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Illumina Body Map 2: averaged replicates
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Results for ALX3
Z-value: 1.58
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Transcription factors associated with ALX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ALX3 | hg19_v2_chr1_-_110613276_110613322 | 0.04 | 8.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_89161432 Show fit | 15.23 |
ENST00000390242.2
|
immunoglobulin kappa joining 1 |
|
| chr2_-_89161064 Show fit | 15.01 |
ENST00000390241.2
|
immunoglobulin kappa joining 2 |
|
| chr2_-_89160770 Show fit | 11.46 |
ENST00000390240.2
|
immunoglobulin kappa joining 3 |
|
| chr4_-_25865159 Show fit | 4.81 |
ENST00000502949.1
ENST00000264868.5 ENST00000513691.1 ENST00000514872.1 |
sel-1 suppressor of lin-12-like 3 (C. elegans) |
|
| chr7_-_87342564 Show fit | 4.20 |
ENST00000265724.3
ENST00000416177.1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
|
| chr2_+_90077680 Show fit | 4.04 |
ENST00000390270.2
|
immunoglobulin kappa variable 3D-20 |
|
| chr14_-_106494587 Show fit | 3.83 |
ENST00000390597.2
|
immunoglobulin heavy variable 2-5 |
|
| chr14_-_107049312 Show fit | 3.72 |
ENST00000390627.2
|
immunoglobulin heavy variable 3-53 |
|
| chr14_-_106668095 Show fit | 3.66 |
ENST00000390606.2
|
immunoglobulin heavy variable 3-20 |
|
| chr13_-_46742630 Show fit | 3.65 |
ENST00000416500.1
|
lymphocyte cytosolic protein 1 (L-plastin) |
Network of associatons between targets according to the STRING database.
First level regulatory network of ALX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 35.2 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.2 | 26.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.4 | 10.2 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.4 | 8.6 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.8 | 5.8 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.6 | 5.4 | GO:1903961 | positive regulation of anion transmembrane transport(GO:1903961) |
| 0.2 | 5.2 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.8 | 4.8 | GO:0002729 | positive regulation of natural killer cell cytokine production(GO:0002729) |
| 0.7 | 4.8 | GO:0048241 | epinephrine transport(GO:0048241) |
| 1.2 | 3.6 | GO:0071449 | cellular response to lipid hydroperoxide(GO:0071449) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 5.5 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 5.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 5.1 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 4.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 4.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 3.9 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.1 | 3.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.7 | 2.8 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 2.6 | GO:0070821 | tertiary granule membrane(GO:0070821) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.4 | GO:0003823 | antigen binding(GO:0003823) |
| 1.5 | 10.2 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.1 | 8.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 8.6 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.1 | 5.8 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 5.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 5.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 5.0 | GO:0051020 | GTPase binding(GO:0051020) |
| 1.2 | 4.8 | GO:0005277 | acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375) |
| 0.7 | 4.2 | GO:0090554 | phosphatidylcholine-translocating ATPase activity(GO:0090554) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.9 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 5.1 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 4.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 3.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 3.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 3.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.4 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.3 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 2.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.2 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 9.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 9.0 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.2 | 5.8 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.3 | 5.1 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 4.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 3.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 3.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 3.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 3.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |