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Illumina Body Map 2: averaged replicates
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Results for AR_NR3C2
Z-value: 2.49
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Transcription factors associated with AR_NR3C2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| AR | hg19_v2_chrX_+_66764375_66764465 | 0.57 | 6.1e-04 | Click! |
| NR3C2 | hg19_v2_chr4_-_149363376_149363492 | -0.36 | 4.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_+_18287721 Show fit | 16.48 |
ENST00000356524.4
|
serum amyloid A1 |
|
| chr11_+_18287801 Show fit | 16.47 |
ENST00000532858.1
ENST00000405158.2 |
serum amyloid A1 |
|
| chr12_+_53443963 Show fit | 11.95 |
ENST00000546602.1
ENST00000552570.1 ENST00000549700.1 |
tensin like C1 domain containing phosphatase (tensin 2) |
|
| chr12_+_53443680 Show fit | 11.91 |
ENST00000314250.6
ENST00000451358.1 |
tensin like C1 domain containing phosphatase (tensin 2) |
|
| chr16_+_56666563 Show fit | 11.40 |
ENST00000570233.1
|
metallothionein 1M |
|
| chr16_+_56716336 Show fit | 8.54 |
ENST00000394485.4
ENST00000562939.1 |
metallothionein 1X |
|
| chr13_-_40924439 Show fit | 7.98 |
ENST00000400432.3
|
RP11-172E9.2 |
|
| chr1_+_22979474 Show fit | 7.90 |
ENST00000509305.1
|
complement component 1, q subcomponent, B chain |
|
| chr10_+_60759378 Show fit | 7.75 |
ENST00000432535.1
|
long intergenic non-protein coding RNA 844 |
|
| chr18_-_48346415 Show fit | 7.59 |
ENST00000431965.2
ENST00000436348.2 |
maestro |
Network of associatons between targets according to the STRING database.
First level regulatory network of AR_NR3C2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 33.0 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.6 | 19.9 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 2.4 | 19.2 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 1.9 | 15.6 | GO:0036018 | cellular response to erythropoietin(GO:0036018) |
| 0.1 | 13.2 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.5 | 8.7 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.5 | 6.4 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.4 | 6.4 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.8 | 5.0 | GO:0042695 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 1.6 | 4.7 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 41.3 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 1.0 | 33.0 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 23.2 | GO:0005730 | nucleolus(GO:0005730) |
| 0.7 | 19.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 3.0 | 15.2 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.1 | 8.2 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 7.5 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 7.4 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.6 | 6.4 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 5.0 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 33.0 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 23.2 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.2 | 19.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 16.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 8.7 | GO:0017022 | myosin binding(GO:0017022) |
| 0.4 | 7.0 | GO:0046870 | cadmium ion binding(GO:0046870) |
| 0.0 | 5.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 4.6 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.0 | 4.4 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 4.2 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 33.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 15.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 7.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 6.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 5.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 4.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 3.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 33.0 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 1.1 | 15.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 6.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 3.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 3.1 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 2.6 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 2.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 2.0 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 1.9 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |