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Illumina Body Map 2: averaged replicates
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Results for BARHL2
Z-value: 1.46
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Transcription factors associated with BARHL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BARHL2 | hg19_v2_chr1_-_91182794_91182860 | 0.06 | 7.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.5 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 2.4 | 7.1 | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
| 0.5 | 6.5 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.4 | 6.5 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 5.6 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 5.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 5.2 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.1 | 5.0 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 4.7 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 4.6 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 10.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 9.8 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 9.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 8.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.5 | 7.2 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 7.0 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 6.9 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.2 | 4.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 4.6 | GO:0031045 | dense core granule(GO:0031045) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 7.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.8 | 7.1 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.0 | 6.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 5.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.7 | 5.7 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.2 | 5.1 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 5.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.5 | 3.5 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 3.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 7.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 6.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 5.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 4.3 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.0 | 3.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 3.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 2.1 | PID SHP2 PATHWAY | SHP2 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 7.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 5.8 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 5.4 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 5.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.3 | 4.6 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 3.6 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 3.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 2.6 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 2.5 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |