1
ENST00000587272.1
ENST00000592237.1
ENST00000311979.3
TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr8_-_61429315 0.40 ENST00000530725.1
ENST00000532232.1
RP11-163N6.2
RP11-163N6.2
chr8_+_61429416 0.38 ENST00000262646.7
ENST00000531289.1
RAB2A
RAB2A, member RAS oncogene family
chr6_-_116601044 0.38 ENST00000368608.3
TSPYL1
TSPY-like 1
chr17_-_56591978 0.38 ENST00000583656.1
MTMR4
myotubularin related protein 4
chr7_+_100303676 0.37 ENST00000303151.4
POP7
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
chr12_+_104235229 0.36 ENST00000551650.1
RP11-650K20.3
Uncharacterized protein
chr4_+_170541678 0.36 ENST00000360642.3
ENST00000512813.1
CLCN3
chloride channel, voltage-sensitive 3
chr1_-_70671216 0.35 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr7_+_1748798 0.35 ENST00000561626.1
ELFN1
extracellular leucine-rich repeat and fibronectin type III domain containing 1
chr5_-_137911049 0.34 ENST00000297185.3
HSPA9
heat shock 70kDa protein 9 (mortalin)
chr4_+_170541835 0.34 ENST00000504131.2
CLCN3
chloride channel, voltage-sensitive 3
chr1_-_100715372 0.34 ENST00000370131.3
ENST00000370132.4
DBT
dihydrolipoamide branched chain transacylase E2
chr1_+_214161272 0.31 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr2_+_87144738 0.30 ENST00000559485.1
RGPD1
RANBP2-like and GRIP domain containing 1
chr2_-_240322643 0.30 ENST00000345617.3
HDAC4
histone deacetylase 4
chr16_+_21964662 0.30 ENST00000561553.1
ENST00000565331.1
UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr1_-_228296956 0.30 ENST00000366744.1
ENST00000348259.5
ENST00000366747.3
ENST00000366746.3
ENST00000295008.4
ENST00000336520.3
ENST00000366731.5
ENST00000411464.2
ENST00000457264.1
ENST00000336300.5
ENST00000430433.1
ENST00000391867.3
MRPL55
mitochondrial ribosomal protein L55
chr5_+_89854595 0.29 ENST00000405460.2
GPR98
G protein-coupled receptor 98
chr22_+_37415676 0.29 ENST00000401419.3
MPST
mercaptopyruvate sulfurtransferase
chr10_+_135192695 0.29 ENST00000368539.4
ENST00000278060.5
ENST00000357296.3
PAOX
polyamine oxidase (exo-N4-amino)
chr10_+_1034338 0.29 ENST00000360803.4
ENST00000538293.1
GTPBP4
GTP binding protein 4
chr9_-_37576333 0.27 ENST00000541607.1
FBXO10
F-box protein 10
chr6_+_18155560 0.25 ENST00000546309.2
ENST00000388870.2
ENST00000397244.1
KDM1B
lysine (K)-specific demethylase 1B
chr22_+_37415776 0.25 ENST00000341116.3
ENST00000429360.2
ENST00000404393.1
MPST
mercaptopyruvate sulfurtransferase
chr13_+_45563721 0.25 ENST00000361121.2
GPALPP1
GPALPP motifs containing 1
chr22_+_37415728 0.24 ENST00000404802.3
MPST
mercaptopyruvate sulfurtransferase
chr11_+_46638805 0.24 ENST00000434074.1
ENST00000312040.4
ENST00000451945.1
ATG13
autophagy related 13
chr13_-_25861530 0.24 ENST00000540661.1
MTMR6
myotubularin related protein 6
chr17_-_27169745 0.24 ENST00000583307.1
ENST00000581229.1
ENST00000582266.1
ENST00000577376.1
ENST00000577682.1
ENST00000581381.1
ENST00000341217.5
ENST00000581407.1
ENST00000583522.1
FAM222B
family with sequence similarity 222, member B
chr4_+_170541660 0.24 ENST00000513761.1
ENST00000347613.4
CLCN3
chloride channel, voltage-sensitive 3
chr13_+_53029564 0.23 ENST00000468284.1
ENST00000378034.3
ENST00000258607.5
ENST00000378037.5
CKAP2
cytoskeleton associated protein 2
chr12_-_74686314 0.22 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr22_+_37415700 0.22 ENST00000397129.1
MPST
mercaptopyruvate sulfurtransferase
chr10_+_1034646 0.20 ENST00000360059.5
ENST00000545048.1
GTPBP4
GTP binding protein 4
chr11_-_46638720 0.20 ENST00000326737.3
HARBI1
harbinger transposase derived 1
chr3_-_46000146 0.20 ENST00000438446.1
FYCO1
FYVE and coiled-coil domain containing 1
chr17_-_45908875 0.18 ENST00000351111.2
ENST00000414011.1
MRPL10
mitochondrial ribosomal protein L10
chr11_-_46638378 0.17 ENST00000529192.1
HARBI1
harbinger transposase derived 1
chr13_+_21750780 0.17 ENST00000309594.4
MRP63
mitochondrial ribosomal protein 63
chr17_+_48624450 0.17 ENST00000006658.6
ENST00000356488.4
ENST00000393244.3
SPATA20
spermatogenesis associated 20
chr19_-_18392422 0.17 ENST00000252818.3
JUND
jun D proto-oncogene
chr2_-_172290482 0.16 ENST00000442541.1
ENST00000392599.2
ENST00000375258.4
METTL8
methyltransferase like 8
chr20_+_37377085 0.16 ENST00000243903.4
ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr11_+_69455855 0.16 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr3_+_49236910 0.14 ENST00000452691.2
ENST00000366429.2
CCDC36
coiled-coil domain containing 36
chr2_-_105946491 0.13 ENST00000393359.2
TGFBRAP1
transforming growth factor, beta receptor associated protein 1
chr3_-_9994021 0.13 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr7_-_74489609 0.13 ENST00000329959.4
ENST00000503250.2
ENST00000543840.1
WBSCR16
Williams-Beuren syndrome chromosome region 16
chr15_+_85523671 0.12 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr2_-_240322685 0.12 ENST00000544989.1
HDAC4
histone deacetylase 4
chr11_+_13690249 0.10 ENST00000532701.1
FAR1
fatty acyl CoA reductase 1
chr20_-_45179213 0.10 ENST00000279028.2
OCSTAMP
osteoclast stimulatory transmembrane protein
chr17_+_48585794 0.09 ENST00000576179.1
ENST00000419930.1
MYCBPAP
MYCBP associated protein
chrX_+_129535937 0.09 ENST00000305536.6
ENST00000370947.1
RBMX2
RNA binding motif protein, X-linked 2
chr10_-_1034237 0.09 ENST00000381466.1
AL359878.1
Uncharacterized protein
chr5_+_138677515 0.09 ENST00000265192.4
ENST00000511706.1
PAIP2
poly(A) binding protein interacting protein 2
chr1_-_235292250 0.08 ENST00000366607.4
TOMM20
translocase of outer mitochondrial membrane 20 homolog (yeast)
chr19_-_5903714 0.08 ENST00000586349.1
ENST00000585661.1
ENST00000308961.4
ENST00000592634.1
ENST00000418389.2
ENST00000252675.5
AC024592.12
NDUFA11
FUT5
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr2_+_240323439 0.07 ENST00000428471.1
ENST00000413029.1
AC062017.1
Uncharacterized protein
chr12_+_79258547 0.07 ENST00000457153.2
SYT1
synaptotagmin I
chr16_-_53537105 0.06 ENST00000568596.1
ENST00000570004.1
ENST00000564497.1
ENST00000300245.4
ENST00000394657.7
AKTIP
AKT interacting protein
chrX_+_1387693 0.06 ENST00000381529.3
ENST00000432318.2
ENST00000361536.3
ENST00000501036.2
ENST00000381524.3
ENST00000412290.1
CSF2RA
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr4_-_77069573 0.06 ENST00000264883.3
NUP54
nucleoporin 54kDa
chr22_-_30162924 0.05 ENST00000344318.3
ENST00000397781.3
ZMAT5
zinc finger, matrin-type 5
chr10_-_73611046 0.05 ENST00000394934.1
ENST00000394936.3
PSAP
prosaposin
chr1_-_186344802 0.03 ENST00000451586.1
TPR
translocated promoter region, nuclear basket protein
chr17_+_75181292 0.03 ENST00000431431.2
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr12_+_79258444 0.02 ENST00000261205.4
SYT1
synaptotagmin I
chr11_-_61560254 0.02 ENST00000543510.1
TMEM258
transmembrane protein 258
chr2_+_172290707 0.02 ENST00000375255.3
ENST00000539783.1
DCAF17
DDB1 and CUL4 associated factor 17
chr12_+_52463751 0.01 ENST00000336854.4
ENST00000550604.1
ENST00000553049.1
ENST00000548915.1
C12orf44
chromosome 12 open reading frame 44
chr8_+_145064233 0.01 ENST00000529301.1
ENST00000395068.4
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr1_+_186344945 0.01 ENST00000419367.3
ENST00000287859.6
C1orf27
chromosome 1 open reading frame 27

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0009440 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.2 2.0 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.2 0.5 GO:0033341 regulation of collagen binding(GO:0033341)
0.2 0.9 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.3 GO:0090425 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.5 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.1 0.3 GO:0009447 putrescine catabolic process(GO:0009447)
0.1 0.5 GO:0050917 sensory perception of umami taste(GO:0050917)
0.1 0.3 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.5 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:0060629 regulation of homologous chromosome segregation(GO:0060629)
0.0 0.8 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.3 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.0 0.1 GO:0090290 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241) positive regulation of osteoclast proliferation(GO:0090290)
0.0 1.2 GO:0001504 neurotransmitter uptake(GO:0001504)
0.0 0.3 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.1 GO:0035927 RNA import into mitochondrion(GO:0035927)
0.0 0.4 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.2 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.0 0.2 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.5 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 0.0 GO:0045799 negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.4 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 GO:0005861 troponin complex(GO:0005861)
0.1 0.4 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.3 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.5 GO:0000835 ER ubiquitin ligase complex(GO:0000835)
0.0 0.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 0.1 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.2 0.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 2.0 GO:0031014 troponin T binding(GO:0031014)
0.1 0.5 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.1 0.3 GO:0046592 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 0.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 1.2 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.4 GO:0005497 androgen binding(GO:0005497)
0.0 0.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.1 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.4 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.5 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.5 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.6 GO:0016790 thiolester hydrolase activity(GO:0016790)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism