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Illumina Body Map 2: averaged replicates

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Results for ALX1_ARX

Z-value: 1.02

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Transcription factors associated with ALX1_ARX

Gene Symbol Gene ID Gene Info
ENSG00000180318.3 ALX homeobox 1
ENSG00000004848.6 aristaless related homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARXhg19_v2_chrX_-_25034065_250340880.096.3e-01Click!
ALX1hg19_v2_chr12_+_85673868_85673885-0.077.1e-01Click!

Activity profile of ALX1_ARX motif

Sorted Z-values of ALX1_ARX motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_95236551 4.62 ENST00000238558.3
goosecoid homeobox
chr14_+_22631122 4.61 ENST00000390458.3
T cell receptor alpha variable 29/delta variable 5 (gene/pseudogene)
chr3_-_27763803 2.76 ENST00000449599.1
eomesodermin
chr3_-_27764190 2.47 ENST00000537516.1
eomesodermin
chr5_+_96840389 2.39 ENST00000504012.1
RP11-1E3.1
chr1_-_151148492 2.25 ENST00000295314.4
tropomodulin 4 (muscle)
chr1_-_151148442 2.23 ENST00000441701.1
ENST00000416280.2
tropomodulin 4 (muscle)
chr6_-_66417107 2.01 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
eyes shut homolog (Drosophila)
chr3_-_3151664 1.96 ENST00000256452.3
ENST00000311981.8
ENST00000430514.2
ENST00000456302.1
interleukin 5 receptor, alpha
chr12_+_54410664 1.91 ENST00000303406.4
homeobox C4
chr3_-_157824292 1.75 ENST00000483851.2
short stature homeobox 2
chr1_-_92371839 1.30 ENST00000370399.2
transforming growth factor, beta receptor III
chr8_-_57472154 1.25 ENST00000499425.1
ENST00000523664.1
ENST00000518943.1
ENST00000524338.1
long intergenic non-protein coding RNA 968
chr17_+_61151306 1.19 ENST00000580068.1
ENST00000580466.1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chrX_-_19817869 1.18 ENST00000379698.4
SH3-domain kinase binding protein 1
chr3_+_138340049 1.13 ENST00000464668.1
Fas apoptotic inhibitory molecule
chr8_-_57472137 1.11 ENST00000519144.1
long intergenic non-protein coding RNA 968
chr2_-_89160770 1.10 ENST00000390240.2
immunoglobulin kappa joining 3
chr1_+_81106951 1.10 ENST00000443565.1
RP5-887A10.1
chrX_+_107288197 1.09 ENST00000415430.3
V-set and immunoglobulin domain containing 1
chrX_+_107288280 1.08 ENST00000458383.1
V-set and immunoglobulin domain containing 1
chr8_+_86999516 1.07 ENST00000521564.1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr7_-_115799942 1.06 ENST00000484212.1
transcription factor EC
chrX_+_107288239 1.05 ENST00000217957.5
V-set and immunoglobulin domain containing 1
chr2_+_176994408 0.94 ENST00000429017.1
ENST00000313173.4
ENST00000544999.1
homeobox D8
chr10_-_29923893 0.93 ENST00000355867.4
supervillin
chr2_-_89161432 0.93 ENST00000390242.2
immunoglobulin kappa joining 1
chr10_-_75226166 0.91 ENST00000544628.1
protein phosphatase 3, catalytic subunit, beta isozyme
chr2_-_145188137 0.87 ENST00000440875.1
zinc finger E-box binding homeobox 2
chr13_+_74805561 0.83 ENST00000419499.1
long intergenic non-protein coding RNA 402
chr7_+_30589829 0.83 ENST00000579437.1
RP4-777O23.1
chr12_-_57873329 0.80 ENST00000424809.2
Rho GTPase activating protein 9
chr6_-_32908792 0.79 ENST00000418107.2
major histocompatibility complex, class II, DM beta
chr11_-_8964580 0.79 ENST00000325884.1
achaete-scute family bHLH transcription factor 3
chr6_-_32908765 0.79 ENST00000416244.2
major histocompatibility complex, class II, DM beta
chr12_-_53601055 0.77 ENST00000552972.1
ENST00000422257.3
ENST00000267082.5
integrin, beta 7
chr4_-_36245561 0.76 ENST00000506189.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_-_121659052 0.75 ENST00000512105.1
CTD-2544H17.1
chr1_+_170632250 0.75 ENST00000367760.3
paired related homeobox 1
chr7_+_93535817 0.74 ENST00000248572.5
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr8_-_57472049 0.73 ENST00000523786.1
ENST00000521483.1
long intergenic non-protein coding RNA 968
chr12_-_53601000 0.73 ENST00000338737.4
ENST00000549086.2
integrin, beta 7
chr14_-_83262540 0.73 ENST00000554451.1
RP11-11K13.1
chr11_+_128563652 0.73 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chrX_-_15332665 0.72 ENST00000537676.1
ENST00000344384.4
ankyrin repeat and SOCS box containing 11
chr12_-_91546926 0.72 ENST00000550758.1
decorin
chr18_-_44181442 0.71 ENST00000398722.4
lipoxygenase homology domains 1
chr1_-_178838404 0.71 ENST00000444255.1
angiopoietin-like 1
chr2_-_145278475 0.68 ENST00000558170.2
zinc finger E-box binding homeobox 2
chr1_+_206557366 0.67 ENST00000414007.1
ENST00000419187.2
SLIT-ROBO Rho GTPase activating protein 2
chr12_-_57873631 0.65 ENST00000393791.3
ENST00000356411.2
ENST00000552249.1
Rho GTPase activating protein 9
chr2_+_36923830 0.64 ENST00000379242.3
ENST00000389975.3
vitrin
chr1_+_192127578 0.64 ENST00000367460.3
regulator of G-protein signaling 18
chr14_-_52436247 0.62 ENST00000597846.1
HCG2013195; Uncharacterized protein
chr12_+_14572070 0.61 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
activating transcription factor 7 interacting protein
chr2_+_36923933 0.60 ENST00000497382.1
ENST00000404084.1
ENST00000379241.3
ENST00000401530.1
vitrin
chr12_-_89746264 0.57 ENST00000548755.1
dual specificity phosphatase 6
chr6_-_133055896 0.57 ENST00000367927.5
ENST00000425515.2
ENST00000207771.3
ENST00000392393.3
ENST00000450865.2
ENST00000392394.2
vanin 3
chr3_+_151591422 0.57 ENST00000362032.5
succinate receptor 1
chr10_-_50396425 0.54 ENST00000374148.1
chromosome 10 open reading frame 128
chr17_+_44588877 0.54 ENST00000576629.1
leucine rich repeat containing 37, member A2
chr12_-_92539614 0.54 ENST00000256015.3
B-cell translocation gene 1, anti-proliferative
chr16_+_68119247 0.54 ENST00000575270.1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr12_-_89746173 0.53 ENST00000308385.6
dual specificity phosphatase 6
chr8_+_77318769 0.53 ENST00000518732.1
long intergenic non-protein coding RNA 1111
chr19_+_50016610 0.52 ENST00000596975.1
Fc fragment of IgG, receptor, transporter, alpha
chr2_+_119699864 0.52 ENST00000541757.1
ENST00000412481.1
macrophage receptor with collagenous structure
chr16_+_68119324 0.52 ENST00000349223.5
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr16_+_68119440 0.52 ENST00000346183.3
ENST00000329524.4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr10_-_50396407 0.51 ENST00000374153.2
ENST00000374151.3
chromosome 10 open reading frame 128
chr2_+_119699742 0.51 ENST00000327097.4
macrophage receptor with collagenous structure
chr8_-_122653630 0.50 ENST00000303924.4
hyaluronan synthase 2
chr12_+_122241928 0.50 ENST00000604567.1
ENST00000542440.1
SET domain containing 1B
chr4_-_68829226 0.49 ENST00000396188.2
transmembrane protease, serine 11A
chr1_+_186265399 0.49 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
proteoglycan 4
chr14_-_75083313 0.49 ENST00000556652.1
ENST00000555313.1
CTD-2207P18.2
chr16_+_53469525 0.48 ENST00000544405.2
retinoblastoma-like 2 (p130)
chr4_+_69313145 0.48 ENST00000305363.4
transmembrane protease, serine 11E
chr16_+_22518495 0.48 ENST00000541154.1
nuclear pore complex interacting protein family, member B5
chrX_-_11284095 0.47 ENST00000303025.6
ENST00000534860.1
Rho GTPase activating protein 6
chr1_+_186798073 0.47 ENST00000367466.3
ENST00000442353.2
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr6_-_133055815 0.47 ENST00000509351.1
ENST00000417437.2
ENST00000414302.2
ENST00000423615.2
ENST00000427187.2
ENST00000275223.3
ENST00000519686.2
vanin 3
chr9_+_44867571 0.46 ENST00000377548.2
RP11-160N1.10
chr2_-_89161064 0.46 ENST00000390241.2
immunoglobulin kappa joining 2
chr8_+_19759228 0.46 ENST00000520959.1
lipoprotein lipase
chr11_+_108094786 0.45 ENST00000601453.1
ataxia telangiectasia mutated
chr3_-_191000172 0.45 ENST00000427544.2
urotensin 2B
chr2_-_145277882 0.45 ENST00000465070.1
ENST00000444559.1
zinc finger E-box binding homeobox 2
chr10_+_69865866 0.45 ENST00000354393.2
myopalladin
chr2_+_36923901 0.45 ENST00000457137.2
vitrin
chr15_+_42066632 0.45 ENST00000457542.2
ENST00000221214.6
ENST00000260357.7
ENST00000456763.2
mitogen-activated protein kinase binding protein 1
chr10_-_31146615 0.44 ENST00000444692.2
zinc finger protein 438
chr12_-_52946923 0.43 ENST00000267119.5
keratin 71
chr3_+_121774202 0.42 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86 molecule
chr1_+_158978768 0.42 ENST00000447473.2
interferon, gamma-inducible protein 16
chr8_-_6420930 0.40 ENST00000325203.5
angiopoietin 2
chr4_-_143227088 0.40 ENST00000511838.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr12_-_118796910 0.40 ENST00000541186.1
ENST00000539872.1
TAO kinase 3
chr17_-_60885645 0.40 ENST00000544856.2
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr11_-_111649015 0.40 ENST00000529841.1
RP11-108O10.2
chr5_+_137722255 0.39 ENST00000542866.1
lysine (K)-specific demethylase 3B
chr4_-_143226979 0.37 ENST00000514525.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr6_+_34204642 0.36 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
high mobility group AT-hook 1
chrX_+_77166172 0.36 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATPase, Cu++ transporting, alpha polypeptide
chr6_+_15401075 0.35 ENST00000541660.1
jumonji, AT rich interactive domain 2
chr17_+_39261584 0.35 ENST00000391415.1
keratin associated protein 4-9
chr1_+_154401791 0.35 ENST00000476006.1
interleukin 6 receptor
chr11_-_96076334 0.35 ENST00000524717.1
mastermind-like 2 (Drosophila)
chr10_-_50396357 0.35 ENST00000453436.1
ENST00000474718.1
chromosome 10 open reading frame 128
chr4_-_68829144 0.35 ENST00000508048.1
transmembrane protease, serine 11A
chr22_-_30642728 0.35 ENST00000403987.3
leukemia inhibitory factor
chr7_-_55620433 0.35 ENST00000418904.1
vesicular, overexpressed in cancer, prosurvival protein 1
chr9_-_95298254 0.35 ENST00000444490.2
extracellular matrix protein 2, female organ and adipocyte specific
chr17_-_60885659 0.33 ENST00000311269.5
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr10_+_97803151 0.32 ENST00000403870.3
ENST00000265992.5
ENST00000465148.2
ENST00000534974.1
cyclin J
chr17_+_74463650 0.32 ENST00000392492.3
aralkylamine N-acetyltransferase
chr11_-_16419067 0.32 ENST00000533411.1
SRY (sex determining region Y)-box 6
chr3_-_186262166 0.31 ENST00000307944.5
crystallin, gamma S
chr17_-_60885700 0.31 ENST00000583600.1
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr10_-_102989551 0.31 ENST00000370193.2
ladybird homeobox 1
chr17_-_38956205 0.31 ENST00000306658.7
keratin 28
chr6_-_26199499 0.30 ENST00000377831.5
histone cluster 1, H3d
chr12_+_1099675 0.30 ENST00000545318.2
ELKS/RAB6-interacting/CAST family member 1
chr6_-_150067696 0.30 ENST00000340413.2
ENST00000367403.3
nucleoporin 43kDa
chr1_-_178840157 0.29 ENST00000367629.1
ENST00000234816.2
angiopoietin-like 1
chr2_+_58655461 0.29 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
long intergenic non-protein coding RNA 1122
chr5_-_39270725 0.29 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr16_-_21875424 0.29 ENST00000541674.1
nuclear pore complex interacting protein family, member B4
chr12_-_125052010 0.28 ENST00000458234.1
nuclear receptor corepressor 2
chr1_+_62439037 0.28 ENST00000545929.1
InaD-like (Drosophila)
chr3_+_138340067 0.27 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr4_-_119759795 0.27 ENST00000419654.2
SEC24 family member D
chrX_+_11311533 0.27 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
amelogenin, X-linked
chr7_-_33842742 0.25 ENST00000420185.1
ENST00000440034.1
RP11-89N17.4
chr7_+_135710494 0.25 ENST00000440744.2
AC024084.1
chr2_+_54683419 0.25 ENST00000356805.4
spectrin, beta, non-erythrocytic 1
chr18_-_52989217 0.25 ENST00000570287.2
transcription factor 4
chr9_+_135854091 0.24 ENST00000450530.1
ENST00000534944.1
growth factor independent 1B transcription repressor
chrX_+_39868501 0.24 ENST00000447651.1
AC092198.1
chr2_+_29001711 0.24 ENST00000418910.1
protein phosphatase 1, catalytic subunit, beta isozyme
chr6_-_137314371 0.24 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
chr14_+_57671888 0.24 ENST00000391612.1
AL391152.1
chr12_-_15815626 0.24 ENST00000540613.1
epidermal growth factor receptor pathway substrate 8
chr8_-_62602327 0.24 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
aspartate beta-hydroxylase
chr18_-_52989525 0.23 ENST00000457482.3
transcription factor 4
chr3_+_12329358 0.23 ENST00000309576.6
peroxisome proliferator-activated receptor gamma
chr3_+_12329397 0.23 ENST00000397015.2
peroxisome proliferator-activated receptor gamma
chr3_-_101039402 0.22 ENST00000193391.7
interphotoreceptor matrix proteoglycan 2
chr10_-_99030395 0.22 ENST00000355366.5
ENST00000371027.1
Rho GTPase activating protein 19
chr6_-_26199471 0.22 ENST00000341023.1
histone cluster 1, H2ad
chr4_+_76649753 0.22 ENST00000603759.1
USO1 vesicle transport factor
chr11_-_58035732 0.22 ENST00000395079.2
olfactory receptor, family 10, subfamily W, member 1
chrX_+_16668278 0.22 ENST00000380200.3
S100 calcium binding protein G
chr3_-_124774802 0.22 ENST00000311127.4
heart development protein with EGF-like domains 1
chr5_-_59783882 0.22 ENST00000505507.2
ENST00000502484.2
phosphodiesterase 4D, cAMP-specific
chr12_-_118628350 0.22 ENST00000537952.1
ENST00000537822.1
TAO kinase 3
chr14_-_81425828 0.22 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
centrosomal protein 128kDa
chr4_-_103940791 0.22 ENST00000510559.1
ENST00000394789.3
ENST00000296422.7
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr15_-_98836406 0.22 ENST00000560360.1
CTD-2544M6.1
chr5_+_68860949 0.21 ENST00000507595.1
general transcription factor IIH, polypeptide 2C
chr5_-_60411762 0.21 ENST00000594278.1
AC008498.1
chr17_-_71228357 0.21 ENST00000583024.1
ENST00000403627.3
ENST00000405159.3
ENST00000581110.1
family with sequence similarity 104, member A
chr14_-_57197224 0.21 ENST00000554597.1
ENST00000556696.1
Uncharacterized protein
chr5_+_140227357 0.21 ENST00000378122.3
protocadherin alpha 9
chr3_-_195310802 0.21 ENST00000421243.1
ENST00000453131.1
apolipoprotein D
chr14_+_22951993 0.20 ENST00000390485.1
T cell receptor alpha joining 53
chr14_-_78083112 0.20 ENST00000216484.2
serine palmitoyltransferase, long chain base subunit 2
chr2_+_161993465 0.20 ENST00000457476.1
TRAF family member-associated NFKB activator
chr5_+_91378410 0.19 ENST00000507217.1
RP11-348J24.2
chr3_-_32544900 0.19 ENST00000205636.3
CKLF-like MARVEL transmembrane domain containing 6
chrX_+_107037451 0.19 ENST00000372379.2
nuclear cap binding protein subunit 2-like
chr6_-_170893268 0.19 ENST00000538195.1
programmed cell death 2
chr6_-_111804905 0.19 ENST00000358835.3
ENST00000435970.1
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr1_+_244214577 0.18 ENST00000358704.4
zinc finger and BTB domain containing 18
chr9_+_123884038 0.18 ENST00000373847.1
centriolin
chr16_+_24549014 0.18 ENST00000564314.1
ENST00000567686.1
retinoblastoma binding protein 6
chr2_-_145275228 0.18 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
zinc finger E-box binding homeobox 2
chr9_+_88556444 0.18 ENST00000376040.1
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr5_-_134735568 0.18 ENST00000510038.1
ENST00000304332.4
H2A histone family, member Y
chr2_+_161993412 0.18 ENST00000259075.2
ENST00000432002.1
TRAF family member-associated NFKB activator
chr21_-_43346790 0.17 ENST00000329623.7
C2 calcium-dependent domain containing 2
chr1_+_158323755 0.17 ENST00000368157.1
ENST00000368156.1
ENST00000368155.3
ENST00000368154.1
ENST00000368160.3
ENST00000368161.3
CD1e molecule
chr2_-_145275828 0.17 ENST00000392861.2
ENST00000409211.1
zinc finger E-box binding homeobox 2
chr4_+_118955500 0.17 ENST00000296499.5
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr4_-_83769996 0.17 ENST00000511338.1
SEC31 homolog A (S. cerevisiae)
chr12_+_59989918 0.17 ENST00000547379.1
ENST00000549465.1
solute carrier family 16 (monocarboxylate transporter), member 7
chr7_-_93520259 0.17 ENST00000222543.5
tissue factor pathway inhibitor 2
chr15_+_43477580 0.16 ENST00000356633.5
cyclin D-type binding-protein 1
chrX_+_36254051 0.16 ENST00000378657.4
chromosome X open reading frame 30
chr2_+_102413726 0.16 ENST00000350878.4
mitogen-activated protein kinase kinase kinase kinase 4
chr12_-_118628315 0.16 ENST00000540561.1
TAO kinase 3
chr5_+_145826867 0.16 ENST00000296702.5
ENST00000394421.2
transcription elongation regulator 1
chr12_+_10163231 0.16 ENST00000396502.1
ENST00000338896.5
C-type lectin domain family 12, member B
chr1_-_154600421 0.16 ENST00000368471.3
ENST00000292205.5
adenosine deaminase, RNA-specific
chr4_+_95128996 0.16 ENST00000457823.2
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr10_+_97709725 0.16 ENST00000472454.2
Protein LOC100652732
chr6_+_3259122 0.15 ENST00000438998.2
ENST00000380305.4
proteasome (prosome, macropain) assembly chaperone 4
chr2_-_31440377 0.15 ENST00000444918.2
ENST00000403897.3
calpain 14
chr8_-_61880248 0.15 ENST00000525556.1
AC022182.3
chr3_+_130569429 0.15 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATPase, Ca++ transporting, type 2C, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ALX1_ARX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.5 4.6 GO:0014034 neural crest cell fate commitment(GO:0014034)
0.5 1.6 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.4 4.5 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.4 2.0 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.3 1.5 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.3 2.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.3 1.3 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.2 1.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 0.5 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.2 0.7 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.1 1.7 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 0.4 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.5 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.5 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 0.5 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.3 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.4 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.3 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.1 0.5 GO:1904868 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.4 GO:0071284 cellular response to lead ion(GO:0071284)
0.1 1.1 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.4 GO:0002384 hepatic immune response(GO:0002384)
0.1 0.2 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 0.6 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.1 0.4 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 2.0 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.2 GO:0006667 sphinganine metabolic process(GO:0006667)
0.1 2.0 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 0.3 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.9 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 0.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.2 GO:1904815 negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
0.1 1.6 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.1 1.0 GO:0015939 pantothenate metabolic process(GO:0015939)
