ISMARA results: ARID5A

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Illumina Body Map 2: averaged replicates

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Results for ARID5A

Z-value: 1.65

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Transcription factors associated with ARID5A

Gene Symbol	Gene ID	Gene Info
ARID5A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000196843.11	AT-rich interaction domain 5A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ARID5A	hg19_v2_chr2_+_97202480_97202499	0.36	4.1e-02	Click!

Activity profile of ARID5A motif

Sorted Z-values of ARID5A motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_217724767 Show fit	4.67	ENST00000236979.2	TNP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	transition protein 1 (during histone to protamine replacement)
chr6_-_49834240 Show fit	3.72	ENST00000335847.4	CRISP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cysteine-rich secretory protein 1
chr6_-_49834209 Show fit	3.63	ENST00000507853.1	CRISP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cysteine-rich secretory protein 1
chr3_-_150421728 Show fit	3.45	ENST00000295910.6 ENST00000491361.1	FAM194A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 194, member A
chr4_-_177116772 Show fit	3.34	ENST00000280191.2	SPATA4 Ensembl NCBI GeneCards UniProt NextProt Show fit	spermatogenesis associated 4
chr1_+_40713573 Show fit	3.20	ENST00000372766.3	TMCO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane and coiled-coil domains 2
chr8_+_24298531 Show fit	3.16	ENST00000175238.6	ADAM7 Ensembl NCBI GeneCards UniProt NextProt Show fit	ADAM metallopeptidase domain 7
chr7_+_142031986 Show fit	2.99	ENST00000547918.2	TRBV7-1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T cell receptor beta variable 7-1 (non-functional)
chr8_+_24298597 Show fit	2.79	ENST00000380789.1	ADAM7 Ensembl NCBI GeneCards UniProt NextProt Show fit	ADAM metallopeptidase domain 7
chr18_-_61329118 Show fit	2.56	ENST00000332821.8 ENST00000283752.5	SERPINB3 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade B (ovalbumin), member 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ARID5A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.8	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
0.1	4.8	GO:2000816	negative regulation of mitotic sister chromatid separation(GO:2000816)
0.7	4.7	GO:0007290	spermatid nucleus elongation(GO:0007290)
0.2	4.7	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	4.2	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2	3.4	GO:0070050	neuron cellular homeostasis(GO:0070050)
1.1	3.3	GO:0044278	cell wall disruption in other organism(GO:0044278)
0.0	3.1	GO:0031295	T cell costimulation(GO:0031295)
0.0	2.9	GO:0016266	O-glycan processing(GO:0016266)
0.9	2.7	GO:0045645	regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)

Showing 1 to 10 of 120 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.6	GO:1904724	tertiary granule lumen(GO:1904724)
0.3	4.9	GO:0000788	nuclear nucleosome(GO:0000788)
0.2	3.4	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	2.8	GO:0035578	azurophil granule lumen(GO:0035578)
0.1	2.3	GO:0097381	photoreceptor disc membrane(GO:0097381)
0.0	1.8	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	1.6	GO:0097225	sperm midpiece(GO:0097225)
0.0	1.6	GO:0008305	integrin complex(GO:0008305)
0.1	1.5	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	1.4	GO:0005901	caveola(GO:0005901)

Showing 1 to 10 of 49 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.8	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	7.8	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1	6.9	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	4.2	GO:0004984	olfactory receptor activity(GO:0004984)
0.2	3.3	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	2.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.9	2.7	GO:0005137	interleukin-5 receptor binding(GO:0005137)
0.1	2.5	GO:0032395	MHC class II receptor activity(GO:0032395)
0.1	2.5	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	2.3	GO:0001530	lipopolysaccharide binding(GO:0001530)

Showing 1 to 10 of 90 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	15.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	8.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.3	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	2.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	2.2	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	1.9	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.5	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	1.3	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	1.3	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	1.3	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.0	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	3.4	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	3.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	2.9	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	2.8	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	2.6	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	2.5	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	2.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	1.6	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	1.6	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall

Showing 1 to 10 of 25 entries

Results for ARID5A

Z-value: 1.65

Motif logo

Transcription factors associated with ARID5A

Activity-expression correlation:

Activity profile of ARID5A motif

Sorted Z-values of ARID5A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ARID5A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: