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Illumina Body Map 2: averaged replicates
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Results for CEBPB
Z-value: 2.61
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Transcription factors associated with CEBPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPB | hg19_v2_chr20_+_48807351_48807384 | 0.31 | 8.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 24.9 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 1.4 | 14.1 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.7 | 11.7 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 2.3 | 11.3 | GO:1904640 | response to methionine(GO:1904640) |
| 1.5 | 10.6 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 0.9 | 10.4 | GO:0001554 | luteolysis(GO:0001554) |
| 1.6 | 7.8 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
| 2.6 | 7.7 | GO:0015920 | lipopolysaccharide transport(GO:0015920) |
| 0.3 | 7.0 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.3 | 6.5 | GO:2000194 | regulation of female gonad development(GO:2000194) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 15.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.4 | 14.1 | GO:0070552 | BRISC complex(GO:0070552) |
| 1.0 | 13.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 12.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 11.0 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.5 | 10.8 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 9.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.4 | 7.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 6.2 | GO:0072562 | blood microparticle(GO:0072562) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 14.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.4 | 14.1 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 11.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 3.0 | 9.1 | GO:0004611 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 0.1 | 9.0 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.4 | 8.8 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.9 | 7.8 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.9 | 7.7 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
| 1.1 | 7.6 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 17.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 16.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 12.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 11.1 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 9.9 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.1 | 9.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 7.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 7.4 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.2 | 4.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 16.8 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.6 | 15.6 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 11.9 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 10.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.5 | 9.1 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.4 | 9.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.5 | 8.8 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 7.5 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.1 | 6.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 5.4 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |