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Illumina Body Map 2: averaged replicates
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Results for CEBPA
Z-value: 3.73
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Transcription factors associated with CEBPA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPA | hg19_v2_chr19_-_33793430_33793470 | 0.49 | 4.5e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 42.9 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.1 | 37.1 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 1.1 | 28.0 | GO:0008228 | opsonization(GO:0008228) |
| 1.1 | 26.4 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 5.0 | 25.1 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.6 | 24.8 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 1.7 | 18.3 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 0.2 | 17.8 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 17.7 | GO:2000257 | regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257) |
| 0.9 | 16.0 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 107.1 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.3 | 71.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 39.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 30.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.2 | 29.3 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.6 | 24.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.9 | 20.3 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 2.0 | 18.2 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 17.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.2 | 16.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 66.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 38.9 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.2 | 28.7 | GO:0002020 | protease binding(GO:0002020) |
| 0.2 | 27.6 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.6 | 22.3 | GO:0001848 | complement binding(GO:0001848) |
| 0.4 | 20.2 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 2.9 | 17.4 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 1.7 | 15.6 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 2.8 | 13.8 | GO:0033265 | choline binding(GO:0033265) |
| 4.4 | 13.1 | GO:0004397 | histidine ammonia-lyase activity(GO:0004397) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 41.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 27.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 26.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 16.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.4 | 16.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 14.6 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 13.0 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.2 | 10.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 10.4 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.3 | 9.6 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 47.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.5 | 26.1 | REACTOME DEFENSINS | Genes involved in Defensins |
| 1.3 | 24.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.5 | 22.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.7 | 22.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 20.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.6 | 20.1 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 1.2 | 16.4 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.5 | 14.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 10.6 | REACTOME AMYLOIDS | Genes involved in Amyloids |