0.1 0.2 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.1 0.2 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.5 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.4 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.0 0.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.9 GO:0007351 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.5 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.7 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.0 0.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 1.1 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.1 GO:0060166 olfactory pit development(GO:0060166)
0.0 0.4 GO:0072718 response to cisplatin(GO:0072718)
0.0 0.3 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.2 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.7 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.2 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0 0.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.4 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.6 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.6 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 1.0 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.4 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.0 GO:0070781 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.2 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.2 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.3 1.3 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.9 GO:0005955 calcineurin complex(GO:0005955)
0.1 4.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 1.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.4 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.2 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 1.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 2.0 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.9 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.7 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.2 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 0.2 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.7 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587) PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.5 GO:0042627 chylomicron(GO:0042627)
0.0 0.2 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.0 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.9 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0070123 transforming growth factor beta receptor activity, type III(GO:0070123)
0.4 2.0 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.2 1.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.8 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1 0.4 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.1 0.3 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 3.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.5 GO:0017129 triglyceride binding(GO:0017129)
0.1 0.5 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.4 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)
0.1 0.3 GO:0046848 hydroxyapatite binding(GO:0046848)
0.1 5.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 2.7 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.3 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.2 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.9 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 5.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 1.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 0.5 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.5 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.2 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.0 2.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 1.6 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.5 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 2.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0035500 MH2 domain binding(GO:0035500)
0.0 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.7 GO:0005262 calcium channel activity(GO:0005262) calcium ion transmembrane transporter activity(GO:0015085)
0.0 0.2 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.5 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.2 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.1 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.4 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 1.4 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.7 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 2.0 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 5.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 ST STAT3 PATHWAY STAT3 Pathway
0.0 1.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.1 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.7 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 1.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.4 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 2.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.1 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 1.2 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.4 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones