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Illumina Body Map 2: averaged replicates
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Results for BACH1_NFE2_NFE2L2
Z-value: 3.18
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Transcription factors associated with BACH1_NFE2_NFE2L2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000156273.11 | BTB domain and CNC homolog 1 | |
| ENSG00000123405.9 | nuclear factor, erythroid 2 | |
| ENSG00000116044.11 | nuclear factor, erythroid 2 like 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFE2L2 | hg19_v2_chr2_-_178128149_178128198 | -0.58 | 4.9e-04 | Click! |
| BACH1 | hg19_v2_chr21_+_30672433_30672464 | -0.08 | 6.8e-01 | Click! |
| NFE2 | hg19_v2_chr12_-_54691668_54691725 | -0.07 | 7.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH1_NFE2_NFE2L2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 30.1 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.8 | 15.6 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 14.8 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.9 | 13.5 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.6 | 13.3 | GO:0043562 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 13.2 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.8 | 10.8 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.0 | 10.2 | GO:0032259 | methylation(GO:0032259) |
| 1.5 | 9.0 | GO:0070541 | response to platinum ion(GO:0070541) |
| 0.6 | 8.9 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 19.2 | GO:0031430 | M band(GO:0031430) |
| 0.3 | 14.1 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.5 | 13.5 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 11.7 | GO:0000502 | proteasome complex(GO:0000502) |
| 0.8 | 9.9 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 9.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.4 | 9.0 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 8.7 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 7.6 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 15.6 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 15.4 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 14.6 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.2 | 13.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.5 | 13.5 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.7 | 12.6 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.3 | 11.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.3 | 9.0 | GO:0004325 | ferrochelatase activity(GO:0004325) |
| 1.8 | 9.0 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 2.1 | 8.6 | GO:0004362 | glutathione-disulfide reductase activity(GO:0004362) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 24.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 23.6 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.1 | 15.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 10.0 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 9.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.6 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.1 | 3.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 3.7 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 3.3 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.3 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.4 | 23.9 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.5 | 13.5 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.4 | 13.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.3 | 11.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.5 | 9.0 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 8.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.7 | 7.9 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.1 | 7.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 6.9 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |